Professor Mark Hampton, Our people, Centre for Redox Biology and Medicine

Principal Investigator

PhD (Otago) MSc(Hons) (Canterbury)

Email mark.hampton@otago.ac.nz
Tel +64 3 372 6770

Mark Hampton is a professor at the Department of Pathology and Biomedical Science on the University of Otago, Christchurch campus, and director of Mātai Hāora - Centre for Redox Biology and Medicine .

He completed his undergraduate and PhD studies in New Zealand before taking up postdoctoral positions at the Karolinksa Institute in Sweden and Harvard in the USA. He subsequently returned to the University of Otago where he was promoted to a professorial role in 2013.

Research interests

Oxidants (also called reactive oxygen species or free radicals) are continuously generated in our body, and we rely on sophisticated antioxidant systems to prevent them from causing damage. However, oxidants also have beneficial roles. They can act as signalling molecules that regulate a number of life and death pathways in cells. Oxidants are also generated by the immune system to destroy microbes. Prof Hampton's research is focused on understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease.

Professor Hampton's current projects include investigations of how disruption of redox homeostasis can promote the killing of cancer cells and pathogenic microbes, and how oxidative stress and mitochondrial dysfunction are associated with the biological processes underlying human ageing.

Affiliations

Publications

Stevens, A., Seddon, A., Hampton, M., & Andrew, D. (2024). Oxidative stress induced changes in DNA methylation. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Redox proteomic analysis of H₂O₂ -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radical Biology & Medicine. Advance online publication. doi: 10.1016/j.freeradbiomed.2024.10.314 Journal - Research Article

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Effect of peroxiredoxin 1 or peroxiredoxin 2 knockout on the thiol proteome of Jurkat cells. Free Radical Biology & Medicine, 225, 595-604. doi: 10.1016/j.freeradbiomed.2024.10.293 Journal - Research Article

Featherston, T., Paumann-Page, M., & Hampton, M. B. (2024). Melanoma redox biology and the emergence of drug resistance. In Advances in cancer research. Elsevier. doi: 10.1016/bs.acr.2024.06.004 Chapter in Book - Research

Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385 Journal - Research Article

2024

Chapter in Book - Research

Featherston, T., Paumann-Page, M., & Hampton, M. B. (2024). Melanoma redox biology and the emergence of drug resistance. In Advances in cancer research. Elsevier. doi: 10.1016/bs.acr.2024.06.004

Journal - Research Article

Featherston, T., Helem, S., Smyth, L. C. D., Hampton, M. B., & Paumann-Page, M. (2024). Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability. Toxicology Mechanisms & Methods. Advance online publication. doi: 10.1080/15376516.2024.2360051

Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032

Conference Contribution - Published proceedings: Abstract

Seddon, A., Das, A., Hampton, M., & Stevens, A. (2024). Understanding how immune oxidants can drive epigenetic change. European Journal of Human Genetics, 32(Suppl. 1), (pp. 720). doi: 10.1038/s41431-023-01482-x

2023

Journal - Research Article

Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23

Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918

Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792

Shearer, H. L., Loi, V. V., Weiland, P., Bange, G., Altegoer, F., Hampton, M. B., … Dickerhof, N. (2023). MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.15035

Taylor, M. F., Black, M. A., Hampton, M. B., & Ledgerwood, E. C. (2023). Insights into H₂O₂-induced signaling in Jurkat cells from analysis of gene expression. Free Radical Research. Advance online publication. doi: 10.1080/10715762.2023.2165073

Seddon, A. R., Das, A. B., Hampton, M. B., & Stevens, A. J. (2023). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Human Molecular Genetics, 32(4), 632-648. doi: 10.1093/hmg/ddac232

Journal - Research Other

Hampton, M. B., & Dickerhof, N. (2023). Inside the phagosome: A bacterial perspective. Immunological Reviews, 314, 197-209. doi: 10.1111/imr.13182

Conference Contribution - Published proceedings: Abstract

Faville, S., Hampton, M. B., Pace, P., Goebl, C., & Helem, S. (2023). Chemoproteomic analyses of the anti-cancer effects of portimines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Helem, S., Pace, P., Seddon, A., Selwood, A., & Hampton, M. (2023). The anti-proliferative properties of the marine derived bioactive compound portimine. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Paumann-Page, M., Smith-Diaz, C., Kumar, A., Chitcholtan, K., Hampton, M., & Winterbourn, C. (2023). Peroxidasin: A novel modulator of melanoma cell invasion. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Smith-Diaz, C., Magon, N. J., McKenzie, J. L., Hore, T., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2023). Transcriptomics and epigenomics analysis of SKM-1 leukaemia response to Vitamin C. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Austad, S., Pace, P., Goebl, C., & Hampton, M. (2023). Unravelling the functional role of peroxiredoxin oligomeric conformations. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Featherston, T., Paumann-Page, M., & Hampton, M. (2023). Treating vemurafenib-resistant metastatic melanoma cells with thioredoxin reductase inhibitors. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Schwartfeger, A., Bozonet, S. M., Magon, N. J., Göbl, C., Morris, V. K., & Hampton, M. B. (2023). Oxidation triggered amyloid assembly of the cell death regulator caspase-8. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Free Radical Biology & Medicine, 208(Suppl. 1), 96. doi: 10.1016/j.freeradbiomed.2023.10.110

Meotti, F., de Souza, L. F., Dempsey, B., Silva, R., Pinz, M., Cruz, L., Pace, P., Hampton, M., & Winterbourn, C. (2023). Peroxiredoxin 2 interacts with granule stress proteins in proliferative leukemic myeloid cells. Free Radical Biology & Medicine, 208(Suppl. 1), 38. doi: 10.1016/j.freeradbiomed.2023.10.053

