Emeritus Professor David Larsen

2024

Journal - Research Article

Payne, F. M., Nie, S., Diffee, G. M., Wilkins, G. T., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2024). The carbon monoxide prodrug oCOm-21 increases Ca²⁺ sensitivity of the cardiac myofilament. Physiological Reports, 12(6), e15974. doi: 10.14814/phy2.15974

2023

Conference Contribution - Published proceedings: Abstract

Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Verbal presentation and other Conference outputs

Thwaite, S. H., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2023, August). Prophylactic organic carbon monoxide donors protect against ischaemia-reperfusion injury in an in-vivo myocardial infarction model. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry, 11, e202200350. doi: 10.1002/ajoc.202200350

Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry, 20, 5812-5819. doi: 10.1039/d2ob01076c

Conference Contribution - Verbal presentation and other Conference outputs

Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

2021

Journal - Research Article

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540

Richardson, A. T., McGhie, T. K., Cordiner, S. B., Stephens, T. T. H., Larsen, D. S., Laing, W. A., & Perry, N. B. (2021). 2-O-β-d-Glucopyranosyl L-ascorbic acid, a stable form of vitamin C, is widespread in crop plants. Journal of Agricultural & Food Chemistry, 69, 966-973. doi: 10.1021/acs.jafc.0c06330

Conference Contribution - Published proceedings: Abstract

Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2021). Can carbon monoxide protect hypertrophic hearts against ischaemia-reperfusion injury. New Zealand Medical Journal, 134(1535), (pp. 98). Retrieved from https://www.nzma.org.nz/journal

Intellectual Property

Sammut, I. A., Harrison, J. C., Hewitt, R. J., Read, M. I., Stanley, N. J., Woods, L. M., Kueh, J. T. B., … Smith, R. A. J., Giles, G., … Larsen, D. S. (2021). Carbon monoxide releasing norbornenone compounds. (11072584). United States.

2020

Journal - Research Article

Kueh, J. T. B., Seifert-Simpson, J. M., Thwaite, S. H., Rodgers, G. D., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2020). Studies towards non-toxic, water soluble, vasoactive norbornene organic carbon monoxide releasing molecules. Asian Journal of Organic Chemistry, 9, 1-10. doi: 10.1002/ajoc.202000546

Robinson, S. A., Yau, J., Terabe, M., Berzofsky, J. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2020). Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues. Organic & Biomolecular Chemistry, 18, 2739-2746. doi: 10.1039/d0ob00223b

Richardson, A. T., Cho, J., McGhie, T. K., Larsen, D. S., Schaffer, R. J., Espley, R. V., & Perry, N. B. (2020). Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris). Phytochemistry, 173, 112297. doi: 10.1016/j.phytochem.2020.112297

Conference Contribution - Published proceedings: Abstract

Hartley, R., Harrison, J. C., Johnston, H., Larsen, D. S., & Sammut, I. A. (2020). Examination of the cardiac mitochondrial-linked preconditioning mechanism of oCOm-58. New Zealand Medical Journal, 133(1518), (pp. 94-95). Retrieved from https://www.nzma.org.nz/journal

2019

Journal - Research Article

Payne, C. M., Cho, K., & Larsen, D. S. (2019). 5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions. RSC Advances, 9, 30736-30740. doi: 10.1039/c9ra06594f

Kramer, K., Al-Barwani, F., Baird, M. A., Young, V. L., Larsen, D. S., Ward, V. K., & Young, S. L. (2019). Functionalisation of virus-like particles enhances antitumour immune responses. Journal of Immunology Research, 2019, 5364632. doi: 10.1155/2019/5364632

Osman, H., Larsen, D. S., & Muralikrishna, A. (2019). A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B. Arabian Journal of Chemistry, 12, 2501-2512. doi: 10.1016/j.arabjc.2015.04.022

Conference Contribution - Poster Presentation (not in published proceedings)

Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2019, September). Can we protect hypertrophic hearts against ischaemia-reperfusion injury using carbon monoxide? Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Other

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2018). MIS416 as a siRNA delivery system with the ability to target antigen-presenting cells [Brief communication]. Nucleic Acid Therapeutics, 28(4), 225-232. doi: 10.1089/nat.2017.0695

Conference Contribution - Published proceedings: Abstract

Sammut, I., Kueh, B., Adams, J., Read, M., Larsen, D., & Harrison, J. (2018). Prophylactic treatment of ischaemically stored organs with novel organic carbon monoxide donor molecules. Cryobiology, 81, (pp. 222). doi: 10.1016/j.cryobiol.2017.12.045

