Associate Professor Margaret Currie, Our people, Mackenzie Cancer Research Group

Margaret Currie

Principal Investigator

Associate Dean (Postgraduate Studies)MSc(Hons)(Cant), PhD(Auck)

Email margaret.currie@otago.ac.nz
Tel +64 3 244 1015

Research interests

Associate Professor Margaret Currie is interested in how the tumour microenvironment affects tumour growth, tumour cell metastasis and tumour response to therapy.

The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. All the various components of the tumour microenvironment can influence tumour growth and spread and, conversely, tumour cells can influence the local tumour microenvironment.

A further layer of complexity exists because the wider tumour microenvironment (i.e. the body within which the tumour develops) alters with age and health, and is affected by systemic changes in metabolism, hormones and immunity.

The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. Initially, their research focused on tumour blood vessel development and anti-angiogenic therapies. However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors.

Current projects

Adipocytes in tumour stroma

In various human cancers, obesity is linked to invasive tumours that are resistant to therapy and have poor outcome. We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. We are also studying tumour samples from normal weight and obese breast cancer patients to better understand the role adipocytes play in promoting aggressive tumour growth and spread, and identify patients likely to benefit from additional treatment during cancer therapy.

Circulating immune cell populations and tumour infiltrating immune cells in human cancers

Cutaneous squamous cell carcinomas (cSCC) are common in NZ, and most are simply treated. However, a small proportion (~5%) of these skin cancers grow aggressively, spread to other organs, and cause death. In patients who have had an organ transplant, we have identified blood vessel and immune characteristics that are correlated to cSCC aggressiveness. We are currently investigating whether these characteristics also account for the aggressiveness of cSCCs in non-transplant patients. A greater understanding of the biology of these tumours may help clinicians identify at-risk patients who could benefit from additional treatment and close surveillance. In addition, the specific immune and blood vessel factors identified are potential targets for developing novel cancer treatments.

Postgraduate supervision

Student: Jessika Wise
Degree: PhD (in progress)
Thesis title: 3D breast tumour models for drug discovery
Supervisors: PE Phillips, K Lim, T Woodfield, M Currie

Student: Ifran Yunianto
Degree: PhD (in progress)
Thesis title: The role of inflammation in ovarian cancer
Supervisors: P Sykes, K Chitcholtan, M Currie

Student: Ben Topham
Degree: BBiomedSc(Hons) (in progress)
Thesis title: Investigating the Relationship Between Ascorbate and the Differentiation of Monocytes in an In-Vitro Melanoma Model
Supervisors: M Currie

2021

Student: Dr Annika Seddon
Degree: PhD
Thesis title: Neutrophils and cancer: regulation of cell death and epigenetic pathways
Supervisors: M Hampton, A Stevens, M Currie, A Kettle

2020

Student: Dr Linda Buss
Degree: PhD
Thesis title: The immune system: A common link mediating exercise effects on the tumour microenvironment and skeletal muscle mitochondria?
Supervisors: G Dachs, M Currie, B Hock, A Ang, B Robinson

Student: Rebekah Crake
Degree: PhD
Thesis title: Local and systemic effects of adipocyte-secreted factors in breast cancer
Supervisors: M Currie, E Phillips, M Strother, B Robinson

2017

Student: Dr Vanessa Lattimore
Degree: PhD
Thesis title: Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression
Supervisors: L Walker, M Currie, B Robinson

2015

Student: Dr Anthony Rahman
Degree: PhD
Thesis title: Venous Thromboembolism (VTE) in cancer patients commencing chemotherapy
Supervisors: B Robinson, M Smith, M Currie, S Gunningham

2013

Student: Caroline Kuiper
Degree: PhD
Thesis title: The role of ascorbate in the regulation of HIF-1 in cancer cells
Supervisors: M Vissers, G Dachs, M Currie

2011

Student: Ekaterina Volkova
Degree: PhD
Thesis title: Obesity and colorectal cancer
Supervisors: M Currie, G Dachs, J Willis, B Robinson

2010

Student: Michelle Hunt
Degree: PhD
Thesis title: Vessel directed enzyme prodrug therapy for cancer
Supervisors: G Dachs, M Currie, A Patterson, B Robinson

Student: Kasia Mackenzie
Degree: PhD
Thesis title: Why are skin cancers more aggressive in renal transplant recipients?
Supervisors: M Currie, B Hock, J Simcock, B Robinson, J Roake

2007

Student: Sarah Gunningham
Degree: PhD
Thesis title: The role of VEGF faminly in breast and colorectal cancer
Supervisors: M Currie, V Cameron, B Robinson, S Fox

Student: So Young Moon
Degree: PhD
Thesis title: Identification of genetic aberrations in chronic lymphocytic leukaemia using array CGH
Supervisors: C Morris, P Ganly, M Currie

