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Current students

PhD

StudentThesis titleSupervisors
Grace BorichevskyUnderstand and predict disease activity in inflammatory bowel diseaseTony Kettle, Richard Gearry
Eleanor BurgessThe role of ascorbate in gliomaGabi Dachs, Elisabeth Phillips, Margreet Vissers, Bridget Robinson
Tess FeatherstonExploiting oxidative stress in the treatment of metastatic melanomaMartina Paumann-Page, Mark Hampton
Oscar GrahamNanopore sequencing of GBAMartin Kennedy,, John Pearson, Tim Anderson
Sarah HeathMolecular analysis of p16 amyloid formationChristoph Goebl, Mark Hampton
HyunWoo JunDeveloping low risk potting mix products to protect gardeners from Legionnaires' disease.Sandy Slow, Steve Chambers
Jaslyn KeeThe application of pharmacogenetics to understanding adverse drug reactionsMartin Kennedy, Simran Maggo
Ayush KumarHydrogen sulfide and substance P in acute pancreatitisMadhav Bhatia, Steve Chambers
Xihua LianInvasive aspergillosisMadhav Bhatia, Aamir Raja, Steve Chambers, John Lewis
Sumeet ManandharThe role of H2S and substance P in NF-B level expression in polmicrobial sepsisMadhav Bhatia, Steve Chambers
Hadley NorthcottAllele-specific expression analysis of BRCA1/2 variants in breast cancer patients.Logan Walker, Vanessa Lattimore
Citra PraditiVitamin C and metastasisMargreet Vissers, Gabi Dachs
Carlos Smith DiazEffect of nutrition and oxidative stress on epigenetic regulation during cellular differentiation and developmentMargreet Vissers, Andrew Das, Mark Hampton, Tim Hore
Cassie StylianouCopy variants and endometrial cancer riskLogan Walker, John Pearson
Eveline van LeeuwenOxidative stress and redox regulation of the cytoskeletonMark Hampton, Margreet Vissers
Jessika Wise3D breast tumour models for drug discoveryElisabeth Phillips, Tim Woodfield, Associate Professor Khoon Lim, Margaret Currie
Zhixing ZhuThe role of exosome miRNA in acute lung injuryMadhav Bhatia, Steve Chambers, Xiangdong Wang, Yiming Zeng

BBiomedSc(Hons)

StudentThesis titleSupervisor(s)
Eira Beverley-StoneThe role of iron in brain cancerGabi Dachs
Alex BothaInvestigating the amyloid state of p16Christoph Goebl, Kenny Chitcholtan, Mark Hampton, Vanessa Morris
Mackenzie FlanneryObserving heterogeneity in neutrophil phagosomesTony Kettle, Louisa Ashby
Shaya HelemIdentifying the mechanism of action of a marine-derived anticancer compoundMark Hampton, Paul Pace, Stephanie Bozonet
Tiffany IlottFunctional analysis of copy number variants associated with endometrial cancerLogan Walker, George Wiggins, Arthur Morley-Bunker
Ashleigh MonsonPotential transcriptional adaptation associated with BRCA1 pathogenic variantsGeorge Wiggins, Logan Walker
Jackson O'NeillAllelic diversity of the pharmacogene CYP2C19 in Pasifika peopleMartin Kennedy, John Pearson
Anh Thu PhanThe microbiome in IBD-related colorectal cancerRachel Purcell, Arthur Morley-Bunker, Logan Walker
Briana SmithInvestigating the redox state of p16Christoph Goebl, Mark Hampton, Nick Magon, Vanessa Morris
Georgia TurnerHuman cytomegalovirus (HCMV) in breast tumour samplesArthur Morley-Bunker, Margaret Currie, Logan Walker

2021

PhD

StudentThesis titleSupervisors
Linda BussThe immune system: A common link mediating exercise effects on the tumour microenvironment and skeletal muscle mitochondria?Gabi Dachs, Margaret Currie, Barry Hock, Abel Ang, Bridget Robinson
Annika SeddonNeutrophils and cancer: regulation of cell death and epigenetic pathwaysMark Hampton, Aaron Stevens, Margaret Currie, Tony Kettle
George WigginsGene expression variability in breast tumour development  Logan Walker, John Pearson, Mik Black

BBiomedSc(Hons)

