Research Professor
Email chris.pemberton@otago.ac.nz
Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand
Current roles
- Director, Translational Biodiscovery Laboratory, Christchurch Heart Institute
- Named Investigator on the current Christchurch Heart Institute HRC Programme grant.
- Principal Investigator on HRC, MBIE and WADA funded signal peptide projects
- Research Professor, Department of Medicine
Research interests
- Novel protein/peptide biomarker identification and measurement
- Cardioendocrine signalling in the circulation and heart tissue
- Ex vivo study of novel cardiovascular diagnostic and therapeutic agents
- Commercialisation of biomedical technologies
Awards and professional memberships
- 2012- Research Commercialisation – Strategic and Implementation Committee, Division of Health Sciences.
- 2012- Corresponding Member, Canterbury, NZ Society of Endocrinology
- 2011 Health Research Council of New Zealand Liley Medal
- 2011- European Society for Cardiology, Working Group on Cellular Biology of the Heart
- 2010- American Association of Clinical Chemistry
- 2007-11 Health Research Council of New Zealand Sir Charles Hercus Fellowship
- 2006-2009 Treasurer, Executive Committee Member, NZ Society of Endocrinology
Publications
Montecillo, J., Troughton, R., Pemberton, C., & Chew-Harris, J. (2024). Removal of glycosylation improves performance of soluble urokinase Plasminogen Activator Receptor (suPAR) levels for acute decompensated heart failure diagnosis. Heart, Lung & Circulation, 33(Suppl. 2), O03. doi: 10.1016/S1443-9506(24)00653-X Conference Contribution - Published proceedings: Abstract
Pickering, J. W., Kavsak, P., Christenson, R. H., Troughton, R. W., Pemberton, C. J., Richards, A. M., Joyce, L., & Than, M. P. (2024). Determination of clinically acceptable analytical variation of cardiac troponin at decision thresholds. Clinical Chemistry, hvae059. Advance online publication. doi: 10.1093/clinchem/hvae059 Journal - Research Article
Montecillo, J., Pirker, T., Pemberton, C., & Chew-Harris, J. (2024). suPAR in cardiovascular disease. In Advances in clinical chemistry. Elsevier. doi: 10.1016/bs.acc.2024.04.005 Chapter in Book - Research
Greer, C. E., Chew-Harris, J., Adamson, P. D., Pemberton, C. J., Pickering, J. W., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Doughty, R. N., & Richards, A. M. (2024). Convalescent growth differentiation factor-15 and long-term outcomes after an acute coronary syndrome. Journal of Applied Laboratory Medicine, jfae032. Advance online publication. doi: 10.1093/jalm/jfae032 Journal - Research Article
Chew-Harris, J., Frampton, C., Greer, C., Appleby, S., Pickering, J. W., Kuan, W. S., … Adamson, P. D., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2024). Prognostic performance of soluble urokinase plasminogen activator receptor for heart failure or mortality in Western and Asian patients with acute breathlessness. International Journal of Cardiology, 406, 132071. doi: 10.1016/j.ijcard.2024.132071 Journal - Research Article
2024
Chapter in Book - Research
Montecillo, J., Pirker, T., Pemberton, C., & Chew-Harris, J. (2024). suPAR in cardiovascular disease. In Advances in clinical chemistry. Elsevier. doi: 10.1016/bs.acc.2024.04.005
Journal - Research Article
Pickering, J. W., Kavsak, P., Christenson, R. H., Troughton, R. W., Pemberton, C. J., Richards, A. M., Joyce, L., & Than, M. P. (2024). Determination of clinically acceptable analytical variation of cardiac troponin at decision thresholds. Clinical Chemistry, hvae059. Advance online publication. doi: 10.1093/clinchem/hvae059
Greer, C. E., Chew-Harris, J., Adamson, P. D., Pemberton, C. J., Pickering, J. W., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Doughty, R. N., & Richards, A. M. (2024). Convalescent growth differentiation factor-15 and long-term outcomes after an acute coronary syndrome. Journal of Applied Laboratory Medicine, jfae032. Advance online publication. doi: 10.1093/jalm/jfae032
Chew-Harris, J., Frampton, C., Greer, C., Appleby, S., Pickering, J. W., Kuan, W. S., … Adamson, P. D., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2024). Prognostic performance of soluble urokinase plasminogen activator receptor for heart failure or mortality in Western and Asian patients with acute breathlessness. International Journal of Cardiology, 406, 132071. doi: 10.1016/j.ijcard.2024.132071
Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Verryt, T., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. Journal of Applied Laboratory Medicine. Advance online publication. doi: 10.1093/jalm/jfae001
