Dr Vanessa Lau

2024

Journal - Research Article

Stylianou, C. E., Wiggins, G. A. R., Lau, V. L., Dennis, J., Shelling, A. N., Wilson, M., Sykes, P., … Pearson, J., & Walker, L. C. (2024). Germline copy number variants and endometrial cancer risk. Human Genetics. Advance online publication. doi: 10.1007/s00439-024-02707-9

2023

Journal - Research Article

Lau, A. W. K., Lau, V. L., & Sakowska, M. M. (2023). Evolution of sentinel lymph node biopsy for breast cancer patients in a rural setting: 10 years' experience. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1575), 42-49. Retrieved from https://journal.nzma.org.nz/

2021

Journal - Research Article

Lattimore, V., Parsons, M. T., Spurdle, A. B., Pearson, J., Lehnert, K., Sullivan, J., … Morrin, H., Robinson, B., & Walker, L. (2021). Under-ascertainment of breast cancer susceptibility gene carriers in a cohort of New Zealand female breast cancer patients. Breast Cancer Research & Treatment, 185, 583-590. doi: 10.1007/s10549-020-05986-8

2020

Conference Contribution - Published proceedings: Abstract

Lattimore, V., Parsons, M., Spurdle, A., Pearson, J., Northcott, H., Lehnert, K., … Morrin, H., Robinson, B., & Walker, L. (2020). Potential under-ascertainment of New Zealand women at high-risk of breast cancer in clinical care [Invited]. Proceedings of the Genetics Otago (GO) Zoom Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Journal - Research Article

Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139

Parsons, M. T., Tudini, E., Li, H., Hahnen, E., Wappenschmidt, B., Feliubadaló, L., … Lattimore, V. L., … Spurdle, A. B. (2019). Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification. Human Mutation, 40, 1557-1578. doi: 10.1002/humu.23818

Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics, 56, 453-460. doi: 10.1136/jmedgenet-2018-105834

Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer, 145, 401-414. doi: 10.1002/ijc.32114

2018

Journal - Research Article

Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

Conference Contribution - Published proceedings: Abstract

Lattimore, V., Lehnert, K., Lintott, C., Sullivan, J., Morrin, H., Robinson, B., & Walker, L. (2018). Evaluating variants in breast cancer associated genes identified by panel sequencing of New Zealand breast cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V. L., Lehnert, K., Lintott, C., Sullivan, J., Morrin, H., Robinson, B., & Walker, L. C. (2018, August). Evaluating variants in breast cancer associated genes identified by panel sequencing of New Zealand breast cancer patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1

Awarded Doctoral Degree

Lattimore, V. (2017). Genetic variation and mRNA splicing in familial breast cancer genes (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/7319

2016

Journal - Research Article

de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094

2015

Journal - Research Other

Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Lattimore, V., Pearson, J., Currie, M., Robinson, B., & Walker, L. (2015). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Lattimore, V., Pearson, J. F., Currie, M., Robinson, B. A., Spurdle, A. B., & Walker, L. C. (2015, August-September). Using splicing assays to interpret variants of unknown clinical significance in BRCA1 and BRCA2. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, & Walker, L. (2014, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Lattimore, V. (2014, October). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

2013

Conference Contribution - Published proceedings: Abstract

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013, September). Elevating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

2012

Conference Contribution - Poster Presentation (not in published proceedings)

Lattimore, V., Robinson, B., Currie, M., & Walker, L. (2012, September). Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.