Conference Contribution - Verbal presentation and other Conference outputs

Larsen, D. S., Kueh, J. T. B., Harrison, J. C., & Sammut, I. A. (2018, August). Nornorn-2-en-7-ones as physiologically triggered carbon monoxide-releasing prodrugs. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Hogue, R. W., Dhers, S., Hellyer, R. M., Luo, J., Hanan, G. S., Larsen, D. S., Garden, A. L., & Brooker, S. (2017). Self-assembly of cyclohelicate [M₃L₃] triangles over [M₄L₄] squares, despite near-linear bis-terdentate L and octahedral M. Chemistry: A European Journal, 23(57), 14193-14199. doi: 10.1002/chem.201702153

Malthus, S. J., Wilson, R. K., Aggarwal, A. V., Cameron, S. A., Larsen, D. S., & Brooker, S. (2017). Carbazole-based N₄-donor Schiff base macrocycles: Obtained metal free and as Cu(II) and Ni(II) complexes. Dalton Transactions, 46(10), 3141-3149. doi: 10.1039/c6dt04598g

Nhu, D., Larsen, L., Perry, N. B., Larsen, D. S., & Hawkins, B. C. (2017). Sweet poisons: Synthetic strategies towards tutin glycosides. Australian Journal of Chemistry, 70(3), 301-306. doi: 10.1071/CH16429

Moodie, L. W. K., Trepos, R., Cervin, G., Larsen, L., Larsen, D. S., Pavia, H., … Svenson, J. (2017). Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. Journal of Natural Products, 80(2), 515-525. doi: 10.1021/acs.jnatprod.6b01056

Conference Contribution - Poster Presentation (not in published proceedings)

Malthus, S. J., Cameron, S., Aggarwal, V., Wilson, R. K., Larsen, D. S., & Brooker, S. (2017, February). Carbazole-based Schiff base macrocycles and complexes for fluorescence, redox and catalytic properties. Poster session presented at the 2nd Southampton, Australia, New Zealand, Magnetism Workshop (SANZ-O-MAG2), Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Harrison, J. C., Adams, J. R., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Sammut, I. A. (2017, September). Organic carbon monoxide releasing molecules as cardioprotective agents. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sammut, I. A., Adams, J. R., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Harrison, J. C. (2017, September). oCOms: Organic carbon monoxide donor molecules as pharmacological preconditioning agents. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

2016

Journal - Research Article

Malthus, S. J., Wilson, R. K., Larsen, D. S., & Brooker, S. (2016). Acridine-based ligands from cobalt(II) mediated rearrangement of diphenylamine-based starting materials. Supramolecular Chemistry, 28(1-2), 98-107. doi: 10.1080/10610278.2015.1091458

Conference Contribution - Published proceedings: Abstract

Sammut, I. A., Harrison, J. C., Read, M. I., Kueh, J. T. B., & Larsen, D. S. (2016). Novel organic carbon monoxide donor molecules provide organ protection during ischaemic events. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Robinson, S. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2016). A synthetic methodology for accessing ceramide based iNKT cell agonists. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/

Hall, E. A., Young, S. L., Ward, V. K., & Larsen, D. S. (2016). Synthesis of mannoside-VLP conjugates for antigen delivery. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/

Larsen, D. S., Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T., Hayman, C. M., … Painter, G. F. (2016). Synthesis and activity of 6"-deoxy-6"-thio-α-GalCer and peptide conjugates. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/

Compton, B. J., Anderson, R. J., Hayman, C. M., Tang, C.-w., Osmond, T. L., Larsen, D. S., … Painter, G. F. (2016). NKT cell-dependent glycolipid-peptide conjugates: Towards generating therapeutic vaccines for cancer. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/

Conference Contribution - Verbal presentation and other Conference outputs

Harrison, J. C., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Sammut, I. A. (2016, August-September). Novel organic carbon monoxide releasing molecules protect the heart against ischaemia reperfusion injury. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Larsen, D. S., Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. L., Hayman, C. M., … Painter, G. F. (2016, August-September). Synthesis and activity of 6ʺ-deoxy-6ʺ-thio-α-GalCer and peptide conjugates. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Painter, G. F., Tang, C., Anderson, R. J., Compton, B. J., Osmond, T., Farrand, K. J., … Larsen, D. S., … Hermans, I. F. (2016, August-September). Bioorthogonal synthesis and antitumour activity of CD1d dependent glycolipid-peptide vaccines. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403

Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. O., Hayman, C. M., Larsen, D. S., Hermans, I. F., & Painter, G. F. (2015). Synthesis and activity of 6''-Deoxy-6''-thio-α-GalCer and peptide conjugates. Organic Letters, 17, 5954-5957. doi: 10.1021/acs.orglett.5b02836

Finichiu, P. G., Larsen, D. S., Evans, C., Larsen, L., Bright, T. P., Robb, E. L., … Smith, R. A. J., & Murphy, M. P. (2015). A mitochondria-targeted derivative of ascorbate: MitoC. Free Radical Biology & Medicine, 89, 668-678. doi: 10.1016/j.freeradbiomed.2015.07.160

Anderson, R. J., Compton, B. J., Tang, C.-W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., … Larsen, D. S., … Weinkove, R., Hermans, I. F., & Painter, G. F. (2015). NKT cell-dependent glycolipid—peptide vaccines with potent anti-tumour activity. Chemical Science, 6(9), 5095-5312. doi: 10.1039/c4sc03599b

Zheng, T., Luo, D., Compton, B. J., Painter, G. F., Alley, M. R., Larsen, D. S., … Heiser, A. (2015). Adjuvanticity of a synthetic phosphatidylinositol dimannoside to a subvirion influenza vaccine in an influenza mouse model. Journal of Vaccines & Vaccination, 6(2), 1000277. doi: 10.4172/2157-7560.1000277

Kueh, J. T. B., Moodie, L. W. K., Lucas, N. T., & Larsen, D. S. (2015). Synthesis of acyloxy-semicyclic dienes using an enyne metathesis/ring closing metathesis approach. European Journal of Organic Chemistry, 2015(7), 1485-1490. doi: 10.1002/ejoc.201403482

Jiménez-Dalmaroni, M. J., Radcliffe, C. M., Harvey, D. J., Wormald, M. R., Verdino, P., Ainge, G. D., Larsen, D. S., … Wilson, I. A. (2015). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity, 21(2), 175-193. doi: 10.1177/1753425914524077

Conference Contribution - Published proceedings: Abstract

Painter, G., Tang, C., Anderson, R., Compton, B., Authier-Hall, A., Hayman, C., … Farrand, K., … Larsen, D., Weinkove, R., & Hermans, I. (2015). Bioorthagonal synthesis and biological activity of CD1d dependent glycolipid-peptide vaccines. Proceedings of the 250th National American Chemical Society (ACS) Fall Meeting. Retrieved from https://www.acs.org

Larsen, D. S., Sammut, I., Harrison, J., Anderson, R., Compton, B. J., Harper, J. L., … Painter, G. F. (2015). Development of immuno-regulatory molecules for cancer and atopic disorders. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Harrison, J. C., Diwan, V., Read, M. I., Larsen, L., Kueh, B., Hewitt, R. J., Stanley, N., Larsen, D., & Sammut, I. A. (2015). Novel carbon monoxide releasing molecules improve renal outcomes in a model of transplant reperfusion. Proceedings of the World Congress of Nephrology. Retrieved from http://www.wcn2015.org/

Other Research Output

Larsen, D. (2015, November). Therapeutic molecules from sweet sugars to poisonous gases. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

2014

Journal - Research Article

Lee, A. M. M., Painter, G. F., Compton, B. J., & Larsen, D. S. (2014). Resolution of orthogonally protected myo-inositols with Novozym 435 providing an enantioconvergent Pathway to Ac₂PIM₁. Journal of Organic Chemistry, 79(22), 10916-10931. doi: 10.1021/jo5019188

Anderson, R. J., Tang, C.-w., Daniels, N. J., Compton, B. J., Hayman, C. M., Johnston, K. A., … Larsen, D. S., … Hermans, I. F. (2014). A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology, 10, 943-949. doi: 10.1038/nchembio.1640

Al-Barwani, F., Young, S. L., Baird, M. A., Larsen, D. S., & Ward, V. K. (2014). Mannosylation of virus-like particles enhances internalization by antigen presenting cells. PLoS ONE, 9(8), e104523. doi: 10.1371/journal.pone.0104523

Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y

Nakatani, Y., Larsen, D. S., Cutfield, S. M., & Cutfield, J. F. (2014). Major change in regiospecificity for the exo-1,3-β-glucanase from Candida albicans following its conversion to a glycosynthase. Biochemistry, 53(20), 3318-3326. doi: 10.1021/bi500239m