Appleby, S., Aitken-Buck, H. M., Holdaway, M. S., Byers, M. S., Frampton, C. M., Paton, L. N., Richards, A. M., Lamberts, R. R., & Pemberton, C. J. (2024). Cardiac effects of myoregulin in ischemia-reperfusion. Peptides, 174, 171156. doi: 10.1016/j.peptides.2024.171156
Conference Contribution - Published proceedings: Abstract
Montecillo, J., Troughton, R., Pemberton, C., & Chew-Harris, J. (2024). Removal of glycosylation improves performance of soluble urokinase Plasminogen Activator Receptor (suPAR) levels for acute decompensated heart failure diagnosis. Heart, Lung & Circulation, 33(Suppl. 2), O03. doi: 10.1016/S1443-9506(24)00653-X
2023
Journal - Research Article
Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082
Doudesis, D., Lee, K. K., Boeddinghaus, J., Bularga, A., Ferry, A. V., Tuck, C., … Pickering, J. W., Than, M. P., … CoDE-ACS Investigators, including Richards, A. M., Pemberton, C., Troughton, R. W., & Aldous, S. J. (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29, 1201-1210. doi: 10.1038/s41591-023-02325-4
Neumann, J. T., Twerenbold, R., Ojeda, F., Aldous, S. J., Allen, B. R., Apple, F. S., … Pickering, J. W., Pemberton, C. J., … Richards, A. M., … Than, M. P., … Troughton, R. W., … the ARTEMIS study group. (2023). Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology, 112, 1288-1301. doi: 10.1007/s00392-023-02206-3
Koh, H. W. L., Pilbrow, A. P., Tan, S. H., Zhao, Q., Benke, P. I., Burla, B., … Pickering, J. W., Troughton, R., Pemberton, C., … Richards, A. M., & Chan, M. Y. (2023). An integrated signature of extracellular matrix proteins and a diastolic function imaging parameter predicts post-MI long-term outcomes. Frontiers in Cardiovascular Medicine, 10, 1123682. doi: 10.3389/fcvm.2023.1123682
Tan, E. S. J., Chan, S.-P., Choi, Y. C., Pemberton, C. J., Troughton, R., Poppe, K., … Richards, A. M. (2023). Regional handling and prognostic performance of circulating insulin-like growth factor binding protein-7 in heart failure. JACC: Heart Failure, 11(6), 662-674. doi: 10.1016/j.jchf.2023.01.016
Conference Contribution - Published proceedings: Abstract
Montecillo, J., Pirker, T., Richards, M., Pemberton, C., & Chew-Harris, J. (2023). Protein glycosylation influences soluble urokinase Plasminogen Activator Receptor (suPAR) measurements. Heart, Lung & Circulation, 32(Suppl. 2), P16. doi: 10.1016/j.hlc.2023.04.237
Pirker, T., Keys, T., Pham, T., Montecillo, J., Byers, M., Pemberton, C., Richards, M., & Chew-Harris, J. (2023). Soluble urokinase Plasminogen Activator Receptor (suPAR) promotes cardioprotective intracellular signalling in myocardial ischaemia. Heart, Lung & Circulation, 32(Suppl. 2), O02. doi: 10.1016/j.hlc.2023.04.208
2022
Journal - Research Article
Eggers, K. M., Hammarsten, O., Aldous, S. J., Cullen, L., Greenslade, J., Lindahl, B., … Pemberton, C. J., Pickering, J. W., Richards, A. M., Troughton, R. W., & Than, M. P. (2022). Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain. PLoS ONE, 17(11), e0276645. doi: 10.1371/journal.pone.0276645
Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126
Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424
Conference Contribution - Published proceedings: Abstract
Chew-Harris, J., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Appleby, S., Frampton, C., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2022). Comparative performances of soluble urokinase plasminogen activator receptor and Mid-regional proADM to predict composite death and new heart failure rehospitalisation in acutely breathless patients. European Heart Journal, 43(Suppl. 2), (pp. 1087). doi: 10.1093/eurheartj/ehac544.1087
Keys, T., Chew-Harris, J., Pemberton, C., Adamson, P., Troughton, R., Doughty, R., & Richards, A. M. (2022). Soluble urokinase plasminogen activator receptor predicts mortality and adverse cardiovascular outcomes following acute coronary syndrome. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S28-S29). doi: 10.1016/j.hlc.2022.05.020
Lewis, L., Raudsepp, S., Whitlow, J., Appleby, S., Pemberton, C., & Richards, A. M. (2022). Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays? European Heart Journal, 43(Suppl. 1), (pp. i76). doi: 10.1093/eurheartj/ehab849.060
Other Research Output
Pemberton, C. (2022, September). Caterpillars, coronaries and COVID: A career spent testing boundaries. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture].