Ledgerwood, E., King-Hudson, T.-R., Pearson, A., Dunstan-Harrison, C., & Hampton, M. (2023). Peroxiredoxins as markers of redox homeostasis in studies of human ageing. Free Radical Biology & Medicine, 208(Suppl. 1), 113. doi: 10.1016/j.freeradbiomed.2023.10.127

2022

Chapter in Book - Research

Shearer, H. L., Hampton, M. B., & Dickerhof, N. (2022). Bactericidal activity of the oxidants derived from mammilian heme peroxidases. In C. L. Hawkins & W. M. Nauseef (Eds.), Mammalian heme peroxidases: Diverse roles in health and disease. (pp. 171-188). Boca Raton, FL: CRC Press. doi: 10.1201/9781003212287

Journal - Research Article

Shearer, H. L., Pace, P. E., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. Journal of Biological Chemistry, 298(9), 102359. doi: 10.1016/j.jbc.2022.102359

Swaminathan, A., Borichevsky, G. M., Edwards, T. S., Hirschfeld, E., Mules, T. C., Frampton, C. M. A., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2022). Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. Journal of Crohn's & Colitis, 16, 1862-1873. doi: 10.1093/ecco-jcc/jjac098

Ashby, L. V., Springer, R., Loi, V. V., Antelmann, H., Hampton, M. B., Kettle, A. J., & Dickerhof, N. (2022). Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. Journal of Leukocyte Biology, 112, 591-605. doi: 10.1002/jlb.4hi1021-538rr

Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2

van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2022). Hypothiocyanous acid disrupts the barrier function of brain endothelial cells. Antioxidants, 11, 608. doi: 10.3390/antiox11040608

Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21

Shearer, H. L., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid. Free Radical Biology & Medicine, 179, 24-33. doi: 10.1016/j.freeradbiomed.2021.12.261

Conference Contribution - Published proceedings: Abstract

Hampton, M. B. (2022). Redox signalling comes of age. Proceedings of the ComBio Conference. (pp. 86). Retrieved from https://combio.org.au/combio2022/

Conference Contribution - Poster Presentation (not in published proceedings)

Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Shearer, H. L., Parker, H. A., Pace, P. E., Hampton, M. B., & Dickerhof, N. (2022, August). Sensitising Streptococcus pneumoniae to oxidative stress. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Dickerhof, N., Parker, H. A., Hampton, M. B., & Kettle, A. J. (2022, August). Gauging the exposure of bacteria to toxic oxidants inside neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Pace, P. E., Peskin, A. V., Winterbourn, C. C., & Hampton, M. B. (2022, August). Disrupting the oligomeric structure of peroxiredoxins in cancer cells using CRISPR. Poster session presented at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M., Kettle, T., Gladyshev, V., & Sly, P. (2022, December). Where are oxidative footprints leading us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

Hampton, M., Winterbourn, C., Dick, T., & Murphy, M. (2022, December). What are redox signals telling us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

Featherston, T., Khor, C., Paumann-Page, M., & Hampton, M. (2022, August). Reprogrammed antioxidant defences in metastatic melanoma cells. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Hampton, M. (2022, July). Redox biology and immunology: Exploring new connections. Plenary presentation at the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference, Dunedin, New Zealand.

Other Research Output

Hampton, M. (2022, October). Redox biology comes of age. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2021

Journal - Research Article

Parker, H. A., Jones, H. M., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021). Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants, 10, 1791. doi: 10.3390/antiox10111791

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Frontiers in Oncology, 11, 709543. doi: 10.3389/fonc.2021.709543

Pearson, A. G., Pullar, J. M., Cook, J., Spencer, E. S., Vissers, M. C. M., Carr, A. C., & Hampton, M. B. (2021). Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration. Redox Biology, 43, 101980. doi: 10.1016/j.redox.2021.101980

Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6

Schindler, L., Smyth, L. C. D., Bernhagen, J., Hampton, M. B., & Dickerhof, N. (2021). Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils. Redox Biology, 41, 101946. doi: 10.1016/j.redox.2021.101946

Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084

Schindler, L., Zwissler, L., Krammer, C., Hendgen-Cotta, U., Rassaf, T., Hampton, M. B., Dickerhof, N., & Bernhagen, J. (2021). Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. Journal of Leukocyte Biology, 110, 893-905. doi: 10.1002/JLB.3A0420-242RRR

Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453

Königstorfer, A., Ashby, L. V., Bollar, G. E., Billiot, C. E., Gray, M. J., Jakob, U., Hampton, M. B., & Winterbourn, C. C. (2021). Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease, 79, ftaa079. doi: 10.1093/femspd/ftaa079

Mayyas, I. M., Weeks, R. J., Day, R. C., Magrath, H. E., O’Connor, K. M., Kardailsky, O., Hore, T. A., Hampton, M. B., & Morison, I. M. (2021). Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics, 16(11), 1251-1259. doi: 10.1080/15592294.2020.1861169

Journal - Research Other

Parker, H. A., Forrester, L., Kaldor, C. D., Dickerhof, N., & Hampton, M. B. (2021). Antimicrobial activity of neutrophils against mycobacteria. Frontiers in Immunology, 12, 782495. doi: 10.3389/fimmu.2021.782495

Conference Contribution - Published proceedings: Abstract

Featherston, T., Paumann-Page, M., Dickerhof, N., Kaldor, C., Winterbourn, C. C., & Hampton, M. B. (2021). Measuring and exploiting oxidative stress in metastatic melanoma. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 281). Retrieved from https://www.faobmb2021.org

Borichevsky, G., Swaminathan, A., Edwards, T., Day, A., Hampton, M., Kettle, A., & Gearry, R. (2021). Faecal myeloperoxidase is a biomarker of endoscopically active inflammatory bowel disease. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 234). Retrieved from https://www.faobmb2021.org

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org

Shearer, H. L., Parker, H. A., Paton, J., Camilli, A., Pace, P. E., Dickerhof, N., & Hampton, M. B. (2021). Sensitising Streptococcus pneumoniae to oxidative stress. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 145). Retrieved from https://www.faobmb2021.org

Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org

Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org

van Leeuwen, E., Smyth, L., Pace, P., & Hampton, M. (2021). Hypothiocyanous acid oxidizes collapsin response mediator protein 2 in brain pericytes. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 277). Retrieved from https://www.faobmb2021.org

Taylor, M., Black, M., Hampton, M., & Ledgerwood, L. (2021). Transcriptional response of Jurkat T lymphoma cells to hydrogen peroxide. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 276). Retrieved from https://www.faobmb2021.org

Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org

2020

Chapter in Book - Research

Magon, N. J., Parker, H. A., Ashby, L. V., Springer, R. J., & Hampton, M. B. (2020). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil: Methods and protocols: Methods in molecular biology (Vol. 2087). (3rd ed.) (pp. 149-164). New York, NY: Humana Press. doi: 10.1007/978-1-0716-0154-9_12

Journal - Research Article

Van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2020). Redox signalling and regulation of the blood-brain barrier. International Journal of Biochemistry & Cell Biology, 125, 105794. doi: 10.1016/j.biocel.2020.105794

Pearson, A. G., Zawari, M., Pearson, J. F., & Hampton, M. B. (2020). Quantifying mitochondrial respiration in human lymphocytes and monocytes challenged with hydrogen peroxide. Free Radical Research, 54(4), 271-279. doi: 10.1080/10715762.2020.1753722

O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092

Meng, Y., Sheen, C. R., Magon, N. J., Hampton, M. B., & Dobson, R. C. J. (2020). Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. Journal of Biological Chemistry, 295(10), 2984-2999. doi: 10.1074/jbc.RA119.012226

Journal - Research Other

Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033

2019

Journal - Research Article

Talla, U., Bozonet, S. M., Parker, H. A., Hampton, M. B., & Vissers, M. C. M. (2019). Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils. Journal of Leukocyte Biology, 106, 1367-1379. doi: 10.1002/jlb.4a0319-079rr

Dickerhof, N., Isles, V., Pattemore, P., Hampton, M. B., & Kettle, A. J. (2019). Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis. Journal of Biological Chemistry, 294(36), 13502-13514. doi: 10.1074/jbc.RA119.009934

de Souza, L. F., Pearson, A. G., Pace, P. E., Dafre, A. L., Hampton, M. B., Meotti, F. C., & Winterbourn, C. C. (2019). Peroxiredoxin expression and redox status in neutrophils and HL-60 cells. Free Radical Biology & Medicine, 135, 227-234. doi: 10.1016/j.freeradbiomed.2019.03.007

Conference Contribution - Published proceedings: Abstract

Fischer, J., Eglinton, T., Frizelle, F., Pace, P., Pearson, A., & Hampton, M. (2019). Marker of oxidative stress as a novel predictor of response to neoadjuvant chemoradiotherapy for rectal cancer. ANZ Journal of Surgery, 89(Suppl. 1), (pp. 25). doi: 10.1111/ans.15180

Conference Contribution - Verbal presentation and other Conference outputs

Das, A. B., Hampton, M. B., & Vissers, M. C. M. (2019, August-September). Creodes and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Edited Book - Research

Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p.

Chapter in Book - Research

Hampton, M. B. (2018). Hydrogen peroxide-dependent redox signaling: Basic concepts and unanswered questions. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 353-364). Boca Raton, FL: CRC Press.

Journal - Research Article

Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407

Richards, S. J. G., Frizelle, F. A., Geddes, J. A., Eglinton, T. W., & Hampton, M. B. (2018). Frailty in surgical patients. International Journal of Colorectal Disease, 33(12), 1657-1666. doi: 10.1007/s00384-018-3163-y

Yewdall, N. A., Peskin, A. V., Hampton, M. B., Goldstone, D. C., Pearce, F. G., & Gerrard, J. A. (2018). Quaternary structure influences the peroxidase activity of peroxiredoxin 3. Biochemical & Biophysical Research Communications, 497(2), 558-563. doi: 10.1016/j.bbrc.2018.02.093

Hampton, M. B., Vick, K. A., Skoko, J. J., & Neumann, C. A. (2018). Peroxiredoxin involvement in the initiation and progression of human cancer. Antioxidants & Redox Signaling, 28(7), 591-608. doi: 10.1089/ars.2017.7422

Journal - Research Other

Fischer, J., Eglinton, T. W., Frizelle, F. A., & Hampton, M. B. (2018). Peroxiredoxins in colorectal cancer: Predictive biomarkers of radiation response and therapeutic targets to increase radiation sensitivity? Antioxidants, 7(10), 136. doi: 10.3390/antiox7100136

Conference Contribution - Published proceedings: Abstract

Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz

Kaldor, C. D., Parker, H. A., & Hampton, M. B. (2018). Oxidant production by Streptococcus pneumoniae associated with neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 108). Retrieved from https://www.nzmsconference.org.nz

Parker, H. A., Jones, M. G., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2018). Timing of reactive oxygen species involvement in formation of neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 100). Retrieved from https://www.nzmsconference.org.nz

Parker, H. A., Hampton, M. B., Rosado, L. A., Messens, J., & Kettle, A. J. (2018). Resistance of Mycobacterium smegmatis to oxygen-dependent killing by neutrophils. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 95-96). Retrieved from https://www.nzmsconference.org.nz

Vick, K., Kaur, G., Doroshow, J., Winterbourn, C., & Hampton, M. (2018). Peroxiredoxins as markers of oxidative stress in cancer cells. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Dagnell, M., Cheng, Q., Pace, P. E., Hampton, M. B., Winterbourn, C. C., & Arnér, E. S. J. (2018). Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S36). doi: 10.1016/j.freeradbiomed.2018.04.123

Conference Contribution - Poster Presentation (not in published proceedings)

