Professor Tim Woodfield, Our people, University of Otago, Christchurch

Research Professor

Rutherford Discovery Fellow 2012-2017

BE(Hons)(Cant) MASc(Tor) PhD(Twente)

Tim B. F. Woodfield, PhD is Professor of Regenerative Medicine in the Department of Orthopaedic Surgery & Musculoskeletal Medicine at the University of Otago, New Zealand. He leads the Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group and is Director of the University of Otago Centre for Bioengineering & Nanomedicine.

His research platform involves development of novel bioinks and bioresins, biofabrication, spheroid bioassembly and additive manufacturing of medical devices applied to regenerative medicine of cartilage and bone, advanced 3D in vitro tissue culture models, and high throughput screening.

He has published over 160 peer reviewed journal articles, book chapters and published conference proceedings (h-index: 42; Scopus) and has over 7100 citations (Scopus). He has received a number of awards and fellowships including a prestigious Rutherford Discovery Fellowship from the Royal Society of New Zealand | Te Apārangi, as well as receiving the 2020 Research Excellence Award from the Australasian Society for Biomaterials & Tissue Engineering (ASBTE) and the University of Otago Research Gold Medal. He was awarded Fellow, Biomaterials Science & Engineering (FBSE) in 2020 by the International Union of Societies in Biomaterials Science and Engineering (IUSBSE).

He has attracted over NZ$28 million in competitive research funding as a Principal or Associate Investigator through grants from the Ministry of Business Innovation & Employment, Royal Society of New Zealand | Te Apārangi, New Zealand Health Research Council, AO Foundation, as well as the European Commission (EU-FP7).

He is the President of the International Society for Biofabrication (ISBF) and former President of the Australasian Society for Biomaterials & Tissue Engineering (ASBTE). He was elected to the Tissue Engineering and Regenerative Medicine International Society Asia Pacific (TERMIS-AP) Council and is an Executive Editorial Board Member for Biofabrication; an Editorial Board Member for Advanced Healthcare Materials and APL Bioengineering; and Associate Editor for Frontiers in Bioengineering & Biotechnology.

Inaugural Professorial Lecture

Roles

Principal Investigator, Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group
Director, University of Otago Centre for Bioengineering & Nanomedicine
Theme Leader, Regenerative Medicine – University of Otago Centre for Bioengineering & Nanomedicine
Adjunct Associate Professor, Institute of Health & Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, Australia
Adjunct Senior Fellow, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
Principal Investigator, Centre of Research Excellence in Medical Technologies
Associate Investigator, Maurice Wilkins Centre for Molecular Diversity

Professional affiliations

President-Elect & Exec Board Member
International Society for Biofabrication
Past President
Australasian Society for Biomaterials & Tissue Engineering (ASBTE)
Council Member
Tissue Engineering & Regenerative Medicine International Society, Asia-Pacific Chapter (TERMIS-AP)
Secretary
Biofabrication Thematic Group, Tissue Engineering & Regenerative Medicine International Society (TERMIS)
Editorial Board Member
Biofabrication (IOPscience)
Associate Editor and Editorial Board Member
Frontiers in Biomaterials
Editorial Board Member
APL Bioengineering

Professional interests

Orthopaedic Tissue Engineering and Regenerative Medicine

Stem cell and scaffold-based regeneration of cartilage and bone
Bio-fabrication and advanced bio-ink/bio-resins
Orthopaedic medical device development

Christchurch Regenerative Medicine and Tissue Engineering (CReATE) Group website
Regenerative Medicine website - Centre for Bioengineering & Nanomedicine

Publications

Murphy, C. A., Lim, K. S., & Woodfield, T. B. F. (2022). Next evolution in organ-scale biofabrication: Bioresin design for rapid high-resolution vat polymerization. Advanced Materials, 34, 2107759. doi: 10.1002/adma.202107759 Journal - Research Other

Shum, J. M., Gadomski, B. C., Tredinnick, S. J., Fok, W., Fernandez, J., Nelson, B., … Hooper, G. J., Puttlitz, C., … Woodfield, T. B. F. (2023). Enhanced bone formation in locally-optimised, low-stiffness additive manufactured titanium implants: An in silico and in vivo tibial advancement study. Acta Biomaterialia, 156, 202-213. doi: 10.1016/j.actbio.2022.04.006 Journal - Research Article

Lindberg, G. C. J., Cui, X., Durham, M., Veenendaal, L., Schon, B. S., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2021). Probing multicellular tissue fusion of cocultured spheroids: A 3D-bioassembly model. Advanced Science, 8(22), 2103320. doi: 10.1002/advs.202103320 Journal - Research Article

Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and applications of photo-cross-linking in bioprinting. Chemical Reviews, 120, 10662-10694. doi: 10.1021/acs.chemrev.9b00812 Journal - Research Article

Groll, J., Burdick, J. A., Cho, D.-W., Derby, B., Gelinsky, M., Heilshorn, S. C., … Woodfield, T. B. F. (2019). A definition of bioinks and their distinction from biomaterial inks. Biofabrication, 11, 013001. doi: 10.1088/1758-5090/aaec52 Journal - Research Other