2021
Journal - Research Article
Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206
Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7
Poh, K. K., Shabbir, A., Ngiam, J. N., Lee, P. S. S., So, J., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2021). Plasma clearance of B-type natriuretic peptide (BNP) before and after bariatric durgery for morbid obesity. Clinical Chemistry, 67(4), 662-671. doi: 10.1093/clinchem/hvaa308
Journal - Research Other
Richards, A. M., & Pemberton, C. J. (2021). Progress in proteomic probing for pathogenic pathways in heart failure with preserved ejection fraction. European Journal of Heart Failure, 23, 1645-1647. doi: 10.1002/ejhf.2332
Richards, A. M., & Pemberton, C. J. (2021). Urinary peptides in heart failure: The need for care with pees and cues. European Journal of Heart Failure, 23, 1888-1890. doi: 10.1002/ejhf.2269
Conference Contribution - Published proceedings: Abstract
Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044
Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S85-S86). doi: 10.1016/j.hlc.2021.05.070
Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Prognostic performance of soluble urokinase plasminogen activator receptor (suPAR) in predicting mortality in Asian and Western patients with acute breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.070
Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in patients with acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.069
2020
Journal - Research Article
Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158
Harris, S. L., Troughton, R., Lewis, L., Austin, N., & Pemberton, C. (2020). Circulating forms of B-type natriuretic peptide in very preterm infants. Journal of Applied Laboratory Medicine, 5(3), 506-515. doi: 10.1093/jalm/jfaa003
Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009
Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001
Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2020). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure, 22, 692-700. doi: 10.1002/ejhf.1660
Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192
Journal - Research Other
Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Pemberton, C. J., & Richards, A. M. (2020). ProBNP processing is decreased by obesity in patients with heart failure. Annals of Translational Medicine, 8(4), 135. doi: 10.21037/atm.2019.12.81
Conference Contribution - Published proceedings: Abstract
Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1695). doi: 10.1093/ehjci/ehaa946.1695
Chew-Harris, J., Appleby, S., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., … Frampton, C., Troughton, R. W., … Richards, A. M., & Pemberton, C. J. (2020). Prognostic performance of soluble urokinase plasminogen activator receptor for 1-year mortality in Asian and Western patients with acute breathlessness. European Heart Journal, 41(Suppl. 2), (pp. 1202). doi: 10.1093/ehjci/ehaa946.1202
Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1696). doi: 10.1093/ehjci/ehaa946.1696
Lewis, L., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Richards, A. M., Prickett, T. C. R., … Pemberton, C. J. (2020). ProBNP glycosylation of threonine 71 is increased with obesity in patients with heart failure. European Heart Journal, 41(Suppl. 1), ehz872.007. doi: 10.1093/ehjci/ehz872.007
2019
Journal - Research Article
Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084
Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010
Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry, 65(9), 1115-1124. doi: 10.1373/clinchem.2019.302547
Journal - Research Other
Richards, A. M., Pemberton, C., & Yandle, T. (2019). How does neprilysin inhibition in heart failure work? European Journal of Heart Failure, 21(5), 606-608. doi: 10.1002/ejhf.1454
Conference Contribution - Published proceedings: Abstract
Pemberton, C. J., Lee, J. A., Aldous, S., Appleby, S., Chew-Harris, J., Than, M., Troughton, R. W., & Richards, A. M. (2019). The signal peptide of CNP is a novel predictor of MI, MACE and bleeding risk in chest pain patients. European Heart Journal, 40(Suppl. 1), (pp. 2029). doi: 10.1093/eurheartj/ehz745.0283
Chew-Harris, J. S., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Soluble urokinase plasminogen activator receptor (suPAR) predicts 1 year mortality in patients with acute breathlessness. European Heart Journal, 40(Suppl. 1), (pp. 1573). doi: 10.1093/eurheartj/ehz748.0939
Pemberton, C. J., Lee, J. A., Aldous, S., Skelton, L., Frampton, C. M., Than, M., Troughton, R. W., Adamson, P., & Richards, A. M. (2019). The protein APRIL predicts adverse outcomes in DAPT patients better than NT-proBNP and troponin. European Heart Journal, 40(Suppl. 1), (pp. 1052). doi: 10.1093/eurheartj/ehz748.0509
