Research Professor Christopher J Charles

2024

Journal - Research Article

Le, Z., Shou, Y., Li, R. R., Liu, L., Tan, R., Charles, C. J., … Tay, A. (2024). Sponge-like microneedles spatially sequester chemokines and deplete monocytes to alleviate inflammatory skin disorders. Advanced Functional Materials. Advance online publication. doi: 10.1002/adfm.202402539

Le, Z., Ramos, M. C., Shou, Y., Li, R. R., Cheng, H. S., Jang, C. J. M., … Charles, C. J., … Tay, A. (2024). Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors. Biomaterials, 311, 122700. doi: 10.1016/j.biomaterials.2024.122700

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Espiner, E. A., Richards, A. M., & Rademaker, M. T. (2024). Haemodynamic, hormonal and renal actions of osteocrin in normal sheep. Experimental Physiology. Advance online publication. doi: 10.1113/EP091826

Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028

2023

Journal - Research Article

Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015

Tian, X., Zeng, Q., Kurt, S. A., Li, R. R., Nguyen, D. T., Xiong, Z., … Charles, C. J., & Ho, J. S. (2023). Implant-to-implant wireless networking with metamaterial textiles. Nature Communications, 14, 4335. doi: 10.1038/s41467-023-39850-2

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure, 11(2), 227-239. doi: 10.1016/j.jchf.2022.11.006

Lim, X. C., Huang, C., Yatim, S. M. J. M., Chong, S. Y., Tan, S. H., Yang, X., … Richards, A. M., Charles, C. J., … Wang, J.-W. (2023). Temporal changes in extracellular vesicle hemostatic protein composition predict favourable left ventricular remodeling after acute myocardial infarction. International Journal of Molecular Sciences, 24, 327. doi: 10.3390/ijms24010327

2022

Journal - Research Article

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models. Frontiers in Bioengineering & Biotechnology, 10, 1032034. doi: 10.3389/fbioe.2022.1032034

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Lee, L. C., Leo, H. L., & Yap, C. H. (2022). Morphological, functional, and biomechanical progression of LV remodelling in a porcine model of HFpEF. Journal of Biomechanics, 144, 111348. doi: 10.1016/j.jbiomech.2022.111348

Zheng, Y., Chan, W. X., Charles, C. J., Richards, A. M., Sampath, S., Ali, A. A. B., … Yap, C. H. (2022). Effects of hypertrophic and dilated cardiac geometric remodeling on ejection fraction. Frontiers in Physiology, 13, 898775. doi: 10.3389/fphys.2022.898775

Ong, C. W., Kumar, G. P., Zuo, K., Koh, L. B., Charles, C. J., Ho, P., … Cui, F. (2022). A novel coating method to reduce membrane infolding through pre-crimping of covered stents: Computational and experimental evaluation. Computers in Biology & Medicine, 145, 105524. doi: 10.1016/j.compbiomed.2022.105524

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Weissmann, J., Charles, C. J., Richards, A. M., Yap, C. H., & Marom, G. (2022). Cardiac mesh morphing method for finite element modeling of heart failure with preserved ejection fraction. Journal of the Mechanical Behavior of Biomedical Materials, 126, 104937. doi: 10.1016/j.jmbbm.2021.104937

Lu, Y., Cui, X., Zhang, L., Wang, X., Xu, Y., Qin, Z., … Lim, K. S., Charles, C. J., … Tang, J. (2022). The functional role of lipoproteins in atherosclerosis: Novel directions for diagnosis and targeting therapy. Aging & Disease, 13(2), 491-520. doi: 10.14336/AD.2021.0929

Journal - Research Other

Li, D., Tian, K., Guo, J., Wang, Q., Qin, Z., Lu, Y., … Scott, N., Charles, C. J., … Cui, X., & Tang, J. (2022). Growth factors: Avenues for the treatment of myocardial infarction and potential delivery strategies. Regenerative Medicine, 17(8), 561-579. doi: 10.2217/rme-2022-0007

