Dr Nicola Scott, Our people, University of Otago, Christchurch

Research Fellow

Dr Nicola Scott conducted her undergraduate studies at the University of Otago, New Zealand, graduating with a BSc Honours in Biochemistry in 2003.

Her Honours Project was The Effect of Cryoprotective Agents and Freezing on the Redox Status of Murine Fibroblasts.

She was awarded a CMRF Summer Studentship in 2003 to determine if Npr-1 knockout and wild-type mice differed in heart weight, blood pressure, infarct size and in plasma levels of cardiac hormones following myocardial infarction.

The Summer Studentship was part of an ongoing study of the gene pathways activated during cardiac remodelling.

During this study Nicola observed that Npr-1-/- mice exhibit cardiac abnormalities including enlarged and displaced hearts, which has led to the development of Nicola's PhD project.

In 2004 Nicola was awarded a PhD Scholarship by the National Heart Foundation of New Zealand. Her PhD topic was The Role of the Natriuretic Peptides in Cardiac Development and Organogenesis.

She graduated in 2008 with a PhD undertaken in the Department of Medicine, University of Otago.

Publications

Scott, N. J. A., Charles, C. J., Prickett, T. C. R., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2024). Phosphodiesterase 9 inhibition combined with valsartan and with sacubitril/valsartan in experimental ovine heart failure. Journal of the American Heart Association, 13, e036689. doi: 10.1161/jaha.124.036689 Journal - Research Article

Janiak, P. P., Rademaker, M. T., Scott, N. J. A., Charles, C. J., Lawson, F. C., Ozoux, M. L., & Kowala, M. C. (2024). COR-1167, a new long-acting CRF2 receptor agonist, decreases congestion by improving cardiorenal function in a sheep model of worsening heart failure (WHF). European Journal of Heart Failure, 26(S2), (pp. 400). doi: 10.1002/ejhf.3326 Conference Contribution - Published proceedings: Abstract

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Espiner, E. A., Richards, A. M., & Rademaker, M. T. (2024). Haemodynamic, hormonal and renal actions of osteocrin in normal sheep. Experimental Physiology. Advance online publication. doi: 10.1113/EP091826 Journal - Research Article

Rademaker, M. T., Scott, N. J. A., Charles, C. J., & Richards, A. M. (2024). Combined inhibition of phosphodiesterases-5 and -9 in experimental heart failure. JACC: Heart Failure, 12(1), 100-113. doi: 10.1016/j.jchf.2023.08.028 Journal - Research Article

Templeton, E. M., Pilbrow, A. P., Kleffmann, T., Pickering, J. W., Rademaker, M. T., Scott, N. J. A., Ellmers, L. J., Charles, C. J., Endre, Z. H., Richards, A. M., Cameron, V. A., & Lassé, M. (2023). Comparison of SPEED, S-Trap, and in-solution-based sample preparation methods for mass spectrometry in kidney tissue and plasma. International Journal of Molecular Sciences, 24(7), 6290. doi: 10.3390/ijms24076290 Journal - Research Article

2024

Journal - Research Article

Conference Contribution - Published proceedings: Abstract

2023

Journal - Research Article

Scott, N. J. A., Prickett, T. C. R., Charles, C. J., Frampton, C. M., Richards, A. M., & Rademaker, M. T. (2023). Augmentation of natriuretic peptide bioactivity via combined inhibition of neprilysin and phosphodiesterase-9 in heart failure. JACC: Heart Failure, 11(2), 227-239. doi: 10.1016/j.jchf.2022.11.006

2022

Journal - Research Article

Templeton, E. M., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J. A., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., Richards, A. M., Rademaker, M. T., & Pilbrow, A. P. (2022). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. International Journal of Molecular Sciences, 23, 1009. doi: 10.3390/ijms23021009

Journal - Research Other

Li, D., Tian, K., Guo, J., Wang, Q., Qin, Z., Lu, Y., … Scott, N., Charles, C. J., … Cui, X., & Tang, J. (2022). Growth factors: Avenues for the treatment of myocardial infarction and potential delivery strategies. Regenerative Medicine, 17(8), 561-579. doi: 10.2217/rme-2022-0007