Aldous, S., Pickering, J., Young, J., George, P., Watson, A., Troughton, R., Pemberton, C., Richards, M., … Than, M. (2019). Rapid rule-out of myocardial infarction with a novel high precision point-of-care troponin assay appears safe and effective. European Heart Journal, 40(Suppl. 1), (pp. 1626). doi: 10.1093/eurheartj/ehz748.0992
2018
Journal - Research Article
Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368
Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1
Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700
van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003
Harris, S. L., More, K., Dixon, B., Troughton, R., Pemberton, C., Horwood, J., Ellis, N., & Austin, N. (2018). Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus. European Journal of Pediatrics, 177(4), 521-532. doi: 10.1007/s00431-018-3089-y
Arrigo, M., Vodovar, N., Nougué, H., Sadoune, M., Pemberton, C. J., Ballan, P., … Mebazaa, A. (2018). The heart regulates the endocrine response to heart failure: Cardiac contribution to circulating neprilysin. European Heart Journal, 39(20), 1794-1798. doi: 10.1093/eurheartj/ehx679
Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343
Conference Contribution - Published proceedings: Abstract
Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Circulation, 138(Suppl. 1), A11125. [Abstract]
Appleby, S., Chew-Harris, J., Troughton, R., Richards, M., & Pemberton, C. (2018). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Circulation, 138(Suppl. 1), A11094. [Abstract]
Pemberton, C. J., Lee, J. A., Jardine, R., Skelton, L., Frampton, C. M., Troughton, R. W., Richards, A. M., on behalf of Christchurch Heart Institute. (2018). The TNF receptor TACI is a novel inflammatory predictor of heart failure. European Heart Journal, 39(Suppl. 1), (pp. 576-577). doi: 10.1093/eurheartj/ehy565.P2791
Nanayakkara, S., Pemberton, C., Patel, H., Vizi, D., Mak, V., Richards, A. M., … Kaye, D. M. (2018). Mid regional atrial natriuretic peptide is an independent predictor of peak pulmonary capillary wedge pressure in patients with heart failure with preserved ejection fraction. European Heart Journal, 39(Suppl. 1), (pp. 222). doi: 10.1093/eurheartj/ehy565.1096
Conference Contribution - Poster Presentation (not in published proceedings)
Mbikou, P. P., Pemberton, C. J., Charles, C. J., & Rademaker, M. T. (2018, August). Characterising the role and the therapeutic potential of novel peptide DWORF in heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018, August). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Chapter in Book - Research
Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4
Journal - Research Article
Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562
Liebetrau, C., Gaede, L., Wolter, J. S., Homann, J., Meyer, A., Dörr, O., … Richards, A. M., & Pemberton, C. J. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers, 22(3-4), 304-310. doi: 10.1080/1354750X.2016.1252965
Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612
Journal - Research Other
Laribi, S., Pemberton, C. J., Kirwan, L., Nouira, S., Turkdogan, K., Yilmaz, M. B., Troughton, R. W., … Richards, M., … on behalf of the GREAT (Global Research on Acute Conditions Team) Network. (2017). Mortality and acute exacerbation of COPD: A pilot study on the influence of myocardial injury. European Respiratory Journal, 49(6), 1700096. doi: 10.1183/13993003.00096-2017
Pemberton, C. (2017). Prognostic outcomes in patients with heart failure: A new SuPAR biomarker for risk prediction? JACC: Heart Failure, 5(4), 278-279. doi: 10.1016/j.jchf.2017.02.009
Conference Contribution - Poster Presentation (not in published proceedings)
Aitken-Buck, H. M., Appleby, S., Pemberton, C. J., & Lamberts, R. R. (2017, September). Myoregulin has no effect on contraction or relaxation of isolated rat hearts. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Pilbrow, A. P., Runesson, A. S. D., Sommer, M. A. W., Jones, G. T., Frampton, C. M., Pemberton, C. J., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2017, September). Using microRNAs to predict heart disease events in the general population. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Intellectual Property
Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2017). Biomarkers. [Marker reference: INSDx] (9,630,985). United States.
2016
Journal - Research Article
Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015
Cullen, L., Greenslade, J. H., Menzies, L., Leong, A., Than, M., Pemberton, C., Aldous, S., Pickering, J., … Parsonage, W. A. (2016). Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emergency Medicine Journal, 33, 390-395. doi: 10.1136/emermed-2015-204978
Conference Contribution - Poster Presentation (not in published proceedings)
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August-September). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Intellectual Property
Pemberton, C. J., Richards, A. M., Charles, C. J., & Siriwardena, M. (2016). Cardiovascular therapeutics. [Marker reference: BNPTx] (2012 8 0050843.1). China.
