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david_larsenPhD, MSc(Auck)

Tel: 03 479 7816
Location: Science II, 2n11
Email: dlarsen@chemistry.otago.ac.nz

Research Interests

My research interests are primarily in the development of methodology the syntheses of natural products and also in the area of the synthesis of carbohydrates, glycolipids and their analogues.

On-going research projects are:

  • Structure, synthesis and biological activity of phosphatidylinositol mannosides from mycobacterium tuberculosis
  • Glycolipids as adjuvants for cancer vaccines
  • Total synthesis of the angucycline antibiotics
  • Carbon monoxide releasing molecules for organ transplant solutions
  • Mannosylation of Virus Like Particles
  • Bacterial cell wall skeletons as transporters of small molecules to APCs

Publications

Payne, F. M., Nie, S., Diffee, G. M., Wilkins, G. T., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2024). The carbon monoxide prodrug oCOm-21 increases Ca2+ sensitivity of the cardiac myofilament. Physiological Reports, 12(6), e15974. doi: 10.14814/phy2.15974 Journal - Research Article

Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839 Conference Contribution - Published proceedings: Abstract

Thwaite, S. H., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2023, August). Prophylactic organic carbon monoxide donors protect against ischaemia-reperfusion injury in an in-vivo myocardial infarction model. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry, 11, e202200350. doi: 10.1002/ajoc.202200350 Journal - Research Article

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