StudentThesis titleSupervisor(s)
Leonie HitchmanAllelic diversity of the pharmacogene CYP2D6 in Māori and PasifikaSimran Maggo, Martin Kennedy, John Pearson
Samantha MeredithCharacterising the role of peroxidasin in breast cancerMartina Paumann-Page
Jenny NaughtonIdentification of key peptide regions in the amyloid state of the tumour suppressor p16Christoph Goebl, Nick Magon, Mark Hampton
Ruth PhangNutritional immunity: Butyrate and colon carcinogenesisJacqui Kennan, Andrew Day, Mark Hampton
Ben TophamInvestigating the relationship between ascorbate and the differentiation of monocytes in an in-vitro melanoma model  Margaret Currie

2020

PhD

StudentThesis titleSupervisors
Bee BathishCharacterising the activity of peroxidasin in the extracellular matrixChristine Winterbourn, Tony Kettle
Rebekah CrakeLocal and systemic effects of adipocyte-secreted factors in breast cancer  Margaret Currie, Elisabeth Phillips, Bridget Robinson, Matthew Strother
Yusmiati (Cen) LiauApplication of second and third generation sequencing in pharmacogeneticsMartin Kennedy, Simran Maggo, Simone Cree, John Pearson
Ali MohammadiDevelopment of detection methods for Legionella longbeachae in clinical and environmental samples  Steve Chambers, David Murdoch, Amy Scott-Thomas
Arthur Morley-BunkerScoping for RNA biomarkers of colorectal cancer Logan Walker, Margaret Currie, John Pearson, Mr Tim Eglinton

BBiomedSc(Hons)

StudentThesis titleSupervisor(s)
Madison HillThe interaction of neutrophils and amyloid-ß in Alzheimer's disease  Leon Smyth, Mark Hampton
Jess PermainBacterial lipopolysaccharide and immune activation in colorectal cancer  Rachel Purcell, Logan Walker
Carlos Smith DiazVitamin C as an epigenetic therapeutic for acute myeloid leukaemiaAndrew Das, Margreet Vissers, Mark Hampton

2019

PhD

StudentThesis titleSupervisors
Priyanka SinhaTranscriptional effects of mood stabiliser drugs in a serotonergic cell lineMartin Kennedy, Simone Cree, John Pearson
Masuma ZawariBioavailability and biological effects of isothiocyanates from broccoli sprout powderMark Hampton, Anitra Carr, Andree Pearson, Dion Thompson

BBiomedSc(Hons)

StudentThesis titleSupervisor(s)
Krista DawsonCharacterising the relationship between Legionella longbeachae and their amoebal hosts: Implications for Legionnaires' disease prevention  Sandy Slow, Steve Chambers, Trevor Anderson, David Murdoch
Tess FeatherstonPeroxiredoxins as biomarkers of oxidative stress in metastatic melanoma cellsMark Hampton, Martina Paumann-Page, Christine Winterbourn
Lorna ForresterMycobacterial resistance to neutrophil oxidants  Mark Hampton, Heather Parker
Jaya MontecilloGene modification of breast cancer cells for cancer imaging  Gabi Dachs

2018

PhD

StudentThesis titleSupervisors
Teagan HoskinOxidative post-translational modifications of calprotectin during inflammationTony Kettle, Nina Dickerhof, Richard Gearry, Andrew Day
Kate VickPeroxiredoxin expression and redox state in human cancersMark Hampton, Christine Winterbourn
Christina WohlrabThe role of ascorbate in controlling hypoxia factors in renal cell carcinoma  Gabi Dachs, Elisabeth Phillips, Margreet Vissers, Bridget Robinson

BBiomedSc(Hons)

StudentThesis titleSupervisor(s)
Eleanor BurgessCan vitamin C reduce metastases in a mouse model of breast cancer?Gabi Dachs
Isabelle ChaiCopy number variants and familial breast and ovarian cancer riskLogan Walker, Vanessa Lattimore
Jessie ChangTargeted enrichment and Nanopore sequencing of RNA transcripts from breast cancer risk genesMartin Kennedy, Logan Walker, Simone Cree, John Pearson
Sarah HeathIntracellular redox changes during TNFα-mediated necroptosis  Mark Hampton
James SwanAspirin's role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin  Jacqui Kennan, Mark Hampton

2017

PhD

StudentThesis titleSupervisors
Andrew DasThe reactions of superoxide with tyrosyl radicals on proteinsTony Kettle, Christine Winterbourn
Ravinder Reddy GaddamThe role of hydrogen sulfide, substance P and Kupffer cells on inflammation and liver sinusoidal endothelial cells in sepsisMadhav Bhatia, Steve Chambers
Hannah KennedyApplication of emerging sequencing and genomic technologies to diagnostic molecular geneticsPeter George, Kit Doudney
Vanessa LattimoreGenetic variation and mRNA splicing in familial breast cancer genesLogan Walker, Margaret Currie, Bridget Robinson, John Pearson
Emma SpencerExploring the anti-cancer and anti-inflammatory properties of isothiocyanatesMark Hampton, Tony Kettle

