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Paul Pace

Senior Research Fellow

BSc(Hons) (London, UK), PhD (Cambridge, UK)

Email paul.pace@otago.ac.nz
Tel +64 3 364 3637

Research interests

Dr Paul Pace previously worked at Imperial College of Science and Technology in London, before moving to the Laboratory of Molecular Biology in Cambridge, where he obtained his PhD studying DNA repair mechanisms.

His expertise is in molecular biology (cloning, mutagenesis, CRISPR applications), protein biochemistry (protein expression and purification, antibody generation and purification, immunocytochemistry, immunoprecipitation, analytical methods) and cell biology (cell culture, transfection, lentiviral expression).  He teaches part of the BBiomedSc(Hons) programme, has supervised two summer students, and currently co-supervises two PhD students.

His current projects include studying the biochemistry of peroxiredoxins, including their roles in cell signalling, including the redox regulation of phosphorylation-dependent cell migration and transformation in cancer.

Publications

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Effect of peroxiredoxin 1 or peroxiredoxin 2 knockout on the thiol proteome of Jurkat cells. Free Radical Biology & Medicine, 225, 595-604. doi: 10.1016/j.freeradbiomed.2024.10.293 Journal - Research Article

Shearer, H. L., Currie, M. J., Agnew, H. N., Trappetti, C., Stull, F., Pace, P. E., … Dobson, R. C. J., & Dickerhof, N. (2024). Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae. Journal of Biological Chemistry, 107282. Advance online publication. doi: 10.1016/j.jbc.2024.107282 Journal - Research Article

Faville, S., Hampton, M. B., Pace, P., Goebl, C., & Helem, S. (2023). Chemoproteomic analyses of the anti-cancer effects of portimines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Helem, S., Pace, P., Seddon, A., Selwood, A., & Hampton, M. (2023). The anti-proliferative properties of the marine derived bioactive compound portimine. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Austad, S., Pace, P., Goebl, C., & Hampton, M. (2023). Unravelling the functional role of peroxiredoxin oligomeric conformations. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

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