2017

Student: Leah Butt
Degree: BBiomedSc(Hons)
Thesis title: Measuring markers of immune response in patients treated with Nivolumab (Opdivo) or Pembrolizumab (Keytruda)
Supervisors: M Currie, B Hock, M Strother

2015

Student: Morgan Jones
Degree: BBiomedSc(Hons)
Thesis title: Does fat provide energy for breast cancer cell invasion and metastasis?
Supervisors: M Currie, E Phillips

Student: Rebekah Crake
Degree: BBiomedSc(Hons)
Thesis title: Obesity and breast cancer development
Supervisors: L Walker, M Currie, E Phillips

Student: Anishah Mandani
Degree: BBiomedSc(Hons)
Thesis title: Development of a breast cancer ApoE/ArKO mouse model
Supervisors: G Dachs, M Currie

2013

Student: Annika Seddon
Degree: BBiomedSc(Hons)
Thesis title: Immune Suppression and Squamous Cell Carcinoma Tumour Biology
Supervisors: M Currie, B Hock

2010

Student: Anna Van Pomeren
Degree: BBiomedSc(Hons)
Thesis title: Myeloid-derived suppressor cells and tumour angiogenesis
Supervisors: M Currie, B Hock

2020

Student: Mohini Puri
Degree: MMedSc
Thesis title: Role of cancer associated adipocytes (CAA) and tumour associated collagen structures (TACS) in breast cancer cell invasion and metastasis
Supervisors: M Currie, E Phillips

2014

Student: Lisa Brennan
Degree: MSc (Massey University)
Thesis title: Biomarkers as predictors of six month survival outcomes of patients presenting with solid tumours
Supervisors: M Currie, A Rahman, B Robinson, C Kendrick

2007

Student:Maiko Kano
Degree: BMedSc
Thesis title: Biology of cancer in Maori
Supervisors: G Dachs, M Currie, B Robinson

Funding

The Mackenzie Charitable Foundation
Cancer Society of New Zealand (& CSNZ Canterbury-West Coast Division)
University of Otago Christchurch Cancer Fellowship
New Zealand Breast Cancer Foundation
University of Otago

Selected Recent Publications

Seddon AR, Hock BD, Miller AP, Frei LP, Pearson JF, McKenzie JL, Simcock JW, Currie MJ. Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Advanced ePub. Journal of Dermatological Science (2016), DOI 10.1016/j.jdermsci.2016.04.013.
Slatter TL, Royds JA, Pilbrow AP, Ahn A, Morrin H, Frampton C, Russell A, Moravec CS, Sweet WE, Tang WH, Currie MJ, Hung NA. The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4A expression. Frontiers in Oncology; 5, 306, 2015. (Times cited=0).
BD Hock, JL McKenzie, NB Cross, MJ Currie. Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology; 32(3), 164-171. June 2015 (IF 1.8). (Times cited=0).
Richardson AK, Currie MJ, Robinson BA, Morrin H, Phung Y, Pearson JF, Anderson TP, Potter JD, Walker LC. Cytomegalovirus and Epstein-Barr virus in breast cancer. PLoS One. 2015, Feb 27; 10(2):e0118989. (IF 3.5). (Times cited=1).

Affiliations

Publications

Immunohistochemical staining for CD66b+ neutrophils surrounding a non-melanoma skin cancer

Lipid-rich mature adipocytes

Immunohistochemical staining for CD44+/CD24-/low cells in invasive breast carcinoma (top right) and ductal carcinoma in situ (bottom left)

Cancer - The Crab (original tile by Morris & James, Matakana, New Zealand

Publications

Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017 Journal - Research Article

van der Woude, H., Phan, K., Kenwright, D. N., Goossens, L., Hally, K. E., Currie, M. J., … Henry, C. E. (2024). Development of a long term, ex vivo, patient-derived explant model of endometrial cancer. PLoS ONE, 19(4), e0301413. doi: 10.1371/journal.pone.0301413 Journal - Research Article

Donovan, K. A., Beaglehole, B., Frampton, C. M. A., Currie, M., Boden, J. M., & Jordan, J. (2023). Tōku Oranga: The subjective wellbeing and psychological functioning of postgraduate and medical students in Ōtautahi Christchurch. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1586), 51-62. Retrieved from https://journal.nzma.org.nz/ Journal - Research Article

Morley-Bunker, A., Currie, M., Pearson, J., Mukundan, R., Gavruskin, A., Hemmings, C., Eglinton, T., & Walker, L. (2023, August). Utilisation of digital pathology and AI methods for the detection of MSI status in colorectal cancer. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Yunianto, I., Currie, M., Chitcholtan, K., & Sykes, P. (2023). Potential drug repurposing of ruxolitinib to inhibit the JAK/STAT pathway for the treatment of patients with epithelial ovarian cancer. Journal of Obstetrics & Gynaecology Research, 49, 2563-2574. doi: 10.1111/jog.15761 Journal - Research Other