Mayyas, I., Weeks, R., Hampton, M., Hore, T., & Morison, I. (2018, August). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Swan, J., Aitchison, A., Hampton, M., & Keenan, J. (2018, September). Asprin's role in preventing e-cadherin cleavage by the carcinogenic Bacteroides Fragilis toxin. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Kaldor, C., Parker, H., Cook, G., & Hampton, M. (2018, September). Streptococcus Pneumoniae adhered to neutrophil extracellular traps produce hydrogen peroxide which is converted into hypochlorous acid. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

2017

Journal - Research Article

Schindler, L., Dickerhof, N., Hampton, M. B., & Bernhagen, J. (2017). Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning. Redox Biology, 15, 135-142. doi: 10.1016/j.redox.2017.11.028

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745

Conference Contribution - Published proceedings: Abstract

Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017). Mechanisms of active DNA demethylation in somatic cells. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 770. Retrieved from http://gen2017.w.events4you.currinda.com

Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185

Conference Contribution - Poster Presentation (not in published proceedings)

Bozonet, S., Hampton, M., & Vissers, M. (2017, September). Hypothiocyanous acid protects endothelial cells from hypochlorous acid-mediated death. Poster session presented at the European Cell Death Organisation (ECDO)25gth Conference: Cell Death and Immunity in Disease: From Molecules to Translational Medicine, Leuven, Belgium.

Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017, September). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pearson, A. G., Zawari, M., & Hampton, M. B. (2017, September). Assessing mitochondrial activity and response to oxidative stress in human monocyte and lymphocytes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Talla, U. R., Parker, H., Bozonet, S., Hampton, M., & Vissers, M. (2017, July). An altered cell death pathway for neutrophils in a hypoxic environment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Hampton, M. B., Dickerhof, N., Pace, P. E., & Bozonet, S. M. (2017, July). Redox signalling and the regulation of immune cell life and death. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Pearson, A., Zawari, M., & Hampton, M. B. (2017, July). Assessment of mitochondrial metabolism in immune cells. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Hoskin, T. S., Dickerhof, N., Hampton, M. B., & Kettle, A. J. (2017, July). Calprotectin is sensitive to oxidants generated by myeloperoxidase. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Parker, H., Jones, M., Hampton, M., & Winterbourn, C. (2017, July). Oxidant-dependent steps in the formation of neutrophil extracellular traps. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Cuddihy, S. L., Drake, S., Harwood, T., Selwood, A. I., McNabb, P. S., & Hampton, M. B. (2016). The marine cytotoxin portimine is a potent and selective inducer of apoptosis. Apoptosis, 21(12), 1447-1452. doi: 10.1007/s10495-016-1302-x

Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995

Yewdall, N. A., Venugopal, H., Desfosses, A., Abrishami, V., Yosaatmadja, Y., Hampton, M. B., … Radjainia, M. (2016). Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state. Structure, 24(7), 1120-1129. doi: 10.1016/j.str.2016.04.013

Poynton, R. A., Peskin, A. V., Haynes, A. C., Lowther, W. T., Hampton, M. B., & Winterbourn, C. C. (2016). Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochemical Journal, 473, 411-421. doi: 10.1042/bj20150572

Journal - Research Other

Bolaños, J. P., Cadenas, E., Duchen, M. R., Hampton, M. B., Mann, G. E., & Murphy, M. P. (2016). Introduction to special issue on mitochondrial redox signaling in health and disease. Free Radical Biology & Medicine, 100, 1-4. doi: 10.1016/j.freeradbiomed.2016.08.004

Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442

Hampton, M. B., & O'Connor, K. M. (2016). Peroxiredoxins and the regulation of cell death. Molecules & Cells, 39(1), 72-76. doi: 10.14348/molcells.2016.2351

Conference Contribution - Published proceedings: Abstract

Pearson, A. G., Moran, S. M., Zawari, M., & Hampton, M. B. (2016). Peroxiredoxins as markers of oxidative stress in circulating blood cells. Free Radical Biology & Medicine, 100(Suppl.), (pp. S106). doi: 10.1016/j.freeradbiomed.2016.10.270

Talla, U. R., Bozonet, S., Parker, H., Hampton, M., & Vissers, M. (2016). Inhibition of neutrophil apoptosis and initiation of an autophagy-like process in hypoxia and effects on neutrophil function. Free Radical Biology & Medicine, 100(Suppl.), (pp. S63). doi: 10.1016/j.freeradbiomed.2016.10.166

Pace, P., Peskin, A. V., Jasoni, C. L., Winterbourn, C., & Hampton, M. (2016). Interaction of peroxiredoxin 2 with collapsin response mediator protein 2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.126

Dagnell, M., Pace, P., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E., Hampton, M., & Winterbourn, C. (2016). Thioredoxin reductase 1 directly protects protein tyrosine phosphatase 1B from inactivation by H₂O₂. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.125

Newman, T., Leeke, B., Carleton, C., Leask, M., Hampton, M., & Horsfield, J. (2016). How zebrafish can help understand craniofacial biology. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 16-17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026

2015

Journal - Research Article

Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology, 6, 648-655. doi: 10.1016/j.redox.2015.10.010

Dickerhof, N., Schindler, L., Bernhagen, J., Kettle, A. J., & Hampton, M. B. (2015). Macrophage migration inhibitory factor (MIF) Is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radical Biology & Medicine, 89, 498-511. doi: 10.1016/j.freeradbiomed.2015.09.009

Balasubramanain, D., Deng, A. X., Doudney, K., Hampton, M. B., & Kennedy, M. A. (2015). Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology, 99, 79-88. doi: 10.1016/j.neuropharm.2015.06.018

Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022

Radjainia, M., Venugopal, H., Desfosses, A., Phillips, A. M., Yewdall, N. A., Hampton, M. B., … Mitra, A. K. (2015). Cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Structure, 23(5), 912-920. doi: 10.1016/j.str.2015.03.019

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422

Bayer, S. B., Hampton, M. B., & Winterbourn, C. C. (2015). Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion, 55(8), 1909-1918. doi: 10.1111/trf.13039

Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208

Journal - Research Other

Winterbourn, C. C., & Hampton, M. B. (2015). Signaling via a peroxiredoxin sensor. Nature Chemical Biology, 11(1), 5-6. doi: 10.1038/nchembio.1722

Conference Contribution - Published proceedings: Abstract

Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145

Conference Contribution - Verbal presentation and other Conference outputs

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2015, September). Myeloperoxidase-derived oxidants render macrophage migration inhibitory factor (MIF) enzymatically inactive while retaining its immunologic function. Verbal presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.