2015
Journal - Research Article
Lee, J., Than, M., Aldous, S., Troughton, R., Richards, M., & Pemberton, C. J. (2015). CNP signal peptide in patients with cardiovascular disease. Frontiers in Cardiovascular Medicine, 2, 28. doi: 10.3389/fcvm.2015.00028
Liebetrau, C., Gaede, L., Dörr, O., Blumenstein, J., Rosenburg, S., Hoffmann, J., … Richards, A. M., & Pemberton, C. J. (2015). Reference values and release kinetics of B-type natriuretic peptide signal peptide in patients with acute myocardial infarction. Clinical Chemistry, 61(12), 1532-1539. doi: 10.1373/clinchem.2015.244327
Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145
Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J. H., Aldous, S., Reichlin, T., … Troughton, R., Pemberton, C. J., Richards, A. M., … Than, M., & Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184C, 208-215. doi: 10.1016/j.ijcard.2015.02.006
Conference Contribution - Published proceedings: Abstract
Pemberton, C. J., Lee, J., Than, M., Pickering, J. W., Troughton, R. W., & Richards, M. (2015). Can copeptin assist the diagnosis of acute kidney injury in breathless patients? European Heart Journal, 36(Suppl. 1), (pp. 800). doi: 10.1093/eurheartj/ehv400
Liebetrau, C., Doerr, O. D., Gaede, L. G., Berkowitsch, A. B., Troidl, C. T., Hamm, C. H., … Richards, A. M., & Pemberton, C. J. (2015). Release kinetics of B-type natriuretic peptide signal peptide (BNPsp) in patients with acute myocardial infarction. European Heart Journal, 36(Suppl. 1), (pp. 71). doi: 10.1093/eurheartj/ehv398
Menzies, L., Cullen, L., Greenslade, J., Leong, A., Than, M., Pemberton, C., Aldous, S., Pickering, J., … Parsonage, W. (2015). The association of delay in presentation and 12-month health outcomes in emergency patients with symptoms of possible acute coronary syndromes. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S167-S168). doi: 10.1016/j.hlc.2015.06.134
Fitzsimons, S., Troughton, R., Gamble, G., Pemberton, C., Devlin, G., Lund, M., Richards, M., & Doughty, R. (2015). High prevalence of iron deficiency in heart failure with preserved ejection fraction. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S78). doi: 10.1016/j.hlc.2015.04.070
Arshad, M., Richards, M., Pemberton, C., & Troughton, R. (2015). Routine measurement of NT-proBNP and post-discharge clinical outcomes: Initial findings from a randomised controlled trial. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S94). doi: 10.1016/j.hlc.2015.04.109
2014
Journal - Research Article
Pemberton, C. J. (2014). Signal peptides: New markers in cardiovascular disease? Biomarkers in Medicine, 8(8), 1013-1019. doi: 10.2217/bmm.14.64
Pemberton, C. J., Siriwardena, M., Kleffmann, T., & Richards, A. M. (2014). C-type natriuretic peptide (CNP) signal peptide fragments are present in the human circulation. Biochemical & Biophysical Research Communications, 449, 301-306. doi: 10.1016/j.bbrc.2014.05.020
Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435
Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019
Conference Contribution - Verbal presentation and other Conference outputs
Pemberton, C. (2014, November). Hunting the Snark: New peptides to measure in the circulation. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.
2013
Chapter in Book - Other
Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Pemberton, C. J., & Kleffmann, T. (2013). Circulating signal peptides: More than just a bus ticket? Cardiovascular Endocrinology, 2(3), 41-45. doi: 10.1097/XCE.0b013e328362e44e
Greenslade, J. H., Cullen, L., Than, M., Aldous, S., Chu, K., Brown, A. F. T., Richards, A. M., Pemberton, C. J., George, P., & Parsonage, W. A. (2013). Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: A prospective cohort study. American Journal of Emergency Medicine, 31(7), 1103-1107. doi: 10.1016/j.ajem.2013.04.016
Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078
Greenslade, J. H., Cullen, L., Kalinowski, L., Parsonage, W., Palmer, S., Aldous, S., Richards, M., … Troughton, R., Pemberton, C., & Than, M. (2013). Examining renal impairment as a risk factor for acute coronary syndrome: A prospective observational study. Annals of Emergency Medicine, 62(1), 38-46. doi: 10.1016/j.annemergmed.2013.01.011
Conference Contribution - Published proceedings: Abstract
Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., … Richards, M., Pemberton, C. J., Than, M., on behalf of the Emergency Cardiology Group. (2013). Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation. European Heart Journal, 34(Suppl. 1), (pp. 86). doi: 10.1093/eurheartj/eht307.P484
Siriwardena, M., Charles, C. J., Byers, M., Richards, A. M., & Pemberton, C. J. (2013). BNP signal peptide is protective in ischaemia reperfusion injury. Heart, Lung & Circulation, 22(7), (pp. 578-579). doi: 10.1016/j.hlc.2013.04.074
Conference Contribution - Poster Presentation (not in published proceedings)
Byers, M. S., Bailey, M., Siriwardena, M., Lewis, L. K., Oliver, J., Troughton, R., Richards, A. M., & Pemberton, C. J. (2013, August). Plasma ghrelin signal peptide can exclude co-existent pneumonia in acute decompensated heart failure. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Pemberton, C., Chase, G., & Willmott, G. (2013, June). Collaborating for Success: Point of care diagnostics. Verbal presentation at the Healthcare Congress: Future of Healthcare in New Zealand, Auckland, New Zealand.
