Research Associate Professor
Email miriam.rademaker@otago.ac.nz
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch
New Zealand
Current roles
- Research Associate Professor, Department of Medicine
- Co-Director, Physiology Division, Christchurch Heart Institute
- Principle Investigator of physiological based studies
- Member of Faculty of the Christchurch School of Medicine
- Member of The Canterbury Medical Research Society
- Editorial Board, American Journal of Physiology: Reg., Int.
- Editorial Board, Clinical Science
Research interests
Research focus is on the integrated cardiovascular, endocrine and renal control of pressure/volume homeostasis.
Particular emphasis is placed on the role that key vasoactive hormones (such as the natriuretic peptides, adrenomedullins, endothelin and the renin-angiotensin-aldosterone system) play in the pathophysiology of circulatory diseases such as hypertension, myocardial infarction and heart failure, and ways of manipulating these systems in order to prevent and treat these diseases.
Over the past decade interest has widened to include the novel urocortin family of peptides, phosphodiesterase 9 inhibition and natriuretic peptide analogues engineered to have distinct vasodilatory or renal activity, as well as renal dysfunction in heart failure (one of the most important risk factors for morbidity and mortality in this disease) and novel implantable devices that may potentially be used to identify early decompensation in heart failure and to optimise anti-failure treatment.
Publications
Scott, N. J. A., Charles, C. J., Prickett, T. C. R., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2024). Phosphodiesterase 9 inhibition combined with valsartan and with sacubitril/valsartan in experimental ovine heart failure. Journal of the American Heart Association, 13, e036689. doi: 10.1161/jaha.124.036689 Journal - Research Article
Janiak, P. P., Rademaker, M. T., Scott, N. J. A., Charles, C. J., Lawson, F. C., Ozoux, M. L., & Kowala, M. C. (2024). COR-1167, a new long-acting CRF2 receptor agonist, decreases congestion by improving cardiorenal function in a sheep model of worsening heart failure (WHF). European Journal of Heart Failure, 26(S2), (pp. 400). doi: 10.1002/ejhf.3326 Conference Contribution - Published proceedings: Abstract
Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Espiner, E. A., Richards, A. M., & Rademaker, M. T. (2024). Haemodynamic, hormonal and renal actions of osteocrin in normal sheep. Experimental Physiology. Advance online publication. doi: 10.1113/EP091826 Journal - Research Article
Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028 Journal - Research Article
Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015 Journal - Research Article
2024
Journal - Research Article
Scott, N. J. A., Charles, C. J., Prickett, T. C. R., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2024). Phosphodiesterase 9 inhibition combined with valsartan and with sacubitril/valsartan in experimental ovine heart failure. Journal of the American Heart Association, 13, e036689. doi: 10.1161/jaha.124.036689
Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Espiner, E. A., Richards, A. M., & Rademaker, M. T. (2024). Haemodynamic, hormonal and renal actions of osteocrin in normal sheep. Experimental Physiology. Advance online publication. doi: 10.1113/EP091826
Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028
Conference Contribution - Published proceedings: Abstract
Janiak, P. P., Rademaker, M. T., Scott, N. J. A., Charles, C. J., Lawson, F. C., Ozoux, M. L., & Kowala, M. C. (2024). COR-1167, a new long-acting CRF2 receptor agonist, decreases congestion by improving cardiorenal function in a sheep model of worsening heart failure (WHF). European Journal of Heart Failure, 26(S2), (pp. 400). doi: 10.1002/ejhf.3326
2023
Journal - Research Article
Wong, L. L., Fadzil, A. B., Chen, Q., Rademaker, M. T., Charles, C. J., Richards, A. M., & Wang, P. (2023). Interrogating the role of miR-125b and its 3’isomiRs in protection against hypoxia. International Journal of Molecular Sciences, 24, 16015. doi: 10.3390/ijms242116015
Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290
Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure, 11(2), 227-239. doi: 10.1016/j.jchf.2022.11.006
2022
Journal - Research Article
Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009
Conference Contribution - Published proceedings: Abstract
Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009
2021
Journal - Research Article
Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312
Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052
Journal - Research Other
