Professor Tony Kettle

2024

Journal - Research Article

Swaminathan, A., Borichevsky, G. M., Frampton, C., Kettle, A. J., Peyrin-Biroulet, L., Siegel, C. A., Day, A. S., & Gearry, R. B. (2024). Development and investigation of a non-invasive disease severity index for inflammatory bowel disease. Journal of Crohn's & Colitis, jjae106. Advance online publication. doi: 10.1093/ecco-jcc/jjae106

Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032

Journal - Research Other

Blake, T. L., Sly, P. D., Anderson, I., Wainwright, C. E., Reid, D. W., Bell, S. C., Smith, B. R., Kettle, A. J., & Dickerhof, N. (2024). Changes in urinary glutathione sulfonamide (GSA) levels between admission and discharge of patients with cystic fibrosis. Journal of Cystic Fibrosis. Advance online publication. doi: 10.1016/j.jcf.2024.04.009

2023

Journal - Research Article

Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry. Advance online publication. doi: 10.1016/j.rbc.2023.100002

Journal - Research Other

Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183

Swaminathan, A., Frampton, C. M., Borichevsky, G. M., Kettle, A. J., & Gearry, R. B. (2023). Response to "Evaluating discriminative accuracy of biomarkers in relation to binary study outcomes: First validate, then celebrate?" Journal of Crohn's & Colitis, 17, 147-148. doi: 10.1093/ecco-jcc/jjac126

Conference Contribution - Published proceedings: Abstract

Kettle, T., Dickerhof, N., Ford, D., Dilly, J. D., Ashby, L. V., Anderson, R. F., & Payne, R. J. (2023). Dioxygenation of tryptophan residues by superoxide and myeloperoxidase. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Flannery, M., McKenzie, J., Ashby, L., & Kettle, T. (2023). Interactions between superoxide and myeloperoxidase inside phagocytic neutrophils. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Ashby, L. V., Flannery, M., Chua, I., & Kettle, A. J. (2023). Measuring oxidant production in phagosomes to identify abnormalities in neutrophil function. Free Radical Biology & Medicine, 201(Suppl. 1), (pp. 13). doi: 10.1016/j.freeradbiomed.2023.03.072

2022

Journal - Research Article

Swaminathan, A., Borichevsky, G. M., Edwards, T. S., Hirschfeld, E., Mules, T. C., Frampton, C. M. A., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2022). Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. Journal of Crohn's & Colitis, 16, 1862-1873. doi: 10.1093/ecco-jcc/jjac098

Ashby, L. V., Springer, R., Loi, V. V., Antelmann, H., Hampton, M. B., Kettle, A. J., & Dickerhof, N. (2022). Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. Journal of Leukocyte Biology, 112, 591-605. doi: 10.1002/jlb.4hi1021-538rr

Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2

Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21

Edwards, T. S., Dickerhof, N., Magon, N. J., Paton, L. N., Sly, P. D., & Kettle, A. J. (2022). Formation of calprotectin-derived peptides in the airways of children with cystic fibrosis. Journal of Immunology, 208, 979-990. doi: 10.4049/jimmunol.2001017

Conference Contribution - Poster Presentation (not in published proceedings)

Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Dickerhof, N., Parker, H. A., Hampton, M. B., & Kettle, A. J. (2022, August). Gauging the exposure of bacteria to toxic oxidants inside neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M., Kettle, T., Gladyshev, V., & Sly, P. (2022, December). Where are oxidative footprints leading us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

2021

Journal - Research Article

Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084

Conference Contribution - Published proceedings: Abstract

Borichevsky, G., Swaminathan, A., Edwards, T., Day, A., Hampton, M., Kettle, A., & Gearry, R. (2021). Faecal myeloperoxidase is a biomarker of endoscopically active inflammatory bowel disease. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 234). Retrieved from https://www.faobmb2021.org

Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org

2020

Journal - Research Article

Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry, 295(36), 12697-12705. doi: 10.1074/jbc.RA120.014504

Dickerhof, N., Paton, L., & Kettle, A. J. (2020). Oxidation of bacillithiol by myeloperoxidase-derived oxidants. Free Radical Biology & Medicine, 158, 74-83. doi: 10.1016/j.freeradbiomed.2020.06.009

Dickerhof, N., Huang, J., Min, E., Michaëlsson, E., Lindstedt, E.-L., Pearson, J. F., Kettle, A. J., & Day, B. J. (2020). Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation. Free Radical Biology & Medicine, 152, 91-99. doi: 10.1016/j.freeradbiomed.2020.03.001

Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394

Carr, A. C., Spencer, E., Hoskin, T. S., Rosengrave, P., Kettle, A. J., & Shaw, G. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. Free Radical Biology & Medicine, 152, 462-468. doi: 10.1016/j.freeradbiomed.2019.11.004

Journal - Research Other

Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033

Conference Contribution - Published proceedings: Abstract

Spencer, E., Hoskin, T., Rosengrave, P., Kettle, A., Shaw, G., & Carr, A. (2020). Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. New Zealand Medical Journal, 133(1524), (pp. 145-146). Retrieved from https://www.nzma.org.nz/journal

2019

Chapter in Book - Research

Garai, D., Pálinkás, Z., Balla, J., Kettle, A. J., & Nagy, P. (2019). Measurements for sulfide-mediated inhibition of myeloperoxidase activity. In J. Beltowski (Ed.), Vascular effects of hydrogen sulfide: Methods and protocols: Methods in molecular biology (Vol. 2007). (pp. 179-203). New York, NY: Humana Press. doi: 10.1007/978-1-4939-9528-8_14

Journal - Research Article

Dickerhof, N., Isles, V., Pattemore, P., Hampton, M. B., & Kettle, A. J. (2019). Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis. Journal of Biological Chemistry, 294(36), 13502-13514. doi: 10.1074/jbc.RA119.009934

Cheng, D., Talib, J., Stanley, C. P., Rashid, I., Michaëlsson, E., Lindstedt, E.-L., … Kettle, A. J., … Stocker, R. (2019). Inhibition of MPO (myeloperoxidase) attenuates endothelial dysfunction in mouse models of vascular inflammation and atherosclerosis. Arteriosclerosis, Thrombosis, & Vascular Biology, 39, 1448-1457. doi: 10.1161/atvbaha.119.312725

Hoskin, T. S., Crowther, J. M., Cheung, J., Epton, M. J., Sly, P. D., Elder, P. A., … Kettle, A. J., & Dickerhof, N. (2019). Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis. Redox Biology, 24, 101202. doi: 10.1016/j.redox.2019.101202

Filbey, K. J., Camberis, M., Chandler, J., Turner, R., Kettle, A. J., Eichenberger, R. M., … Le Gros, G. (2019). Intestinal helminth infection promotes IL-5- and CD4⁺ T cell-dependent immunity in the lung against migrating parasites. Mucosal Immunology, 12, 352-362. doi: 10.1038/s41385-018-0102-8

2018

Edited Book - Research

Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p.