Pemberton, C. J., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2013, August). BNP signal peptide in the diagnosis of acute coronary syndromes. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Intellectual Property
Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2013). Biomarkers. [Marker reference: GHRDx] (8,507,209). United States.
2012
Journal - Research Article
Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). High-sensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emergency Medicine Journal, 29(10), 805-810. doi: 10.1136/emermed-2011-200222
Pemberton, C. J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S. C., Yandle, T. G., & Richards, A. M. (2012). First identification of circulating Prepro-A-Type natriuretic peptide (PreproANP) signal peptide fragments in humans: Initial assessment as cardiovascular biomarkers. Clinical Chemistry, 58(4), 757-767. doi: 10.1373/clinchem.2011.176990
Journal - Research Other
Siriwardena, M., Campbell, V., Richards, A. M., & Pemberton, C. J. (2012). Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clinical Chemistry, 58(10), 1492-1494. doi: 10.1373/clinchem.2012.187682
Aldous, S., Pemberton, C., Troughton, R., Than, M., & Richards, A. M. (2012). Heart fatty acid binding protein and myoglobin do not improve early rule out of acute myocardial infarction when highly sensitive troponin assays are used. Resuscitation, 83(2), e27-e28. doi: 10.1016/j.resuscitation.2011.09.031
Journal - Professional & Other Non-Research Articles
Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). Authors' response. Emergency Medicine Journal, 29(7), 601-602. doi: 10.1136/emermed-2012-201216
Conference Contribution - Published proceedings: Abstract
Pemberton, C. (2012). Existing and new BNP peptides. New Zealand Journal of Medical Laboratory Science, 66(3), (pp. 93). [Abstract]
Pemberton, C. (2012). Endogenous peptides as therapeutic agents: Some new candidates. Proceedings of the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives. Retrieved from http://bioactives.otago.ac.nz/
Pemberton, C. J. (2012). Signal peptides: Time to leave the ER behind? Proceedings of the Medical Sciences Congress (MedSci). (pp. 38). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Byers, M. S., Siriwardena, M., Ruygrok, P., Yandle, T., Kleffmann, T., Richards, A. M., & Pemberton, C. J. (2012). Ghrelin signal peptide (GHRSP): Identification, immunoassay and circulating profile. Proceedings of the Medical Sciences Congress (MedSci). (pp. 18). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Pemberton, C. (2012, February). Endogenous peptides as therapeutic agents: Some new candidates. Invited presentation at the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
Pemberton, C. J. (2012, August). Signal peptides: Time to leave the ER behind? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Intellectual Property
Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2012). Methods of diagnosing acute cardiac disorders using BNP-SP. [Marker reference: BNPDx] (8,289,772). United States.
2011
Journal - Research Article
Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2011). B-type natriuretic peptides: Looking to the future. Annals of Medicine, 43(3), 188-197. doi: 10.3109/07853890.2010.526630
Journal - Research Other
Pemberton, C. J., Richards, A. M., Siriwardena, M., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Kleffmann, T., & Ruygrok, P. (2011). [Response to letter regarding article, B-Type natriuretic peptide signal peptide circulates in human blood: Evaluation as a potential biomarker of cardiac ischemia]. Circulation, 123(6), e234. doi: 10.1161/CIRCULATIONAHA.110.003574
Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Pemberton, C. (2011, March). Biomarkers: Searching for a new signal. Verbal presentation at the NZBIO Conference: Enabling Successful Bio Enterprise, Auckland, New Zealand.