BBiomedSc(Hons)

StudentThesis titleSupervisor
Leah ButtMeasuring markers of immune response in patients treated with Nivolumab (Opdivo) or Pembrolizumab (Keytruda)Margaret Currie

2016

PhD

StudentThesis titleSupervisors
Abel AngRole of endogenous hydrogen sulfide synthesised by cystathionine-gamma-lyase in the inflammatory response in acute pancreatitisMadhav Bhatia, Greg Giles
Sarah ApplebyTelomere length as a putative biomarker of health and diseaseMartin Kennedy, Mark Hampton, John Pearson
Alireza BadieiEffect of cystathionine-gamma-lyase gene silencing with siRNA on inflammation in acute pancreatitisMadhav Bhatia, Steve Chambers
Janice Chew-HarrisBiomarkers of kidney function; Validity of estimates in clinical practiceChris Florkowski, Peter George
Aaron StevensThe interaction of G-Quadruplex DNA structure and cytosine methylationMartin Kennedy, Simone Cree

BBiomedSc(Hons)

StudentThesis titleSupervisors
Rosie BurnA validation study to detect markers of proliferation adequacy in the endometriumMartin Kennedy, Gloria Evans, John Evans
Linda BussThe influence of exercise and hyperlipidaemia on breast cancerGabi Dachs, Margreet Vissers
Lucy de JongDiagnostic applications of a Nanopore sequencing deviceMartin Kennedy
Tara SwadiA novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitorsSteve Chambers

2015

PhD

StudentThesis titleSupervisors
Diana BalasubramanainGene expression changes induced by mood stabilizer drugs in a serotonergic cell lineMartin Kennedy, Peter Joyce, Mark Hampton
Simone BayerRedox State Of Erythrocyte Peroxiredoxin 2 During Oxidative Stress And Its Effect On Membrane BindingChristine Winterbourn, Mark Hampton
Lizzie CampbellRegulation of Hypoxia-Inducible Factor-Mediated Tumour Growth by AscorbateGabi Dachs, Bridget Robinson, Margreet Vissers
Eng Wee ChuaUnderstanding Adverse Drug Reactions Using Genomic SequencingMartin Kennedy, Ruth Savage
Tony RahmanVenous thromboembolism in patients with cancer undertaking chemotherapyBridget Robinson, Margaret Currie, Mark Smith
Usha Rani Talla (Pujary)The Effect of Hypoxia on Neutrophil Survival and FunctionMargreet Vissers, Mark Hampton, Heather Parker

BBiomedSc(Hons)

StudentThesis titleSupervisors
Mark BrinsdenMeasuring Mitochondrial Dysfunction in HumansAndree Pearson, Mark Hampton
Rebekah CrakeExploring Molecular Links between Obesity and Breast CancerLogan Walker, Margaret Currie, Elisabeth Phillips
Sarah DrakeInvestigating the pro-apoptotic properties of portimineMark Hampton
Melanie HamzahInactivation of a Thiol-Dependent Enzyme by Urate HydroperoxideTony Kettle, Mark Hampton
Morgan JonesDoes fat provide energy for breast tumour cell invasion and metastasis?Margaret Currie, Elisabeth Phillips, Mark Hampton
Anishah MandaniDevelopment of a metabolic syndrome mouse model of breast cancerGabi Dachs, Margaret Currie, Elisabeth Phillips
Millie TaylorImpact of G-quadruplex structures and DNA methylation on allelic drop-out during in vitro amplification of imprinted genesMartin Kennedy, Simone Cree

2014

PhD

StudentThesis titleSupervisors
James FalveyMacrophage Migration Inhibitory Factor and Inflammatory Bowel DiseaseRichard Gearry, Mark Hampton, Rebecca Roberts
Rebecca PoyntonPeroxiredoxin 3 and oxidative stress in mitochondriaMark Hampton, Christine Winterbourn, Andrea Betz

BBiomedSc(Hons)

StudentThesis TitleSupervisor
Bee BathishThe effect of cell metabolism on epigenetic processes in cancer cellsMargreet Vissers
Masuma ZawariInvolvement of mitochondria and peroxiredoxin in TNF-mediated necroptosisMark Hampton