Conference Contribution - Published proceedings: Abstract

Templeton, E., Lassé, M., Cameron, V., Pickering, J., Kleffmann, T., Hertzberg, D., Frampton, C., Ellmers, L., Palmer, S., … Scott, N., Charles, C., … Richards, M., … Troughton, R., Rademaker, M., & Pilbrow, A. (2022). Harnessing the power of 'Omics': Discovering novel microRNA and protein biomarkers of acute kidney injury in acute heart failure. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S23-S24). doi: 10.1016/j.hlc.2022.05.009

2021

Journal - Research Article

Rademaker, M. T., Pilbrow, A. P., Ellmers, L. J., Palmer, S. C., Davidson, T., Mbikou, P., Scott, N. J. A., Permina, E., Charles, C. J., Endre, Z. H., & Richards, A. M. (2021). Acute decompensated heart failure and the kidney: Physiological, histological and transcriptomic responses to development and recovery. Journal of the American Heart Association, 10, e021312. doi: 10.1161/jaha.121.021312

Rademaker, M. T., Scott, N. J. A., Koh, C. Y., Manjunatha Kini, R., & Richards, A. M. (2021). Natriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failure. Cardiovascular Research, 117, 508-519. doi: 10.1093/cvr/cvaa052

Conference Contribution - Published proceedings: Abstract

Templeton, E., Lassé, M., Kleffmann, T., Ellmers, L. J., Palmer, S. C., Davidson, T., Scott, N. J., Pickering, J. W., Charles, C. J., Endre, Z. H., Cameron, V. A., & Richards, A. M. (2021). Identifying candidate protein markers of acute kidney injury in acute decompensated heart failure. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S66). doi: 10.1016/j.hlc.2021.05.020

2020

Journal - Research Other

Charles, C. J., Rademaker, M. T., Scott, N. J. A., & Richards, A. M. (2020). Large animal models of heart failure: Reduced vs. preserved ejection fraction. Animals, 10, 1906. doi: 10.3390/ani10101906

2019

Journal - Research Article

Scott, N. J. A., Rademaker, M. T., Charles, C. J., Espiner, E. A., & Richards, A. M. (2019). Hemodynamic, hormonal, and renal actions of phosphodiesterase-9 inhibition in experimental heart failure. JACC, 74(7), 889-901. doi: 10.1016/j.jacc.2019.05.067

2018

Journal - Research Article

Buss, L. A., Mandani, A., Phillips, E., Scott, N. J. A., Currie, M. J., & Dachs, G. U. (2018). Characterisation of a mouse model of breast cancer with metabolic syndrome. In Vivo, 32(5), 1071-1080. doi: 10.21873/invivo.11348

2017

Journal - Research Article

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

2015

Journal - Research Article

Ellmers, L. J., Scott, N. J. A., Cameron, V. A., Richards, A. M., & Rademaker, M. T. (2015). Chronic urocortin 2 administration improves after cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction. Journal of Cardiovascular Pharmacology, 65(3), 269-275. doi: 10.1097/FJC.0000000000000190

2014

Journal - Research Article

Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005

Conference Contribution - Published proceedings: Full paper

Zainon, R., Ronaldson, J. P., Anderson, N. G., Butler, A. P. H., Butler, P. H., Gieseg, S. P., Janmale, T., & Scott, N. J. (2014). High resolution spectral micro-CT imaging of atherosclerotic plaque. Proceedings of the Region 10 Symposium (TENSYMP). (pp. 568-571). IEEE. doi: 10.1109/TENCONSpring.2014.6863099

2012

Journal - Research Article

Ronaldson, J. P., Zainon, R., Scott, N. J. A., Gieseg, S. P., Butler, A. P., Butler, P. H., & Anderson, N. G. (2012). Toward quantifying the composition of soft tissues by spectral CT with Medipix3. Medical Physics, 39(11), 6847-6857. doi: 10.1118/1.4760773