2024

Journal - Research Article

2023

Journal - Research Article

Symonds, E. K. C., Black, B., Brown, A., Meredith, I., Currie, M. J., Hally, K. E., & Danielson, K. M. (2023). Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti-inflammatory phenotype in vitro. Journal of Extracellular Biology, 2, e104. doi: 10.1002/jex2.104

Journal - Research Other

Conference Contribution - Verbal presentation and other Conference outputs

2022

Journal - Research Article

Rajesh, A., Saito, M., Morrin, H., Tschirley, A., Simcock, J., Currie, M., & Hibma, M. (2022). Characterisation of the immune microenvironment of cutaneous squamous cell carcinoma in immunosuppression. Experimental Dermatology, 31, 1720-1728. doi: 10.1111/exd.14650

Journal - Research Other

van der Woude, H., Hally, K. E., Currie, M. J., Gasser, O., & Henry, C. E. (2022). Importance of the endometrial immune environment in endometrial cancer and associated therapies. Frontiers in Oncology, 12, 975201. doi: 10.3389/fonc.2022.975201

Allan, J., Buss, L. A., Draper, N., & Currie, M. J. (2022). Exercise in people with cancer: A spotlight on energy regulation and cachexia. Frontiers in Physiology, 13, 836804. doi: 10.3389/fphys.2022.836804

Conference Contribution - Published proceedings: Abstract

van der Woude, H., Hally, K., Currie, M., & Henry, C. (2022). Ex vivo culture of patient-derived endometrial cancer tumour for immunological characterisation and exploration of levonorgestrel resistance. Proceedings of the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference. (pp. 12). Retrieved from https://nzasi2022.com/programme

Conference Contribution - Verbal presentation and other Conference outputs

Symonds, E., Hally, K., Smith, R., Brown, A., Currie, M., Phillips, E., … Dennett, E., Meredith, I., & Danielson, K. (2022, August). Messengers in the microenvironment: The role of extracellular vesicles in fat graft retention for breast reconstruction. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Symonds, E., Hally, K., Brown, A., Currie, M., Dennett, E., Meredith, I., & Danielson, K. (2022, August). ADSC-EVs and macrophage polarisation in fat grafting for breast reconstruction post-mastectomy. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

van der Woude, H., Hally, K., Currie, M., & Henry, C. (2022, August). Ex vivo culture of patient-derived endometrial cancer tumour. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765

Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1

Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021). Gene and protein expression is altered by ascorbate availability in murine macrophages cultured under tumour-like conditions. Antioxidants, 10(3), 430. doi: 10.3390/antiox10030430

Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202

Journal - Research Other

Buss, L. A., Dachs, G. U., Goddard, L., Ang, A. D., Robinson, B. A., Currie, M. J., & Hock, B. (2021). Is the immunogenicity of PD-1 blocking antibodies a confounding variable in murine studies? Immunology Letters, 234, 13-15. doi: 10.1016/j.imlet.2021.04.003

2020

Journal - Research Article

Hock, B. D., McKenzie, J. L., Strother, M., Goddard, L., Butt, L., & Currie, M. J. (2020). Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies. Cancer Immunology, Immunotherapy, 69(12), 2453-2464. doi: 10.1007/s00262-020-02636-2

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1

Conference Contribution - Published proceedings: Abstract

Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2020). An exploratory patient study assessing CYP450 enzyme function in women receiving chemotherapy for breast cancer. New Zealand Medical Journal, 133(1524), (pp. 144). Retrieved from https://www.nzma.org.nz/journal

2019

Journal - Research Article

Crake, R. L. I., Phillips, E., Kleffmann, T., & Currie, M. J. (2019). Co-culture with human breast adipocytes differentially regulates protein abundance in breast cancer cells. Cancer Geonomics & Proteomics, 16(5), 319-332. doi: 10.21873/cgp.20137

Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675

Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

Conference Contribution - Published proceedings: Abstract

Ang, A., Currie, M., & Dachs, G. (2019). Effect of ascorbate on tumour-associated macrophage phenotype ex vivo. Proceedings, 5(1), 3 (6.7). doi: 10.3390/proceedings2019005003

2018

Journal - Research Article

Buss, L. A., Mandani, A., Phillips, E., Scott, N. J. A., Currie, M. J., & Dachs, G. U. (2018). Characterisation of a mouse model of breast cancer with metabolic syndrome. In Vivo, 32(5), 1071-1080. doi: 10.21873/invivo.11348

Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

Journal - Research Other

Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018). Vitamin C and immune cell function in inflammation and cancer. Biochemical Society Transactions, 46, 1147-1159. doi: 10.1042/bst20180169