2013

PhD

StudentThesis titleSupervisors
Caroline Kuiper*The role of ascorbate in the regulation of HIF-1 in cancer cellsMargreet Vissers, Gabi Dachs, Margaret Currie
Nick MagonOxidative Modification of Calprotectin During Inflammation: Development as a BiomarkerMark Hampton, Tony Kettle, Richard Gearry
Anja WernoDevelopment of improved diagnostic testing methods for invasive pneumococcal diseaseDavid Murdoch, Peter George

*Divisional Exceptional Thesis

BBiomedSc(Hons)

StudentThesis titleSupervisors
Teresa FlettGene transfer to restore vitamin C synthesis in human cell lineGabi Dachs, Margreet Vissers
Zac GerringEvaluating molecular markers of breast tumour progressionLogan Walker, Gavin Harris
Annika SeddonImmune suppression and squamous cell carcinoma tumour biologyMargaret Currie
Kate VickFunctional consequences of lowering mitochondrial peroxiredoxin 3 expressionMark Hampton

2012

PhD

StudentThesis titleSupervisors
Shrawan BhandariInvestigation of the biosynthesis of 2-Pentylfuran from 'Aspergillus fumigatus in vitro' and 'in vivo'Steve Chambers, Amy Scott-Thomas, Chris Charles, Richard Weld

2011

PhD

StudentThesis titleSupervisors
Melanie Coker*The role of reactive chlorine species in bacterial killing by neutrophilsProf Tony Kettle, Christine Winterbourn
Sarah DengGene regulation by antidepressant drugsMartin Kennedy, Peter Joyce
Alice JohnstoneImplications for drug addiction development from expressional analyses of rattus norvegicus striatal
tissue following methamphetamine and benzylpiperazine exposure
Martin Kennedy
Vikas KumarOxidative changes in cardiac proteome during ischemia/reperfusionChristine Winterbourn, Mark Hampton
Amy (Marshall) Osborne*Assessment of genetic variation in the threatened New Zealand sea lion, Phocarctos hookeri, and its association with fitnessNeil Gemmell, Martin Kennedy
Katya VolkovaTumour angiogenesis : the role of metabolic syndrome and insulin resistenceMargaret Currie, Gabi Dachs, Bridget Robinson

* Divisional Exceptional Thesis

BBiomedSc(Hons)

StudentThesis titleSupervisors
Lizzie CampbellHydrogen Sulfide: Investigation into the Effects of Different H2S Donors on the Upregulation of Inflammatory CytokinesMadhav Bhatia
Teagan HoskinNeutrophil Activation in Inflammatory Bowel DiseaseRichard Gearry, Prof Tony Kettle
Sarah Jodczyk (Appleby)Establishment and validation of a telomere length assayMartin Kennedy
Emma SpencerInhibiting the pro-inflammatory cytokine MIFMark Hampton

2010

PhD

StudentThesis titleSupervisors
Ryan Davis*The molecular basis of fibrinogen disease: Structure, function and pathologyStephen Brennan, Peter George
Michelle HuntVessel-directed enzyme-prodrug therapy for cancerGabi Dachs, Margaret Currie, Bridget Robinson
Kasia MackenzieWhy are skin cancers more aggressive in renal transplant recipients?Margaret Currie, Barry Hock, Bridget Robinson, Gabi Dachs, Andrew Miller, Justin Roake, Mr Jeremy Simcock
Karina O'ConnorThe effect of oxidative stress on DNA methylationMark Hampton, Christine Winterbourn, Anthony Reeve
Melissa StaceyCell antioxidant pathways for disposal of MPO-derived oxidantsChristine Winterbourn, Margreet Vissers

* Divisional Exceptional Thesis

BBiomedSc(Hons)

StudentThesis titleSupervisor
Andrew GibbDoes promoter variation in the USP46 gene influence antidepressant response?Martin Kennedy
Min-Hi HanAssessing a blood biomarker of lung infectionChristine Winterbourn
Aaron HayesDetecting 2-aminoacetophenone and pyocyanin from clinical strains of Pseudomonas aeruginosaAmy Scott-Thomas
Hannah KennedyDevelopment of an assay for interferon beta bioavailability in relapsing-remitting MS patientsStephen Brennan
Tamas MajorEvaluation of The Four-and-a-half LIM 2 (FHL2) Single Polypeptide As A Potential Biomarker of Cardio-Renal Syndrome (CRS)Chris Pemberton
Anna van PomerenMyeloid-Derived Suppressor Cells, Tumour Angiogenesis, and Cancer ProgressionMargaret Currie