Chapter in Book - Research

Forbes, L. V., & Kettle, A. J. (2018). Myeloperoxidase: Unleashing the power of hydrogen peroxide. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 281-304). Boca Raton, FL: CRC Press.

Journal - Research Article

Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237

Rashid, I., Maghzal, G. J., Chen, Y.-C., Cheng, D., Talib, J., Newington, D., … Kettle, A. J., … Stocker, R. (2018). Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque. European Heart Journal, 39(35), 3301-3310. doi: 10.1093/eurheartj/ehy419

Albrett, A. M., Ashby, L. V., Dickerhof, N., Kettle, A. J., & Winterbourn, C. C. (2018). Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe. Journal of Biological Chemistry, 293(40), 15715-15724. doi: 10.1074/jbc.RA118.004789

Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038

Khalilova, I. S., Dickerhof, N., Mocatta, T. J., Bhagra, C. J., McClean, D. R., Obinger, C., & Kettle, A. J. (2018). A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients. PLoS ONE, 13(3), e0192952. doi: 10.1371/journal.pone.0192952

Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039

Das, A. B., Sadowska-Bartosz, I., Königstorfer, A., Kettle, A. J., & Winterbourn, C. C. (2018). Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast. Free Radical Biology & Medicine, 116, 114-122. doi: 10.1016/j.freeradbiomed.2018.01.001

Forbes, L. V., & Kettle, A. J. (2018). A multi-substrate assay for finding physiologically effective inhibitors of myeloperoxidase. Analytical Biochemistry, 544, 13-21. doi: 10.1016/j.ab.2017.12.022

Journal - Professional & Other Non-Research Articles

van der Vliet, A., Dick, T. P., Aust, S. D., Koppenol, W. H., Ursini, F., Kettle, A. J., … Janssen-Heininger, Y. M. W. (2018). Rust never sleeps: The continuing story of the Iron Bolt. Free Radical Biology & Medicine, 124, 353-357. doi: 10.1016/j.freeradbiomed.2018.06.017

Conference Contribution - Published proceedings: Abstract

Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz

Parker, H. A., Hampton, M. B., Rosado, L. A., Messens, J., & Kettle, A. J. (2018). Resistance of Mycobacterium smegmatis to oxygen-dependent killing by neutrophils. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 95-96). Retrieved from https://www.nzmsconference.org.nz

Chami, B., Vallejo, A., KumJew, S., Dickerhof, N., Kettle, A. J., Dennis, J. M., & Witting, P. (2018). Role for neutrophil-derived myeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPO. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S38). doi: 10.1016/j.freeradbiomed.2018.04.131

Conference Contribution - Poster Presentation (not in published proceedings)

Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

2017

Journal - Research Article

Green, J. N., Chapman, A. L. P., Bishop, C. J., Winterbourn, C. C., & Kettle, A. J. (2017). Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide. Free Radical Biology & Medicine, 113, 363-371. doi: 10.1016/j.freeradbiomed.2017.10.343

Dickerhof, N., Pearson, J. F., Hoskin, T. S., Berry, L. J., Turner, R., Sly, P. D., Kettle, A. J., on behalf of AREST CF. (2017). Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency. Free Radical Biology & Medicine, 113, 236-243. doi: 10.1016/j.freeradbiomed.2017.09.028

Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327

Dickerhof, N., Turner, R., Khalilova, I., Fantino, E., Sly, P. D., Kettle, A. J., on behalf of AREST CF. (2017). Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. Journal of Cystic Fibrosis, 16(2), 214-221. doi: 10.1016/j.jcf.2016.10.012

Conference Contribution - Verbal presentation and other Conference outputs

Dickerhof, N., Pearson, J. F., Hoskin, T. S., Sly, P. D., & Kettle, A. J. (2017, August). Myeloperoxidase is associated with bronchiectasis in children with cystic fibrosis. Verbal presentation at the 10th International Human Peroxidase Meeting, Breckenridge, USA.

Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Hoskin, T. S., Dickerhof, N., Hampton, M. B., & Kettle, A. J. (2017, July). Calprotectin is sensitive to oxidants generated by myeloperoxidase. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Chapter in Book - Research

Kettle, A. J., & Winterbourn, C. C. (2016). Myeloperoxidase: Structure and function of the green heme peroxidase of neutrophils. In E. Raven & B. Dunford (Eds.), Heme peroxidases. (pp. 272-308). Cambridge, UK: Royal Society of Chemistry. doi: 10.1039/9781782622628-00272

Journal - Research Article

Kato, Y., Oki, K., Suga, N., Ono, S., Ishisaka, A., Miura, Y., … Kettle, A. J. (2016). A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis. Free Radical Biology & Medicine, 101, 500-510. doi: 10.1016/j.freeradbiomed.2016.11.023

Terrill, J. R., Duong, M. N., Turner, R., Le Guiner, C., Boyatzis, A., Kettle, A. J., … Arthur, P. G. (2016). Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy. Redox Biology, 9, 276-286. doi: 10.1016/j.redox.2016.08.016

Journal - Research Other

Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442

Conference Contribution - Published proceedings: Abstract

Dickerhof, N., Berry, L. J., Turner, R., Hoskin, T., Sly, P. D., & Kettle, A. J. (2016). Glutathione deficiency and neutrophil-mediated oxidative stress in the lungs of young children with cystic fibrosis. Free Radical Biology & Medicine, 100(Suppl.), (pp. S190). doi: 10.1016/j.freeradbiomed.2016.10.519

Cheng, D., Chen, Y. C., Stanley, C., Talib, J., Rashid, I., Lindstedt, E.-L., Kettle, A. J., … Stocker, R. (2016). Pharmacological inhibition of myeloperoxidase improves endothelial function and stabilizes atherosclerotic lesions in a mouse model of vulnerable plaque. Free Radical Biology & Medicine, 100(Suppl.), (pp. S151-S152). doi: 10.1016/j.freeradbiomed.2016.10.399