Venugopal, H., Radjainia, M., Desfosses, A., Phillips, A. J., Yewdall, A. J., Hampton, M. B., … Mitra, A. K. (2015, August-September). High resolution cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Chapter in Book - Research

Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19

Journal - Research Article

Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612

Poynton, R. A., & Hampton, M. B. (2014). Peroxiredoxins as biomarkers of oxidative stress. Biochimica et Biophysica Acta: General Subjects, 1840(2), 906-912. doi: 10.1016/j.bbagen.2013.08.001

Conference Contribution - Published proceedings: Abstract

Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). No association between telomere length and exposure to life course stress or adversity in two longitudinal New Zealand cohorts. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 1325M. Retrieved from http://www.ashg.org/

Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). Association between telomere length and life stress in two New Zealand cohorts. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal

Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define structure activity relationships. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 88). Retrieved from http://www.crystal29.com/

Conference Contribution - Poster Presentation (not in published proceedings)

Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014, August). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define design strategies. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jodczyk, S., Pearson, J., Fergusson, D., Horwood, J., Spittlehouse, J., Joyce, P., Hampton, M., & Kennedy, M. (2014, September). No association between telomere length and exposure to life course stress in two longitudinal New Zealand cohorts. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M. (2014, December). Mitochondrial redox changes during TNF-mediated necroptosis. Verbal presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.

2013

Journal - Research Article

Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2013). Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis. World Journal of Gastroenterology, 19(39), 6656-6664. doi: 10.3748/wjg.v19.i39.6656

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030

Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB Journal, 27(8), 3315-3322. doi: 10.1096/fj.13-227298

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2013). Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biology & Medicine, 58, 109-117. doi: 10.1016/j.freeradbiomed.2013.01.021

Conference Contribution - Published proceedings: Abstract

Hampton, M. (2013). New ways of thinking about and measuring oxidative stress. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/

Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S35-S36). doi: 10.1016/j.freeradbiomed.2013.10.470

Conference Contribution - Poster Presentation (not in published proceedings)

Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

O'Connor, K. M., & Hampton, M. B. (2013, August). Using the Seahorse Bioscience Extracellular Flux Analyzer to measure the consequences of oxidative stress on mitochondrial function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Ejje, N., Deuss, F. A., Puskar, L., Hampton, M. B., & Giles, G. I. (2013, August). Analysis of the intracellular targets of auranofin drug action by Synchrotron Radiation Fourier Transform Infrared Spectroscopy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Vick, K. A., Betz, A., O'Connor, K. M., Hughes, S. M., Ledgerwood, E. C., & Hampton, M. B. (2013, August). Functional consequences of lowering mitochondrial peroxiredoxin 3 expression. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pujary, U. R., Hampton, M., Parker, H., & Vissers, M. (2013, August). Effect of hypoxia on neutrophil survival and function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Poynton, R. A., Peskin, A. V., Dickerhof, N., Lowther, T. W., Betz, A., Winterbourn, C. C., & Hampton, M. B. (2013, August). Kinetics and biochemical properties of peroxiredoxin 3 hyperoxidation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Newman, T. A. C., Hampton, M. B., & Horsfield, J. A. (2013, August). The developmental consequences of oxidative stress. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013, August). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Gommans, A., Hampton, M. B., Tyndall, J. D. A., & Wilbanks, S. M. (2013, August). Improved-resolution structure of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Gommans, A. L., Tyndall, J. D. A., Hampton, M. B., & Wilbanks, S. M. (2013, February). Improved resolution of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Verbal presentation at the 38th Lorne Conference on Protein Structure and Function, Lorne, Australia.

Hampton, M. (2013, February). Exploring nature's medicine chest. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand.

2012

Journal - Research Article

Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004

Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552

Stacey, M. M., Cuddihy, S. L., Hampton, M. B., & Winterbourn, C. C. (2012). Protein thiol oxidation and formation of S-glutathionylated cyclophilin A in cells exposed to chloramines and hypochlorous acid. Archives of Biochemistry & Biophysics, 527(1), 45-54. doi: 10.1016/j.abb.2012.07.011

Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601

Keenan, J. I., Salm, N., Wallace, A. J., & Hampton, M. B. (2012). Using food to reduce H. pylori-associated inflammation. Phytotherapy Research, 26(11), 1620-1625. doi: 10.1002/ptr.4618