Conference Contribution - Published proceedings: Abstract

Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009

2021

Journal - Research Article

Kalidasan, V., Yang, X., Xiong, Z., Li, R. R., Yao, H., Godaba, H., … Charles, C. J., & Ho, J. S. (2021). Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds. Nature Biomedical Engineering, 5(10), 1217-1227. doi: 10.1038/s41551-021-00802-0

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Conference Contribution - Published proceedings: Abstract

Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020

2020

Journal - Research Article

Charles, C. J., Li, R. R., Yeung, T., Mazlan, S. M. I., Lai, R. C., de Kleijn, D. P. V., … Richards, A. M. (2020). Systemic mesenchymal stem cell-derived exosomes reduce myocardial infarct size: Characterization with MRI in a porcine model. Frontiers in Cardiovascular Medicine, 7, 601990. doi: 10.3389/fcvm.2020.601990

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Ibraham Mazlan, S. M., Tay, Z. W., … Richards, A. M. (2020). A porcine model of heart failure with preserved ejection fraction: Magnetic resonance imaging and metabolic energetics. ESC Heart Failure, 7, 93-103. doi: 10.1002/ehf2.12536

Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192

Journal - Research Other

Charles, C. J., Rademaker, M. T., Scott, N. J. A., & Richards, A. M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals, 10, 1906. doi: 10.3390/ani10101906

2019

Journal - Research Article

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Lee, P., Li, R. R., Yeung, T., Mazlan, S. M. I., Tay, Z. W., … Richards, A. M. (2019, September). A porcine model of heart failure with preserved ejection fraction: Characterization with MRI metabolic energetics. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513

Conference Contribution - Poster Presentation (not in published proceedings)

Mbikou, P. P., Pemberton, C. J., Charles, C. J., & Rademaker, M. T. (2018, August). Characterising the role and the therapeutic potential of novel peptide DWORF in heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Chapter in Book - Research

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Journal - Research Article

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

2016

Journal - Research Article

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Conference Contribution - Poster Presentation (not in published proceedings)

Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August-September). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Charles, C. J., & Siriwardena, M. (2016). Cardiovascular therapeutics. [Marker reference: BNPTx] (2012 8 0050843.1). China.

2015

Journal - Research Article

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011

Charles, C. J., Rademaker, M. T., Melton, I. C., Gutfinger, D., Eigler, N. L., Qu, F., & Troughton, R. W. (2015). Thoracic impedance measures tissue characteristics in the vicinity of the electrodes, not intervening lung water: Implications for heart failure monitoring. Journal of Clinical Monitoring & Computing, 29(1), 65-76. doi: 10.1007/s10877-014-9570-x

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J. (2015, August-September). Heart hormones: Physiology as the key link between discovery and translation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Charles, C. J. (2015, August-September). How do natriuretic peptides alter sympathetic control to the heart? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Rademaker, M. T., Charles, C. J., & Richards, M. (2014). Sheep for the study of the urocortins and other hormones. Cardiovascular Endocrinology, 3(1), 39-43. doi: 10.1097/XCE.0000000000000024

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013

Conference Contribution - Published proceedings: Abstract

Wong, L. L., Lew, K. S., Chen, Q., Rademaker, M. T., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2014). Identification of microRNA in an ovine model of heart failure. Circulation, 130(Suppl. 2), A16470. [Abstract]

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Systemic angiotensin II does not increase cardiac sympathetic nerve activity in conscious sheep. Endocrine Reviews, 35(3, Suppl.), MON-0865. Retrieved from http://press.endocrine.org/series/endo-meetings

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. (2014, November). Snaring, wiring and pacing hearts: Sheep models unravelling cardiovascular disease. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