Moodie, L. W. K., & Larsen, D. S. (2014). A ring-closing enyne metathesis approach to functionalized semicyclic dienes: The total synthesis of (–)-tetrangomycin. European Journal of Organic Chemistry, 2014(8), 1684-1694. doi: 10.1002/ejoc.201301627

Pun, P. B. L., Logan, A., Darley-Usmar, V., Chacko, B., Johnson, M. S., Huang, G. W., … Larsen, L., Larsen, D. S., … Smith, R. A. J., & Murphy, M. P. (2014). A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes. Free Radical Biology & Medicine, 67, 437-450. doi: 10.1016/j.freeradbiomed.2013.11.025

Journal - Professional & Other Non-Research Articles

Al-Barwani, F., Larsen, D. S., Baird, M. A., Young, S. L., & Ward, V. K. (2014). Enhancing the functionality of RHDV virus-like particles. CRS Newsletter, 31(4), 10-13.

Conference Contribution - Poster Presentation (not in published proceedings)

Lee, A. M. M., Larsen, D. S., & Compton, B. J. (2014, August). Chemoenzymatic approaches to phosphatidylinositol mannosides and other phospholipids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2013

Journal - Research Article

Logan, A., Cochemé, H. M., Li Pun, P. B., Apostolova, N., Smith, R. A. J., Larsen, L., Larsen, D. S., … Murphy, M. P. (2013). Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), 923-930. doi: 10.1016/j.bbagen.2013.05.026

Rankin, G. M., Maxwell-Cameron, I., Painter, G. F., & Larsen, D. S. (2013). The Dimethoxyphenylbenzyl Protecting Group: An alternative to the p-methoxybenzyl group for protection of carbohydrates. Journal of Organic Chemistry, 5264-5272. doi: 10.1021/jo4004184

Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a

Conference Contribution - Published proceedings: Abstract

Lee, A. M. M., Larsen, D. S., & Compton, B. J. (2013). Chemoenzymatic approaches to phosphatidylinositol mannosides and other phospholipids. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]

Larsen, D. S., & Moodie, L. W. K. (2013). A ring-closing enyne metathesis approach to functionalised semi-cyclic dienes: The total synthesis of (-)-tetrangomycin. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]

Painter, G. F., Tang, C., Anderson, R. J., Compton, B. J., Hayman, C. M., Johnston, K. A., Young, K., Hook, S., Larsen, D. S., & Hermans, I. F. (2013). Synthetic self-adjuvanting peptide vaccines. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]

Zheng, T., Luo, D., Compton, B., Painter, G., Larsen, D., Buddle, B., & Heiser, A. (2013). Phosphatidylinositol di-mannosides and aluminium hydroxide enhance protection of a subvirion influenza vaccine in a mouse influenza challenge model. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 162). Retrieved from http://www.asi2013.org/

Al-Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2013). Enhancement of VLP functionality though mannosylation. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 69). Retrieved from http://www.asi2013.org/

Al Barwani, F., Baird, M., Young, S., Larsen, D., & Ward, V. (2013). Mannosylated VLP: Potent antigen delivery vehicles. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/

Al Barwani, F., Young, S., Baird, M., Kirman, J., Larsen, D., & Ward, V. (2013). The sweetening of VLP. Proceedings of 15th Conference on Formulation and Delivery of Bioactives: Found in Translation. Retrieved from http://bioactives.otago.ac.nz/

2012

Journal - Research Article

Rankin, G. M., Compton, B. J., Johnston, K. A., Hayman, C. M., Painter, G. F., & Larsen, D. S. (2012). Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides. Journal of Organic Chemistry, 77(16), 6743-6759. doi: 10.1021/jo301189y

Conference Contribution - Published proceedings: Abstract

Al Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2012). The sweetening of VLP. Proceedings of the Virus-Like Particle & Nano-Particle Vaccines (VLPNPV) International Conference. [CD-ROM] [Abstract]

Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., & Rades, T. (2012). Investigating the interfacial behaviour of novel PIM Mimetics in pure and mixed monolayers using the Langmuir-trough technique. Proceedings of the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives. Retrieved from http://bioactives.otago.ac.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Cameron, S. A., Larsen, D. S., & Brooker, S. (2012, January-February). Toward new families of expanded porphyrin-like ligands and complexes. Poster session presented at the 7th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Dunedin, New Zealand.