Conference Contribution - Published proceedings: Abstract

Pujary, U. R., Hampton, M., Winterbourn, C., & Vissers, M. (2012). Hypoxia extends neutrophil survival but does not necessarily retain cell function. Proceedings of the Oxygen Theme Meeting. (pp. 35). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Pace, P., Peskin, A., Hampton, M., & Winterbourn, C. (2012). Hydrogen peroxide-dependent interaction of peroxiredoxin 2 with ERp46. Proceedings of the Oxygen Theme Meeting. (pp. 32). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Spencer, E., Tyndall, J., Smith, R. A. J., & Hampton, M. (2012). Biological properties of isothiocyanates. Proceedings of the Oxygen Theme Meeting. (pp. 21). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Newman, T., Hampton, M., & Horsfield, J. (2012). A developmental role for Peroxiredoxin 3. Proceedings of the Oxygen Theme Meeting. (pp. 15). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Poynton, R., Peskin, A., Dickerhof, N., Paton, L., Winterbourn, C., & Hampton, M. (2012). Kinetics of peroxiredoxin 2 and 3 hyperoxidation. Proceedings of the Oxygen Theme Meeting. (pp. 14). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Hampton, M. (2012). Peroxiredoxin 3 as a mitochondrial antioxidant and sensor and marker of mitochondrial oxidative stress. Proceedings of the Oxygen Theme Meeting. (pp. 13). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Ulcerative Colitis (UC): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Falvey, J. D., Munday, J. S., Keenan, J. I., Dyer, A. E., Gearry, R. B., & Hampton, M. B. (2012). Clinical assessment of murine Dextran Sodium Sulphate (DSS) colitis: Prospective validation of a novel scoring tool. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Crohn's disease (CD): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Pace, P. E., Peskin, A. V., Hampton, M. B., & Winterbourn, C. C. (2012). Hydrogen peroxide dependent interaction of peroxiredoxin 2 with ERp46. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2012.08.440

Peskin, A. V., Dickerhof, N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2012). Kinetics of hyperoxidation of human peroxiredoxin 2. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210-S211). doi: 10.1016/j.freeradbiomed.2012.08.441

Conference Contribution - Poster Presentation (not in published proceedings)

Newman, T., Hampton, M., & Horsfield, J. (2012, September). Peroxiredoxin 3 protects zebrafish development against mitochondrial oxidative stress. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M., Bayer, S., Moran, S., Maghzal, G., Stocker, R., Choe, C. F., Lunt, H., Chambers, S., Peskin, A., & Winterbourn, C. (2012, November). Peroxiredoxins as biomarkers of oxidative stress. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.

Balasubramanain, D., Hampton, M., & Kennedy, M. (2012, November). Effect of valproate on SPR gene expression in a serotonergic cell line. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.

2011

Journal - Research Article

Brown, K. K., & Hampton, M. B. (2011). Biological targets of isothiocyanates. Biochimica et Biophysica Acta: General Subjects, 1810(9), 888-894. doi: 10.1016/j.bbagen.2011.06.004

Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355

Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2011). Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling. Antioxidants & Redox Signaling, 15(1), 167-174. doi: 10.1089/ars.2010.3843

Conference Contribution - Published proceedings: Abstract

Falvey, J. D., Munday, J. S., Keenan, J. I., Gearry, R. B., & Hampton, M. B. (2011). Assessing the efficacy of isothiocyanates in experimental colitis. New Zealand Medical Journal, 124(1347). Retrieved from http://journal.nzma.org.nz/journal/124-1347/5015/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M. (2011, September). Peroxiredoxins as redox sensors and signalling proteins. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Tyndall, J. D. A., Dale, E. J., Spencer, E. S., Falvey, J. D., Smith, R. A. J., & Hampton, M. B. (2011, November-December). Isothiocyanate inhibitors of the proinflammatory cytokine macrophage migration inhibitory factor. Verbal presentation at the New Zealand Institute of Chemistry (NZIC) Conference, Hamilton, New Zealand.

2010

Chapter in Book - Research

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0

Requejo, R., Chouchani, E. T., Hurd, T. R., Menger, K. E., Hampton, M. B., & Murphy, M. P. (2010). Measuring mitochondrial protein thiol redox state. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 123-147). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0

Journal - Research Article

Bernal, A. B., Vickers, M. H., Hampton, M. B., Poynton, R. A., & Sloboda, D. M. (2010). Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS ONE, 5(12), e15558. doi: 10.1371/journal.pone.0015558

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313-321. doi: 10.1042/BJ20101156

Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection & Immunity, 78(12), 5054-5061. doi: 10.1128/IAI.00299-10

Keenan, J. I., Salm, N., Hampton, M. B., & Wallace, A. J. (2010). Individual and combined effects of foods on Helicobacter pylori growth. Phytotherapy Research, 24(8), 1229-1233. doi: 10.1002/ptr.3167

Brown, K. K., Cox, A. G., & Hampton, M. B. (2010). Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Letters, 584, 1257-1262. doi: 10.1016/j.febslet.2010.02.042

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541

Conference Contribution - Published proceedings: Abstract

Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2010). Gene-gene interaction between Macrophage Migration Inhibitory Factor (MIF) and NOD2 alters susceptibility to ileal Crohn's disease. New Zealand Medical Journal, 123(1327). Retrieved from http://journal.nzma.org.nz/journal/123-1327/4492/content.pdf

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479

Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2010). Redox proteomics of EGF signaling. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S128). doi: 10.1016/j.freeradbiomed.2010.10.350

Brown, K. K., & Hampton, M. B. (2010). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2010.10.468

Conference Contribution - Poster Presentation (not in published proceedings)

Poynton, R. A., Sloboda, D. M., Vickers, M. H., Winterbourn, C. C., & Hampton, M. B. (2010, September). Peroxiredoxin 3 and oxidative stress in mitochondria. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2010, November-December). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Davies, M. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Removal of amino acid, peptide and protein peroxide by reaction with peroxiredoxin 2 and peroxiredoxin 3. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Cellular interactions of peroxiredoxin 2. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

2009

Journal - Research Article

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092

Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242

Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g

Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23

Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j.febslet.2009.02.018

Conference Contribution - Published proceedings: Abstract

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009). Peroxiredoxin 3 is a key regulator of mitochondrial hydrogen peroxide. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2009). Rapid removal of amino acid, peptide and protein peroxides. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S150-S151). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P., Hampton, M., & Winterbourn, C. (2009, December). Cellular interactions of peroxiredoxins. Poster session presented at the 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

2008

Journal - Research Article

Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2008). Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis, 29(12), 2400-2405. doi: 10.1093/carcin/bgn218