Conference Contribution - Published proceedings: Abstract

Phillips, E., Kleffmann, T., Morrin, H., Robinson, B., & Currie, M. (2018). Differential secretome analysis of cancer-associated adipocytes (CAA) and mature adipocytes to identify adipocyte-driven micro-environmental regulators of breast cancer progression. ESMO Open, 3(Suppl. 2), (pp. A348). doi: 10.1136/esmoopen-2018-EACR25.820

Morley-Bunker, A., Pearson, J., Currie, M., Morrin, H., Whitehead, M., Eglinton, T., & Walker, L. (2018). Intratumoural assessment of candidate colorectal cancer prognostic markers using RNA in situ hybridization. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018). Exercise reduces hypoxia and increases perfusion in tumours from mice with melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Ang, A., Currie, M., & Dachs, G. (2018). Effect of ascorbate on tumour associated macrophage phenotype ex vivo. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2018). An exploratory breast cancer patient study to assess the impact of obesity-related inflammation and physical activity on chemotherapy drug metabolism. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Wise, J., Lim, K., Morrin, H., Woodfield, T., Currie, M., & Phillips, E. (2018). Engineering a 3D model system for studying breast cancer-adipocyte interactions within the tumour microenvironment. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Crake, R., Phillips, E., Morrin, H., Strother, M., Robinson, B., & Currie, M. (2018). Transwell co-culture with human breast adipocytes alters the proteome expression profiles of mcf-7 and mda-mb-231 human breast cancer cells. ESMO Open, 3(Suppl. 2), (pp. A111-A112). doi: 10.1136/esmoopen-2018-EACR25.268

Conference Contribution - Poster Presentation (not in published proceedings)

Mehta-Mujoo, P., Landmann, M., Pilbrow, A. P., Currie, M. J., Morrin, H. R., Hung, N. A., & Slatter, T. L. (2018, August). Visualisation of long non-coding RNA ANRIL in breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). Post-tumour-implantation exercise does not alter tumour growth rate in mice with subcutaneous B16-F10 melanoma. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Crake, R., Kleffmann, T., Morrin, H., Strother, M., Robinson, B., Phillips, E., & Currie, M. (2018, August). Cancer-associated adipocytes alter protein expression profiles of human breast cancer cells in vitro. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Wise, J., Lim, K., Currie, M., Morrin, H., Woodfield, T., & Phillips, E. (2018, August). Development of a 3D breast cancer-adipocyte model: A tool for studying tumour microenvironment interactions in vitro. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2018, November). An exploratory breast cancer patient study to assess the impact of obesity-related inflammation and physical activity on chemotherapy drug metabolism. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Buss, L., Currie, M., Ang, A., Hock, B., & Dachs, G. (2018, August). T-cell distribution in melanoma from exercising mice. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Ang, A., Currie, M., & Dachs, G. (2018, August). Effect of ascorbate on tumour associated macrophage phenotype ex vivo. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

2017

Journal - Research Article

Robinson, B., Currie, M., Phillips, E., Dachs, G., Strother, M., Morrin, H., Davey, V., & Frampton, C. (2017). Body mass index (BMI): Association with clinicopathological factors and outcome of women with newly diagnosed breast cancer in New Zealand. New Zealand Medical Journal, 130(1451), 46-56. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Yunianto, I., Chitcholtan, K., Currie, M., & Sykes, P. (2017). JAK/STAT pathway inhibition for the treatment of ovarian cancer. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 98). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Phillips, E., Lim, K., Woodfield, T., & Currie, M. J. (2017). Towards 3D culture models for the investigation of adipocyte/tumour interaction. New Zealand Medical Journal, 130(1459), (pp. 79). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Currie, M., Hock, B., McKenzie, J., Miller, A., Simcock, J., Mackenzie, K., Seddon, A., & Kennedy, B. (2017, July). Functional and prognostic significance of neutrophil subpopulations in cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Tschirley, A. M., Currie, M. J., Simcock, J. W., & Hibma, M. H. (2017, July). Mapping the contribution of β-human papillomaviruses to aggressive cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Kennedy, B. R., McCall, J. L., Miller, A. P., Gibbs, D. D., Kemp, R. A., & Currie, M. J. (2017, July). Identifying neutrophil subpopulations in colorectal cancer. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Ang, A., Currie, M., & Dachs, G. (2017, July). Does ascorbate affect the interaction between tumour and immune cells? Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334

Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16^INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306

2015

Journal - Research Article

Dachs, G. U., Phillips, E., Phung, Y., Dyer, A., Willis, J. A., Currie, M. J., & Robinson, B. A. (2015). Tumour growth in mice resistant to diet-induced obesity. Journal of Molecular Biochemistry, 4(2), 42-49.