Vasconcelos, I., Adão, R., Rademaker, M. T., Leite-Moreira, A. F., Fontes-Sousa, A. P., & Brás-Silva, C. (2021). Urocortins as biomarkers in cardiovascular disease. Clinical Science, 136, 1-14. doi: 10.1042/cs20210732
2020
Journal - Research Article
Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192
Journal - Research Other
Charles, C. J., Rademaker, M. T., Scott, N. J. A., & Richards, A. M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals, 10, 1906. doi: 10.3390/ani10101906
2019
Journal - Research Article
Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096
Conference Contribution - Published proceedings: Abstract
Gearry, R., Frampton, C., Inns, S., Poppelwell, D., Rademaker, M., & Suppiah, R. (2019). VITALITY: Impact of adalimumab (HUMIRA ®) on disability in New Zealand patients with psoriasis, Crohn's disease (CD) or rheumatoid arthritis (RA). Australasian Journal of Dermatology, 60(Suppl. 1), (pp. 82). doi: 10.1111/ajd.13027
2018
Journal - Research Article
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513
Adão, R., Mendes-Ferreira, P., Santos-Ribeiro, D., Maia-Rocha, C., Pimentel, L. D., Pinto, C., … Rademaker, M. T., … Brás-Silva, C. (2018). Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. Cardiovascular Research, 114(8), 1165-1177. doi: 10.1093/cvr/cvy076
Conference Contribution - Poster Presentation (not in published proceedings)
Mbikou, P. P., Pemberton, C. J., Charles, C. J., & Rademaker, M. T. (2018, August). Characterising the role and the therapeutic potential of novel peptide DWORF in heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Journal - Research Article
Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x
Journal - Research Other
Rademaker, M. T., & Richards, A. M. (2017). Urocortins: Actions in health and heart failure. Clinica Chimica Acta, 474, 76-87. doi: 10.1016/j.cca.2017.09.003
2016
Journal - Research Article
Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341
Conference Contribution - Poster Presentation (not in published proceedings)
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August-September). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011
Ellmers, L. J., Scott, N. J. A., Cameron, V. A., Richards, A. M., & Rademaker, M. T. (2015). Chronic urocortin 2 administration improves after cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction. Journal of Cardiovascular Pharmacology, 65(3), 269-275. doi: 10.1097/FJC.0000000000000190
Adão, R., Santos-Ribeiro, D., Rademaker, M. T., Leite-Moreira, A. F., & Brás-Silva, C. (2015). Urocortin 2 in cardiovascular health and disease. Drug Discovery Today, 20(7), 906-914. doi: 10.1016/j.drudis.2015.02.012
Charles, C. J., Rademaker, M. T., Melton, I. C., Gutfinger, D., Eigler, N. L., Qu, F., & Troughton, R. W. (2015). Thoracic impedance measures tissue characteristics in the vicinity of the electrodes, not intervening lung water: Implications for heart failure monitoring. Journal of Clinical Monitoring & Computing, 29(1), 65-76. doi: 10.1007/s10877-014-9570-x
Conference Contribution - Published proceedings: Abstract
Santos-Ribeiro, D., Mendes-Ferreira, P., Adao, R., Maia-Rocha, C., Alves, B. S., Rademaker, M., … Bras-Silva, C. (2015). Urocortin-2 improves right ventricular function in pulmonary arterial hypertension. European Journal of Heart Failure, 17(Suppl. 1), (pp. 242). doi: 10.1002/ejhf.277
2014
Journal - Research Article
Rademaker, M. T., Charles, C. J., & Richards, M. (2014). Sheep for the study of the urocortins and other hormones. Cardiovascular Endocrinology, 3(1), 39-43. doi: 10.1097/XCE.0000000000000024
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013
Conference Contribution - Published proceedings: Abstract
Wong, L. L., Lew, K. S., Chen, Q., Rademaker, M. T., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2014). Identification of microRNA in an ovine model of heart failure. Circulation, 130(Suppl. 2), A16470. [Abstract]
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Systemic angiotensin II does not increase cardiac sympathetic nerve activity in conscious sheep. Endocrine Reviews, 35(3, Suppl.), MON-0865. Retrieved from http://press.endocrine.org/series/endo-meetings
2013
Chapter in Book - Research
Richards, M., & Rademaker, M. (2013). Urocortins. In A. Kastin (Ed.), Handbook of biologically active peptides. (2nd ed.) (pp. 1428-1436). San Diego, CA: Academic Press. doi: 10.1016/B978-0-12-385095-9.00194-9
Chapter in Book - Other
Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Trainor, K. E., Roberts, A., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Comparative pathology of an implantable left atrial pressure sensor. ASAIO Journal, 59(5), 486-492. doi: 10.1097/MAT.0b013e31829bdffd
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2013). Interactions of enhanced urocortin 2 and mineralocorticoid receptor antagonism in experimental heart failure. Circulation: Heart Failure, 6(4), 825-832. doi: 10.1161/circheartfailure.112.000205