Bathish, B., Turner, R., Kettle, T., & Winterbourn, C. (2016). Peroxidasin-catalysed oxidative modifications of proteins in the extracellular matrix. Free Radical Biology & Medicine, 100(Suppl.), (pp. S19-S20). doi: 10.1016/j.freeradbiomed.2016.10.044

2015

Journal - Research Article

Dickerhof, N., Schindler, L., Bernhagen, J., Kettle, A. J., & Hampton, M. B. (2015). Macrophage migration inhibitory factor (MIF) Is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radical Biology & Medicine, 89, 498-511. doi: 10.1016/j.freeradbiomed.2015.09.009

Patrício, E. S., Prado, F. M., da Silva, R. P., Carvalho, L. A. C., Prates, M. V. C., Dadamos, T., … Kettle, A. J., & Meotti, F. C. (2015). Chemical characterization of urate hydroperoxide, A pro-oxidant intermediate generated by urate oxidation in inflammatory and photoinduced processes. Chemical Research in Toxicology, 28(8), 1556-1566. doi: 10.1021/acs.chemrestox.5b00132

Chandler, J. D., Min, E., Huang, J., McElroy, C. S., Dickerhof, N., Mocatta, T., … Kettle, A. J., … Day, B. J. (2015). Antiinflammatory and antimicrobial effects of thiocyanate in a cystic fibrosis mouse model. American Journal of Respiratory Cell & Molecular Biology, 53(2), 193-205. doi: 10.1165/rcmb.2014-0208OC

Odobasic, D., Muljadi, R. C. M., O'Sullivan, K. M., Kettle, A. J., Dickerhof, N., Summers, S. A., … Holdsworth, S. R. (2015). Suppression of autoimmunity and renal disease in pristane-induced lupus by myeloperoxidase. Arthritis & Rheumatology, 67(7), 1868-1880. doi: 10.1002/art.39109

Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022

Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422

Conference Contribution - Published proceedings: Abstract

Patricio, E., Prates, M., Prado, F., Dadamos, T., Carvalho, L. A. D. C., Bertotti, M., … Kettle, A. J., & Meotti, F. C. (2015). Urate hydroperoxide as a pro-oxidant intermediate generated by urate oxidation in inflammatory and photo-induced processes. Proceedings of the 250th National American Chemical Society (ACS) Fall Meeting. Retrieved from https://www.acs.org

Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145

Nagy, P., Das, A., Nauser, T., Koppenol, W. H., Kettle, A. J., & Winterbourn, C. C. (2015). Superoxide-mediated post-translational modification of tyrosine residues. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S17-S18). doi: 10.1016/j.freeradbiomed.2015.07.073

Brockway, B., Senthilmohan, R., Jones, S., Cowan, J., Herbison, P., Hancox, B., Taylor, R., Van Dalen, C. J., & Kettle, T. (2015). Elevated sputum 3-bromotyrsoine levels are associated with loss of control in asthma. American Journal of Respiratory & Critical Care Medicine, 191(Meeting Abstracts). Retrieved from http://www.atsjournals.org/series/ajrccm-conference

Conference Contribution - Verbal presentation and other Conference outputs

Dickerhof, N., Fantino, E., Turner, R., Sly, P., & Kettle, A. J. (2015, December). Evaluation of glutathione sulphonamide and allantoin as blood and urine based indicators of exacerbations in children with cystic fibrosis. Verbal presentation at the Society for Free Radical Research Australasia & Japan Seventh Joint Meeting, Christchurch, New Zealand.

Kettle, T. (2015, September). Paradoxes inside the neutrophil phagosome. Invited presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2015, September). Myeloperoxidase-derived oxidants render macrophage migration inhibitory factor (MIF) enzymatically inactive while retaining its immunologic function. Verbal presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.

2014

Journal - Research Article

Green, J. N., Kettle, A. J., & Winterbourn, C. C. (2014). Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radical Biology & Medicine, 77, 49-56. doi: 10.1016/j.freeradbiomed.2014.08.013

Kato, Y., Ono, S., Kitamoto, N., & Kettle, A. J. (2014). Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine–4,5-dione. Redox Biology, 2, 983-990. doi: 10.1016/j.redox.2014.08.004

Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612

Seidel, A., Parker, H., Turner, R., Dickerhof, N., Khalilova, I. S., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2014). Uric acid and thiocyanate as competing substrates of lactoperoxidase. Journal of Biological Chemistry, 289(32), 21937-21949. doi: 10.1074/jbc.M113.544957

Stamp, L. K., Turner, R., Khalilova, I. S., Zhang, M., Drake, J., Forbes, L. V., & Kettle, A. J. (2014). Myeloperoxidase and oxidation of uric acid in gout: Implications for the clinical consequences of hyperuricaemia. Rheumatology, 53(11), 1958-1965. doi: 10.1093/rheumatology/keu218

Rees, M. D., Maiocchi, S. L., Kettle, A. J., & Thomas, S. R. (2014). Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate. Free Radical Biology & Medicine, 72, 91-103. doi: 10.1016/j.freeradbiomed.2014.03.037

Kettle, A. J., Turner, R., Gangell, C. L., Harwood, D. T., Khalilova, I. S., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2014). Oxidation contributes to low glutathione in the airways of children with cystic fibrosis. European Respiratory Journal, 44, 122-129. doi: 10.1183/09031936.00170213

Das, A. B., Nauser, T., Koppenol, W. H., Kettle, A. J., Winterbourn, C. C., & Nagy, P. (2014). Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition. Free Radical Biology & Medicine, 70, 86-95. doi: 10.1016/j.freeradbiomed.2014.02.006

Ronsein, G. E., Winterbourn, C. C., Di Mascio, P., & Kettle, A. J. (2014). Cross-linking methionine and amine residues with reactive halogen species. Free Radical Biology & Medicine, 70, 278-287. doi: 10.1016/j.freeradbiomed.2014.01.023

Maghzal, G. J., Cergol, K. M., Shengule, S. R., Suarna, C., Newington, D., Kettle, A. J., … Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. Journal of Biological Chemistry, 289(9), 5580-5595. doi: 10.1074/jbc.M113.539486

Kettle, A. J., Albrett, A. M., Chapman, A. L., Dickerhof, N., Forbes, L. V., Khalilova, I., & Turner, R. (2014). Measuring chlorine bleach in biology and medicine. Biochimica et Biophysica Acta: General Subjects, 1840(2), 781-793. doi: 10.1016/j.bbagen.2013.07.004