Hock, B. D., McKenzie, J. L., Cross, N. B., & Currie, M. J. (2015). Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology, 32(3), 164-171. doi: 10.1016/j.trim.2015.05.001

Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989

Journal - Research Other

Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Seddon, A. R., Hock, B. D., Miller, A. P., Frei, L. P., Pearson, J. F., McKenzie, J. L., Simcock, J. W., & Currie, M. J. (2015). Neutrophils in cutaneous squamous cell carcinoma: Potential prognostic markers? New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Lattimore, V., Pearson, J., Currie, M., Robinson, B., & Walker, L. (2015). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Currie, M. (2015, August-September). The emerging roles of neutrophils in tumour biology. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lattimore, V., Pearson, J. F., Currie, M., Robinson, B. A., Spurdle, A. B., & Walker, L. C. (2015, August-September). Using splicing assays to interpret variants of unknown clinical significance in BRCA1 and BRCA2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2014). Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radical Biology & Medicine, 69, 308-317. doi: 10.1016/j.freeradbiomed.2014.01.033

Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2014). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer. Frontiers in Oncology, 4, 10. doi: 10.3389/fonc.2014.00010

Volkova, E., Robinson, B. A., Willis, J., Currie, M. J., & Dachs, G. U. (2014). Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells. Oncology Letters, 7(2), 311-320. doi: 10.3892/ol.2013.1710

Conference Contribution - Published proceedings: Abstract

Kuiper, C., Dachs, G., Currie, M., Pearson, J., Munn, D., & Vissers, M. (2014). Tumor ascorbate content is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, & Walker, L. (2014, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Rahman, A., Winter, A., DeRyke, R., Fenwick, J., Griffin, N., Frampton, C., Smith, M., Currie, M., & Robinson, B. (2014, October). Venous thromboembolism in cancer patients undertaking chemotherapy. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

2013

Journal - Research Article

Currie, M. J., Beardsley, B. E., Harris, G. C., Gunningham, S. P., Dachs, G. U., Dijkstra, B., Morrin, H. R., Wells, J. E., & Robinson, B. A. (2013). Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: Relationships with markers of tumor hypoxia and microvascularity. Human Pathology, 44(3), 402-411. doi: 10.1016/j.humpath.2012.06.004

Conference Contribution - Published proceedings: Abstract

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013, September). Elevating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2013, August). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in patients with colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Hock, B. D., Mackenzie, K. A., Cross, N. B., Taylor, K. G., Currie, M. J., Robinson, B. A., Simcock, J. W., & McKenzie, J. L. (2012). Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology Dialysis Transplantation, 27(1), 402-410. doi: 10.1093/ndt/gfr264

Hunt, M. A., Li, D., Hay, M. P., Currie, M. J., Robinson, B. A., Patterson, A. V., & Dachs, G. U. (2012). Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro. Journal of Gene Medicine, 14(1), 62-74. doi: 10.1002/jgm.1635

Conference Contribution - Published proceedings: Abstract

Rahman, A. H. B., Waghorn, R. H., Patterson, D. M., Denholm, A., Gunningham, S. P., Currie, M. J., Frampton, C. M. A., Smith, M. P., & Robinson, B. A. (2012). The effect of malignancy and chemotherapy on thrombin generation in cancer patients. Thrombosis Research, 129(Suppl. 1), (pp. S187). [Abstract]

Dachs, G., Kuiper, C., Currie, M. J., & Vissers, M. C. M. (2012). Impact of ascorbate levels on hypoxia inducible factor-1 activity in cancer cells in culture and in endometrial tumours. Mutagenesis, 27(1), (pp. 114). doi: 10.1093/mutage/ger068

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Robinson, B., Currie, M., & Walker, L. (2012, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, September). Intracellular ascorbate and HIF-1 inhibition in cancer cells. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2012, August). Intracellular ascorbate and modification of the tumour response to the microenvironment. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Pflüger, H.-J., Field, L. H., Nishino, H., & Currie, M. J. (2011). Neuromodulatory unpaired median neurons in the New Zealand tree weta, Hemideina femorata. Journal of Insect Physiology, 57(10), 1420-1430. doi: 10.1016/j.jinsphys.2011.07.010

MacKenzie, K. A., Miller, A. P., Hock, B. D., Gardner, J., Simcock, J. W., Roake, J. A., Dachs, G. U., Robinson, B. A., & Currie, M. J. (2011). Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients. Histopathology, 58(6), 875-885. doi: 10.1111/j.1365-2559.2011.03845.x

Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2011). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, 104, 51-59. doi: 10.1038/sj.bjc.6606005

Conference Contribution - Published proceedings: Abstract

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2011). Low ascorbate levels are associated with high hypoxia-inducible factor-1 activity and a more aggressive tumor phenotype in endometrial cancer. Clinical and Experimental Metastasis. 28(2), (pp. 175). doi: 10.1007/s10585-010-9361-9

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2011). Optimal intracellular ascorbate concentrations suppress hypoxia-inducible factor-la and its transcriptional activity differentially in cancer and normal cells. Clinical & Experimental Metastasis. 28(2), (pp. 231-232). doi: 10.1007/s10585-010-9361-9

2010

Journal - Research Article

Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., … Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Māori breast cancer patients. BMC Cancer, 10, 543. doi: 10.1186/1471-2407-10-543

Hunt, M. A., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2010). Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. Journal of Biomolecular Techniques, 21, 66-72.