Roberts, A., Trainor, K. E., Weeks, B., Jackson, N., Troughton, R. W., Charles, C. J., Rademaker, M. T., Melton, I. C., Crozier, I. G., … Clubb, Jr, F. J. (2013). Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor. Journal of Histotechnology, 36(1), 17-27. doi: 10.1179/2046023613Y.0000000021
2012
Journal - Research Article
Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Haemodynamic, endocrine and renal actions of adrenomedullin 5 in an ovine model of heart failure. Clinical Science, 122(9), 429-437. doi: 10.1042/cs20110483
Patel, K., Rademaker, M. T., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T. G., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166(6), 1916-1925. doi: 10.1111/j.1476-5381.2012.01904.x
Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Jardine, D. L., Chan, W., Ellmers, L. J., Troughton, R. W., & Richards, A. M. (2012). Urocortin 2: Neurohumoral mechanisms in heart disease. Heart, Lung & Circulation, 21(12), (pp. 863). doi: 10.1016/j.hlc.2012.08.033
2011
Journal - Research Article
Rademaker, M. T., Charles, C. J., Nicholls, G., & Richards, M. (2011). Urocortin 2 sustains haemodynamic and renal function during introduction of beta-blockade in experimental heart failure. Journal of Hypertension, 29, 1787-1795. doi: 10.1097/HJH.0b013e3283493776
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4
Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2011). Hemodynamic, hormonal, and renal actions of adrenomedullin-5 in normal conscious sheep. Journal of Cardiovascular Pharmacology, 58(1), 25-31. doi: 10.1097/FJC.0b013e31821a9473
Rademaker, M. T., Charles, C. J., Melton, I. C., Richards, A. M., Frampton, C. M., Siou, J., … Troughton, R. W. (2011). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Clinical Science, 120(5), 207-217. doi: 10.1042/CS20100388
Conference Contribution - Published proceedings: Abstract
Ellmers, L. J., Richards, M. A., Charles, C. J., & Rademaker, M. T. (2011). (Pro)renin receptor blockade improves cardiac function and reduces ventricular remodeling following myocardial infarction in mice. European Heart Journal, 32(Suppl. 1), (pp. 693). doi: 10.1093/eurheartj/ehr324
Charles, C., Rademaker, M., Melton, I., Siou, J., Shah, R., Qu, F., … Troughton, R. (2011). New discoveries regarding the limitations of impedance monitoring for heart failure management. Journal of Cardiac Failure, 17(8, Suppl. 1), (pp. S99). doi: 10.1016/j.cardfail.2011.06.332
2010
Chapter in Book - Other
Rademaker, M. T., & Espiner, E. (2010). Hormones of the cardiovascular system. In J. L. Jameson & L. J. De Groot (Eds.), Endocrinology: Adult and pediatric (Vol. II). (6th ed.) (pp. 2036-2052). Philadelphia, PA: Saunders.
Journal - Research Article
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2010). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Peptides, 31, 878-882. doi: 10.1016/j.peptides.2010.02.010
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505
Conference Contribution - Published proceedings: Abstract
Ellmers, L., Scott, N., Cameron, V., Richards, M., & Rademaker, M. (2010). Chronic urocortin 2 treatment significantly improves cardiovascular function and attenuates cardiac injury and remodelling after experimental myocardial infarction. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S49). doi: 10.1016/j.hlc.2010.06.784
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M., Charles, C., Melton, I., Richards, M., Frampton, C., Siou, J., … Troughton, R. (2010, November-December). Monitoring of heart failure: Comparison of left atrial pressure with intrathoracic impedance and natriuretic peptide measurements in an experimental model of ovine heart failure. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Article
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2009). Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circulation: Heart Failure, 2(6), 532-540. doi: 10.1161/CIRCHEARTFAILURE.109.861336
Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2009). Sympathoinhibitory actions of the urocortin peptides suggest therapeutic potential in acute cardiac injury. Clinical Autonomic Research. 19(5), (pp. 284). doi: 10.1007/s10286-009-0030-5
Ellmers, L., Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., & Rademaker, M. T. (2009). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. European Heart Journal. 30(Suppl. 1), (pp. 288). doi: 10.1093/eurheartj/ehp416
2008
Journal - Research Article
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal, and renal actions of adrenomedullin 2 in experimental heart failure. Circulation: Heart Failure, 1, 134-142. doi: 10.1161/circheartfailure.107.755504
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60.