Woodfield, T. B. F., Malda, J., de Wijn, J., Péters, F., Riesle, J., & van Blitterswijk, C. A. (2004). Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique. Biomaterials, 25(18), 4149-4161. doi: 10.1016/j.biomaterials.2003.10.056 Journal - Research Article

Cui, X., Alcala-Orozco, C. R., Baer, K., Li, J., Murphy, C. A., Durham, M., Lindberg, G., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). 3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs. Biofabrication, 14(3), 034101. doi: 10.1088/1758-5090/ac61a3 Journal - Research Article

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1 Journal - Research Article

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c Journal - Research Article

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404 Journal - Research Article

Major, G. S., Simcock, J. W., Woodfield, T. B. F., & Lim, K. S. (2022). Overcoming functional challenges in autologous and engineered fat grafting trends. Trends in Biotechnology, 40(1), 77-92. doi: 10.1016/j.tibtech.2021.04.006 Journal - Research Article

Parrish, J., Lim, K., Zhang, B., Radisic, M., & Woodfield, T. B. F. (2019). New frontiers for biofabrication and bioreactor design in microphysiological system development. Trends in Biotechnology, 37(12), 1327-1343. doi: 10.1016/j.tibtech.2019.04.009 Journal - Research Article

Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018). A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models. Lab on a Chip, (18), 2757-2775. doi: 10.1039/c8lc00485d Journal - Research Article

Schon, B. S., Schrobback, K., van der Ven, M., Stroebel, S., Hooper, G. J., & Woodfield, T. B. F. (2012). Validation of a high-throughput microtissue fabrication process for 3D assembly of tissue engineered cartilage constructs. Cell & Tissue Research, 347(3), 629-642. doi: 10.1007/s00441-011-1311-6 Journal - Research Article

Melchels, F., Malda, J., Fedorovich, N., Alblas, J., & Woodfield, T. (2011). Organ printing. In P. Ducheyne, K. E. Healy, D. W. Hutmacher, D. W. Grainger & C. J. Kirkpatrick (Eds.), Comprehensive biomaterials (vol. 5). (pp. 587-606). Elsevier Science. Chapter in Book - Research

Nguyen, T. L., Staiger, M. P., Dias, G. J., & Woodfield, T. B. F. (2011). A novel manufacturing route for fabrication of topologically-ordered porous magnesium scaffolds. Advanced Engineering Materials, 13(9), 872-881. doi: 10.1002/adem.201100029 Journal - Research Article

Woodfield, T. B. F., Guggenheim, M., von Rechenberg, B., Riesle, J., van Blitterswijk, C. A., & Wedler, V. (2009). Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small joints. Cell Proliferation, 42(4), 485-497. doi: 10.1111/j.1365-2184.2009.00608.x Journal - Research Article

Schrobback, K., Wrobel, J., Hutmacher, D. W., Woodfield, T. B. F., & Klein, T. J. (2013). Stage-specific embryonic antigen-4 is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells. Tissue Engineering Part A, 19(11-12), 1316-1326. doi: 10.1089/ten.tea.2012.0496 Journal - Research Article

Nguyen, T., Waterman, J., Staiger, M., & Woodfield, T. (2012). Controlling in vitro corrosion rate of pure Mg with rough surface texture via biomimetic coating systems. Corrosion Engineering, Science & Technology, 47(5), 358-364. doi: 10.1179/1743278212y.0000000023 Journal - Research Article

Staiger, M. P., Kolbeinsson, I., Kirkland, N. T., Nguyen, T., Dias, G., & Woodfield, T. B. F. (2010). Synthesis of topologically-ordered open-cell porous magnesium. Materials Letters, 64(23), 2572-2574. doi: 10.1016/j.matlet.2010.08.049 Journal - Research Article

Kirkland, N. T., Birbilis, N., Walker, J., Woodfield, T., Dias, G. J., & Staiger, M. P. (2010). In-vitro dissolution of magnesium-calcium binary alloys: Clarifying the unique role of calcium additions in bioresorbable magnesium implant alloys. Journal of Biomedical Materials Research Part B, 95B(1), 91-100. doi: 10.1002/jbm.b.31687 Journal - Research Article

Woodfield, T. B. F., Moroni, L., & Malda, J. (2009). Combinatorial approaches to controlling cell behaviour and tissue formation in 3D via rapid-prototyping and smart scaffold design. Combinatorial Chemistry & High Throughput Screening, 12(6), 562-579. Journal - Research Article

Dalton, P. D., Woodfield, T., & Hutmacher, D. W. (2009). Snapshot: Polymer scaffolds for tissue engineering [biomaterials 30/4 (2009) 701-702]. Biomaterials, 30(4), 701-702. doi: 10.1016/j.biomaterials.2009.01.049 Journal - Research Article

Woodfield, T. B. F., Miot, S., Martin, I., van Blitterswijk, C. A., & Riesle, J. (2006). The regulation of expanded human nasal chondrocyte re-differentiation capacity by substrate composition and gas plasma surface modification. Biomaterials, 27, 1043-1053. doi: 10.1016/j.biomaterials.2005.07.032 Journal - Research Article