Conference Contribution - Published proceedings: Abstract

Stamp, L. K., Chapman, P. T., O'Donnell, J. L., Khalilova, I., Turner, R., & Kettle, A. (2014). Oxidative stress from use of allopurinol: Is there a reason for patients with gout to take vitamin C? Arthritis & Rheumatology, 66(10, Suppl.), (pp. S532-S533). doi: 10.1002/art.38914

Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Free Radical Biology & Medicine, 76(Suppl. 1), (pp. S163). doi: 10.1016/j.freeradbiomed.2014.10.047

Harper, J. L., McLaughlin, R. M., Grainger, R., He, S., Harrison, A. A., Martin, W.-J., Kettle, T., & Stamp, L. K. (2014). Soluble urate: An endogenous driver of immune moderation. Proceedings of the Medical Sciences Congress (MedSci). (pp. 13). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Conference Contribution - Poster Presentation (not in published proceedings)

Forbes, L. V., Parker, H., Turner, R., Albrett, A., & Kettle, A. J. (2014, December). Myeloperoxidase and protein oxidation in the neutrophil phagosome. Poster session presented at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014, November). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Verbal presentation at the Society for Free Radical Biology and Medicine (SFRBM) 21st Annual Meeting, Seattle, WA.

Kettle, T. (2014, December). Love at first sight: The joy of working with a beautiful green enzyme [Special Services Award Lecture]. Plenary presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.

2013

Chapter in Book - Other

Winterbourn, C., & Kettle, T. (2013). Centre for Free Radical Research. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 75-78). Christchurch, New Zealand: University of Otago.

Journal - Research Article

Forbes, L. V., Sjögren, T., Auchère, F., Jenkins, D. W., Thong, B., Laughton, D., … Turner, R., … Kettle, A. J. (2013). Potent reversible inhibition of myeloperoxidase by aromatic hydromates. Journal of Biological Chemistry, 288(51), 36636-36647. doi: 10.1074/jbc.M113.507756

Paumann-Page, M., Furtmüller, P. G., Hofbauer, S., Paton, L. N., Obinger, C., & Kettle, A. J. (2013). Inactivation of human myeloperoxidase by hydrogen peroxide. Archives of Biochemistry & Biophysics, 539(1), 51-62. doi: 10.1016/j.abb.2013.09.004

Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970

Klebanoff, S. J., Kettle, A. J., Rosen, H., Winterbourn, C. C., & Nauseef, W. M. (2013). Myeloperoxidase: A front-line defender against phagocytosed microorganisms. Journal of Leukocyte Biology, 93(2), 185-198. doi: 10.1189/jlb.0712349

Winterbourn, C. C., & Kettle, A. J. (2013). Redox reactions and microbial killing in the neutrophil phagosome. Antioxidants & Redox Signaling, 18(6), 642-660. doi: 10.1089/ars.2012.4827

Conference Contribution - Published proceedings: Abstract

Jameson, G. N. L., Seidel, A., Parker, H., Turner, R., Dickerhof, N., Wilbanks, S. M., Kettle, A. J., Young, V. L., & Ward, V. K. (2013). Uric acid modulates the activity of lactoperoxidase. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]

Kettle, T., Turner, R., Gangell, C., Khalilova, I., Harwood, T., Chapman, A., Winterbourn, C., … on behalf of AREST CF. (2013). The battle between chlorine bleach and glutathione in the lungs of kids with cystic fibrosis. Proceedings of the George Abbott Symposium. Retrieved from http://www.otago.ac.nz/george-abbott

Turner, R., Wu, Y., Li, L., Tang, W., Hazen, S. L., & Kettle, A. (2013). Uric acid oxidation as a biomarker of cardiovascular disease. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S74). doi: 10.1016/j.freeradbiomed.2013.10.566

Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535

Kettle, A., Turner, R., Gangell, C. L., Khalilova, I., Harwood, D. T., Chapman, A., Winterbourn, C. C., & Sly, P. (2013). Oxidation of glutathione by hypochlorous acid in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62). doi: 10.1016/j.freeradbiomed.2013.10.534

Forbes, L. V., Sjögren, T., Auchère, F., Thong, B., Eriksson, H., Unitt, J. F., & Kettle, A. (2013). Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S127). doi: 10.1016/j.freeradbiomed.2013.10.712

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S35-S36). doi: 10.1016/j.freeradbiomed.2013.10.470

Das, A., Nagy, P., Lecthe, T., Koppenol, W. H., Winterbourn, C. C., & Kettle, A. (2013). Detection of glutathione conjugated to oxidised tyrosine residues on proteins. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S55). doi: 10.1016/j.freeradbiomed.2013.10.520

Conference Contribution - Poster Presentation (not in published proceedings)

Seidel, A., Jameson, G., Turner, R., Kettle, A., & Wilbanks, S. (2013, July). Urate as a potential physiological substrate for lactoperoxidase. Poster session presented at the XVIth International Conference on Biological Inorganic Chemistry, Grenoble, France.

Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, September). Urate as potential physiological substrate for lactoperoxidase. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand.

Turner, R., Wu, Y., Li, L., Tang, W. H. W., Hazen, S. L., & Kettle, A. J. (2013, August). Uric Acid oxidation as a biomarker of cardiovascular disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Khalilova, I. S., Dickerhof, N., Mocatta, T., & Kettle, A. J. (2013, August). Pro-myeloperoxidase is present in circulation and a potential participant in cardiovascular disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, August). Urate as a potential physiological substrate for lactoperoxidase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Das, A. B., Nagy, P., Lechte, T., Winterbourn, C. C., & Kettle, A. J. (2013, August). Detection of glutathione conjugated to oxidized tyrosine residues on protein. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, T. (2013, September). Oxidation of uric acid during inflammation and cardiovascular disease. Verbal presentation at the 8th International Human Peroxidase Meeting, Sydney, Australia.

Seidel, A., Parker, H., Turner, R., Dickerhof, N., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2013, September). Urate as a potential physiological substrate for lactoperoxidase. Verbal presentation at the 8th International Human Peroxidase Meeting, Sydney, Australia.

Forbes, L. V., Sjögren, T., Auchère, F., Jenkins, D. W., Thong, B., Laughton, D., … Kettle, A. J. (2013, August). Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2013, August). Neutrophil extracellular traps: Friends or foe. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kettle, A. J., Turner, R., Stamp, L., Wu, Y., Li, L., Tang, W. H. W., … Akerstrom, B. (2013, August). Oxidation of uric acid during inflammation and cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kettle, T. (2013, September). The battle between chlorine bleach and gluthathione in the lungs of kids with cystic fibrosis. Verbal presentation at the Ozone Research Group Public Symposium, Dunedin, New Zealand.