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure. Clinical Science, 114(10), 635-642. doi: 10.1042/CS20070364
Conference Contribution - Published proceedings: Abstract
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2008). Sympathoinhibitory actions of the urocortins suggest therapeutic potential in acute cardiac injury. Proceedings of the 2nd Cardiovascular Control Conference. CCC. Retrieved from http://cccindia08.florey.edu.au/India08%20Abstracts.pdf
Rademaker, M. T., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2008). Hemodynamic, hormonal and renal actions of adrenomedullin 2 in experimental heart failure. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S807-S808). [Abstract]
Charles, C., Jardine, D., Nicholls, G., Rademaker, M., & Richards, M. (2008). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Heart, Lung & Circulation, 17(Suppl. 1), (pp. S1). doi: 10.1016/j.hlc.2007.11.002
Conference Contribution - Verbal presentation and other Conference outputs
Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., Rademaker, M. T., & Ellmers, L. J. (2008, November). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2008, November). Adrenomedullin 2 attenuates the pressor but not adrenal responses to angiotensin II in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Rademaker, M. (2008, October). Pre-clinical models of heart failure. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.
2007
Journal - Research Article
Rademaker, M. T., Charles, C. J., & Richards, A. M. (2007). Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 293, H1536-H1544. doi: 10.1152/ajpheart.00377.2007
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep. Clinical Science, 112, 485-491.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.
Conference Contribution - Published proceedings: Abstract
Khoury, D. S., Naware, M., . . ., Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Physiologic monitoring of congestive heart failure by multiple impedance vectors. Heart Rhythm. 4(5 (Suppl. S)), (pp. S393). [Abstract]
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 inhibits cardiac sympathetic nerve activity in normal conscious sheep. Endocrine Journal. 54(Suppl.), (pp. 194). [Abstract]
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulent sheep. Journal of Molecular & Cellular Cardiology, 42(6, Suppl. 1), (pp. S35). [Abstract]
Sheth, B., Ohlander, M., Naware, M., Siou, J., Gutfinger, D., Khoury, D., Rademaker, M., & Panescu, D. (2007). Monitoring congestive heart failure using multi-vector device-based impedance trends. Europace Supplements. 9(Suppl. 3), (pp. iii156-iii157). [Abstract]
Nabutovsky, Y., Holmstrom, N., Pillai, A., Illindala, U., Blomqvist, A., Khoury, D., Rademaker, M., & Panescu, D. (2007). Device-based cardiogenic impedance for heart failure monitoring. Europace Supplements. 9(Suppl. 3), (pp. iii159-iii160). [Abstract]
Charles, C. J., Rademaker, M. T., Yandle, T. G., & Richards, A. M. (2007). Arterio-venous trans-organ sampling in normal and heart failure sheep: Determining the source of circulating hormones. Endocrine Journal. 54(Suppl.), (pp. 80). [Abstract]
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in ambulant sheep. European Journal of Heart Failure Supplements, 6(Suppl. 1), (pp. 145). doi: 10.1016/S1567-4215(07)60405-6
Khoury, D., Naware, M., Siou, J., Gutfinger, D., Eigler, N., Ohlander, M., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Heart failure trending by multiple-vector impedance. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S129). doi: 10.1016/j.cardfail.2007.06.498
Nabutovsky, Y., Naware, M., Siou, J., Pillai, A., Illindala, U., Holmstrom, N., … Rademaker, M., Charles, C., Troughton, R., & Panescu, D. (2007). Pilot investigation of cardiogenic impedance during heart failure induction using a new prototype ICD. Journal of Cardiac Failure, 13(6, Suppl. 2), (pp. S123). doi: 10.1016/j.cardfail.2007.06.478
Conference Contribution - Poster Presentation (not in published proceedings)
Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2007, July). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Poster session presented at the FASEB Summer Research Conferences, Sydney, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2007, November). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
Rademaker, M. (2007, August). Urocortin. Verbal presentation at the Cardiac Society of Australia and New Zealand 55th Annual Scientific Meeting, Christchurch, New Zealand.
2006
Chapter in Book - Other
Rademaker, M. T., & Espiner, E. A. (2006). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology (Vol. 3). (5th ed.) (pp. 2549-2566). Philadelphia: Elsevier Saunders.
Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). Urocortin 3: Haemodynamic, hormonal, and renal effects in expermental heart failure. European Heart Journal, 27(17), 2088-2098.
Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Plasma urocortin 1 in sheep: Regional sampling and effects of experimental heart failure. Peptides, 27, 1801-1805.
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. Journal of Endocrinology, 189(3), 701-710.
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2006). Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep. Endocrinology, 147(4), 1871-1877.
Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005
Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019
Journal - Research Other
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2006). [Response to the letter regarding Article by Rademaker et al, ″Integrated hemodynamic, hormonal, and renal actions of Urocortin 2 in normal and paced sheep: Beneficial effects in heart failure″]. Circulation, 113. Retrieved from http://www.circ.ahajournals.org/cgi/content/full/113/15/e710
Conference Contribution - Published proceedings: Abstract
Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., Richards, A. M., on behalf of Christchurch Cardioendocrine Research Group. (2006). Urocortin 2 infusion in humans with mild heart failure: Haemodynamics, neurohormonal and renal responses. European Heart Journal, 27(Suppl. 1), (pp. 488). [Abstract]
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2006). Urocortin 2 infusion in healthy humans induces marked hemodynamic, neurohormonal, and renal responses. Journal of the American College of Cardiology. 47(4, Suppl. A), (pp. 310A). [Abstract]
2005
Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2005). Urotensin II: Evidence for cardiac, hepatic and renal production. Peptides, 26, 2211-2214. doi: 10.1016/j.peptides.2005.03.043
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Endogenous urocortins reduce vascular tone and renin-aldosterone / endothelin activity in experimental heart failure. European Heart Journal, 26(19), 2046-2054. doi: 10.1093/eurheartj/ehi227
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Lainchbury, J. G., & Richards, A. M. (2005). Four-day urocortin-I administration has sustained beneficial haemodynamic, hormonal, and renal effects in experimental heart failure. European Heart Journal, 26, 2055-2062. doi: 10.1093/eurheartj/ehi351
Rademaker, M. T., Cameron, V. A., Charles, C. J., & Richards, A. M. (2005). Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure. Circulation, 112, 3624-3632. doi: 10.1161/CIRCULATIONAHA.105.561308
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2005). Effect of urocortin I infusion in humans with stable congestive cardiac failure. Clinical Science, 109(4), 381-388. doi: 10.1042/CS20050079
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin in heart failure: Potential therapeutic implications. Future Cardiology, 1(2), 235-243.
Rademaker, M. T., & Richards, A. M. (2005). Cardiac natriuretic peptides for cardiac health. Clinical Science, 108, 23-36. doi: 10.1042/CS20040253
Conference Contribution - Published proceedings: Abstract
Davis, M. E., Skinner, M. H., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Frampton, C. M., & Richards, A. M. (2005). First report of urocortin 2 infusion in normal humans. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S111-S112). doi: 10.1016/j.hlc.2005.04.007
Rademaker, M. T., Charles, C. J., Cameron, V. A., & Richards, A. M. (2005). Urocortin 2 has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. The Journal of Heart Disease. 4(1), (pp. 129). [Abstract]
2004
Journal - Research Article
Charles, C. J., Rademaker, M. T., & Richards, A. M. (2004). Urocortins: Putative role in cardiovascular disease. Current Medicinal Chemistry: Cardiovascular & Hematological Agents, 2, 43-47.
Rademaker, M. T. (2004). Urocortin: Cardiovascular actions and therapeutic implications. Letters in Drug Design & Discovery, 1, 168-172.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2004). Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. Clinical Science, 106, 569-576.
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin-1 infusion in normal humans. Journal of Clinical Endocrinology & Metabolism, 89(3), 1402-1409.
Conference Contribution - Published proceedings: Abstract
Charles, C., Rademaker, M., Richards, M., & Nicholls, G. (2004). Potential for targeting adrenomedullin mechanisms in heart failure. Journal of Molecular & Cellular Cardiology, 37(S37E), (pp. 345). doi: 10.1016/j.yjmcc.2004.05.003
Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Palmer, B. R., Frampton, C. M., Gunningham, S. P., Currie, M. J., McKenzie, J. L., … Cameron, V. A. (2004). Cytokine induced changes in cultured cardiac fibroblasts: Cell morphology and natriuretic peptide receptor expression. Proceedings of the 12th International Congress of Endocrinology. (pp. 145). [Abstract]
Rademaker, M., Charles, C., Espiner, E., Lainchbury, J., Nicholls, G., & Richards, M. (2004). Chronic urocortin administration in experimental heart failure. Proceedings of the 12th International Congress of Endocrinology. (pp. 174-175). [Abstract]
Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin infusion in humans with stable congestive cardiac failure. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S117-S118). doi: 10.1016/j.hlc.2004.05.001
2003
Journal - Research Article
Rademaker, M. T., Cameron, V. A., Charles, C. J., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2003). Adrenomedullin and heart failure. Regulatory Peptides, 112(1-3), 51-60.
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2003). Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep. Clinical Science, 104(4), 429-436.
Nicholls, M. G., Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2003). Adrenomedullin in heart failure. Hypertension Research, 26(Suppl.), S135-S140. doi: 10.1291/hypres.26.S135
Charles, C. J., Lainchbury, J. G., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Troughton, R. W. (2003). Adrenomedullin and the renin-angiotensin-aldosterone system. Regulatory Peptides, 112(1-3), 41-49.