2013

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Journal - Research Article

Trainor, K. E., Roberts, A., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Comparative pathology of an implantable left atrial pressure sensor. ASAIO Journal, 59(5), 486-492. doi: 10.1097/MAT.0b013e31829bdffd

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205

Roberts, A., Trainor, K. E., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor. Journal of Histotechnology, 36(1), 17-27. doi: 10.1179/2046023613Y.0000000021

Conference Contribution - Published proceedings: Abstract

Siriwardena, M., Charles, C. J., Byers, M., Richards, A. M., & Pemberton, C. J. (2013). BNP signal peptide is protective in ischaemia reperfusion injury. Heart, Lung & Circulation, 22(7), (pp. 578-579). doi: 10.1016/j.hlc.2013.04.074

2012

Journal - Research Article

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Haemodynamic, endocrine and renal actions of adrenomedullin 5 in an ovine model of heart failure. Clinical Science, 122(9), 429-437. doi: 10.1042/cs20110483

Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Rademaker, M. T., Jardine, D. L., Chan, W., Ellmers, L. J., Troughton, R. W., & Richards, A. M. (2012). Urocortin 2: Neurohumoral mechanisms in heart disease. Heart, Lung & Circulation, 21(12), (pp. 863). doi: 10.1016/j.hlc.2012.08.033

Charles, C. J., Jardine, D. L., & Richards, A. M. (2012). B-type natriuretic peptide at non hypotensive doses raises cardiac sympathetic nerve activity in sheep. Proceedings of the Medical Sciences Congress (MedSci). (pp. 29). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Chan, W., Jardine, D., Butler, J., Charles, C., Troughton, R., & Richards, M. (2012). Urocortin-2 increases muscle sympathetic nerve activity (MSNA) in healthy man. Heart, Lung & Circulation, 21(8), (pp. 482). doi: 10.1016/j.hlc.2012.03.022

2011

Journal - Research Article

Rademaker, M. T., Charles, C. J., Nicholls, G., & Richards, M. (2011). Urocortin 2 sustains haemodynamic and renal function during introduction of beta-blockade in experimental heart failure. Journal of Hypertension, 29, 1787-1795. doi: 10.1097/HJH.0b013e3283493776

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4

Charles, C. J. (2011). Update on apelin peptides as putative targets for cardiovascular drug discovery. Expert Opinion on Drug Discovery, 6(6), 633-644. doi: 10.1517/17460441.2011.571251

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2011). Hemodynamic, hormonal, and renal actions of adrenomedullin-5 in normal conscious sheep. Journal of Cardiovascular Pharmacology, 58(1), 25-31. doi: 10.1097/FJC.0b013e31821a9473

Rademaker, M. T., Charles, C. J., Melton, I. C., Richards, A. M., Frampton, C. M., Siou, J., … Troughton, R. W. (2011). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Clinical Science, 120(5), 207-217. doi: 10.1042/CS20100388

Conference Contribution - Published proceedings: Abstract

Ellmers, L. J., Richards, M. A., Charles, C. J., & Rademaker, M. T. (2011). (Pro)renin receptor blockade improves cardiac function and reduces ventricular remodeling following myocardial infarction in mice. European Heart Journal, 32(Suppl. 1), (pp. 693). doi: 10.1093/eurheartj/ehr324

Charles, C., Rademaker, M., Melton, I., Siou, J., Shah, R., Qu, F., … Troughton, R. (2011). New discoveries regarding the limitations of impedance monitoring for heart failure management. Journal of Cardiac Failure, 17(8, Suppl. 1), (pp. S99). doi: 10.1016/j.cardfail.2011.06.332

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2010

Journal - Research Article

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2010). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Peptides, 31, 878-882. doi: 10.1016/j.peptides.2010.02.010

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505

Conference Contribution - Poster Presentation (not in published proceedings)

