Professor
Email steve.chambers@otago.ac.nz
Tel +64 3 364 3615
Research interests
Professor Steve Chambers' research interests relate to diagnostics in respiratory infections, the treatment of infectious diseases and intermediary metabolism with particular emphasis on the relationship between bacterial and human metabolism.
He is interested in the effective delivery of treatment for infectious disease that minimises harm to the patient depends on rapid, accurate diagnosis of the infecting organism.
Clinical studies undertaken by Professor Chambers and his team have confirmed the limitations of current methods such as culture and PCR, particularly in children, which depend on the collection of sputum and other specimens. This lead the concept of diagnostic breath testing, which can be performed on readily available samples that can be easily repeated, to follow microbial metabolism. Markers of bacterial metabolisms are obvious diagnostic candidates particularly as they are specific to a particular respiratory pathogen.
In the media
Professors Steve Chambers and David Murdoch were interviewed for Radio New Zealand's Our Changing World series in March 2014.
Publications
Shahid, A., Chambers, S., Scott-Thomas, A. J., & Bhatia, M. (2024). Gut microbiota and liver dysfunction in sepsis: The role of inflammatory mediators and therapeutic approaches. International Journal of Molecular Sciences, 25(24), 13415. doi: 10.3390/ijms252413415 Journal - Research Other
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2024). Novel monoclonal antibodies 1D2 and 4E4 against aspergillus glycoprotein antigens detect early invasive aspergillosis in mice. Journal of Fungi, 10(12), 832. doi: 10.3390/jof10120832 Journal - Research Article
Jun, H., Chambers, S. T., Williman, J., Slow, S., Murdoch, D. R., & Scott-Thomas, A. (2024). The inhibitory effect of copper, zinc, and manganese on Legionella longbeachae in potting mix leachate. Letters in Applied Microbiology, 77, ovae081. doi: 10.1093/lambio/ovae081 Journal - Research Article
Pairman, L., & Chambers, S. T. (2024). Quinolones or macrolides for adults with Legionnaires’ disease and respiratory failure? European Journal of Internal Medicine. Advance online publication. doi: 10.1016/j.ejim.2024.07.026 Journal - Research Other
Zhu, Z., Chambers, S., & Bhatia, M. (2024). Substance P promotes leukocyte infiltration in the liver and lungs of mice with sepsis: A key role for adhesion molecules on vascular endothelial cells. International Journal of Molecular Sciences, 25(12), 6500. doi: 10.3390/ijms25126500 Journal - Research Article
2024
Journal - Research Article
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2024). Novel monoclonal antibodies 1D2 and 4E4 against aspergillus glycoprotein antigens detect early invasive aspergillosis in mice. Journal of Fungi, 10(12), 832. doi: 10.3390/jof10120832
Jun, H., Chambers, S. T., Williman, J., Slow, S., Murdoch, D. R., & Scott-Thomas, A. (2024). The inhibitory effect of copper, zinc, and manganese on Legionella longbeachae in potting mix leachate. Letters in Applied Microbiology, 77, ovae081. doi: 10.1093/lambio/ovae081
Zhu, Z., Chambers, S., & Bhatia, M. (2024). Substance P promotes leukocyte infiltration in the liver and lungs of mice with sepsis: A key role for adhesion molecules on vascular endothelial cells. International Journal of Molecular Sciences, 25(12), 6500. doi: 10.3390/ijms25126500
Zhu, Z., Chambers, S., & Bhatia, M. (2024). Suppressing the substance P-NK1R signalling protects mice against sepsis-associated acute inflammatory injury and ferroptosis in the liver and lungs. Antioxidants, 13, 300. doi: 10.3390/antiox13030300
Campbell, P. O., Bauro, T., Rimon, E., Timeon, E., Bland, C., Ioteba, N., Douglas, N. M., … Chambers, S. T. (2024). Single-dose rifampicin leprosy chemoprophylaxis for household contacts in Kiribati: An audit of a combined retrospective and prospective approach. Tropical Medicine & Infectious Disease, 9, 58. doi: 10.3390/tropicalmed9030058
