A role for plasminogen receptors and serotonin in Lp(a) catabolism?

Elevated levels of lipoprotein(a) [Lp(a)] are associated with multiple forms of cardiovascular disease. There are currently several drugs in phase 3 clinical trials aimed at reducing the synthesis of Lp(a). An alternative approach to lowering Lp(a) is to promote its uptake and clearance from circulation. However, the receptors responsible for Lp(a) uptake in the liver are not well established. Here I will present our studies showing a role for plasminogen receptors in promoting Lp(a) uptake in liver cells. I will discuss some of the compounds we have found that upregulate plasminogen-receptor-mediated Lp(a) uptake, including the serotonin-based antidepressants, and present follow-up studies that are currently underway.