The specific long term objectives for the Kidney and Disease Research Network are to:
- Elucidate key mechanisms of renal epithelial and endothelial cell damage following injury by different agents or mediators
- Elucidate the genetic and cellular processes that lead to irreversible fibrosis or repair
- Define new targets for intervention in the pathways leading to cell injury and death
This knowledge will lead to more focused interventions that will reduce the rapidly increasing incidence of chronic kidney disease and the need for renal replacement therapy (dialysis and transplantation).