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263

Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482

2009

Journal - Research Other

Mackenzie, K. A., Simcock, J. W., Lainchbury, J. G., Currie, M. J., & Lynn, K. L. (2009). Myocardial metastasis of cutaneous squamous cell carcinoma in a renal transplant recipient [Case report]. Transplantation Proceedings, 41(10), 4414-4415. doi: 10.1016/j.transproceed.2009.09.056

Conference Contribution - Published proceedings: Abstract

Dachs, G. U., Hunt, M., Patterson, A. V., Ackerley, D., Currie, M. J., & Robinson, B. A. (2009). Vascular targeted gene therapy of cancer. Journal of Vascular Research, 46(Suppl. 2), (pp. 18). doi: 10.1159/000230992

Volkova, E., Willis, J., Robinson, B., Dachs, G., & Currie, M. (2009). Obesity and tumour angiogenesis in colon cancer. Journal of Vascular Research, 46(Suppl. 2), (pp. 17). doi: 10.1159/000230992

Hunt, M., Keown, D., Patterson, A., Currie, M., Robinson, B., & Dachs, G. (2009). Novel prodrugs for enzyme prodrug gene therapy against tumor endothelium. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Volkova, E., Willis, J. A., Gunningham, S. P., Hanrahan, V., Pearson, J., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2009). Role of obesity in colon tumor angiogenesis and cancer progression. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Kuiper, C., Molenaar, I., Dachs, G., Currie, M., Sykes, P., & Vissers, M. (2009). Low ascorbate levels in endometrial tumours are associated with high HIF-1 activity and a more aggressive phenotype. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S172-S173). [Abstract]

MacKenzie, K. A., Wells, E., Currie, M., Simcock, J., Lynn, K., & Robinson, B. (2009). Incidence and subsequent non-melanoma skin cancers in Canterbury renal transplant recipients: What can we learn? ANZ Journal of Surgery, 79(Suppl. 1), (pp. A56). doi: 10.1111/j.1445-2197.2009.04927.x

Conference Contribution - Poster Presentation (not in published proceedings)

Hunt, M. A., Keown, D. A., Patterson, A. V., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2009, September). Novel prodrugs for enzyme prodrug gene therapy against tumour endothelium. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Currie, M. (2009, August). Obesity and tumour angiogenesis in colon cancer. Verbal presentation at the 14th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Queenstown, New Zealand.

2008

Journal - Research Article

Dachs, G. U., Currie, M. J., Mckenzie, F., Jeffreys, M., Cox, B., Foliaki, S., … Robinson, B. A. (2008). Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people. Lancet Oncology, 9(5), 473-484. doi: 10.1016/S1470-2045(08)70127-X

Conference Contribution - Published proceedings: Abstract

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2008). Cancer Society Tissue Bank (CSTB) New Zealand: The increasing importance of supplementary sample banking for breast cancer research. Cell Preservation Technology, 6(2), (pp. 157). doi: 10.1089/cpt.2008.9998

Kano, M., Volkova, E., Harris, G. C., Morrin, H. R., Cheale, M., Frampton, C., Wells, E., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2008). A comparison of patient, tumour and circulating factors in breast cancer patients of different ethnicities in New Zealand. Proceedings of the American Association for Cancer Research (AACR) 99th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Gunningham, S. P., Lai, C.-Y., Currie, M. J., Hanrahan, V., Lambie, N., Cameron, V. A., Robinson, B. A., & Fox, S. B. (2008). The angiogenic receptor neuropilin-1 is associated with tumor stage and lymph node status in colorectal cancer. Proceedings of the American Association for Cancer Research (AACR) 99th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Hunt, M. A., Dachs, G. U., Currie, M. J., Patterson, A. V., & Robinson, B. A. (2008). Vessel directed enzyme-prodrug therapy for cancer. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

2007

Journal - Research Article

Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007). Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radical Biology & Medicine, 42, 765-772.

Gunningham, S. P., Currie, M. J., Morrin, H. R., Tan, E. Y., Turley, H., Dachs, G. U., Watson, A. I., Frampton, C., Robinson, B. A., & Fox, S. B. (2007). The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is asociated with P-selectin expression in breast cancers. Journal of Pathology, 212, 335-344.