Bhandari, S., Charles, C. J., Miller, A. P., Scott-Thomas, A., Syhre, M., & Chambers, S. T. (2010, September). Cyclophosphamide pulmonary toxicity limiting sheep model of immunosuppression. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M., Charles, C., Melton, I., Richards, M., Frampton, C., Siou, J., … Troughton, R. (2010, November-December). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2009

Journal - Research Article

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation: Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2009). Sympathoinhibitory actions of the urocortin peptides suggest therapeutic potential in acute cardiac injury. Clinical Autonomic Research. 19(5), (pp. 284). doi: 10.1007/s10286-009-0030-5

Prickett, T. C., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Regional sampling and effects of glucocorticoids: Differential responses in A, B and C-type natriuretic peptides in growing lambs. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

2008

Journal - Research Article

Charles, C. J. (2008). The apelin peptides as putative targets in cardiovascular drug discovery and development. Expert Opinion on Drug Discovery, 3(1), 51-64. doi: 10.1517/17460441.3.1.51

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure. Circulation: Heart Failure, 1, 134-142. doi: 10.1161/circheartfailure.107.755504

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60.

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure. Clinical Science, 114(10), 635-642. doi: 10.1042/CS20070364

Charles, C. J., Katafuchi, T., Yandle, T. G., & Minamino, N. (2008). Identification and biological activity of ovine and caprine calcitonin receptor-stimulating peptides 1 and 2. Journal of Endocrinology, 198(2), 429-437. doi: 10.1677/JOE-08-0106

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2008). Sympathoinhibitory actions of the urocortins suggest therapeutic potential in acute cardiac injury. Proceedings of the 2nd Cardiovascular Control Conference. CCC. Retrieved from http://cccindia08.florey.edu.au/India08%20Abstracts.pdf

Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal and renal actions of adrenomedullin 2 in experimental heart failure. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S807-S808). [Abstract]

Charles, C., Jardine, D., Nicholls, G., Rademaker, M., & Richards, M. (2008). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Heart, Lung & Circulation, 17(Suppl. 1), (pp. S1). doi: 10.1016/j.hlc.2007.11.002

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2008, November). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Charles, C. (2008, October). ″Sympathetic scientist gets hormonal about hearts″: Hearts, hormones and cardiac sympathetic drive in animal models of normal health and cardiac injury. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.

2007

Journal - Research Article

Charles, C. J. (2007). Putative role for apelin in pressure/volume homeostasis and cardiovascular disease. Cardiovascular & Hematological Agents in Medicinal Chemistry, 5, 1-10.

Rademaker, M. T., Charles, C. J., & Richards, A. M. (2007). Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 293, H1536-H1544. doi: 10.1152/ajpheart.00377.2007

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep. Clinical Science, 112, 485-491.

Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart & Circulatory Physiology, 293, H433-H439. doi: 10.1152/ajpheart.01262.2006

Chambers, S. T., Pithie, A., Gallagher, K., Liu, T., Charles, C. J., & Seaward, L. (2007). Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: Efficacy in a sheep model. Journal of Antimicrobial Chemotherapy, 59, 779-782.

Conference Contribution - Published proceedings: Abstract

Khoury, D. S., Naware, M., . . ., Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Physiologic monitoring of congestive heart failure by multiple impedance vectors. Heart Rhythm. 4(5 (Suppl. S)), (pp. S393). [Abstract]

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 inhibits cardiac sympathetic nerve activity in normal conscious sheep. Endocrine Journal. 54(Suppl.), (pp. 194). [Abstract]

Jardine, D. L., & Charles, C. J. (2007). The immediate effects of IV beta-blockade on cardiac sympathetic nerve activity in the conscious sheep model. Clinical Autonomic Research. 17, (pp. 277). [Abstract]

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S35). [Abstract]

Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S8). [Abstract]

Charles, C. J., Rademaker, M. T., Yandle, T. G., & Richards, A. M. (2007). Arterio-venous trans-organ sampling in normal and heart failure sheep: Determining the source of circulating hormones. Endocrine Journal. 54(Suppl.), (pp. 80). [Abstract]