Conference Contribution - Published proceedings: Abstract
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003). First report of urocortin infusion and actions in normal humans. Circulation, 108(17 Suppl. IV), (pp. 242). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, November). First report of urocortin infusion and actions in normal humans. Verbal presentation at the American Heart Association Conference 2003, Orlando, USA.
Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, July). First report of urocortin infusion and actions in normal humans. Verbal presentation at the Christchurch Medical Research Conference 2003, Christchurch, NZ.
2002
Chapter in Book - Research
Rademaker, M. T., & Espiner, E. A. (2002). Cardiovascular hormones. In G. M. Besser & M. O. Thorner (Eds.), Comprehensive Clinical Endocrinology. (3rd ed.) (pp. 485-499). Edinburgh: Mosby.
Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Long-Term adrenomedullin administration in experimental heart failure. Hypertension, 40(5), 667-672.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C. M. J., Lainchbury, J. G., Nicholls, M. G., Richards, A. M., & Vale, W. W. (2002). Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: Comparison with normal sheep. JACC, 40(8), 1495-1505.
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure. Clinical Science, 102(6), 653-660.
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2002). Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure. Hypertension, 39(1), 93-98.
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2002). Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep. Journal of Endocrinology, 173(1), 123-129.
Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Espiner, E. A., Fisher, S., Frampton, C. M., Kirkpatrick, C., Lainchbury, J. G., Nicholls, M. G., & Richards, A. M. (2002). Urocortin has beneficial hemodynamic, endocrine and renal effects in experimental heart failure. Abstracts presented at the Joint Meeting of the 19th Scientific Meeting of the International Society of Hypertension and the 12th European Meeting on Hypertension. 20(supplement), (pp. P1300). Prague, Czech Republic: Lippincott Williams & Wilkins Healthcare. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002, November). Chronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). hronic adrenomedullin administration in experimental heart failure. Verbal presentation at the 3rd International Symposium on Adrenomedullin and PAMP, Osaka, Japan.
2001
Chapter in Book - Research
Rademaker, M. T., & Espiner, E. A. (2001). The endrocrine heart. In K. Becker (Ed.), Principles and Practice of Endocrinology and Metabolism (3rd edition). (pp. 1622-1634). Philadelphia: Lippincott Williams and Wilkins.
Rademaker, M. T., & Espiner, E. A. (2001). Hormones of the cardiovascular system. In L. J. DeGroot & J. L. Jameson (Eds.), Endocrinology. (4th ed.) (pp. 1791-1809). Philadelphia: W. B. Saunders Company.
Journal - Research Article
Aitken, G. D., Cameron, V. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Increased atrial but not ventricular ANP and BNP expression in a paced model of heart failure. Journal of Biochemistry, Molecular Biology & Biophysics, 5, 199-207.
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2001). Adrenomedullin augments the neurohumoral response to haemorrhage in non-pregnant but not in pregnant sheep. Journal of Endocrinology, 171(2), 363-371.
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Comparative actions of adrenomedullin and nitroprusside: Interactions with ANG II and norepinephrine. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 281(6), R1887-R1894.
Conference Contribution - Published proceedings: Abstract
Espiner, E. A., Cameron, A. V., Charles, C., Nicholls, M. G., Rademaker, M. T., Richards, A. M., & Yandle, T. (2001). The endocrine heart. Proceedings of the New Zealand Endocrine Society Annual Meeting. (pp. A43). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001). Andrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.
Rademaker, M. T., Charles, C. J., Lewis, L. K., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2001). Combined adrenomedullin adminstration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch.
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2001, August). Adrenomedullin augments the neurohumoral response to hemorrhage in non-pregnant but not pregnant sheep. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2001, August). Combined adrenomedullin administration and angiotensin-converting enzyme inhibition in experimental heart failure. Verbal presentation at the 34th International Congress of Physiological Sciences, Christchurch, New Zealand.
2000
Chapter in Book - Research
Richards, A. M., Lainchbury, J. G., Nicholls, M. G., & Rademaker, M. T. (2000). Adrenomedullin in heart failure: Biochemical curiosity or pathophysiological player? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (2nd ed.) (pp. 105-125). London: Martin Dunitz.
Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. Journal of Cardiovascular Pharmacology, 36, 526-532.
Cameron, V. A., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct. Endocrinology, 141(12), 4690-4697. doi: 10.1210/endo.141.12.7847
Troughton, R. W., Rademaker, M. T., Powell, J. D., Yandle, T. G., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (2000). Beneficial renal and hemodynamic effects of omapatrilat in mild and severe heart failure. Hypertension, 36(4), 523-530.
Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Myocardial infarction with and without reperfusion in sheep: Early cardiac and neurohumoral changes. Clinical Science, 98, 703-711.
Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (2000). Adrenomedullin attenuates pressor response to angiotensin II in concious sheep. 11th International Congress of Endocrinology. 36. [Abstract]
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (2000). Interactions of adrenomedullin with incremental infusions of angiotensin II and norepinephrine in conscious sheep; comparison with nitroprusside. Proceedings of 11th International Congress of Endocrinology. (pp. 985). Sydney. [Abstract]
Charles, C. J., Rademaker, M. T., & Nicholls, M. G. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. 18th Scientific Meeting of the International Society of Hypertension. (pp. 3). Chicago. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000, October/November). Combined adrenomedullin administration and neutral endopeptidase inhibition in heart failure. Verbal presentation at the 11 th International Congress of Endocrinology, Sydney.
Charles, C. J., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2000). Adrenomedullin augments the neurohumoral response to hemorrhage in normal conscious sheep. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Queensland.
1999
Journal - Research Article
Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Bioactivity of natriuretic peptide coinfusions: no evidence for unique effects of BNP in conscious sheep. Journal of Cardiovascular Pharmacology, 33(2), 229-236.
Charles, C. J., Lainchbury, J. G., Lewis, L. K., Rademaker, M. T., Richards, A. M., Yandle, T. G., & Nicholls, M. G. (1999). The role of adrenomedullin. American Journal of Hypertension, 12(2 Part 1), 166-173.
Conference Contribution - Published proceedings: Abstract
Troughton, R. W., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Nicholls, M. G. (1999). Acute and chronic administration of Omapatrilat in an ovine model in mild and severe heart failure. 72nd Scientific Sessions, American Heart Foundation. (pp. I-300). [Abstract]
Cameron, A. V., Rademaker, M. T., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Regional and temporal comparison of atrial and brain natriuretic peptide gene expression in an ovine model of myocardial infarction. 1st International Congress on Heart Disease - New Trends in Research, Diagnosis and Treatment. 1(1). The Journal of Heart Disease. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999, August). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress on Heart Disease, Washington DC, USA.
Cameron, A. V., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Comparison of atrial and brain natriuretic peptide expression in ovine heart after myocardial infarction. Verbal presentation at the 2nd BCCH Symposium, Sydney, Australia.
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). Acute and chronic administration of omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the 47th Annual Meeting Cardiac Society of Australia and New Zealand, Wellington, New Zealand.
Charles, C. J., Elliott, J. M., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1999). Myocardial infarction with and without reperfusion in sheep: Cardiac, neurohumoral and hemodynamic effects. Verbal presentation at the 1st International Congress in Heart Disease, Washington DC, USA.
1998
Journal - Research Article
Charles, C. J., Espiner, E. A., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: bioactivity at low physiological levels. Clinical Science, 95(6), 701-708.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1998). Combined neutral endopeptidase and angiotensin-converting enzyme inhibition in heart failure: role of natriuretic peptides and angiotensin II. Journal of Cardiovascular Pharmacology, 31(1), 116-125.
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208.
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., & Nicholls, M. G. (1998). Hemodynamic, hormonal and renal effects of intracerebroventricular adrenomedullin in conscious sheep. Endocrinology, 139(4), 1746-1751. doi: 10.1210/endo.139.4.5862
Conference Contribution - Published proceedings: Abstract
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Natriuretic peptides and endothelin on an ovine coronary artery ligation model of mild heart failure. 80th Annual Endocrine Society Meeting Programme. (A326). [Abstract]
Charles, C. J., Espiner, E. A., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1998). Chronic infusions of brain natriuretic peptide in conscious sheep: Bioactivity at low physiological levels. Journal of Hypertension. 16(Suppl. 2), (pp. S143). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998). Netriuretic peptides and endothelin un an ovine coronary ligation model of mild heart failure. Verbal presentation at the Endo '98, New Orleans.
Rademaker, M. T., Troughton, R. W., Charles, C. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1998, November). Acute and chronic administration of Omapatrilat in an ovine model of mild and severe heart failure. Verbal presentation at the American Heart Association Meeting, Atlanta, USA.
Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1998). Adrenomedullin in heart failure. Verbal presentation at the Centre of Excellence International Symposium on Adrenomedullin and PAMP, Osaka, Japan.
1997
Journal - Research Article
Charles, C. J., Rademaker, M. T., Richards, A. M., Cooper, G. J. S., Coy, D. H., Jing, N. N., & Nicholls, M. G. (1997). Hemodynamic, hormonal, and renal effects of adrenomedullin in conscious sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 272(6 pt.2), R2040-R2047.
