2024
Journal - Research Article
Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Naughton, J. D., … Göbl, C. (2024). Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Nature Communications, 15(1), 5535. doi: 10.1038/s41467-024-49581-7
2023
Journal - Research Article
Praditi, C., Bozonet, S. M., Dachs, G. U., & Vissers, M. C. M. (2023). Ascorbate uptake and retention by breast cancer cell lines and the intracellular distribution of sodium-dependent vitamin C transporter 2. Antioxidants, 12, 1929. doi: 10.3390/antiox12111929
Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792
Conference Contribution - Published proceedings: Abstract
Praditi, C., Dachs, G., Bozonet, S., Pearson, J. A., Wiggins, G., & Vissers, M. (2023). The role of ascorbate in the activation of hypoxic response in breast cancer cell lines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Schwartfeger, A., Bozonet, S. M., Magon, N. J., Göbl, C., Morris, V. K., & Hampton, M. B. (2023). Oxidation triggered amyloid assembly of the cell death regulator caspase-8. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Conference Contribution - Verbal presentation and other Conference outputs
Goebl, C., Heath, S., O'Connor, K. M., Bozonet, S., Botha, A., Smith, B., Hamzah, E., … Sethi, A., & Morris, V. K. (2023, August). A novel amyloid formation mechanism: Oxidation-induced transition of the tumour suppressor protein p16 into amyloid fibrils. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
2021
Journal - Research Article
Carr, A. C., Bozonet, S., Pullar, J., Spencer, E., Rosengrave, P., & Shaw, G. (2021). Neutrophils isolated from septic patients exhibit elevated uptake of vitamin C and normal intracellular concentrations despite a low vitamin C milieu. Antioxidants, 10(10), 1607. doi: 10.3390/antiox10101607
2019
Journal - Research Article
Talla, U., Bozonet, S. M., Parker, H. A., Hampton, M. B., & Vissers, M. C. M. (2019). Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils. Journal of Leukocyte Biology, 106, 1367-1379. doi: 10.1002/jlb.4a0319-079rr
Tang, J. S., Bozonet, S. M., McKenzie, J. L., Anderson, R. F., Melton, L. D., & Vissers, M. C. M. (2019). Physiological concentrations of blueberry-derived phenolic acids reduce monocyte adhesion to human endothelial cells. Molecular Nutrition & Food Research, 63, 1900478. doi: 10.1002/mnfr.201900478
Bozonet, S. M., & Carr, A. C. (2019). The role of physiological vitamin C concentrations on key functions of neutrophils isolated from healthy individuals. Nutrients, 11(6), 1363. doi: 10.3390/nu11061363
2018
Journal - Research Article
Pullar, J. M., Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2018). High vitamin C status is associated with elevated mood in male tertiary students. Antioxidants, 7(7), 91. doi: 10.3390/antiox7070091
Tang, J. S., Vissers, M. C. M., Anderson, R. F., Sreebhavan, S., Bozonet, S. M., Scheepens, A., & Melton, L. D. (2018). Bioavailable blueberry-derived phenolic acids at physiological concentrations enhance Nrf2-regulated antioxidant responses in human vascular endothelial cells. Molecular Nutrition & Food Research, 62(5), 1700647. doi: 10.1002/mnfr.201700647
2017
Journal - Research Article
Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327
Conference Contribution - Poster Presentation (not in published proceedings)
Bozonet, S., Hampton, M., & Vissers, M. (2017, September). Hypothiocyanous acid protects endothelial cells from hypochlorous acid-mediated death. Poster session presented at the European Cell Death Organisation (ECDO)25gth Conference: Cell Death and Immunity in Disease: From Molecules to Translational Medicine, Leuven, Belgium.