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulant sheep. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 145). doi: 10.1016/S1567-4215(07)60405-6

Khoury, D., Naware, M., Siou, J., Gutfinger, D., Eigler, N., Ohlander, M., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Heart failure trending by multiple-vector impedance. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S129). doi: 10.1016/j.cardfail.2007.06.498

Nabutovsky, Y., Naware, M., Siou, J., Pillai, A., Illindala, U., Holmstrom, N., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Pilot investigation of cardiogenic impedance during heart failure induction using a new prototype ICD. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S123). doi: 10.1016/j.cardfail.2007.06.478

Charles, C. J., Jardine, D. L., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 154). doi: 10.1016/S1567-4215(07)60431-7

Conference Contribution - Poster Presentation (not in published proceedings)

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007, July). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Poster session presented at the FASEB Summer Research Conferences, Sydney, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007, November). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Charles, C. (2007, August). Adrenomedullins. Verbal presentation at the Cardiac Society of Australia and New Zealand 55th Annual Scientific Meeting, Christchurch, New Zealand.

2006

Journal - Research Article

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep. Endocrinology, 147(4), 1871-1877.

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098.

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure. Peptides, 27, 1801-1805.

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. Journal of Endocrinology, 189(3), 701-710.

Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019

Journal - Research Other

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). [Response to the letter regarding Article by Rademaker et al, ″Integrated hemodynamic, hormonal, and renal actions of Urocortin 2 in normal and paced sheep: Beneficial effects in heart failure″]. Circulation, 113. Retrieved from http://www.circ.ahajournals.org/cgi/content/full/113/15/e710

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2006). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

2005

Journal - Research Article

Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2005). Urotensin II: Evidence for cardiac, hepatic and renal production. Peptides, 26, 2211-2214. doi: 10.1016/j.peptides.2005.03.043

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Journal of Endocrinology, 187, 275-281.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351

Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308

Jardine, D. L., Charles, C. J., Ashton, R. K., Bennett, S. I., Whitehead, M., Frampton, C. M., & Nicholls, M. G. (2005). Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model. Journal of Physiology, 565(1), 325-333. doi: 10.1113/jphysiol.2004.082198

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin in heart failure: Potential therapeutic implications. Future Cardiology, 1(2), 235-243.

Conference Contribution - Published proceedings: Abstract

Rademaker, M. T., Charles, C. J., Cameron, V. A., & Richards, A. M. (2005). Urocortin 2 has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. The Journal of Heart Disease. 4(1), (pp. 129). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005, October). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Verbal presentation at the 16th International Symposium on the Autonomic Nervous System, Los Cabos, Mexico.

Jardine, D. L., Charles, C. J., & Nicholls, M. G. (2005, October). Cardiac sympathetic nerve activity ″at the death″. Verbal presentation at the 16th International Symposium on the Autonomic Nervous System, Los Cabos, Mexico.

Charles, C. J. (2005, December). Adrenomedullins: Integrative physiological studies indicate a role in pressure-volume homeostasis and in heart disease [Invited]. Verbal presentation at the 2nd Medical Sciences Congress: Genome to therapy, Queenstown, New Zealand.

2004

Journal - Research Article

Charles, C. J., Rademaker, M. T., & Richards, A. M. (2004). Urocortins: Putative role in cardiovascular disease. Current Medicinal Chemistry: Cardiovascular & Hematological Agents, 2, 43-47.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576.