Zainon, R., Ronaldson, J. P., Janmale, T., Scott, N. J., Buckenham, T. M., Butler, A. P. H., … Gieseg, S. P., Roake, J. A., & Anderson, N. G. (2012). Spectral CT of carotid atherosclerotic plaque: Comparison with histology. European Radiology, 22(12), 2581-2588. doi: 10.1007/s00330-012-2538-7

Scott, N. J. A., Cameron, V. A., Raudsepp, S., Lewis, L. K., Simpson, E. R., Richards, A. M., & Ellmers, L. J. (2012). Generation and characterization of a mouse model of the metabolic syndrome: Apolipoprotein E and aromatase double knockout mice. American Journal of Physiology: Endocrinology & Metabolism, 302, E576-E584. doi: 10.1152/ajpendo.00222.2011

2011

Journal - Research Article

Butler, A. P. H., Butzer, J., Schleich, N., Cook, N. J., Anderson, N. G., Scott, N., de Ruiter, N., … Butler, P. H. (2011). Processing of spectral X-ray data with principal components analysis. Nuclear Instruments & Methods in Physics Research Section A, 633(Suppl. 1), S140-S142. doi: 10.1016/j.nima.2010.06.149

Conference Contribution - Verbal presentation and other Conference outputs

Ronaldson, J., Zainon, R., Sedayo, A., Scott, N., Butler, A., Butler, P., & Anderson, N. (2011, November-December). Towards quantifying the composition of soft-tissues by spectral CT imaging with Medipix3. Verbal presentation at the 97th Radiological Society of North America (RSNA) Scientific Assembly and Annual Meeting, Chicago, IL.

Butler, A., Ronaldson, P., Scott, N., Zainon, R., Butler, P., Geiseg, S., … Anderson, N. (2011, September). Soft tissue imaging with the MARS spectral CT scanner. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2010

Journal - Research Article

Anderson, N. G., Butler, A. P., Scott, N. J. A., Cook, N. J., Butzer, J. S., Schleich, N., … de Ruiter, N., … Butler, P. H. (2010). Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE. European Radiology, 20, 2126-2134. doi: 10.1007/s00330-010-1768-9

Conference Contribution - Published proceedings: Abstract

Scott, N. J. A., Ellis, K. L., Ellmers, L. J., Frampton, C. M., Skelton, L., Doughty, R. N., … Whalley, G. A., Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010). Apolipoprotein E isoforms are associated with age of onset of coronary disease but not subsequent mortality in a coronary disease cohort. Endocrine Journal. 57(Suppl. 2), (pp. S575). [Abstract]

Scott, N. J. A., Ellmers, L. J., Raudsepp, S., Simpson, E. R., Richards, A. M., & Cameron, V. A. (2010). Characterising the Aromatase and apolipoprotein E deficient mouse for studying the metabolic syndrome. Endocrine Journal. 57(Suppl. 2), (pp. S574-S575). [Abstract]

Scott, N. J. A., Carr, J. M., Clark, M. J., Cook, N. J., Anderson, N. G., Butler, A. P., … Butler, A. P., & Berg, K. B. (2010). Pilot study to confirm that ovine fat and liver can be distinguished by spectroscopic tissue response on a Medipix-All-Resolution-System-CT (MARS-CT). Endocrine Journal. 57(Suppl. 2), (pp. S421-S422). [Abstract]

Scott, N., Cameron, V., Simpson, E., Richards, M., & Ellmers, L. (2010). Metabolic syndrome alters expression levels of metabolic disease risk loci genes. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S59). doi: 10.1016/j.hlc.2010.06.807

Ellmers, L., Scott, N., Cameron, V., Richards, M., & Rademaker, M. (2010). Chronic urocortin 2 treatment significantly improves cardiovascular function and attenuates cardiac injury and remodelling after experimental myocardial infarction. Heart, Lung & Circulation, 19(Suppl. 2), (pp. S49). doi: 10.1016/j.hlc.2010.06.784