Conference Contribution - Published proceedings: Abstract

Gunningham, S., Currie, M., Hanrahan, V., Dachs, G., Morrin, H., Frampton, C., Robinson, B., & Fox, S. (2007). The short mRNA isoform of vascular endothelial growth factor receptor-3 (VEGFR-3) is down-regulated by estrogen and progesterone in breast cancer. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2006

Journal - Research Article

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Dachs, G. U., Steele, A. J., Coralli, C., Kanthou, C., Brooks, A. C., Gunningham, S. P., Currie, M. J., Watson, A. I., Robinson, B. A., & Tozer, G. M. (2006). Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-I and gene expression. BMC Cancer, 6, 280. doi: 10.1186/1471-2407-6-280

Conference Contribution - Published proceedings: Abstract

Currie, M. J., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Dachs, G. U., Frampton, C., Fox, S. B., & Robinson, B. A. (2006). Increased Ang1 and Tie2 gene expression is associated with survival in colorectal cancer patients. Proceedings of the American Association for Cancer Research (AACR) 97th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Vissers, M., Gunningham, S., Morrison, M., Dachs, G., & Currie, M. (2006). Modulation of hypoxia-inducible factor 1-α in cultured primary cells by intracellular ascorbate: An important function for vitamin C. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Morrin, H. R., Gunningham, S. P., Currie, M. J., Dachs, G. U., Fox, S. B., & Robinson, B. A. (2006). The Christchurch Tissue Bank: A biorepository for cancer research. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Dachs, G. U., Watson, A. I., Currie, M. J., Gunningham, S. P., Tupper, J., & Robinson, B. A. (2006). Using gene therapy to activate paracetemol for anti-vascular treatment of cancer. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

2005

Journal - Research Article

Currie, M. J., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Frampton, C., Han, C., Robinson, B. A., & Fox, S. B. (2005). Expression of HIF-1α in human tumours. Journal of Clinical Pathology, 58, 335-336.

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2005). The Christchurch Tissue Bank to support cancer research. New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1735/content.pdf

Conference Contribution - Published proceedings: Abstract

Gunningham, S. P., Currie, M. J., Morrin, H. R., Dachs, G. U., Scott, P. A. E., Frampton, C. M., Robinson, B. A., & Fox, S. B. (2005). The angiogenic factor thymidine phosphorylase upregulates the cell adhesion factor p-selectin in human endothelial cells. Proceedings of the American Association for Cancer Research (AACR) 96th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2004

Journal - Research Article

Currie, M., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Frampton, C., Han, C., Robinson, B. A., & Fox, S. B. (2004). Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1α) and the HIF-1α target gene DEC1, but not lymph node metastasis in primary human breast carcinomas. Journal of Clinical Pathology, 57, 829-834.

Conference Contribution - Published proceedings: Abstract

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Palmer, B. R., Frampton, C. M., Gunningham, S. P., Currie, M. J., McKenzie, J. L., … Cameron, V. A. (2004). Cytokine induced changes in cultured cardiac fibroblasts: Cell morphology and natriuretic peptide receptor expression. Proceedings of the 12^th International Congress of Endocrinology. (pp. 145). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2004, June). The Christchurch tissue bank: An investment in cancer research. Poster session presented at the New Zealand Society of Oncology Conference, Christchurch, New Zealand.

2003

Journal - Research Article

Hanrahan, V., Currie, M., Gunningham, S. P., Morrin, H., Scott, P. A. E., Robinson, B. A., & Fox, S. B. (2003). The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. Journal of Pathology, 200(2), 183-194.

Conference Contribution - Poster Presentation (not in published proceedings)

Jarvis, M. D., Currie, M., Gunningham, S. P., Palmer, B. R., Richards, A. M., Yandle, T. G., & Cameron, V. A. (2003, June). The effect of cytokines on expression of natriuretic peptide receptors in cultured ovine cardiac fibroblasts. Poster session presented at the The Endocrine Society's 85th Annual Meeting: Shaping the future of endocrinology: Today's research...tomorrow's care, Philadelphia, PA.

2002

Journal - Research Article

Currie, M., Gunningham, S. P., Cheng, H., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2002). Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; Regulation by the von Hippel-Lindau gene and hypoxia. Journal of Pathology, 198, 502-510.

Conference Contribution - Published proceedings: Abstract

Fox, S. B., Gunningham, S. P., Hanrahan, V., Currie, M. J., Morrin, H. R., Scott, P. A. E., Robinson, B. A., & Wilson, W. R. (2002). 5,6-dimethylxanthenone-4-acetic acid may cause tumour infarction in WiDr xenograft model by up-regulating soluble neuropilin-1. Proceedings of the New Zealand Society of Oncology Meeting. [Abstract]

Currie, M., Gunningham, S. P., Hanrahan, V., Morrin, H., Scott, P. A. E., Robinson, B. A., & Fox, S. B. (2002). VEGF-D expression is associated with lymph node status in primary human breast carcinomas and regulated by estrogen in breast carcinoma cell lines. In F. A. Frizelle (Ed.), Proceedings of the Scientific Meeting and 32nd Annual General Meeting of the Christchurch Medical Research Society. 115(1157), (pp. 27). Christchurch: New Zealand Medical Journal. [Abstract]