Richards, A. M., & Charles, C. (2004). Urotensin II in the cardiovascular system. Peptides, 25(10), 1795-1802. doi: 10.1016/j.peptides.2004.04.017

Conference Contribution - Published proceedings: Abstract

Charles, C., Rademaker, M., Richards, M., & Nicholls, G. (2004). Potential for targeting adrenomedullin mechanisms in heart failure. Journal of Molecular & Cellular Cardiology, 37(S37E), (pp. 345). doi: 10.1016/j.yjmcc.2004.05.003

Rademaker, M., Charles, C., Espiner, E., Lainchbury, J., Nicholls, G., & Richards, M. (2004). Chronic urocortin administration in experimental heart failure. Proceedings of the 12^th International Congress of Endocrinology. (pp. 174-175). [Abstract]

2003

Journal - Research Article

Rademaker, M. T., Cameron, V. A., Charles, C. J., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2003). Adrenomedullin and heart failure. Regulatory Peptides, 112(1-3), 51-60.

Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Nicholls, M. G. (2003). A neural mechanism for sudden death after myocardial infarction. Clinical Autonomic Research, 13, 339-341.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2003). Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep. Clinical Science, 104(4), 429-436.

Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135

Charles, C. J., Lainchbury, J. G., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Troughton, R. W. (2003). Adrenomedullin and the renin-angiotensin-aldosterone system. Regulatory Peptides, 112(1-3), 41-49.

2002

Journal - Research Article

Jardine, D., Charles, C. J., Melton, I., May, C. N., Forrester, M. D., Frampton, C. M., … Ikram, H. (2002). Continual recordings of cardiac sympathetic nerve activity in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 282, H93-H99.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2002). Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep. Journal of Endocrinology, 173(1), 123-129.

Conference Contribution - Published proceedings: Abstract

Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2002). Urocortin has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. Abstracts presented at the Joint Meeting of the 19th Scientific Meeting of the International Society of Hypertension and the 12th European Meeting on Hypertension. 20(supplement), (pp. P1300). Prague, Czech Republic: Lippincott Williams & Wilkins Healthcare. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002, November). Chronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

Charles, C. J., Jardine, D. L., & Nicholls, M. G. (2002). Cardiac sympathetic nerve activity in conscious sheep: Effect of myocardial infarction. Verbal presentation at the Xth World Congress of Cardiology, Sydney, Australia.

Jardine, D. L., Charles, C. J., Brennan, R. K., Frampton, C. M., & Nicholls, M. G. (2002). Cardiac sympathetic nerve activity during myocardial infarction. Verbal presentation at the 13th International Symposium on the Autonomic Nervous System, Hilton Head Island, USA.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). hronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

2001

Journal - Research Article

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Comparative actions of adrenomedullin and nitroprusside: Interactions with ANG II and norepinephrine. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 281(6), R1887-R1894.

Aitken, G. D., Cameron, V. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Increased atrial but not ventricular ANP and BNP expression in a paced model of heart failure. Journal of Biochemistry, Molecular Biology & Biophysics, 5, 199-207.

Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2001). Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep. Journal of Endocrinology, 171(2), 363-371.

Conference Contribution - Published proceedings: Abstract

Espiner, E. A., Cameron, A. V., Charles, C., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Yandle, T. (2001). The endocrine heart. Proceedings of the New Zealand Endocrine Society Annual Meeting. (pp. A43). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Ikram, H. (2001). The neural mechanism for sudden cardiac death. Verbal presentation at the The Sympathetic Nervous System in Disease: Official Satellite to IUPS, Christchurch.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Charles, C. J., Jardine, D., Forrester, M. D., & Nicholls, M. G. (2001). Continuous recording of cardiac sympathetic nerve activity in conscious sheep. Verbal presentation at the International Society for Heart Research Australasian Meeting: Models in Cardiovascular Research, Brisbane.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Andrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001, August). Adrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.

2000

Journal - Research Article

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. Journal of Cardiovascular Pharmacology, 36, 526-532.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Myocardial infarction with and without reperfusion in sheep: Early cardiac and neurohumoral changes. Clinical Science, 98, 703-711.