Other Research Output

Kettle, T. (2013, March). Free radicals spark the fires of inflammation. University of Otago Christchurch Health Lecture Series. Christchurch, New Zealand. [Public Seminar].

2012

Journal - Research Article

Kato, Y., Peskin, A. V., Dickerhof, N., Harwood, D. T., & Kettle, A. J. (2012). Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione. Chemical Research in Toxicology, 25(11), 2322-2332. doi: 10.1021/tx300218f

Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004

Stamp, L. K., Khalilova, I., Tarr, J. M., Senthilmohan, R., Turner, R., Haigh, R. C., … Kettle, A. J. (2012). Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology, 51(10), 1796-1803. doi: 10.1093/rheumatology/kes193

Forbes, L. V., Furtmüller, P. G., Khalilova, I., Turner, R., Obinger, C., & Kettle, A. J. (2012). Isoniazid as a substrate and inhibitor of myeloperoxidase: Identification of amine adducts and the influence of superoxide dismutase on their formation. Biochemical Pharmacology, 84(7), 949-960. doi: 10.1016/j.bcp.2012.07.020

Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. Journal of Leukocyte Biology, 91(3), 369-376. doi: 10.1189/jlb.0711387

Journal - Research Other

Turner, R., Stamp, L. K., & Kettle, A. J. (2012). Detection of allantoin in clinical samples using hydrophilic liquid chromatography with stable isotope dilution negative ion tandem mass spectrometry [Short communication]. Journal of Chromatography B, 891-892, 85-89. doi: 10.1016/j.jchromb.2012.02.009

Conference Contribution - Published proceedings: Abstract

Turner, R., Mocatta, T., McClean, D., Marshall, C. J., Cameron, V. A., & Kettle, A. J. (2012). Allantoin as a biomarker of severity of heart disease and its relationship with myeloperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 33). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Khalilova, I. S., Dickerhof, N., Mocatta, T., & Kettle, A. J. (2012). Detection of pro-myeloperoxidase in circulation. Proceedings of the Oxygen Theme Meeting. (pp. 29). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Parker, H., Albrett, A., Kettle, A., & Winterbourn, C. (2012). Complex roles of reactive oxygen species in the formation and antimicrobial action of neutrophil NETs. Proceedings of the Oxygen Theme Meeting. (pp. 28). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Chapman, A., Turner, R., & Kettle, A. J. (2012). Seeking evidence for a halogenating intermediate of myeloperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 25). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Modulation of HOCl production in neutrophil phagosomes. Proceedings of the Oxygen Theme Meeting. (pp. 24). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Seidel, A., Turner, R., Wilbanks, S. M., Kettle, A. J., & Jameson, G. N. L. (2012). Urate oxidation by Lactoperoxidase. Proceedings of the Oxygen Theme Meeting. (pp. 9). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Das, A. B., Nagy, P., Lechte, T., Kettle, A. J., & Winterbourn, C. C. (2012). Conjugation of glutathione to oxidised tyrosine residues on proteins. Proceedings of the Oxygen Theme Meeting. (pp. 7). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Maghzal, G. J., Cergol, K., Suarna, C., Newington, D., Kettle, A. J., Payne, R. J., & Stocker, R. (2012). In vivo detection of myeloperoxidase activity by LC/MS/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology & Medicine, 53(Suppl. 2), (pp. S24). doi: 10.1016/j.freeradbiomed.2012.10.059

Stamp, L. K., Khalilova, I., Zhang, M., Turner, R., & Kettle, A. (2012). Oxidation of urate to allantoin by myeloperoxidase in gout. Arthritis & Rheumatism, 64(10, Suppl.), (pp. S808). doi: 10.1002/art.37735

Turner, R., Mocatta, T., McClean, D., Marshall, C., & Kettle, A. (2012). Allantoin as a biomarker of severity of heart disease and its relationship with myeloperoxidase. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S135-S136). doi: 10.1016/j.freeradbiomed.2012.08.283

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Complex roles of reactive oxygen species in the formation and anti-microbial action of neutrophil NETs. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2012.08.349

Maghzal, G. J., Cergol, K., Suarna, C., Newington, D., Kettle, A. J., Payne, R. J., … et al (2012). In vivo detection of myeloperoxidase activity by LC/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S223-S224). doi: 10.1016/j.freeradbiomed.2012.08.469

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, T. (2012, November-December). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Verbal presentation at the Free Radical and Metal Biology Conference, Brisbane, Australia.

2011

Journal - Research Article

Tidén, A.-K., Sjögren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchère, F., … Forbes, L. V., Magon, N. J., Paton, L. N., Jameson, G. N. L., … Kettle, A. J. (2011). 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. Journal of Biological Chemistry, 286(43), 37578-37589. doi: 10.1074/jbc.M111.266981

Moya-Olano, L., Milne, H. M., Robinson, J. M., Hill, J. V., Frampton, C. M., Abbott, H. F., Turner, R., Kettle, A. J., & Endre, Z. H. (2011). Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy. Pathology International, 61(11), 652-661. doi: 10.1111/j.1440-1827.2011.02721.x

Kettle, A. J., Maroz, A., Woodroffe, G., Winterbourn, C. C., & Anderson, R. F. (2011). Spectral and kinetic evidence for reaction of superoxide with compound I of myeloperoxidase. Free Radical Biology & Medicine, 51(12), 2190-2194. doi: 10.1016/j.freeradbiomed.2011.09.019

Meotti, F. C., Jameson, G. N. L., Turner, R., Harwood, D. T., Stockwell, S., Rees, M., … Kettle, A. J. (2011). Urate as a physiological substrate for myeloperoxidase: Implications for hyperuricemia and inflammation. Journal of Biological Chemistry, 286(15), 12901-12911. doi: 10.1074/jbc.M110.172460

Conference Contribution - Published proceedings: Abstract

Marshall, C. J., McKenzie, J. L., Moccata, T., Nallaratnam, M., Blake, J., Frampton, C., Richards, M., Kettle, A. J., & McClean, D. R. (2011). Neutrophil activation at the culprit lesion in acute ST-segment elevation myocardial infarction with multiple complex coronary plaques. Heart, 97(Suppl. 1), (pp. A11-A12). doi: 10.1136/heartjnl-2011-300198.13

Conference Contribution - Poster Presentation (not in published proceedings)

Kato, Y., Miura, Y., Naito, M., Kitamoto, N., & Kettle, A. J. (2011, January). Immunohistochemical detection of serotonin oxidation products in human atherosclerotic lesion. Poster session presented at the International Symposium on Free Radical Research: Contribution to Medicine, Kyoto, Japan.