Mainini, F., Eccles, M., Young, S., Larsen, D., & Webster, G. (2012, August). Development of a new microparticle vaccine adjuvant with the ability to deliver peptides to dendritic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Hubert, M., Rades, T., Larsen, D., Hayman, C., Compton, B., & Hook, S. (2012, March). Physicochemical and biological characterization of PIM mimetics, novel immune modulating agents. Poster session presented at the 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey.

Conference Contribution - Verbal presentation and other Conference outputs

Larsen, D. S., Rankin, G. M., Ainge, G. D., Dyer, B. S., Compton, B. J., Hayman, C. M., … Painter, G. F. (2012, August). Mannosylated phospolipids for the mycobacterial cell wall: Synthesis and immune-regulating properties. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Ainge, G. D., Martin, W. J., Compton, B. J., Hayman, C. M., Larsen, D. S., Yoon, S.-I., … Painter, G. F. (2011). Synthesis and toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. Journal of Medicinal Chemistry, 54(20), 7268-7279. doi: 10.1021/jm2008419

Feltham, H. L. C., Klöwer, F., Cameron, S. A., Larsen, D. S., Lan, Y., Tropiano, M., … Powell, A. K., & Brooker, S. (2011). A family of 13 tetranuclear zinc(II)-lanthanide(III) complexes of a [3 + 3] Schiff-base macrocycle derived from 1‚4-diformyl-2‚3-dihydroxybenzene. Dalton Transactions, 40, 11425-11432. doi: 10.1039/c1dt11038a

Ainge, G. D., Compton, B. J., Hayman, C. M., Martin, W. J., Toms, S. M., Larsen, D. S., Harper, J. L., & Painter, G. F. (2011). Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside. Journal of Organic Chemistry, 76(12), 4941-4951. doi: 10.1021/jo200588u

Harper, J. L., Hayman, C. M., Larsen, D. S., Painter, G. F., & Singh-Gill, G. (2011). A PIM₂ analogue suppresses allergic airway disease. Bioorganic & Medicinal Chemistry, 19, 2, 917-925. doi: 10.1016/j.bmc.2010.11.058

Conference Contribution - Poster Presentation (not in published proceedings)

Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2011, October). Investigating the interfacial behavior of novel PIM mimetics in pure and mixed monolayers using the Langmuir-trough technique. Poster session presented at the American Association of Pharmaceutical Sciences (AAPS) Annual Meeting and Exposition, Washington, D.C.

Conference Contribution - Verbal presentation and other Conference outputs

Larsen, D. (2011, December). The synthesis, structure and immune regulatory properties of phosphatidylinositol mannosides. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.

Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2011, February). Monolayer study of PIM mimetics: Novel immunomodulating agents. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 13th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

2010

Journal - Research Article

Kitchen, J. A., Larsen, D. S., & Brooker, S. (2010). Alkylations of N⁴-(4-Pyridyl)-3,5-di(2-pyridyl)-1,2,4-triazole: First observation of room-temperature rearrangement of an N⁴-substituted triazole to the N¹ analogue. Chemistry: An Asian Journal, 5(4), 910-918. doi: 10.1002/asia.200900485

Conference Contribution - Published proceedings: Abstract

Brooker, S., Feltham, H. L., Cameron, S. A., Sanyal, R., Kitchen, J. A., Milway, V. A., Larsen, D. S., Kloewer, F., … Clerac, R. (2010). Magnetically and electrochemically interesting di- and poly-metallic complexes of new generation Schiff-base macrocycles. Proceedings of the International Chemical Congress of Pacific Basin Societies (Pacifichem). Retrieved from http://pacifichem.abstractcentral.com/planner

Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2010). Synthesis and physical characterisation of PIM mimetics as novel immunomodulating agents. In L. Emmerton, A. Peters, D. Ross & B. Ross (Eds.), Proceedings of the Australasian Pharmaceutical Science Association (APSA) Annual Conference: Focus on the Future: Research and Education for a Healthier Community. (pp. 33). APSA. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Hubert, M., Hook, S., Rades, T., Hayman, C., Painter, G., Rendle, P., & Larsen, D. (2010, February). Formulation and immunological characterization of novel carbohydrate containing immunopharmaceuticals. Poster session presented at the New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

2009

Journal - Research Article

Jimenez-Dalmaroni, M. J., Xiao, N., Corper, A. L., Verdino, P., Ainge, G. D., & Larsen, D. S. (2009). Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE, 4(10), e7411. doi: 10.1371/journal.pone.0007411

Denis, M., Ainge, G. D., Larsen, D. S., Severn, W. B., & Painter, G. F. (2009). A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant. Immunopharmacology & Immunotoxicology, 31(4), 577-582. doi: 10.3109/08923970902824862