2009

PhD

StudentThesis titleSupervisors
Michael BlandGenetic and functional analysis of novel serotonergic candidate genes in psychiatric disordersMartin Kennedy, Peter Joyce, Rebecca Roberts
Kristin Brown*Cellular targets of isothiocyanatesMark Hampton, Christine Winterbourn, Sarah Cuddihy
Andy Cox*Peroxiredoxin 3 and the regulation of mitochondrial hydrogen peroxideMark Hampton, Christine Winterbourn, Sarah Cuddihy
Dylan GlubbPharmacogenomics of the antidepressant ParoxetineMartin Kennedy, Peter Joyce
Jessie Green*Oxidant production inside the phagosomes of neutrophilsChristine Winterbourn, Tony Kettle, Mark Hampton

* Divisional Exceptional Thesis

2008

PhD

StudentThesis titleSupervisors
Sarah GunninghamThe role of vascular endothelial growth factors and their receptors in breast and colorectal tumour angiogenesisMargaret Currie, Vicky Cameron, Bridget Robinson, Stephen Fox
Tim HarwoodGlutathione sulfonamide as a biomarker of oxidative stress during inflammationChristine Winterbourn, Tony Kettle
Felicia LowThe antioxidant activity of erythrocyte peroxiredoxin 2 and its role in protecting haemoglobinChristine Winterbourn, Mark Hampton
So-Young MoonIdentification of genetic aberrations in chronic lymphocytic leukaemia using array CGHMargaret Currie, Peter Ganly, Christine Morris
Campbell SheenMolecular characterisation of coagulation disordersStephen Brennan, Christine Morris, Mark Smith
Selma Stuffrein-RobertsAllelic expression patterns in psychiatric candidate genesMartin Kennedy, Vicky Cameron, Michael Eccles
Rachel WilkieOxidative stress and apoptosis in the phagocytic neutrophilsMark Hampton, Margreet Vissers

2007

PhD

StudentThesis titleSupervisors
Mathew LittlejohnPharmacogenetics of the B2 adrenergic receptor and related moleculesMartin Kennedy, Prof Tony Kettle,
Robyn MidwinterThe role of chloramines on the inflammatory process in endothelial cellsChristine Winterbourn, Margreet Vissers,
Logan WalkerGenetic aberrations in breast cancerBridget Robinson, Christine Morris

2006

PhD

StudentThesis titleSupervisors
Amy DearAssembly and secretion of Fibrinogen: Evidence from human mutationStephen Brennan, Peter George
Patrick McHughA cellular model for investigating antidepressant pharmacogenomicsMartin Kennedy, Peter Joyce, Geraldine Rogers
Jennifer ScotterThe laboratory diagnosis of invasive aspergillosisStephen Chambers, Peter Ganly, David Murdoch
Malina StorerDevelopment of laboratory tests for assessing vitamin statusStephen Chambers, Michael Lever

2005

PhD

StudentThesis titleSupervisors
Vickie HanrahanThe role of homeobox gene HLX1 in haematopoiesis and leukaemiaMartin Kennedy, Stephen Brennan, Geraldine Rogers

2004

PhD

StudentThesis titleSupervisors
James BatyHydrogen peroxide-sensitive thiol proteins: Potential targets in redox signallingChristine Winterbourn, Mark Hampton,
Warwick DellowGlycine Betaine and Diabetes MellitusStephen Chambers, Peter George, Dr Michael Lever
Ghassan MaghzalThe effects of genes and the environment on the structure and function of fibrinogenStephen Brennan, Peter George

2003

PhD

StudentThesis titleSupervisors
Fook Choe CheahLung inflammation and oxidative injury in hyaline membrane disease: The role of NF-kB activation in pulmonary leukocytesChristine Winterbourn, Brian Darlow
Sheryl GoughMolecular analysis of a novel chromosome translocation associated with acute lymphoid leukemiaPeter Ganly, Christine Morris
Harold NealCRESCENTIC GLOMERULONEPHRITIS: Associations of Eosinophils and Transforming Growth FactorsRobin Fraser

2002

PhD

StudentThesis titleSupervisors
Suzanne BenjesBCR-ABL1 Recombination Mechanisms in Chronic Myeloid Leukaemia: Clues from ComplexityVicky Cameron, Christine Morris
Sangeeta BudhiaIsolation and Characterisation of Novel Human Dendritic Cell-Associated Molecule, DD1.1Barry Hock, Martin Kennedy, Justin Roake
Anna ChapmanAggregation and chlorination of proteins by hypochlorous acid: Insights into reactions within neutrophilsTony Kettle, Porf Christine Winterbourn
Victoria MetcalfThe Molecular Evolution of Serum Albumin in Non-Mammalian Vertebrate SpeciesStephen Brennan, Peter George
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