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, A. J., Meotti, F., Turner, R., Mocatta, T., Jameson, G., Marshall, C., … Stamp, L. (2011, August). Interactions of myeloperoxidase and urate during inflammation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kettle, T. (2011, May). Myeloperoxidase, urate and inflammation. Verbal presentation at the 7th International Human Peroxidase Meeting, Brussels, Belgium.

2010

Journal - Research Article

Thomson, E., Brennan, S., Senthilmohan, R., Gangell, C. L., Chapman, A. L., Sly, P., & Kettle, A. J. (2010). Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis. Free Radical Biology & Medicine, 49(9), 1354-1360. doi: 10.1016/j.freeradbiomed.2010.07.010

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2010). Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide. Free Radical Biology & Medicine, 49, 792-799. doi: 10.1016/j.freeradbiomed.2010.05.033

Das, A. B., Nagy, P., Abbott, H. F., Winterbourn, C. C., & Kettle, A. J. (2010). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology & Medicine, 48, 1540-1547. doi: 10.1016/j.freeradbiomed.2010.02.039

Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., … Kettle, A. J., … Davies, M. J. (2010). Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochemical Pharmacology, 79, 1156-1164. doi: 10.1016/j.bcp.2009.11.024

Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2010). Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochemical Journal, 425(1), 285-293. doi: 10.1042/BJ20090776

Conference Contribution - Published proceedings: Abstract

Stamp, L. K., Khalilova, I., & Kettle, T. (2010). Acute gout results in increased plasma myeloperoxidase: A potential mechanism for increased cardiovascular risk? Arthritis & Rheumatism, 62(Suppl. 10). doi: 10.1002/art.30166

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479

Conference Contribution - Poster Presentation (not in published proceedings)

Forbes, L. V., & Kettle, A. J. (2010, November-December). Hydrazides as inhibitors of myeloperoxidase. Poster session presented at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, T. (2010, November-December). A radical history of oxygen. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Stamp, L., Khalilova, I. S., Tarr, J. M., Senthilmohan, R., Haigh, R. C., Whiteman, M., … Kettle, A. J. (2010, November-December). Myeloperoxidase and oxidative stress in rheumatoid arthritis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Kettle, A. J., Turner, R., Gangell, C. L., Khalilova, I. S., Harwood, D. T., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2010, November-December). Oxidation of glutathione in the airways of children with cystic fibrosis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Turner, R., Khalilova, I., Stamp, L., Meotti, F. C., Thomas, S., Rees, M. D., & Kettle, A. J. (2010, November-December). Interactions between urate and myeloperoxidase in gout. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Chapman, A. L. P., Chen, B., Mocatta, T. J., Winterbourn, C. C., & Kettle, A. J. (2010, November-December). Studying the inhibition of myeloperoxidase by ceruloplasmin. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Kettle, A., Meotti, F. C., Jameson, G. N. L., Stamp, L., Turner, R., Harwood, T., Stockwell, S. C., … Thomas, S. R. (2010, August). Linking myeloperoxidase and uric acid to cardiovascular disease. Verbal presentation at the New Zealand Rheumatology Association Annual Scientific Meeting, Christchurch, New Zealand.

Kettle, T. (2010, September). A radical look at health and disease. Verbal presentation at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

2009

Journal - Research Article

van Dalen, C. J., Aldridge, R. E., Chan, T., Senthilmohan, R., Hancox, R. J., Cowan, J. O., Taylor, D. R., Town, G. I., & Kettle, A. J. (2009). Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. Annals of Allergy, Asthma & Immunology, 103(4), 348-353.

Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009). Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry, 48(42), 10175-10182. doi: 10.1021/bi901266w

Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J., & Davies, M. J. (2009). Hypobromous acid and bromamine production by neutrophils and modulation by superoxide. Biochemical Journal, 417(3), 773-781. doi: 10.1042/BJ20071563

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009). Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer. Journal of Biological Chemistry, 284(22), 14723-14733. doi: 10.1074/jbc.M809396200

Harwood, D. T., Kettle, A. J., Brennan, S., & Winterbourn, C. C. (2009). Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877, 3393-3399. doi: 10.1016/j.jchromb.2009.04.018

Conference Contribution - Published proceedings: Abstract

Thai, T., Rees, M., Dang, L., Harwood, D. T., Winterbourn, C. C., Kettle, A. J., Maghzal, G., … Thomas, S. R. (2009). Myeloperoxidase and endothelial dysfunction. Journal of Vascular Research, 46(Suppl. 2), (pp. 10). doi: 10.1159/000230992

Tiden, A.-K., Sjögren, T., Senthilmohan, R., Auchere, F., Eriksson, H., & Kettle, A. J. (2009). Development of inhibitors for myeloperoxidase (AVZ115X71). Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S74). [Abstract]

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, A. M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S22-S23). doi: 10.1016/j.hlc.2009.04.052

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S119-S120). doi: 10.1016/j.hlc.2009.05.270

Marshall, C. J., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2009). Acute systemic and local neutrophil and monocyte degranulation prior to primary percutaneous coronary intervention in ST elevation myocardial infarction. JACC, 53(10, Suppl. 1), (pp. A307-A308). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Kettle, T. (2009, December). Urate is a physiological substrate for myeloperoxidase that is converted to a reactive hydroperoxide in the presence of superoxide. Poster session presented at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009, September). Superoxide mediated protein oxidation: A potential mechanism for superoxide toxicity. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, A. (2009, December). Development of inhibitors for myeloperoxidase. Verbal presentation at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

van Dalen, C., Senthilmohan, R., Kettle, A., Harding, E., Cheng, S., Pearce, N., … Douwes, J. (2009, June). Sputum granulocyte activation in adolescents with asthma. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand.

2008

Journal - Research Article

Coker, M. S. A., Hu, W.-P., Senthilmohan, S. T., & Kettle, A. J. (2008). Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases. Chemical Research in Toxicology, 21(12), 2334-2343. doi: 10.1021/tx800232v

Harwood, D. T., Nimmo, S. L., Kettle, A. J., Winterbourn, C. C., & Ashby, M. T. (2008). Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid. Chemical Research in Toxicology, 21(5), 1011-1016.