Feltham, H. L. C., Larsen, D. S., & Brooker, S. (2009). A hexanuclear iron(III) complex of a hexadentate fully conjugated diimine ligand derived from 1,4-diformyl-2,3-dihydroxybenzene. New Journal of Chemistry, 33, 2001-2003. doi: 10.1039/b9nj00347a

Driessen, N. N., Ummels, R., Maaskant, J. J., Gurcha, S. S., Besra, G. S., Ainge, G. D., Larsen, D. S., … Appelmelk, B. J. (2009). Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN. Infection & Immunity, 77(10), 4538-4547. doi: 10.1128/iai.01256-08

Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009). Cobalt and silver complexes of terdentate pyrazine-based amide ligands and assembly of monocobalt building blocks through a silver connector. European Journal of Inorganic Chemistry, (9), 1162-1171. doi: 10.1002/ejic.200801187

Osman, H., Larsen, D. S., & Simpson, J. (2009). Synthesis of orthogonally protected D-olivoside, 1,3-di-O-acetyl-4-O-benzyl-2,6-dideoxy-D-arabinopyranose, as a C-glycosyl donor. Tetrahedron, 65(21), 4092-4098. doi: 10.1016/j.tet.2009.03.092

Conference Contribution - Published proceedings: Abstract

Larsen, D. S., Ainge, G. D., Dyer, B. S., Denis, M., Rendle, P., & Painter, G. F. (2009). The structure, chemical syntheses and adjuvant properties of phosphatidylinositol mannosides from mycobacteria. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Cowan, M. G., Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009, February). Self-organisation of supramolecular building blocks via silver bridges. Poster session presented at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.

Cameron, S. A., Larsen, D. S., & Brooker, S. (2009, February). Towards new families of expanded porphyrin-like ligands and complexes. Poster session presented at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kitchen, J. A., White, N. G., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., & Brooker, S. (2009, February). Generating magnetically interesting dinuclear iron(II) complexes with designer 1,2,4-triazole ligands. Verbal presentation at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.

Intellectual Property

Snow, A. D., Nguyen, B. P., Castillo, G. M., Sanders, V. J., Lake, T. P., Larsen, L., Weavers, R. T., Lorimer, S. D., Larsen, D. S., … Coffen, C. (2009). Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease. (US 7,514,583).

2008

Journal - Research Article

Compton, B. J., Larsen, D. S., Larsen, L., & Weavers, R. T. (2008). Reactive diene for synthesis of substituted catechols. Tetrahedron Letters, 49(2), 219-221. doi: 10.1016/j.tetlet.2007.11.085

Parlane, N. A., Denis, M., Severn, W. B., Skinner, M. A., Painter, G. F., La Flamme, A. C., Ainge, G. D., Larsen, D. S., & Buddle, B. M. (2008). Phosphatidylinositol mannosides are efficient mucosal adjuvants. Immunological Investigations, 37(2), 129-142. doi: 10.1080/08820130701690782

Osman, H., Larsen, D. S., Hanton, L. R., & Simpson, J. (2008). Phenyl 2,3-O-isopropylidene-1-thio-α-D-rhamnopyranoside. Acta Crystallographica Section E, E64, o24-o25. doi: 10.1107/S1600536807061004

Conference Contribution - Poster Presentation (not in published proceedings)

Larsen, D., Dyer, B., Ainge, G., & Painter, G. (2008, November-December). Synthesis and structure of PIMS. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Moodie, L., & Larsen, D. (2008, November-December). The synthesis of Angucycline antibiotics. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kitchen, J. A., White, N. G., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., & Brooker, S. (2008, November-December). Spin crossover and anion •••€ interactions in iron(II) triazole complexes. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Painter, G. F., Ainge, G. D., Denis, M., & Larsen, D. S. (2008, November-December). Synthetic phosphatidylinositol mannoside analogues: Potent vaccine adjuvants. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Kitchen, J. A., White, N., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., … Brooker, S. (2008, April). Spin crossover complexes. Verbal presentation at the 3rd Korea-New Zealand Material Science Workshop, Dunedin, New Zealand.