Conference Contribution - Verbal presentation and other Conference outputs
Talla, U. R., Parker, H., Bozonet, S., Hampton, M., & Vissers, M. (2017, July). An altered cell death pathway for neutrophils in a hypoxic environment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Hampton, M. B., Dickerhof, N., Pace, P. E., & Bozonet, S. M. (2017, July). Redox signalling and the regulation of immune cell life and death. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
2016
Journal - Research Article
Campbell, E. J., Vissers, M. C. M., Wohlrab, C., Hicks, K. O., Strother, R. M., Bozonet, S. M., Robinson, B. A., & Dachs, G. U. (2016). Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radical Biology & Medicine, 99, 451-462. doi: 10.1016/j.freeradbiomed.2016.08.027
Carr, A. C., Pullar, J. M., Bozonet, S. M., & Vissers, M. C. M. (2016). Marginal ascorbate status (Hypovitaminosis C) results in an attenuated response to vitamin C supplementation. Nutrients, 8(6), 341. doi: 10.3390/nu8060341
Conference Contribution - Published proceedings: Abstract
Campbell, E., Vissers, M., Wohlrab, C., Hicks, K., Strother, M., Robinson, B., Bozonet, S., & Dachs, G. (2016). High-dose ascorbate administration increases tumor ascorbate levels and decreases hypoxia-inducible factor-1 activity and tumor growth in mice. Free Radical Biology & Medicine, 100(Suppl.), (pp. S132). doi: 10.1016/j.freeradbiomed.2016.10.346
Talla, U. R., Bozonet, S., Parker, H., Hampton, M., & Vissers, M. (2016). Inhibition of neutrophil apoptosis and initiation of an autophagy-like process in hypoxia and effects on neutrophil function. Free Radical Biology & Medicine, 100(Suppl.), (pp. S63). doi: 10.1016/j.freeradbiomed.2016.10.166
Vissers, M. C. M., Campbell, E. J., Kuiper, C., Carr, A. C., Wohlrab, C., Bozonet, S. M., Morrin, H., Robinson, B. A., & Dachs, G. U. (2016). Ascorbate as an anti-cancer therapy? Investigations into feasibility and potential mechanism of action. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
2015
Journal - Research Article
Bozonet, S. M., Carr, A. C., Pullar, J. M., & Vissers, M. C. M. (2015). Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients, 7(4), 2574-2588. doi: 10.3390/nu7042574
Campbell, E. J., Vissers, M. C. M., Bozonet, S., Dyer, A., Robinson, B. A., & Dachs, G. U. (2015). Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo−/− mice. Cancer Medicine, 4(2), 303-314. doi: 10.1002/cam4.349
Conference Contribution - Published proceedings: Abstract
Carr, A., Pullar, J., Bozonet, S., & Vissers, M. (2015). Marginal ascorbate status (hypovitaminosis C) results in an attenuated response to supplementation. Proceedings of the Nutrition Society of Australia, 39, (pp. 71). Sydney, Australia: Nutrition Society of Australia. [Abstract]
2014
Conference Contribution - Published proceedings: Abstract
Campbell, E. J., Bozonet, S. M., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014). Restoring physiological levels of ascorbate alleviates HIF-1 activation and reduces tumour growth in Gulo-/- mice. Proceedings of the American Association for Cancer Research (AACR) 105th Annual Meeting. Retrieved from http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014.aspx
Conference Contribution - Poster Presentation (not in published proceedings)
Campbell, E. J., Bozonet, S., Robinson, B. A., Vissers, M. C. M., & Dachs, G. U. (2014, August). Pharmacokinetic and anti-cancer properties of high dose vitamin C in tumour bearing Gulo-/- mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Chapter in Book - Research
Vissers, M. C. M., Carr, A. C., Pullar, J. M., & Bozonet, S. M. (2013). The bioavailability of vitamin C from kiwifruit. In M. Boland & P. J. Moughan (Eds.), Nutritional benefits of kiwifruit. (pp. 125-147). Waltham, MA: Academic Press. doi: 10.1016/b978-0-12-394294-4.00007-9
Journal - Research Article
Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2013). A randomised cross-over pharmacokinetic bioavailability study of synthetic versus kiwifruit-derived vitamin C. Nutrients, 5(11), 4451-4461. doi: 10.3390/nu5114451
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C. Nutrients, 5(9), 3684-3695. doi: 10.3390/nu5093684
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013). Mood improvement in young adult males following supplementation with gold kiwifruit, a high-vitamin C food. Journal of Nutritional Science, 2, e24. doi: 10.1017/jns.2013.12
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. American Journal of Clinical Nutrition, 97, 800-807. doi: 10.3945/ajcn.112.053207