Meotti, F. C., Senthilmohan, R., Harwood, D. T., Missau, F. C., Pizzolatti, M. G., & Kettle, A. J. (2008). Myricitrin as a substrate and inhibitor of myeloperoxidase: Implications for the pharmacological effects of flavonoids. Free Radical Biology & Medicine, 44(1), 109-120. doi: 10.1016/j.freeradbiomed.2007.09.017

Senthilmohan, S. T., Kettle, A. J., McEwan, M. J., Dummer, J., Edwards, S. J., Wilson, P. F., & Epton, M. J. (2008). Detection of monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry and their relevance as breath markers. Rapid Communications in Mass Spectrometry, 22(5), 677-681. doi: 10.1002/rcm.3418

Conference Contribution - Published proceedings: Abstract

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A. J., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2008). Increased neutrophil and monocyte degranulation with release of intracellular leucocyte elastase and myeloperoxidase in acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S2). doi: 10.1016/j.hlc.2008.03.003

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. (2008). Increased systemic and local neutrophil and monocyte degranulation in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S106). doi: 10.1016/j.hlc.2008.05.255

Nallaratnam, M., Mocatta, T., Marshall, C., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., Kettle, A. J., & McClean, D. R. (2008). Local leukocyte elastase release at site of occlusive plaque rupture predicts downstream microvascular reperfusion injury and impaired left ventricular function in ST elevation myocardial infarction. JACC, 1(2 (Suppl. B)), (pp. B64). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, T. (2008, November). Liberation of chloramine gases during bacterial killing by neutrophils. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.

2007

Journal - Research Article

Åkerström, B., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2007). The lipocalin α₁-microglobulin has radical scavenging activity. Journal of Biological Chemistry, 282(43), 31493-31503.

Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897.

Conference Contribution - Published proceedings: Abstract

Rodger, E. J., Revell, A. F., Jones, G. T., Kleffmann, T., Kettle, A. J., & McCormick, S. P. A. (2007). Proteomic analysis of livers from mice with an atherogenic lipoprotein profile. Journal of Clinical Lipidology, 1(5), (pp. 417). doi: 10.1016/j.jacl.2007.08.016

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Plasma myeloperoxidase levels are highest in the Infarct-Related Artery (IRA) in patients with ST Elevation MI. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S25). doi: 10.1016/j.hlc.2007.06.065

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Heparin, but not bilvalirudin, liberates endothelial myeloperoxidase in patients with ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 16(Suppl. 2), (pp. S24-S25). doi: 10.1016/j.hlc.2007.06.064

2006

Journal - Research Article

Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869.

Brooks, W. M., Lash, H., Kettle, A. J., & Epton, M. J. (2006). Optimising hydrogen peroxide measurement in exhaled breath condensate. Redox Report, 11(2), 78-84.

Harwood, D. T., Kettle, A. J., & Winterbourn, C. C. (2006). Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method. Biochemical Journal, 399, 161-168.

Senthilmohan, R., & Kettle, A. J. (2006). Bromination and chlorination reactions of myeloperoxidase at physiological concentrations of bromide and chloride. Archives of Biochemistry & Biophysics, 445, 235-244.

van Dalen, C. J., Winterbourn, C. C., & Kettle, A. J. (2006). Mechanism of nitrite oxidation by eosinophil peroxidase: Implications for oxidant production and nitration by eosinophils. Biochemical Journal, 394, 707-713.

2005

Journal - Research Article

Ximenes, V. F., Silva, S., Rodrigues, M. R., Catalani, L. H., Maghzal, G. J., Kettle, A. J., & Campa, A. (2005). Superoxide-dependent oxidation of melatonin by myeloperoxidase. Journal of Biological Chemistry, 280(46), 38160-38169.

Kettle, A. J., & Winterbourn, C. C. (2005). Do neutrophils produce ozone? An appraisal of current evidence. BioFactors, 24, 41-45.

Dypbukt, J. M., Bishop, C., Brooks, W. M., Thong, B., Eriksson, H., & Kettle, A. J. (2005). A sensitive and selective assay for chloramine production by myeloperoxidase. Free Radical Biology & Medicine, 39, 1468-1477.

2004

Journal - Research Article

Kettle, A. J., Chan, T., Osberg, I., Senthilmohan, R., Chapman, A. L. P., Mocatta, T. J., & Wagener, J. S. (2004). Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis. American Journal of Respiratory & Critical Care Medicine, 170, 1317-1323.

Kettle, A. J., Clark, B. M., & Winterbourn, C. C. (2004). Superoxide converts indigo carmine to isatin sulfonic acid. Journal of Biological Chemistry, 279(18), 18521-18525.

Winterbourn, C. C., & Kettle, A. J. (2004). Reactions of superoxide with myeloperoxidase and its products. Japanese Journal of Infectious Diseases, 57, S31-S33.

Conference Contribution - Verbal presentation and other Conference outputs

Senthilmohan, R., & Kettle, A. J. (2004, December). Comparative reactivities of hypochlorous acid and hypobromous acid with human serum albumin. Verbal presentation at the 13th Annual Conference of the Society for Free Radical Research (Australasian): Oxidants and Antioxidants in Chemistry and Biology. Christchurch.

2003

Journal - Research Article

Winterbourn, C. C., & Kettle, A. J. (2003). Radical-radical reactions of superoxide: A potential route to toxicity. Biochemical & Biophysical Research Communications, 305, 729-736.

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: Association with adverse respiratory outcome. Pediatric Research, 53(3), 455-462.

Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.

Conference Contribution - Published proceedings: Abstract

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants - association with adverse respiratory outcome. Proceedings of the 7th Annual Congress of the Perinatal Society of Australia and New Zealand. [Abstract]

2002

Journal - Research Article

Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762.

Upston, J., Niu, X., Brown, A., Mashima, R., Wang, H., Senthilmohan, R., Kettle, A. J., … Stocker, R. (2002). Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. American Journal of Pathology, 160(2), 701-710.

Aldridge, R. E., Chan, T. P., van Dalen, C. J., Senthilmohan, R., Winn, M., Venge, P., Town, G. I., & Kettle, A. J. (2002). Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics. Free Radical Biology & Medicine, 33(6), 847-856.

