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Steve ChambersProfessor

MB ChB, MD(Otago), MSc(Lond), FRACP

Email steve.chambers@otago.ac.nz
Tel +64 3 364 3615

Research interests

Professor Steve Chambers' research interests relate to diagnostics in respiratory infections, the treatment of infectious diseases and intermediary metabolism with particular emphasis on the relationship between bacterial and human metabolism.

He is interested in the effective delivery of treatment for infectious disease that minimises harm to the patient depends on rapid, accurate diagnosis of the infecting organism.

Clinical studies undertaken by Professor Chambers and his team have confirmed the limitations of current methods such as culture and PCR, particularly in children, which depend on the collection of sputum and other specimens. This lead the concept of diagnostic breath testing, which can be performed on readily available samples that can be easily repeated, to follow microbial metabolism. Markers of bacterial metabolisms are obvious diagnostic candidates particularly as they are specific to a particular respiratory pathogen.

In the media

Professors Steve Chambers and David Murdoch were interviewed for Radio New Zealand's Our Changing World series in March 2014.

Publications

Jun, H., Chambers, S. T., Williman, J., Slow, S., Murdoch, D. R., & Scott-Thomas, A. (2024). The inhibitory effect of copper, zinc, and manganese on Legionella longbeachae in potting mix leachate. Letters in Applied Microbiology, 77, ovae081. doi: 10.1093/lambio/ovae081 Journal - Research Article

Pairman, L., & Chambers, S. T. (2024). Quinolones or macrolides for adults with Legionnaires’ disease and respiratory failure? European Journal of Internal Medicine. Advance online publication. doi: 10.1016/j.ejim.2024.07.026 Journal - Research Other

Zhu, Z., Chambers, S., & Bhatia, M. (2024). Substance P promotes leukocyte infiltration in the liver and lungs of mice with sepsis: A key role for adhesion molecules on vascular endothelial cells. International Journal of Molecular Sciences, 25(12), 6500. doi: 10.3390/ijms25126500 Journal - Research Article

Zhu, Z., Chambers, S., & Bhatia, M. (2024). Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs. Antioxidants, 13, 300. doi: 10.3390/antiox13030300 Journal - Research Article

Campbell, P. O., Bauro, T., Rimon, E., Timeon, E., Bland, C., Ioteba, N., Douglas, N. M., … Chambers, S. T. (2024). Single-dose rifampicin leprosy chemoprophylaxis for household contacts in Kiribati: An audit of a combined retrospective and prospective approach. Tropical Medicine & Infectious Disease, 9, 58. doi: 10.3390/tropicalmed9030058 Journal - Research Article

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