Cox, A. G., Brown, K. K., Arner, E. S. J., & Hampton, M. B. (2008). The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochemical Pharmacology, 76(9), 1097-1109. doi: 10.1016/j.bcp.2008.08.021

Winterbourn, C. C., & Hampton, M. B. (2008). Thiol chemistry and specificity in redox signaling. Free Radical Biology & Medicine, 45(5), 549-561. doi: 10.1016/j.freeradbiomed.2008.05.004

Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2008). Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxidants & Redox Signaling, 10(9), 1621-1629. doi: 10.1089/ars.2008.2081

Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology & Medicine, 44(6), 1001-1009. doi: 10.1016/j.freeradbiomed.2007.11.017

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229

Thomson, S. J., Cox, A. G., Cuddihy, S. L., Pullar, J. M., & Hampton, M. B. (2008). Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochemical & Biophysical Research Communications, 375(1), 145-150. doi: 10.1016/j.bbrc.2008.07.133

Brown, K. K., Eriksson, S. E., Arnér, E. S. J., & Hampton, M. B. (2008). Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radical Biology & Medicine, 45(4), 494-502. doi: 10.1016/j.freeradbiomed.2008.04.030

Cuddihy, S. L., Brown, K. K., Thomson, S. J., & Hampton, M. B. (2008). Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-X_L. Cancer Letters, 271(2), 215-221. doi: 10.1016/j.canlet.2008.06.002

Conference Contribution - Published proceedings: Abstract

Cox, A. G., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. New Zealand Medical Journal, 121(1271). Retrieved from Oxidation of mitochondrial peroxiredoxin 3 during the initiation of http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2008). Impact of oxidative stress on DNA methylation. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Wilkie, R., Vissers, M. C. M., & Hampton, M. B. (2008). A functional NADPH oxidase promotes neutrophil apoptosis by a caspase-independent mechanism. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Chitcholtan, K., Hampton, M., & Keenan, J. (2008). Outer membrane vesicles (OMVs) of Helicobacter pylori alter cellular signalling pathways in human gastric epithelial cells. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Brown, K. K., & Hampton, M. B. (2008). Pro-apoptotic isothiocyanates inactivate proteins involved in maintaining mitochondrial redox homeostasis. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Poster session presented at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2007

Chapter in Book - Research

Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Neutrophil methods and protocols. (pp. 319-332). Totowa, USA: Humana Press.

Journal - Research Article

Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897.

Wilkie, R. P., Vissers, M. C. M., Dragunow, M., & Hampton, M. B. (2007). A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection & Immunity, 75(7), 3256-3263.

Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617.

Cox, A. G., & Hampton, M. B. (2007). Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide. Carcinogenesis, 28(10), 2166-2171.

Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H₂O₂ is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892.

Conference Contribution - Published proceedings: Abstract

Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2007). Mitochondrial peroxiredoxin 3 is oxidized during Fas and TNF-a mediated apoptosis. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Chitcholtan, K., Hampton, M., & Keenan, J. (2007). H. pylori outer membrane vesicles induce DNA damage in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 155). [Abstract]

Salm, N., Hampton, M., Wallace, A. J., & Keenan, J. (2007). Broccoli sprouts inhibit the release of interleukin-8 from AGS cells co-cultured with Helicobacter pylori. Zoonoses and Public Health. 54(Suppl. 1), (pp. 97-98). [Abstract]

Davis, K. A., Chitcholtan, K., Hampton, M., & Keenan, J. I. (2007). Helicobacter pylori outer membrane vesicles induce cytoskeletal rearrangements and cell signaling events in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 151). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2007, August). Impact of oxidative stress on DNA methylation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2006

Chapter in Book - Research

Hampton, M. B., Baty, J. W., & Winterbourn, C. C. (2006). Use of a proteomic technique to identify oxidant-sensitive thiol proteins in cultured cells. In I. Dalle-Donne, A. Scaloni & D. A. Butterfield (Eds.), Redox Proteomics: From protein modifications to cellular dysfunction and diseases. (pp. 253-265). Hoboken, NJ: John Wiley & Sons.

Journal - Research Article

Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869.

Thomson, S. J., Brown, K. K., Pullar, J. M., & Hampton, M. B. (2006). Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Research, 66(13), 6772-6777.

Conference Contribution - Published proceedings: Abstract

Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract]

Wilkie, R., Vissers, M., & Hampton, M. (2006). Role of NADPH oxidase: Derived oxidants in neutrophil apoptosis. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf

2005

Journal - Research Article

Baird, S. K., Reid, L., Hampton, M. B., & Gieseg, S. P. (2005). OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta: Molecular Cell Research, 1745, 361-369. doi: 10.1016/j.bbamcr.2005.07.001

Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-_KB activation. Journal of Leukocyte Biology, 77, 432-437.

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2005). Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochemical Journal, 390(3), 785-795.

Keenan, J. I., Peterson, II, R. A., & Hampton, M. B. (2005). NADPH oxidase involvement in the pathology of Helicobacter pylori infection. Free Radical Biology & Medicine, 38, 1188-1196.

Conference Contribution - Published proceedings: Abstract

Parker, H., Ismail, S., Neal, S., Hampton, M., & Keenan, J. (2005). Association of Helicobacter pylori outer membrane vesicles with gastric epithelial cells. In V. Korolik, A. Lee, H. Mitchell, G. Mendz, B. Fry & P. Coloe (Eds.), Proceedings of the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms. (pp. 72). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Pullar, J. M., Baty, J. W., Csordas, A., Winterbourn, C. C., & Hampton, M. B. (2005, December). Oxidation of thiol proteins in cultured cells: Comparison of H₂O₂ with receptor-mediated signalling. Verbal presentation at the 3rd Joint Meeting of the Society for Free Radical Research Australasia and Japan, Queensland, Australia.