Conference Contribution - Published proceedings: Abstract
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013). Mood and vitality improvement in young adult males following supplementation with gold kiwifruit, a high vitamin C food. Australasian Medical Journal, 6(11), (pp. 667). [Abstract]
Carr, A. C., Pullar, J. M., Bozonet, S. M., Moran, S., & Vissers, M. C. M. (2013). Bioavailability of vitamin C from a common food source (kiwifruit) in young adult males. Australasian Medical Journal, 6(11), (pp. 658). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013, August). Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013, August). Mood improvement and reduced fatigue in young adult males following supplementation with kiwifruit, a high vitamin C food. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Vissers, M. C. M., Kuiper, C., Dachs, G. U., Campbell, E., Pujary, U.-R., Bozonet, S. M., Pullar, J. M., & Carr, A. C. (2013, August). The role of vitamin C in managing metabolic stress and its impact in tumour biology and inflammation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Vissers, M. C. M., Bozonet, S. M., Pearson, J. F., & Braithwaite, L. J. (2011). Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: Tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit). American Journal of Clinical Nutrition, 93, 292-301. doi: 10.3945/ajcn.110.004853
2010
Journal - Research Article
Bozonet, S. M., Scott-Thomas, A. J., Nagy, P., & Vissers, M. C. M. (2010). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation in endothelial cells. Free Radical Biology & Medicine, 49(6), 1054-1063. doi: 10.1016/j.freeradbiomed.2010.06.028
Conference Contribution - Poster Presentation (not in published proceedings)
Bozonet, S. (2010, September). Hypothiocyanous acid is a selective inhibitor of caspase activation and apoptosis. Poster session presented at the 18th Euroconference on Apoptosis and the 7th Training Course on 'Concepts and Methods in Programmed Cell Death', Ghent, Belgium.
Conference Contribution - Verbal presentation and other Conference outputs
Bozonet, S. M., Scott-Thomas, A., Nagy, P., & Vissers, M. C. M. (2010, November-December). Hypothiocyanous acid is a selective inhibitor of caspase activation and apoptosis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Vissers, M. C. M., Bozonet, S. M., & Kuiper, C. (2010, November-December). The vital role of ascorbate as an enzyme co-factor and implications for its role in health and nutrition. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
2009
Conference Contribution - Published proceedings: Abstract
Morgan, B., Veal, E., Bozonet, S., Day, A., Findley, V., & Ross, S. (2009). The regulation of oxidative stress responses using yeast as a model organism. Mutagenesis, 24(1), (pp. 100). doi: 10.1093/mutage/gen055
Vissers, M., & Bozonet, S. (2009). Oxidative stress in the blood vessel wall and the development of atherosclerosis. Journal of Vascular Research, 46(Suppl. 2), (pp. 11). doi: 10.1159/000230992
Bozonet, S. M., Scott-Thomas, A., Nagy, P., & Vissers, M. (2009). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S55). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Bozonet, S. (2009, August). Hypothiocyanous acid is a selective inhibitor of caspase activation and apoptosis. Poster session presented at the 14th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Queenstown, New Zealand.
Bozonet, S. (2009, November). Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3. Poster session presented at the Society for Free Radical Biology and Medicine (SFRBM) 16th Annual Meeting, San Francisco, CA.
2008
Conference Contribution - Poster Presentation (not in published proceedings)
Bozonet, S. (2008, November). Hypothiocyanous acid targets endothelial intracellular proteins. Poster session presented at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.
2006
Awarded Doctoral Degree
Bozonet, S. M. (2006). Role of peroxiredoxins in the stress responses of schizosaccharomyces pombe (PhD). University of Newcastle upon Tyne, Newcastle, UK. 247p.
2005
Journal - Research Article
Bozonet, S. M., Findlay, V. J., Day, A. M., Cameron, J., Veal, E. A., & Morgan, B. A. (2005). Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. Journal of Biological Chemistry, 280(24), 23319-23327. doi: 10.1074/jbc.M502757200
2004
Journal - Research Article
Veal, E. A., Findlay, V. J., Day, A. M., Bozonet, S. M., Evans, J. M., Quinn, J., & Morgan, B. A. (2004). A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Molecular Cell, 15(1), 129-139.