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. L. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Clinical & Experimental Pharmacology & Physiology, 24(11), 807-813.
Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A. A., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1997). Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. American Journal of Physiology: Heart & Circulatory Physiology, 273(5 pt.2), H2372-H2379.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., & Richards, A. M. (1997). Comparative bioactivity of atrial and brain natriuretic peptides in an ovine model of heart failure. Clinical Science, 92(2), 159-165.
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Cooper, G. J., Coy, D. H., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Circulation, 96(6), 1983-1990.
Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550.
Journal - Research Other
Begg, E. J., Nicholls, M. G., Rademaker, M. T., & Charles, C. J. (1997). Pharmacokinetics of adrenomedullin in a sheep model of heart failure. Proceedings of ASCEPT, 3, 34.
Conference Contribution - Published proceedings: Abstract
Charles, C. J., Rademaker, M. T., Nicholls, M. G., & Richards, A. M. (1997). Biological effects of intracerebroventricular adrenomedullin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract]
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. The Journal of Heart Failure. 4(1), (pp. 74). [Abstract]
Charles, C. J., Rademaker, M. T., Richards, A. M., & Nicholls, M. G. (1997). Biological effects of intracerebroventricular adrenomedulin in normal conscious sheep. Proceedings of the Endocrine Society of Australia. 40, (pp. 16). [Abstract]
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Lewis, L. K., Yandle, T. G., Rademaker, M. T., Charles, C. J., … Lynn, K. (1997). Comparison of the effects of ouabain and brain natriuretic peptide in saline-loaded sheep. Proceedings of the 32nd Annual Meeting of Australian and New Zealand Society of Nephrology. 51, (pp. 1308). [Abstract]
Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Lainchbury, J. G., Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997). Adrenomedullin in heart failure. Verbal presentation at the 1st International Symposium on Adrenomedullin and PAMP, Osaka.
Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibiting natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.
Rademaker, M. T., Charles, C. J., Lewis, L. K., Yandle, T. G., Richards, A. M., & Nicholls, M. G. (1997, June). Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure. Verbal presentation at the 8th European Society of Hypertension, Milan.
Espiner, E. A., Rademaker, M. T., Charles, C. J., Kosoglou, T., Protter, A., Nicholls, M. G., & Richards, A. M. (1997). Inhibitory natriuretic peptide metabolism has beneficial renal hemodynamic effects, induces natriuresis and inhibits aldosterone in experimental heart failure. Verbal presentation at the 23rd Aldosterone Conference, Minneapolis.
1996
Journal - Research Article
Rademaker, M. T., Charles, C. J., Espiner, E. A., Frampton, C. M., Nicholls, M. G., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptide responses to acute and chronic ventricular pacing in sheep: evidence for differential secretion of ANP and BNP. American Journal of Physiology: Heart & Circulatory Physiology, 270, H594-H600.
Pidgeon, G. B., Richards, A. M., Nicholls, M. G., Charles, C. J., Rademaker, M. T., Lynn, K. L., … Lewis, L. K., & Yandle, T. G. (1996). Chronic ouabain infusion does not cause hypertension in sheep. American Journal of Physiology: Endocrinology & Metabolism, 270(3), E386-E392.
Rademaker, M. T., Fitzpatrick, M. A., Richards, A. M., Charles, C. J., Nicholls, M. G., Frampton, C. M., & Ikram, H. (1996). Nitric oxide inhibition in an ovine model of heart failure. Clinical & Experimental Pharmacology & Physiology, 23, 403-409.
Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Richards, A. M., Nicholls, M. G., Espiner, E. A., & Sybertz, E. (1996). Comparison of chronic neutral endopeptidase inhibition and furosemide in an ovine model of heart failure. Journal of Cardiovascular Pharmacology, 27(3), 439-446.
Rademaker, M. T., Charles, C. J., Espiner, E. A., Nicholls, M. G., Richards, A. M., & Kosoglou, T. (1996). Neural endopeptidase inhibition: augmented atrial and brain natriuretic peptide, haemodynamic and natriuretic responses in ovine heart failure. Clinical Science, 91, 283-291.
1995
Journal - Research Article
Rademaker, M. T., Fitzpatrick, M. A., Charles, C. J., Frampton, C. M., Richards, A. M., Nicholls, M. G., & Espiner, E. A. (1995). Central angiotensin II AT1-receptor antagonism in normal and heart failed sheep. American Journal of Physiology: Heart & Circulatory Physiology, 269, H425-H432.