Vlasiuk, E., Zawari, M., Storer, M., Maze, M. J., Williman, J., Chambers, S. T., & Carr, A. C. (2024). SunGold kiwifruit consumption restores adequate to optimal vitamin C status in people with a history of severe respiratory infections. Antioxidants, 13, 272. doi: 10.3390/antiox13030272
Manandhar, S., Gaddam, R. R., Chambers, S., & Bhatia, M. (2024). Kupffer cell inactivation alters endothelial cell adhesion molecules in cecal ligation and puncture-induced sepsis. Biomolecules, 14, 84. doi: 10.3390/biom14010084
Journal - Research Other
Shahid, A., Chambers, S., Scott-Thomas, A. J., & Bhatia, M. (2024). Gut microbiota and liver dysfunction in sepsis: The role of inflammatory mediators and therapeutic approaches. International Journal of Molecular Sciences, 25(24), 13415. doi: 10.3390/ijms252413415
Pairman, L., & Chambers, S. T. (2024). Quinolones or macrolides for adults with Legionnaires’ disease and respiratory failure? European Journal of Internal Medicine. Advance online publication. doi: 10.1016/j.ejim.2024.07.026
2023
Journal - Research Article
Manandhar, S., Chambers, S., Miller, A., Ishii, I., & Bhatia, M. (2023). Pharmacological inhibition and genetic deletion of cystathionine gamma-lyase in mice protects against organ injury in sepsis: A key role of adhesion molecules on endothelial cells. International Journal of Molecular Sciences, 24, 13650. doi: 10.3390/ijms241713650
Carr, A. C., Vlasiuk, E., Zawari, M., Scott-Thomas, A., Storer, M., Maze, M., & Chambers, S. T. (2023). Low vitamin C concentrations in patients with community-acquired pneumonia resolved with pragmatic administration of intravenous and oral vitamin C. Antioxidants, 12, 1610. doi: 10.3390/antiox12081610
Chambers, S. T., Scott-Thomas, A., Storer, M., Slow, S., Williman, J., Epton, M., Murdoch, D. R., Metcalf, S., Carr, A., Isenman, H., & Maze, M. (2023). Adjunctive intravenous then oral vitamin C for moderate and severe community-acquired pneumonia in hospitalized adults: Feasibility of randomized controlled trial. Scientific Reports, 13, 11879. doi: 10.1038/s41598-023-37934-z
Jun, H., Scott-Thomas, A., Slow, S., Williman, J., Murdoch, D. R., & Chambers, S. T. (2023). The inhibitory effect of copper, zinc, and manganese on Legionella longbeachae and other Legionella spp. in vitro. Letters in Applied Microbiology, 76, 1-9. doi: 10.1093/lambio/ovad074
Campbell, P. O., Gallagher, K., Dalton, S. C., Metcalf, S. C. L., Douglas, N. M., & Chambers, S. T. (2023). Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study. International Journal of Infectious Diseases. Advance online publication. doi: 10.1016/j.ijid.2023.06.008
Munk, P., Brinch, B., Møller, F. D., Petersen, T. N., Hendriksen, R. S., Seyfarth, A. M., … Global Sewage Surveillance Consortium, including Jeunen, G.-J., Gemmell, N., Chambers, S. T., … Aarestrup, F. M. (2023). Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications, 14(1), 7251. doi: 10.1038/s41467-022-34312-7
Campbell, P. O., Chin, P. K. L., Dalton, S. C., Metcalf, S. C. L., Douglas, N. M., & Chambers, S. T. (2023). Frequency of pharmacological target attainment with flucloxacillin and cefazolin in invasive methicillin-susceptible Staphylococcus aureus infection: A prospective cohort study in hospitalized patients. International Journal of Antimicrobial Agents, 61, 106695. doi: 10.1016/j.ijantimicag.2022.106695
Cheung, J., Nordmeier, K., Kelland, S., Harrington, M., Williman, J., Storer, M., Beaglehole, B., Beckert, L., Chambers, S. T., Epton, M. J., Freeman, J., Murdoch, D. R., Werno, A. M., & Maze, M. J. (2023). Symptom persistence and recovery among COVID-19 survivors during a limited outbreak in Canterbury, New Zealand: A prospective cohort study. Internal Medicine Journal, 53, 37-45. doi: 10.1111/imj.15930