Conference Contribution - Published proceedings: Full paper

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Cheah, F. C., Kettle, A. J., & Winterbourn, C. C. (2002). 3-Chlorotyrosine in tracheal aspirate samples from very-low-birthweight infants: Associations with myeloperoxidase, protein carbonyls and clinical outcome. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch, New Zealand. [Full Paper]

2001

Journal - Research Article

van Dalen, C. J., & Kettle, A. J. (2001). Substrates and products of eosinophil peroxidase. Biochemical Journal, 358, 233-239.

Kettle, A. J., & Winterbourn, C. C. (2001). A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry, 40, 10204-10212.

Conference Contribution - Published proceedings: Abstract

Senthilmohan, R., Mocatta, T., Buss, H., Darlow, B. A., Wagner, J., Kettle, A. J., & Winterbourn, C. C. (2001). Oxidative modification of protein in cystic fibrosis and in chronic lung disease of preterm infants. The 8th Annual Meeting of the Oxygen Society. 31(269 (Suppl 1)), (pp. S89). Free Radical Biology and Medicine. [Abstract]

2000

Chapter in Book - Research

Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer.

Journal - Research Article

Winterbourn, C. C., & Kettle, A. J. (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biology & Medicine, 29, 403-409.

Vile, G., Rothwell, L. A., & Kettle, A. J. (2000). Initiation of rapid, p53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species. Archives of Biochemistry & Biophysics, 377, 122-128.

van Dalen, C. J., Winterbourn, C. C., Senthilmohan, R., & Kettle, A. J. (2000). Nitrite as a substrate and inhibitor of myeloperoxidase: Implications for nitration and hypochlorous acid production at sites of inflammation. Journal of Biological Chemistry, 275, 11638-11644.

Kettle, A. J., & Candaeis, L. P. (2000). Oxidation of tryptophan by redox intermediates of myeloperoxidase and inhibition of hypochlorous acid production. Redox Report, 5, 179-184.

Burner, U., Furtmuller, P. G., Kettle, A. J., Koppenol, W. H., & Obinger, C. (2000). Mechanism of reaction of myeloperoxidase with nitrite. Journal of Biological Chemistry, 275, 20597-20601.

Chapman, A. L. P., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2000). Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins. Archives of Biochemistry & Biophysics, 377(1), 95-100.

Journal - Research Other

Kettle, A. J., & Obinger, C. (2000). Mammalian peroxidases brought into focus [Editorial]. Redox Report, 5(4), 167-168.

Winterbourn, C. C., Vissers, M. C., & Kettle, A. J. (2000). Myeloperoxidase. Current Opinion in Hematology, 7, 53-58. [Review].

1999

Journal - Research Article

Burner, U., Obinger, C., Paumann, M., Furtmuller, P. G., & Kettle, A. J. (1999). Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. Journal of Biological Chemistry, 274, 9494-9592. doi: 10.1074/jbc.274.14.9494

Kettle, A. J. (1999). Detection of 3-chlorotyrosine in proteins exposed to neutrophil oxidants. Methods in Enzymology, 300, 111-120.

Conference Contribution - Verbal presentation and other Conference outputs

Senthilmohan, R., Chapman, A. L. P., Winterbourn, C. C., & Kettle, A. J. (1999, December). A gas chromatographic-mass spectral assay for the simultaneous quantification of modified Tyrosyl residues and Hydroxylated phenylalanine residues in biological samples. Verbal presentation at the Oxidative Pathways in Health and Disease Conference, Sydney, Australia.

1998

Journal - Research Article

Graham, G. G., & Kettle, A. J. (1998). The activation of gold complexes by cyanide produced by polymorphonuclear leukocytes. III. The formation of aurocyanide by myeloperoxidase. Biochemical Pharmacology, 56, 307-312.

Vile, G., Rothwell, L. A., & Kettle, A. J. (1998). Hypoclhlorus acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts. Archives of Biochemistry & Biophysics, 359, 51-56.

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017.

1997

Chapter in Book - Research

McPherson, K. G., Kettle, A. J., & Winterbourn, C. C. (1997). Mechanism of activation of NFKB by hydrogen peroxide in Jurkat JR cells. In L. Montagnier, R. Olivier & C. Pasquier (Eds.), Oxidative Stress and Redox Regulation: Cellular Signalling, Aids, Cancer and Other Diseases. (pp. 83-87). New York: Marcel Dekker.

Journal - Research Article

Winterbourn, C. C., Pichorner, H., & Kettle, A. J. (1997). Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils. Archives of Biochemistry & Biophysics, 338(1), 15-21.

Van Dalen, C. J., Whitehead, M. W., Winterbourn, C. C., & Kettle, A. J. (1997). Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochemical Journal, 327(2), 487-492.

Panousis, C., Kettle, A. J., & Phillips, D. R. (1997). Neutrophil-mediated activation of mitoxantrone to metabolites which form adducts with DNA. Cancer Letters, 113(1/2), 173-178.

Kettle, A. J., Gedye, C. A., & Winterbourn, C. C. (1997). Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochemical Journal, 321(2), 503-508.

Journal - Research Other

Kettle, A. J., & Winterbourn, C. C. (1997). Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Report, 3(1), 3-15. doi: 10.1080/13510002.1997.11747085

Journal - Professional & Other Non-Research Articles

Kettle, A. J., Van Dalen, C. J., & Winterbourn, C. C. (1997). Peroxynitrite and myeloperoxidase leave the same foorprint in protein nitration. Redox Report, 3, 257-258.

1996

Chapter in Book - Research

Kettle, A. J., & Winterbourn, C. C. (1996). Reaction mechanisms of myeloperoxidase. In C. Obinger, U. Burner, R. Ebermann, C. Penel & H. Greppin (Eds.), Plant Peroxidases: Biochemistry and Physiology. (pp. 134-139). Geneva: University of Geneva.

Journal - Research Article

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517.

Kettle, A. J. (1996). Detection of chlorotyrosine in albumin exposed to stimulated human neutrophils. FEBS Letters, 379(1), 103-106.

Journal - Professional & Other Non-Research Articles

Kettle, A. J. (1996). Crisis for biomedical research in New Zealand [Letter]. Lancet, 347(8994), 124. doi: 10.1016/S0140-6736(96)90251-2

1994

Journal - Research Article

Kettle, A. J., Carr, A. C., & Winterbourn, C. C. (1994). Assays using horseradish peroxidase and phenolic substrates require superoxide dismutase for accurate determination of hydrogen peroxide production by neutrophils. Free Radical Biology & Medicine, 17(2), 161-164.