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Stephanie BozonetSenior Research Fellow

BSc(Hons), PhD(Newcastle)

Email stephanie.bozonet@otago.ac.nz
Tel +64 3 372 6781

Research interests

Dr Stephanie Bozonet graduated from Newcastle University in the UK with an honours degree in medical microbiology, followed by a PhD in redox cell biology and signalling. After postdoctoral work in Newcastle she moved to New Zealand, joining the Mātai Hāora – Centre for Redox Biology and Medicine in 2008.

In addition to academia, Dr Bozonet has also worked in the brewing and pharmaceutical industries, gaining expertise in microbiology, cell and molecular biology, microscopy, flow cytometry, protein expression and analysis, enzyme kinetics, neutrophil function and HPLC.

Her research interests lie in the field of redox biology and the effects of oxidants on cell systems. She has been involved in several studies into the bioavailability of ascorbate (vitamin C), an essential enzyme co-factor as well as an important biological antioxidant, and its role in the immune system. Her current focus is the role of oxidants in innate immunity, and their contribution to inflammation and disease. Immune cells such as neutrophils produce oxidants to fight infection but they can also damage host cells and tissues. Dr Bozonet's is currently characterising the effects of oxidants on the regulation of cell death pathways.

Dr Bozonet has co-supervised three PhD students, she is the biological compliance officer for the centre and is a university health & safety worker representative.

Publications

Ayora, I., Graham, O., Miller, A., Bozonet, S., Helem, S., & Kennedy, M. (2024). Analysis of gene expression impacts of valproate on a human induced pluripotent stem cell line using long read RNA-sequencing. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract

Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Naughton, J. D., … Göbl, C. (2024). Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Nature Communications, 15(1), 5535. doi: 10.1038/s41467-024-49581-7 Journal - Research Article

Praditi, C., Dachs, G., Bozonet, S., Pearson, J. A., Wiggins, G., & Vissers, M. (2023). The role of ascorbate in the activation of hypoxic response in breast cancer cell lines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Schwartfeger, A., Bozonet, S. M., Magon, N. J., Göbl, C., Morris, V. K., & Hampton, M. B. (2023). Oxidation triggered amyloid assembly of the cell death regulator caspase-8. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Praditi, C., Bozonet, S. M., Dachs, G. U., & Vissers, M. C. M. (2023). Ascorbate uptake and retention by breast cancer cell lines and the intracellular distribution of sodium-dependent vitamin C transporter 2. Antioxidants, 12, 1929. doi: 10.3390/antiox12111929 Journal - Research Article

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