2007

Journal - Research Article

Ainge, G. D., Parlane, N. A., Denis, M., Dyer, B. S., Härer, A., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2007). Phosphatidylinositol mannoside ether analogues: Syntheses and interleukin-12-inducing properties. Journal of Organic Chemistry, 72(14), 5291-5296. doi: 10.1021/jo070639m

Dyer, B. S., Jones, J. D., Ainge, G. D., Denis, M., Larsen, D. S., & Painter, G. F. (2007). Synthesis and structure of phosphatidylinositol dimannoside. Journal of Organic Chemistry, 72, 3282-3288.

de Geest, D. J., Noble, A., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007). Dicopper(II) complexes of a new pyrazolate-containing Schiff-base macrocycle and related acyclic ligand. Dalton Transactions, 467-475.

Hellyer, R. M., Joule, J. A., Larsen, D. S., & Brooker, S. (2007). 4-(Pyrrol-1-yl)-1,2,4-triazole. Acta Crystallographica Section C, C63, o358-o360.

Conference Contribution - Poster Presentation (not in published proceedings)

Hellyer, R. M., Larsen, D. S., & Brooker, S. (2007, March). Mixed-metal Ag(I)-Co(III) complexes. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.

Noble, A., de Geest, D. J., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007, March). Macrocyclic and acyclic pyrazolate-containing Schiff-base dicopper(II) complexes. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.

2006

Journal - Research Article

Larsen, D. S., Osman, H., Caygill, G. B., McFarlane, B. S., & McMorran, D. A. (2006). rac-Hatomarubigin C. Acta Crystallographica Section E, E62, o5748-o5750.

Ainge, G. D., Parlane, N. A., Denis, M., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2006). Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides. Bioorganic & Medicinal Chemistry, 14, 7615-7624.

Hayman, C. M., Larsen, D. S., Simpson, J., Bailey, K. B., & Gill, G. S. (2006). A stereoselective synthesis of 6,6,6-trifluoro-L-daunosamine and 6,6,6-trifluoro-L-acosamine. Organic & Biomolecular Chemistry, 4, 2794-2800.

Ainge, G. D., Hudson, J., Larsen, D. S., Painter, G. F., Gill, G. S., & Harper, J. L. (2006). Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease. Bioorganic & Medicinal Chemistry, 14, 5632-5642.

2004

Journal - Research Article

Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2004). Studies related to carba-pyranoses: A radical decarboxylation approach to monocarba-disaccharides. Organic & Biomolecular Chemistry, 2, 1934-1942.

Li, R., Evans, L. S., Larsen, D. S., Gale, P. A., & Brooker, S. (2004). Synthesis and anion binding behaviour of diamide derivatives of pyrrole-2,5-diacetic acid. New Journal of Chemistry, 28, 1340-1343.

2003

Journal - Research Article

Li, R., Larsen, D. S., & Brooker, S. (2003). Syntheses, structures and tautomers of 2,5-disubstituted pyrroles. New Journal of Chemistry, 27, 1353-1359.

Landells, J. S., Larsen, D. S., & Simpson, J. (2003). Remote stereochemical control in asymmetric Diels-Alder reactions: Synthesis of the angucycline antibiotics, (-)-tetrangomycin and MM 47755. Tetrahedron Letters, 44, 5193-5196.

2002

Journal - Research Article

Dufour, J.-P., Wierda, R., Leus, M., Lissens, G., Delvaux, F., Derdelinckx, G., & Larsen, D. S. (2002). Quantitative analysis of beer aromatic alcohols using stable isotope dilution assay. Journal of the American Society of Brewing Chemists, 60(2), 88-96.

2001

Journal - Research Article

Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2001). Studies related to carba-pyranoses: a strategy for the synthesis of β-1,3-glycosidically linked aminomonocarba-disaccharides. Journal of the Chemical Society, Perkin Transactions 1, 1(18), 2204-2212. doi: 10.1039/B105374B

Caygill, G. B., Larsen, D. S., & Brooker, S. (2001). Total synthesis of (+)-Hatomarubigin B. Journal of Organic Chemistry, 66, 7427-7431.

Conference Contribution - Published proceedings: Abstract

Wierda, R., Dufour, J.-P., Leus, M., Lissens, G., Delvaux, F., David, L., & Larsen, D. S. (2001). Quantitative analysis of beer aromatic alcohols using stable isotope dilution assay. NZIFST Annual Conference - 2001: A Food Odyssey. (pp. 32). Dunedin: NZIFST. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Brooker, S., Larsen, D. S., & Li, R. (2001, December). Synthesis of, and tautomerism in, 2,5-disubstituted pyrroles. Poster session presented at the New Zealand Institute of Chemestry ″Molecules for Life″ Conference, Napier.