Conference Contribution - Poster Presentation (not in published proceedings)

Scott, N. J. A., Ellis, K. L., Ellmers, L. J., Frampton, C. M., Skelton, L., Doughty, R. N., … Yandle, T. G., Richards, A. M., & Cameron, V. A. (2010, November-December). Apolipoprotein E isoforms are associated with age of onset of coronary disease but not subsequent mortality in a coronary disease cohort. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Scott, N. J. A., Cameron, V. A., Richards, A. M., Simpson, E. R., & Ellmers, L. J. (2010, November-December). Metabolic syndrome alters cardiorenal expression of metabolic risk loci genes. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

2009

Journal - Research Article

Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2009). Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1792(12), 1175-1184. doi: 10.1016/j.bbadis.2009.09.009

Conference Contribution - Published proceedings: Full paper

Berg, K. B., Carr, J. M., Clark, M. J., Cook, N. J., Anderson, N. G., Scott, N. J., … Butler, A. P. (2009). Pilot study to confirm that fat and liver can be distinguished by spectroscopic tissue response on a MARS-CT. In S. C. Hendy & I. W. M. Brown (Eds.), Proceedings of the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4): (AIP Conference Proceedings. Vol. 1151). (pp. 106-109). [Full Paper]

Firsching, M., Butler, A. P., Scott, N., Anderson, N. G., Michel, T., & Anton, G. (2009). Contrast agent recognition in small animal CT using the Medipix2 detector. Nuclear Instruments and Methods in Physics Research A. 607(1), (pp. 179-182). doi: 10.1016/j.nima.2009.03.141

Conference Contribution - Published proceedings: Abstract

Ellmers, L., Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., & Rademaker, M. T. (2009). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. European Heart Journal. 30(Suppl. 1), (pp. 288). doi: 10.1093/eurheartj/ehp416

Anderson, N. G., Butler, A. P., Scott, N., Cook, N. J., Butzer, J., Schleich, N., & Firsching, M. (2009). Colour CT X-ray spectroscopic images of mice using Medipix-2 detector. European Radiology. 19(Suppl. 1), (pp. S228). [Abstract]

Scott, N. J. A., Ellmers, L. J., Raudsepp, S., Simpson, E., Richards, A. M., & Cameron, V. A. (2009). Characterising a novel mouse model of the metabolic syndrome. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S240). doi: 10.1016/j.hlc.2009.05.594

2008

Journal - Research Article

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, A. M., … Cameron, V. A. (2008). Transforming growth factor-β blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology, 149(11), 5828-5834. doi: 10.1210/en.2008-0165

Conference Contribution - Published proceedings: Abstract

Butzer, J. S., Butler, A. P., Butler, P. H., Cook, N. J., Schleich, N., Firsching, M., Scott, N., Anderson, N., … Selkirk, J. (2008). Spectroscopic contrast agent imaging with the Medipix CT-scanner "MARS". Australasian Physical & Engineering Sciences in Medicine, 31(4), (pp. 472-473). [Abstract]

Scott, N. J. A., Ellmers, L. J., Richards, A. M., Cameron, V. A., Lainchbury, J. G., Maeda, N., & Smithies, O. (2008). Natriuretic peptide signaling has distinct roles in cardiac development and cardiac remodeling in the NPR1-/-mouse. Arquivos Brasileiros de Endocrinologia & Metabologia. 52(Suppl. 6 (Parte II)), (pp. S962). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Carter, E., Scott, N. J. A., Richards, A. M., Cameron, V. A., Rademaker, M. T., & Ellmers, L. J. (2008, November). Urocortin 2 treatment reduces genes involved in cardiac remodelling in an ovine model of heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Butzer, J. S., Butler, A. P., Cook, N. J., Butler, P. H., Ross, F., Schleich, N., … Scott, N., … Anderson, N. (2008, October). MARS: A 3D spectroscopic x-ray imaging device based on Medipix. Verbal presentation at the IEEE Nuclear Science Symposium and Medical Imaging Conference, Dresden, Germany.