Habibovic, P., Woodfield, T., de Groot, K., & van Blitterswijk, C. (2006). Predictive value of in vitro and in vivo assays in bone and cartilage repair: What do they really tell us about the clinical performance? In J. P. Fisher (Ed.), Advances in experimental medicine & biology: (Vol. 5) Tissue engineering. (pp. 327-360). New York: Springer. doi: 10.1007/978-0-387-34133-0_22 Chapter in Book - Research

Woodfield, T. B. F., van Blitterswijk, C. A., de Wijn, J., Sims, T. J., Hollander, A. P., & Riesle, J. (2005). Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs. Tissue Engineering Part A, 11(9/10), 1297-1311. doi: 10.1089/ten.2005.11.1297 Journal - Research Article

Miot, S., Woodfield, T., Daniels, A. U., Suetterlin, R., Peterschmitt, I., Heberer, M., … Martin, I. (2005). Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition. Biomaterials, 26(15), 2479-2489. doi: 10.1016/j.biomaterials.2004.06.048 Journal - Research Article

Malda, J., Woodfield, T. B. F., van der Vloodt, F., Wilson, C., Martens, D. E., Tramper, J., … Riesle, J. (2005). The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials, 26(1), 63-72. doi: 10.1016/j.biomaterials.2004.02.046 Journal - Research Article

Malda, J., Woodfield, T. B. F., van der Vloodt, F., Kooy, F. K., Martens, D. E., Tramper, J., … Riesle, J. (2004). The effect of PEGT/PBT scaffold architecture on oxygen gradients in tissue engineered cartilaginous constructs. Biomaterials, 25(26), 5773-5780. doi: 10.1016/j.biomaterials.2004.01.028 Journal - Research Article

Woodfield, T. B. F., Bezemer, J. M., Pieper, J. S., van Blitterswijk, C. A., & Riesle, J. (2002). Scaffolds for tissue engineering of cartilage. Critical Reviews in Eukaryotic Gene Expression, 12(3), 209-236. doi: 10.1615/CritRevEukaryotGeneExpr.v12.i3.40 Journal - Research Article

Groll, J., Boland, T., Blunk, T., Burdick, J. A., Cho, D.-W., Dalton, P. D., … Woodfield, T. B. F., … Malda, J. (2016). Biofabrication: Reappraising the definition of an evolving field [Perspective]. Biofabrication, 8(1), 013001. doi: 10.1088/1758-5090/8/1/013001 Journal - Research Article

Chen, F., Hochleitner, G., Woodfield, T., Groll, J., Dalton, P. D., & Amsdem, B. G. (2016). Additive manufacturing of a photo-cross-linkable polymer via direct melt electrospinning writing for producing high strength structures. Biomacromolecules, 17(1), 208-214. doi: 10.1021/acs.biomac.5b01316 Journal - Research Article

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002 Journal - Research Article

Hutmacher, D. W., Woodfield, T. B. F., & Dalton, P. D. (2015). Scaffold design and fabrication. In C. A. van Blitterswijk & J. de Boer (Eds.), Tissue engineering. (2nd ed.) (pp. 311-346). London, UK: Academic Press. doi: 10.1016/B978-0-12-420145-3.00010-9 Chapter in Book - Research

Schrobback, K., Klein, T. J., & Woodfield, T. B. F. (2015). The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. Tissue Engineering Part A, 21(11-12), 1785-1794. doi: 10.1089/ten.tea.2014.0691 Journal - Research Article

Walker, J., Shadanbaz, S., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). Magnesium biomaterials for orthopedic application: A review from a biological perspective. Journal of Biomedical Materials Research Part B, 102(6), 1316-1331. doi: 10.1002/jbm.b.33113 Journal - Research Article

Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005 Journal - Research Article

Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015 Journal - Research Article

Lang, M., Chen, X., Wang, W., & Woodfield, T. B. F. (2012). Injection system for cellular assembly of 3D bio-tissue engineered constructs. Proceedings of the International Conference on Automation Science and Engineering (CASE). (pp. 291-296). IEEE. doi: 10.1109/CoASE.2012.6386394 Conference Contribution - Published proceedings: Full paper

Hooper, G. J., Maxwell, A. R., Wilkinson, B., Mathew, J., Woodfield, T. B. F., Penny, I. D., Burn, P. J., & Frampton, C. (2012). The early radiological results of the uncemented Oxford medial compartment knee replacement. Journal of Bone & Joint Surgery (Br), 94(3), 334-338. doi: 10.1302/0301-620X.94B3.27407 Journal - Research Article

Malda, J., Radisic, M., Levenberg, S., Woodfield, T., Bomens, C., Baaijens, F., … Vunjak-Novakovic, G. (2008). Cell nutrition. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 327-362). London, UK: Academic Press. Chapter in Book - Research

Hutmacher, D., Woodfield, T., Dalton, P., & Lewis, J. (2008). Scaffold design and fabrication. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 403-454). London, UK: Academic Press. Chapter in Book - Research

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Inaugural Professorial Lecture

Roles

Professional affiliations

Professional interests

Publications