Keenan, J., Peterson, R., Ismail, S., Hock, B., Frampton, C., & Hampton, M. (2005, September). Host iron deficiency alters the outcome of infection in Helicobacter pylori-infected mice. Verbal presentation at the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, Gold Coast, Australia.

2004

Journal - Research Article

Baird, S. K., Hampton, M. B., & Gieseg, S. P. (2004). Oxidized LDL triggers phosphatidylserine exposure in human monocyte cell lines by both caspase-dependent and -independent mechanisms. FEBS Letters, 578, 169-174.

Pullar, J. M., Thomson, S. J., King, M. J., Turnbull, C. I., Midwinter, R. G., & Hampton, M. B. (2004). The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis. Carcinogenesis, 25(5), 765-772.

Conference Contribution - Published proceedings: Full paper

Vissers, M. C. M., & Hampton, M. B. (2004). The role of oxidants and vitamin C on neutrophil apoptosis and clearance. Biochemical Society Transactions. 32(3), (pp. 499-501). [Full Paper]

Conference Contribution - Published proceedings: Abstract

Keenan, J. I., Peterson, R. A., & Hampton, M. B. (2004). Role of neutrophil oxidants in the gastric pathology associated with Helicobacter pylori infection. Helicobacter. 9(5), (pp. 591-592). [Abstract]

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. M. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Proceedings of the Perinatal Society of Australia and New Zealand: 8th Annual Congress. (pp. P133). Sydney, Australia: PSANZ. [Abstract]

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Pediatric Research. 56(3), (pp. 474). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Thomson, S. J., Pullar, J. M., & Hampton, M. B. (2004, December). Phenethyl isothiocyanate triggers apoptosis in cells over-expressing Bcl-2. Poster session presented at the 13th Annual Conference of the Society for Free Radical Research (Australasia), Christchurch, New Zealand.

Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris.

2003

Journal - Research Article

Ismail, S., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infection & Immunity, 71(10), 5670-5675.

Conference Contribution - Published proceedings: Abstract

Ismail, S., Parker, H., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and IL-8 production by gastric epithelial cells. International Journal of Medical Microbiology, 293(Suppl. 35), (pp. 116). [Abstract]

2002

Journal - Research Article

Hampton, M. B., & Winterbourn, C. C. (2002). Redox regulation of neutrophil function. Antioxidants & Redox Signaling, 4(1), 1-3.

Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762.

Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Journal of Biological Chemistry, 277(22), 19402-19407.

Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781.

Hampton, M. B., Stamenkovic, G., & Winterbourn, C. C. (2002). Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Letters, 517, 229-232.

Hampton, M. B., Morgan, P., & Davies, M. (2002). Inactivation of cellular caspases by peptide-derived tryptophan and tyrosine peroxides. FEBS Letters, 527, 289-292.

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2002). Detection of oxidant-sensitive thiol proteins by fluorescent labeling and two dimensional electrophoresis. Proteomics, 2, 1261-1266.

Conference Contribution - Published proceedings: Abstract

Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Free Radical Biology and Medicine. 33(Suppl. 1), (pp. S91-S92). [Abstract]

2001

Journal - Research Article

Vissers, M. C. M., Lee, W. G., & Hampton, M. B. (2001). Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants. Journal of Biological Chemistry, 276(50), 46835-46840. doi: 10.1074/jbc.M107664200

2000

Chapter in Book - Research

Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer.

Conference Contribution - Published proceedings: Abstract

Keenan, J. I., Hampton, M. B., & Allardyce, R. A. (2000). H. pylori proteases and the develpoment of gastric cancer. Gut. 47(Suppl. 1), (pp. A27). [Abstract]

1999

Journal - Research Article

Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999). Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochemical Journal, 344, 443-449.

Hampton, M. B., & Winterbourn, C. C. (1999). Methods for quantifying phagocytosis and bacterial killing by human neutrophils. Journal of Immunological Methods, 232, 15-22.

Stridh, H., Orrenius, S., & Hampton, M. B. (1999). Caspase involvement in the induction of apoptosis by the environmental toxicants tributylin and triphenyltin. Toxicology & Applied Pharmacology, 156, 141-146.

Journal - Professional & Other Non-Research Articles

Hampton, M. B. (1999). Mitochondria: unravelling the secrets of life and death. Redox Report, 4, 137-139.

1998

Journal - Research Article

Hampton, M. B., Zhivotovsky, B., Burgess, D. H., Slater, A. F. G., & Orrenius, S. (1998). Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts. Biochemical Journal, 329, 95-99.

Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death. BioFactors, 8, 1-5.

Stridh, H., Kimland, M., Jones, D. P., Orrenius, S., & Hampton, M. B. (1998). Cytochrome c release a cascade activation in hydrogen peroxide and tributyltin induced apoptosis. FEBS Letters, 429, 351-355.

Hampton, M. B., Fadeel, B., & Orrenius, S. (1998). Redox regulation of the caspases during apoptosis. Annals of the New York Academy of Sciences, 854, 328-335.

Fadeel, B., Ahlin, A., Henter, J., Orrenius, S., & Hampton, M. B. (1998). Involvement of caspases in neutrophil apoptosis: Evidence for a regulatory role of reactive oxygen species. Blood, 92, 4808-4818.

Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death in the immune system. Toxicology Letters, 102-103, 355-358.

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017.

Vollebregt, M., Hampton, M. B., & Winterbourn, C. C. (1998). Activation of NF-KB in human neutrophils during phagocytosis of bacteria independently of oxidant generation. FEBS Letters, 432, 40-44.

1997

Journal - Research Article

Hampton, M. B., & Orrenius, S. (1997). Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis. FEBS Letters, 414, 552-556.

Journal - Research Other

Orrenius, S., Burgess, D. H., & Hampton, M. B. (1997). Mitochondria as the focus of apoptosis research. Cell Death & Differentiation, 4, 427-428.

1996

Journal - Research Article

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517.