Currie, M., Gunningham, S. P., Morrin, H., Robinson, B. A., Scott, P., & Fox, S. B. (2002). VEGF-D expression in primary human breast carcinomas is associated with lymph node status and is regulated by estrogen in T47D but not MCF-7 breast cell lines. Keystone Symposia 2002 Abstract book. Silverthorne, United States of America: Keystone Symposia. [Abstract]

Hanrahan, V., Currie, M., Gunningham, S. P., Morrin, H., Scott, P. A. E., Robinson, B. A., & Fox, S. B. (2002). Gene expression of VEGF-A, VEGF-B, VEGF-C and their tyrosine kinase receptors in human colorectal cancer. Proceedings of the Scientific meeting and 32nd Annual General meeting of the Christchurch Medical Research Society. 115(1157), (pp. 27). Christchurch: New Zealand Medical Journal. [Abstract]

Jarvis, M. D., Currie, M., Gunningham, S. P., Hanrahan, V., Palmer, B. R., Ellmers, L. J., Richards, A. M., & Cameron, V. A. (2002). Expression of natriuretic peptides in cultured ovine cardiac fibroblasts. Proceedings of the 12th Annual Queenstown Molecular Biology Meeting. (pp. T6). Queenstown: Queenstown Molecular Biology Meeting, Inc. [Abstract]

2001

Journal - Research Article

Currie, M., Gunningham, S. P., Han, C., Scott, P. A. E., Robinson, B. A., Harris, A., & Fox, S. B. (2001). Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. Clinical Cancer Research, 7(4), 918-927.

Gunningham, S. P., Currie, M. J., Han, C., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2001). VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis. Journal of Pathology, 193(3), 325-332.

Gunningham, S. P., Currie, M. J., Han, C., Turner, K. S., Scott, P. A. E., Robinson, B. A., … Fox, S. B. (2001). Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: Regulation by the von Hippel-Lindau gene and hypoxia. Cancer Research, 61(7), 3206-3211.

Conference Contribution - Published proceedings: Abstract

Currie, M., Gunningham, S. P., Turner, K., Cheng, H., Scott, P. A. E., Robinson, B. A., … Fox, S. B. (2001). Angiopoietin -2 expression in human renal clear cell carcinomas:Regualtion by the Von Hippel Lindau gene and hypoxia. Proceedings of XXXIV International Congress of Physiological Sciences. http://iups.mcw.edu: IUPA (International Union of Physiological Sciences. [Abstract]

Gunningham, S. P., Currie, M., Cheng, H., Turner, K., Scott, P., Robinson, B. A., … Fox, S. B. (2001). VEGF-B and VEGF-C expression in renal cell carcinomas: Regulation by the Von Hippel Lindau gene and hypoxia. In G. Nicholls (Ed.), Proceedings of the Christchurch Medical Research Society Meeting, April 2001. 114(1138), (pp. 385-386). Dunedin, New Zealand: New Zealand Medical Association. [Abstract]

Gunningham, S. P., Currie, M., Cheng, H., Turner, K., Scott, A. E., Robinson, B. A., … Fox, S. B. (2001). VEGF-B and VEGF-C expression in renal cell carcinomas: Regulation by the Von Hippel-Lindau gene and hypoxia. 2001 Proceedings of the American Association for Cancer Research. 42. AACR. [Abstract]

2000

Journal - Research Article

Gunningham, S. P., Currie, M. J., Han, C., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2000). The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factor C is related to lymph node metastasis in human breast cancers. Clinical Cancer Research, 6(11), 4278-4286.

Conference Contribution - Published proceedings: Abstract

Currie, M., Gunningham, S. P., Scott, P., Robinson, B. A., & Fox, S. B. (2000). Expression of Angiopoietin-1, Angiopoietin-2 & Tie 2 in kidney and breast carcinomas. In G. Nicholls (Ed.), Proceedings of the Scientific meeting of the Christchurch Medical Research Society. 113(1111), (pp. 231-232). Dunedin, New Zealand: New Zealand Medical Association. [Abstract]

1997

Journal - Research Article

Bassett, N. S., Currie, M., Breier, B. H., Klempt, M., Min, S. H., McCutcheon, S. N., … Gluckman, P. (1997). The effects of ovine placental bitogen and bovine growth hormone on hepatic and mammary gene expression in lactating sheep. Growth Hormone & IGF Research, 8(6), 439-446.

Currie, M. J., Bassett, N. S., & Gluckman, P. D. (1997). Ovine glucose transporter - 1 and 3: DNA partial sequences and development gene expression in the placenta. Placenta, 18, 393-401.

Currie, M., Bassett, N. S., & Gluckman, P. (1997). Ovine glucose transporter - 1 and 3: DNA partial sequences and development gene expression in the placenta. Placenta, 18, 393-491.