Smith, M. W., Espiner, E. A., Yandle, T. G., Charles, C. J., & Richards, A. M. (2000). Delayed metabolism of human brain natriuretic peptide reflects resistance to neutral endopeptidase. Journal of Endocrinology, 167(2), 239-246.

Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. 11th International Congress of Endocrinology. 36. [Abstract]

Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2000). Interactions of adrenomedullin with incremental infusions of angiotensin II and norepinephrine in conscious sheep; comparison with nitroprusside. Proceedings of 11th International Congress of Endocrinology. (pp. 985). Sydney. [Abstract]

Charles, C. J., Rademaker, M. T., & Nicholls, M. G. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. 18th Scientific Meeting of the International Society of Hypertension. (pp. 3). Chicago. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.

Troughton, R. W., McGregor, D. O., Charles, C. J., Lewis, L. K., Yandle, T., Richards, A. M., & Nicholls, M. G. (2000). Biological effects of adrenomedullin infusion in healthy volunteers, essential hypertension and chronic renal failure. Verbal presentation at the 2nd International Symposium on Adrenomedullin and PAMP, Japan.

Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Queensland.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October/November). Combined adrenomedullin administration and neutral endopeptidase inhibition in heart failure. Verbal presentation at the 11 th International Congress of Endocrinology, Sydney.

1999

Journal - Research Article

Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Bioactivity of natriuretic peptide coinfusions: no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology, 33(2), 229-236.

Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173.

Conference Contribution - Published proceedings: Abstract

Troughton, R. W., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Nicholls, M. G. (1999). Acute and chronic administration of Omapatrilat in an ovine model in mild and severe heart failure. 72nd Scientific Sessions, American Heart Foundation. (pp. I-300). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999, August). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress on Heart Disease, Washington DC, USA.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Acute and chronic administration of omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 47th Annual Meeting Cardiac Society of Australia and New Zealand, Wellington, New Zealand.

Jardine, D. L., Charles, C. J., Forrester, M. D. E., Bennett, S. I., Melton, I. C., & May, C. N. (1999). Continuous recordings of efferent cardiac sympathetic nerve activity in ambulant sheep. Verbal presentation at the 47th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Wellington, New Zealand.

Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress in Heart Disease, Washington DC, USA.

1998

Journal - Research Article

Charles, C. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1998). Arginine vasopressin V1 receptor antagonism in an ovine model of acute myocardial infarction. Journal of Cardiovascular Pharmacology, 32(5), 777-782.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1998). Combined neutral endopeptidase and angiotensin-converting enzyme inhibition in heart failure: role of natriuretic peptides and angiotensin II. Journal of Cardiovascular Pharmacology, 31(1), 116-125.

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208.

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (1998). Hemodynamic, hormonal and renal effects of intracerebroventricular adrenomedullin in conscious sheep. Endocrinology, 139(4), 1746-1751. doi: 10.1210/endo.139.4.5862

Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: bioactivity at low physiological levels. Clinical Science, 95(6), 701-708.

Conference Contribution - Published proceedings: Abstract

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Natriuretic peptides and endothelin on an ovine coronary artery ligation model of mild heart failure. 80th Annual Endocrine Society Meeting Programme. (A326). [Abstract]

Charles, C. J., Espiner, E. A., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: Bioactivity at low physiological levels. Journal of Hypertension. 16(Suppl. 2), (pp. S143). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Netriuretic peptides and endothelin un an ovine coronary ligation model of mild heart failure. Verbal presentation at the Endo '98, New Orleans.

Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998, November). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the American Heart Association Meeting, Atlanta, USA.

Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin in heart failure. Verbal presentation at the Centre of Excellence International Symposium on Adrenomedullin and PAMP, Osaka, Japan.

1997

Journal - Research Article

Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., Jing, N. N., & Nicholls, M. G. (1997). Hemodynamic, hormonal, and renal effects of adrenomedullin in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 272(6 pt.2), R2040-R2047.