2010
Journal - Research Article
Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937
Prosser, H. C., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2010). Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system. Peptides, 31, 1540-1545. doi: 10.1016/j.peptides.2010.05.009
Conference Contribution - Published proceedings: Abstract
Kleffmann, T., Siriwardena, M., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). Characterisation of unusual modifications of the circulating signal peptide of B-type naturetic peptide: A potential biomarker of cardiac ischemia. Proceedings of the 9th Human Proteome World Congress (HUPO): Launch of the Human Proteome Project. (pp. 106). Retrieved from http://www.hupo.org/congress/congress_2010/downloads/HUPO2010%20World%20Congress%20Abstract%20Book.pdf
Yandle, T. G., Mahagamasekera, P. M. G., Ruygrok, P., Palmer, S. C., Ansell, G., Nicholls, G., Pemberton, C. J., & Richards, M. (2010). Cardiac tissue, coronary sinus and circulating forms of B-type natriuretic peptide in in patients with and without heart failure. Endocrine Journal. 57(Suppl. 2), (pp. S325). [Abstract]
2009
Journal - Research Article
Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x
Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2009). Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Cardiovascular Research, 82(1), 40-50. doi: 10.1093/cvr/cvp003
2008
Journal - Research Article
Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008). Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Peptides, 29(5), 770-777. doi: 10.1016/j.peptides.2007.08.013
Pemberton, C. J., & Richards, A. M. (2008). Biochemistry of ghrelin precursor peptides. Vitamins & Hormones, 77, 13-30. doi: 10.1016/S0083-6729(06)77002-9
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229
Journal - Research Other
Pemberton, C. J. (2008). Leptin-induced cardiac hypertrophy: RhoAing a lipid raft down a protective p38 MAPK signalling stream? [Editorial]. Cardiovascular Research, 77(1), 4-5. doi: 10.1093/cvr/cvm053
Conference Contribution - Published proceedings: Abstract
Siriwardena, M., Nicholls, M. G., Yandle, T. G., Frampton, C. M., Richards, A. M., & Pemberton, C. J. (2008). Immunoreactive BNP-signal peptide: A potential early biomarker of AMI. Heart, Lung & Circulation, 17(Suppl. 3), (pp. S104). doi: 10.1016/j.hlc.2008.05.250
Pemberton, C. J., Rothwell, S. E., & Richards, A. M. (2008). The novel adipocytokine resistin worsens cardiac ischaemia-reperfusion injury. European Heart Journal. 29(Suppl. 1), (pp. 629). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008, November). Cardiac chymase activity converts proangiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Pemberton, C. (2008, October). Biomarkers: Searching for a signal. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.
Mahagamasekera, M. G. P., Ruygrok, P. N., Palmer, S., Ansell, G., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (2008, November). B-type natriuretic peptide and its degradation products in the heart and circulation in end-stage heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
2007
Journal - Research Article
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.
Bang, A. S., Soule, S. G., Yandle, T. G., Richards, A. M., & Pemberton, C. J. (2007). Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology, 192, 313-323.
Journal - Research Other
Pemberton, C. J. (2007). Hypertension, cardiotrophin-1 and gp130: Three points to heart failure? [Editorial comment]. Journal of Hypertension, 25(10), 2008-2010. doi: 10.1097/HJH.0b013e3282ef5632
Conference Contribution - Published proceedings: Abstract
Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2007). Direct effects of proangiotensin-12 on the isolated rat heart. European Heart Journal. 28(Abstract Suppl.), (pp. 365). [Abstract]
2006
Journal - Research Article
Prosser, H. C. G., Leprince, J., Vaudry, H., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2006). Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Peptides, 27, 3261-3268.
Rothwell, S. E., Richards, A. M., & Pemberton, C. J. (2006). Resistin worsens cardiac ischaemia-reperfusion injury. Biochemical & Biophysical Research Communications, 349, 400-407.
Conference Contribution - Published proceedings: Abstract
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., Richards, A. M., on behalf of Christchurch Cardioendocrine Research Group. (2006). Urocortin 2 infusion in humans with mild heart failure: Haemodynamics, neurohormonal and renal responses. European Heart Journal, 27(Suppl. 1), (pp. 488). [Abstract]
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2006). Urocortin 2 infusion in healthy humans induces marked hemodynamic, neurohormonal, and renal responses. Journal of the American College of Cardiology. 47(4, Suppl. A), (pp. 310A). [Abstract]
2005
Journal - Research Article
Pemberton, C. J., Raudsepp, S. D., Yandle, T. G., Cameron, V. A., & Richards, A. M. (2005). Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch. Cardiovascular Research, 68(1), 109-117.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2005). Effect of urocortin I infusion in humans with stable congestive cardiac failure. Clinical Science, 109(4), 381-388. doi: 10.1042/CS20050079
Soule, S., Pemberton, C., Hunt, P., Cole, D., Raudsepp, S., & Inder, W. (2005). Prandial regulation of ghrelin secretion in humans: Does glucagon contribute to the preprandial increase in circulating ghrelin? Clinical Endocrinology, 63(4), 412-417. doi: 10.1111/j.1365-2265.2005.02357.x
Conference Contribution - Published proceedings: Abstract
Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Zhang, M., & Pemberton, C. (2005). Metformin pharmacokinetics and the effect on hormones involved in appetite regulation. Proceedings of the Joint Meeting of ASCEPT and APSA. ASCEPT: Melbourne, Australia. [Abstract]
Pemberton, C., Raudsepp, S. D., Cameron, V. A., Yandle, T. G., & Richards, A. M. (2005). Cardiotrophin-1: A complex cytokine stimulated by ventricular stretch. European Heart Journal, 26(Suppl. 1), (pp. 66). doi: 10.1093/eurheartj/26.suppl_1.1
Davis, M. E., Skinner, M. H., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Frampton, C. M., & Richards, A. M. (2005). First report of urocortin 2 infusion in normal humans. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S111-S112). doi: 10.1016/j.hlc.2005.04.007
2004
Journal - Research Article
Pemberton, C. J., Tokola, H., Bagi, Z., Koller, A., Pöntinen, J., Ola, A., … Ruskoaho, H. (2004). Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion. American Journal of Physiology: Heart & Circulatory Physiology, 287, H1522-H1529.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin-1 infusion in normal humans. Journal of Clinical Endocrinology & Metabolism, 89(3), 1402-1409.
