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Nick MagonResearch Fellow

BSc(Hons)(Cant), PhD(Otago)

Email nick.magon@otago.ac.nz

Research interests

Dr Nick Magon carried out his PhD at the Centre for Free Radical Research under the supervision of Professors' Mark Hampton, Tony Kettle and Richard Gearry. He investigated inflammatory biomarkers produced as a result of neutrophil activation, primarily using protein purification and mass spectrometry.

After his PhD, he worked as a Postdoctoral Fellow in the Department of Pathology and Immunology at the University of Geneva. There he investigated the molecular mechanisms of red blood cell ageing during cold storage using a range of techniques, including flow cytometry.

His current projects involve using mass spectrometry to characterise oxidative modifications to the neutrophil protein calprotectin that may be useful as biomarkers of inflammation, and to identify proteins that are being oxidatively-modified during the early stages of necroptosis. He is also responsible for maintaining and further developing our commercial oxidative biomarker ELISA kit.

Publications

Heath, S. G., Naughton, J. D., Magon, N. J., Gray, S. G., Smith, B. R., Morris, V. K., & Göbl, C. (2024). Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2024.107590 Journal - Research Article

Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Naughton, J. D., … Göbl, C. (2024). Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Nature Communications, 15(1), 5535. doi: 10.1038/s41467-024-49581-7 Journal - Research Article

Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017 Journal - Research Article

Smith-Diaz, C., Magon, N. J., McKenzie, J. L., Hore, T., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2023). Transcriptomics and epigenomics analysis of SKM-1 leukaemia response to Vitamin C. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

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