Journal - Research Other
Coleman, M., Hill, J., Timeon, E., Rimon, E., Bauro, T., Ioteba, N., … Douglas, N. M., … Campbell, P. O., Williman, J., Priest, P., … Chambers, S. T. (2023). Effectiveness of population-wide screening and mass drug administration for leprosy control in Kiribati: The COMBINE protocol. BMJ Open, 13, e065369. doi: 10.1136/bmjopen-2022-065369
Chin, P. K. L., Than, M., & Chambers, S. (2023). One giant leap for cephalexin dosing, one small step for antimicrobial stewardship. Canadian Journal of Emergency Medicine, 25, 7-8. doi: 10.1007/s43678-022-00442-6
2022
Journal - Research Article
Carr, A. C., Vlasiuk, E., Zawari, M., Meijer, N., Lauren, C., MacPherson, S., Williman, J., & Chambers, S. T. (2022). Supplementation with oral vitamin C prior to and during myeloablative chemotherapy and autologous haematopoietic stem cell transplantation: A pilot study. Antioxidants, 11(10), 1949. doi: 10.3390/antiox11101949
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., & Chambers, S. T. (2022). A novel monoclonal antibody 1D2 that broadly inhibits clinically important Aspergillus species. Journal of Fungi, 8, 960. doi: 10.3390/jof8090960
Manandhar, S., Scott-Thomas, A., Harrington, M., Sinha, P., Pilbrow, A., Richards, A. M., Cameron, V., Bhatia, M., & Chambers, S. T. (2022). Hydrogen sulfide and substance P levels in patients with Escherichia coli and Klebsiella pneumoniae bacteraemia. International Journal of Molecular Sciences, 23, 8639. doi: 10.3390/ijms23158639
Téllez, A., Ambrosioni, J., Hernández-Meneses, M., Llopis, J., Ripa, M., Chambers, S. T., … Raymond, N., … the International Collaboration on Endocarditis (ICE) Investigators, including Murdoch, D. R. (2022). Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci. Journal of Infection, 85, 137-146. doi: 10.1016/j.jinf.2022.05.023
Lian, X., Chambers, S., Lewis, J. G., Scott-Thomas, A., & Bhatia, M. (2022). Two monoclonal antibodies that specifically recognize aspergillus cell wall antigens and can detect circulating antigens in infected mice. International Journal of Molecular Sciences, 23, 252. doi: 10.3390/ijms23010252
Palmer, D., Soule, S., Gaddam, R. R., Elder, P., Chambers, S., & Doogue, M. (2022). Unbound vitamin D concentrations are not decreased in critically ill patients. Internal Medicine Journal, 52, 89-94. doi: 10.1111/imj.15096
Journal - Research Other
Lian, X., Scott-Thomas, A., Lewis, J. G., Bhatia, M., MacPherson, S. A., Zeng, Y., & Chambers, S. T. (2022). Monoclonal antibodies and invasive aspergillosis: Diagnostic and therapeutic perspectives. International Journal of Molecular Sciences, 23, 5563. doi: 10.3390/ijms23105563
Coleman, M., Hill, J., Timeon, E., Tonganibeia, A., Eromanga, B., Islam, T., … Chambers, S. T., … Marais, B. J. (2022). Population-wide active case finding and prevention for tuberculosis and leprosy elimination in Kiribati: The PEARL study protocol. BMJ Open, 12, e055295. doi: 10.1136/bmjopen-2021-055295
Zhu, Z., Chambers, S., Zeng, Y., & Bhatia, M. (2022). Gases in sepsis: Novel mediators and therapeutic targets. International Journal of Molecular Sciences, 23, 3669. doi: 10.3390/ijms23073669
2021
Journal - Research Article
Scott, P., Zhang, J., Anderson, T., Priest, P. C., Chambers, S., Smith, H., Murdoch, D. R., French, N., & Biggs, P. J. (2021). Whole-genome sequencing and ad hoc shared genome analysis of Staphylococcus aureus isolates from a New Zealand primary school. Scientific Reports, 11(1), 20328. doi: 10.1038/s41598-021-99080-8
Chambers, S. T., Withers, A., Dawson, K., Anderson, T., Williman, J., Murdoch, D., Scott-Thomas, A., & Slow, S. (2021). How safe are gloves and masks used for protection against Legionella longbeachae infection when gardening? Letters in Applied Microbiology, 73, 616-622. doi: 10.1111/lam.13546
