2024
Journal - Research Article
Davidson, A., Morley-Bunker, A., Wiggins, G., Walker, L., Harris, G., Mukundan, R., & kConFab Investigators. (2024). Deep learning segmentation of chromogenic dye RNAscope from breast cancer tissue. Journal of Imaging Informatics in Medicine. Advance online publication. doi: 10.1007/s10278-024-01301-9
Burgess, E. R., Praditi, C., Phillips, E., Vissers, M. C. M., Robinson, B. A., Dachs, G. U., & Wiggins, G. A. R. (2024). Role of sodium-dependent vitamin C transporter-2 and ascorbate in regulating the hypoxic pathway in cultured glioblastoma cells. Journal of Cellular Biochemistry, e30658. Advance online publication. doi: 10.1002/jcb.30658
Parsons, M. T., de la Hoya, M., Richardson, M. E., Tudini, E., Anderson, M., Berkofsky-Fessler, W., … Wiggins, G. A. R., … Spurdle, A. B. (2024). Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel. American Journal of Human Genetics. Advance online publication. doi: 10.1016/j.ajhg.2024.07.013
Conference Contribution - Published proceedings: Full paper
Davidson, A., Morley-Bunker, A., Wiggins, G., Walker, L., Harris, G., Mukundan, R., & kConFab Investigators. (2024). Grey level texture features for segmentation of chromogenic dye RNAscope from breast cancer tissue. In R. Su, Y.-D. Zhang & A. F. Frangi (Eds.), International Conference on Medical Imaging and Computer-Aided Diagnosis (MICAD 2023): Lecture notes in electrical engineering (Vol. 1166). (pp. 72-82). Singapore: Springer. doi: 10.1007/978-981-97-1335-6_7
2023
Journal - Research Article
Walker, L. C., de la Hoya, M., Wiggins, G. A. R., Lindy, A., Vincent, L. M., Parsons, M. T., … & ClinGen Sequence Variant Interpretation Working Group. (2023). Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup. American Journal of Human Genetics, 110(7), 1046-1067. doi: 10.1016/j.ajhg.2023.06.002
Conference Contribution - Published proceedings: Abstract
Praditi, C., Dachs, G., Bozonet, S., Pearson, J. A., Wiggins, G., & Vissers, M. (2023). The role of ascorbate in the activation of hypoxic response in breast cancer cell lines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Wiggins, G. (2023). Modifiers of BRCA1-associated breast cancer risk and potential preventative strategies [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go
2022
Journal - Research Article
Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6
Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8
Burgess, E. R., Crake, R. L. I., Phillips, E., Morrin, H. R., Royds, J. A., Slatter, T. L., Wiggins, G. A. R., Vissers, M. C. M., Robinson, B. A., & Dachs, G. U. (2022). Increased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival. Frontiers in Oncology, 12, 829524. doi: 10.3389/fonc.2022.829524
2021
Journal - Research Article
Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765
Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y
Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5
McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320
2020
Journal - Research Other
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015
Conference Contribution - Published proceedings: Abstract
Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal
Awarded Doctoral Degree
Wiggins, G. A. R. (2020). Gene expression variability in breast tumour development (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10587
2019
Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Conference Contribution - Published proceedings: Abstract
Wiggins, G. (2019). Expression variability is associated with breast tumour subtype. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research
2018
Conference Contribution - Published proceedings: Abstract
Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018). Expression variability is associated with breast tumour subtype. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Conference Contribution - Poster Presentation (not in published proceedings)
Wiggins, G., Pearson, J., Black, M., Dunbier, A., & Walker, L. (2018, August). Expression variability is associated with breast tumour subtype. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Journal - Research Article
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6
Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203
Conference Contribution - Published proceedings: Abstract
Pearson, J. F., Wiggins, G. A. R., Black, M., Dunbier, A., & Walker, L. C. (2017). Expression variability is associated with breast cancer tumour subtype. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 746. Retrieved from http://www.ashg.org/2017meeting/
2016
Journal - Research Article
Wiggins, G., & Legge, M. (2016). Cyclic variation of cellular clock proteins in the mouse estrous ovary. Journal of Reproduction & Infertility, 17(4), 192-198.
Conference Contribution - Verbal presentation and other Conference outputs
Wiggins, G. A. R., Pearson, J., Dunbier, A., Black, M., & Walker, L. (2016, August-September). Gene expression variability in breast tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407
2014
Journal - Research Article
Chen, A., Beetham, H., Black, M. A., Priya, R., Telford, B. J., Guest, J., Wiggins, G. A. R., Godwin, T. D., … Guilford, P. J. (2014). E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition. BMC Cancer, 14, 552. doi: 10.1186/1471-2407-14-552
2013
Journal - Research Article
Willson, J. S. B., Godwin, T. D., Wiggins, G. A. R., Guilford, P. J., & McCall, J. L. (2013). Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation. Journal of Hepatology, 59(4), 904-907. doi: 10.1016/j.jhep.2013.05.024
2011
Conference Contribution - Poster Presentation (not in published proceedings)
Wiggins, G., & Legge, M. (2011, September). Investigation of a molecular clock in mouse ovaries. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Research Fellow