Butzer, J. S., Butler, A. P., Butler, P. H., Cook, N. J., Firsching, M., Scott, N., Anderson, N., … Selkirk, J. (2008, November). Spectroscopic contrast-agent imaging with the Medipix CT-scanner ″MARS″. Verbal presentation at the Engineering and Physical Sciences in Medicine and the Australian Biomedical Engineering Conference, Christchurch, New Zealand.

2007

Journal - Research Article

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of Molecular Endocrinology, 38, 245-257.

Conference Contribution - Published proceedings: Abstract

Ellmers, L., Scott, N. J., Protter, A. A., Medicherla, S., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2007). The role of TGF-beta 1 in ventricular remodelling during recovery from experimental myocardial infarction. European Heart Journal. 28(Abstract Suppl.), (pp. 435). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Ellmers, L. J., Scott, N. J. A., Protter, A. A., Medicherla, S., Pilbrow, A. P., Richards, A. M., & Cameron, V. A. (2007, November). Transforming growth factor-beta blockade down-regulates the renin-angiotensin system and modifies cardiac remodelling post-myocardial infarction. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2007, November). Natriuretic peptide signalling has distinct roles in cardiac development and cardiac remodelling in the NPR-1^-/- mouse. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Cameron, V. A., Pilbrow, A. P., Ellis, K. L., Jarvis, M. D., Palmer, B. R., Ellmers, L. J., Scott, N. J. A., Frampton, C. M., Troughton, R. W., & Richards, A. M. (2007, November). Big hearts, bad hearts: Deconstructing the distinction. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Awarded Doctoral Degree

Scott, N. J. A. (2007). The role of natriuretic peptide signalling in cardiac development in the Npr1^{-/ -} mouse (PhD). University of Otago, Dunedin, New Zealand. 278p.

2006

Conference Contribution - Published proceedings: Abstract

Scott, N. J. A., Ellmers, L. J., Lainchbury, J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2006). Getting to the heart of it: The role of the natriuretic peptides in cardiac development. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Ellmers, L. J., Scott, N. J. A., Protter, A. A., Medicherla, S., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2006). The role of TGF-β in ventricular remodelling during recovery from experimental myocardial infarction. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Scott, N., Ellmers, L., Lainchbury, J., Maeda, N., Smithies, O., & Cameron, V. (2006). Changes in gene expression and the role of the natriuretic peptides in cardiac development. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Ventricular gene expression changes during the development of cardiac hypertrophy in Npr-1 knockout mice. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

2005

Conference Contribution - Published proceedings: Abstract

Cameron, V. A., Scott, N., Ellmers, L., Lainchbury, J., Maeda, N., Smithies, O., & Richards, M. (2005). The role of natriuretic peptides in cardiac development. FASEB Journal, 19(4), (pp. A788). [Abstract]

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2005). Gene expression changes during cardiac development and the development of cardiac hypertrophy in NPR-1 knockout mice. Proceedings of the Medical Sciences Congress. (pp. 48). [Abstract]

2004

Conference Contribution - Published proceedings: Abstract

Scott, N. J. A., Ellmers, L. J., Lainchbury, J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2004). The role of the natriuretic peptides in gestation in Npr-1-/-mice. Proceedings of the 12th International Congress of Endocrinology. (pp. 275). [Abstract]

Cameron, V. A., Palmer, B. R., Pilbrow, A. P., Ellmers, L. J., Scott, N. J. A., Troughton, R. W., Frampton, C. M., Lainchbury, J. G., Yandle, T. G., & Richards, A. M. (2004). Prediction and protection in heart disease. Proceedings of the Medical Sciences Congress 2004. (pp. 27). [Abstract]

Ellmers, L. J., Scott, N. J., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2004). Temporal changes in ventricular natriuretic peptide gene expression during developing hypertrophy in Npr-1 knockout mice. Proceedings of the 12th International Congress of Endocrinology. (pp. 276). [Abstract]