2000

Journal - Research Article

Kerr, J. L., Landells, J. S., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis and structure of N-ferrocenylglycosylamines; redox chemistry of O-ferrocenylglycosides and N-ferrocenylglycosylamines. Journal of the Chemical Society, Dalton Transactions, 9, 1411-1417.

Andrews, F. L., Larsen, D. S., & Larsen, L. (2000). Synthetic approaches to the angucycline antibiotics. A route to C-Glycosidic Benz[a]anthraquinones. Australian Journal of Chemistry, 53, 15-24.

Watt, D. K., Brasch, D. J., Larsen, D. S., Melton, L. D., & Simpson, J. (2000). Oligosaccharides related to xyloglucan: Synthesis and X-ray crystal structure of methyl α-L-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-D-xylopyranoside and the synthesis of methyl α-L-fucopyranosyl-(1→2)- β-D-galactopyranosy1]-(1→2)-β-D-xylopyranoside. Carbohydrate Research, 325, 300-312.

Landells, J. S., Kerr, J. L., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis of water soluble O-glycosides of N-(hydroxyalkyl)-aminomethylferrocenes. Journal of the Chemical Society, Dalton Transactions, 1403-1409.

Sum Idris, M., Larsen, D. S., Pritchard, R. G., Schofield, A., Stoodley, R. J., & Tiffin, P. D. (2000). Regio- and stereo-selective bromo(alkoxylation)s of (E)-α-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxymethylene) carbonyl compounds; A route to near-stereopure α-bromo α-dioxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 1(14), 2195-2204. doi: 10.1039/B002749I

Trotter, N. S., Larsen, D. S., Stoodley, R. J., & Brooker, S. (2000). A Diels-Alder strategy to 1,4-glycosidically linked monocarba-disaccharides. Tetrahedron Letters, 41, 8957-8962.

Conference Contribution - Published proceedings: Abstract

Dufour, J.-P., Leus, M., Lissens, G., Wierda, R., Delvaux, F., & Larsen, D. (2000). Quantitative analysis of beer aromatic alcohols using stable isotope dilution analysis. American Society of Brewing Chemists, News Letter. 60, (pp. 33). [Abstract]

1999

Journal - Research Article

Watts, D. K., Brasch, D. J., Larsen, D. S., & Melton, L. D. (1999). Isolation, characterization, and NMR study of xyloglucan from enzymically depectinized and non-depectinized apple pomace. Carbohydrate Polymers, 39, 165-180.

Hayman, C. M., Hanton, L. R., Larsen, D. S., & Guthrie, J. M. (1999). A stereoselective synthesis of 2,6-dideoxy-6,6,6-trifluoro-arabino-hexoses via an asymmetric Diels-Alder strategy. Australian Journal of Chemistry, 52, 921-927.

1998

Journal - Research Article

Hayman, C. M., Larsen, D. S., & Brooker, S. (1998). A facile synthesis of 2,6-dideoxy,6,6,6-trifluorinated carbohydrate analogues. Australian Journal of Chemistry, 51, 545-553.

1997

Journal - Research Article

Caygill, G. B., Larsen, D. S., & McFarlane, B. S. (1997). Synthetic approaches to the angucycline antibiotics: a synthesis of (+/-) hatomarubigin B and C. Australian Journal of Chemistry, 50(4), 301-308.

Larsen, D. S., Rutledge, P. S., & Woodgate, P. D. (1997). Iodination of thallium (I) salts of phenols. Australian Journal of Chemistry, 50(7), 767-769.

1996

Journal - Research Article

Larsen, D. S., & O'Shea, M. D. (1996). Synthetic approaches to the angucycline antiobiotics: a concise entry to the ring system of PD 116740 and TAN 1085. Journal of Organic Chemistry, 61, 5681-5683.

Watt, D. W., Brasch, D. J. A., Larsen, D. S., Melton, L. D., & Simpson, J. (1996). Oligosaccharides related to xyloglucan: synthesis and x-ray crystal structure of methyl 2O(a-L-fucopyranosyl)-b-D-galactopyranoside. Carbohydrate Research, 285, 1-15.

Larsen, D. S., Schofield, A. E. M., Stoodley, R. J., & Tiffin, P. D. (1996). Diastereoselective hydrogenations of a-alkyl a-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyloxy)methylene carbonyl compounds. New route to stereopure a-alkyl a-oxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 2487-2493.

Larsen, D. S., O'Shea, M. D., & Brooker, S. (1996). Total syntheses of the angucyclinone antibiotics (+)-emycin A and (+)-ochromycinone. Chemical Communications, 203-204.