Conference Contribution - Published proceedings: Abstract
Pemberton, C. J., Rothwell, S. E., Yandle, T. G., & Richards, A. M. (2004). Ghrelin and resistin: Metabolic hormones influencing cardiac function. First Annual Canterbury Health Research Scientific Conference. (pp. 31). [Abstract]
Pemberton, C. J., Raudsepp, S., Yandle, T. G., & Richards, A. M. (2004). Cardiotrophin-1: Circulating levels, cardiac secretion and molecular forms in cardiovascular disease. New Zealand Medical Sciences Congress AGM. [Abstract]
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin infusion in humans with stable congestive cardiac failure. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S117-S118). doi: 10.1016/j.hlc.2004.05.001
Conference Contribution - Poster Presentation (not in published proceedings)
Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris.
Conference Contribution - Verbal presentation and other Conference outputs
Rothwell, S. E., Pemberton, C. J., & Richards, A. M. (2004, November). Resistin: A link between metabolic syndrome and cardiovascular disease. Verbal presentation at the Medical Sciences Congress: Physiological Society of New Zealand, Queenstown, New Zealand.
2003
Journal - Research Article
Pemberton, C. J., Wimalasena, P., Yandle, T. G., Soule, S. G., & Richards, A. M. (2003). C-terminal pro-ghrelin peptides are present in the human circulation. Biochemical & Biophysical Research Communications, 310(2), 567-573.
Conference Contribution - Published proceedings: Abstract
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003). First report of urocortin infusion and actions in normal humans. Circulation, 108(17 Suppl. IV), (pp. 242). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, November). First report of urocortin infusion and actions in normal humans. Verbal presentation at the American Heart Association Conference 2003, Orlando, USA.
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, July). First report of urocortin infusion and actions in normal humans. Verbal presentation at the Christchurch Medical Research Conference 2003, Christchurch, NZ.
2002
Journal - Research Article
Pemberton, C. J., Yandle, T. G., & Espiner, E. A. (2002). Immunoreactive forms of natriuretic peptides in ovine brain: Response to heart failure. Peptides, 23(12), 2235-2244.
Conference Contribution - Published proceedings: Full paper
Pemberton, C. J., Tokola, H., Pontinen, J., Ola, A., Vuolteenaho, O., & Ruskoaho, H. (2002). Ghrelin has a coronary vasoconstrictor action: role of L-Type Ca2+ channels and PK-C. The Endocrine Society of Australia, Proceedings 2002. 45, (pp. 165). Adelaide, Australia: Endocrine Society of Australia. [Full Paper]
2000
Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.
Pemberton, C. J., Johnson, M. L., Yandle, T. G., & Espiner, E. A. (2000). Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Hypertension, 36(3), 355-359.
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.
1999
Journal - Research Article
Seidler, T., Pemberton, C. J., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). The amino terminal regions of proBNP and proANP: Oligomerise through leucine zipper-like coiled-coil motifs. Biochemical & Biophysical Research Communications, 255, 495-501.
Conference Contribution - Published proceedings: Full paper
Pemberton, C. J., Johnson, M., Yandle, T. G., & Espiner, E. A. (1999). The in vivo Half-life of NT-ProBNP is 14-fold Longer Than Mature BNP in Ovine Plasma. In A. Zanchetti & G. Mancia (Eds.), Ninth European Meeting on Hypertension - Abstracts. 9, (pp. S55-S56). Hagerstown, United States of America: International Society of Hypertension. [Full Paper]
1998
Journal - Research Article
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208.
1997
Journal - Research Article
Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550.
Conference Contribution - Published proceedings: Abstract
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]
1996
Journal - Research Article
Charles, C. J., Kaaja, R. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptides in sheep with pressure overload left venticular hypertrophy. Clinical & Experimental Hypertension, 18(8), 1051-1071.