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. L. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Clinical & Experimental Pharmacology & Physiology, 24(11), 807-813.

Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1997). Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 273(5 pt.2), H2372-H2379.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (1997). Comparative bioactivity of atrial and brain natriuretic peptides in an ovine model of heart failure. Clinical Science, 92(2), 159-165.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.

Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550.

Ikram, H., Rogers, S. J., Charles, C. J., Sands, J., Richards, A. M., Bridgman, P. G., & Gooneratne, R. (1997). An ovine model of acute myocardial infarction and chronic left ventricular dysfunction. Angiology, 48(8), 679-688. doi: 10.1177/000331979704800803

Charles, C. J., Rogers, S. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1997). Hypothalamo-pituitary-adrenal axis response to coronary artery embolization: An ovine model of acute myocardial infarction. Journal of Endocrinology, 152(3), 489-493.

Journal - Research Other

Begg, E. J., Nicholls, M. G., Rademaker, M. T., & Charles, C. J. (1997). Pharmacokinetics of adrenomedullin in a sheep model of heart failure. Proceedings of ASCEPT, 3, 34.

Conference Contribution - Published proceedings: Abstract

Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1997). Biological effects of intracerebroventricular adrenomedullin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract]

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. The Journal of Heart Failure. 4(1), (pp. 74). [Abstract]

Charles, C. J., Rogers, S. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1997). Hypothalamo-pituitary-adrenal axis response in an ovibe model of acute myocardial infarction. Journal of Heart Failure. 4, (pp. 14). [Abstract]

Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (1997). Biological effects of intracerebroventricular adrenomedulin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract]

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Proceedings of the 32nd Annual Meeting of Australian and New Zealand Society of Nephrology. 51, (pp. 1308). [Abstract]

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin in heart failure. Verbal presentation at the 1st International Symposium on Adrenomedullin and PAMP, Osaka.

Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibiting natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.

Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997, June). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Verbal presentation at the 8th European Society of Hypertension, Milan.

Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibitory natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.

1996

Journal - Research Article

Charles, C. J., Espiner, E. A., Richards, A. M., Yandle, T. G., Nicholls, M. G., Protter, A., & Kosoglou, T. (1996). Clearance receptors and endopeptidase 24.11: equal role in natriuretic peptide metabolism in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 271, R373-R380.

Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Charles, C. J., Rademaker, M. T., Lynn, K. L., … Lewis, L. K., & Yandle, T. G. (1996). Chronic ouabain infusion does not cause hypertension in sheep. American Journal of Physiology: Endocrinology & Metabolism, 270(3), E386-E392.

Charles, C. J., Kaaja, R. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptides in sheep with pressure overload left venticular hypertrophy. Clinical & Experimental Hypertension, 18(8), 1051-1071.

Rademaker, M. T., Fitzpatrick, M. A., Richards, A. M., Charles, C. J., Nicholls, M. G., Frampton, C. M., & Ikram, H. (1996). Nitric oxide inhibition in an ovine model of heart failure. Clinical & Experimental Pharmacology & Physiology, 23, 403-409.

Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Sybertz, E. (1996). Comparison of chronic neutral endopeptidase inhibition and furosemide in an ovine model of heart failure. Journal of Cardiovascular Pharmacology, 27(3), 439-446.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1996). Neural endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure. Clinical Science, 91, 283-291.

Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptide responses to acute and chronic ventricular pacing in sheep: evidence for differential secretion of ANP and BNP. American Journal of Physiology: Heart & Circulatory Physiology, 270, H594-H600.

Charles, C. J., Espiner, E. A., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1996). Comparative bioactivity of a trial, brain and C-type natriuretic peptides in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 270, R1324-R1331.

1995

Journal - Research Article

Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Espiner, E. A. (1995). Central angiotensin II AT1-receptor antagonism in normal and heart failed sheep. American Journal of Physiology: Heart & Circulatory Physiology, 269, H425-H432.