Mohammadi, A., Chambers, S. T., Slow, S., Anderson, T., Williman, J., Scott, P., Murdoch, D., & Scott-Thomas, A. (2021). Presence of Legionella Longbeachae in pine but not composted green waste used in manufacture of potting soils in New Zealand. Journal of Applied & Environmental Microbiology, 9(1), 1-4. doi: 10.12691/jaem-9-1-1
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
Journal - Research Other
Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal
Lockett, H., Koning, A., Lacey, C., Every-Palmer, S., Scott, K. M., Cunningham, R., Dowell, T., Smith, L., Masters, A., … Chambers, S. (2021). Addressing structural discrimination: Prioritizing people with mental health and addiction issues during the COVID-19 pandemic. New Zealand Medical Journal, 134(1538), 128-134. Retrieved from https://www.nzma.org.nz/journal
Chambers, S. T., & Raymond, N. J. (2021). Challenge for COVID-19 vaccines to protect the New Zealand population. New Zealand Medical Journal, 134(1534), 11-16. Retrieved from https://www.nzma.org.nz/journal
Chambers, S. T., Slow, S., Scott-Thomas, A., & Murdoch, D. R. (2021). Legionellosis caused by non-Legionella pneumophila species, with a focus on Legionella longbeachae. Microorganisms, 9, 291. doi: 10.3390/microorganisms9020291
Other Research Output
Chambers, S. (2021, July). Leprosy: The forgotten disease in the Pacific: Progress on elimination. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2020
Journal - Research Article
Thompson, L., Ioteba, N., & Chambers, S. (2020). Leprosy in kiribati: The lived experience. Leprosy Review, 91, 353-366. doi: 10.47276/lr.91.4.353
Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal
Green, J., Howard, J., Shankar, A., Clinghan, R., Luff, T., Birch, M., Pithie, A., … Metcalf, S., & Chambers, S. (2020). Assessing the impact of a ‘bundle of care’ approach to Staphylococcus aureus bacteraemia in a tertiary hospital. Infection Prevention in Practice, 2, 100096. doi: 10.1016/j.infpip.2020.100096
Mohammadi, A., Chambers, S. T., Scott-Thomas, A., Lewis, J. G., Anderson, T., Podmore, R., Williman, J., Murdoch, D., & Slow, S. (2020). Enhancement of culture of Legionella longbeachae from respiratory samples using immunomagnetic separation and antimicrobial decontamination. Journal of Clinical Microbiology, 58(11), e01218-20. doi: 10.1128/jcm.01218-20
Carr, A. C., Spencer, E., Das, A., Meijer, N., Lauren, C., MacPherson, S., & Chambers, S. T. (2020). Patients undergoing myeloablative chemotherapy and hematopoietic stem cell transplantation exhibit depleted vitamin C status in association with febrile neutropenia. Nutrients, 12(6), 1879. doi: 10.3390/nu12061879
Baxter-Parker, G., Gaddam, R. R., Moltchanova, E., Carr, A. C., Shaw, G., Chambers, S., & Gieseg, S. P. (2020). Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis. Pteridines, 31(1), 68-82. doi: 10.1515/pteridines-2020-0015
Chambers, S. T., Ioteba, N., Timeon, E., Rimon, E., Murdoch, H., Green, J., … Williman, J., & Priest, P. (2020). Surveillance of leprosy in Kiribati, 1935-2017. Emerging Infectious Diseases, 26(5), 833-840. doi: 10.3201/eid2605.181746
Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972
Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal
Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004
Journal - Research Other
Murdoch, D., Addidle, M., Andersson, H.-S., Arnold, B., Balm, M., Benschop, J., … Birch, M., … Brunton, C., … Chambers, S., … Dalton, S., … Everts, R., … Freeman, J., French, N., … Hudson, B., … Ikram, R., Jack, S., Kelly, M., Lamont, I., Maze, M. J., … Metcalf, S., … Murton, S., … Pink, R., Pithie, A., … Priest, P., Raymond, N., … Taylor, J., … Upton, A., Ussher, J., Werno, A., & Wiles, S. (2020). Politicians: Please work together to minimise the spread of COVID-19. New Zealand Medical Journal, 133(1511), 7-8. Retrieved from https://www.nzma.org.nz/journal
Havlernik, J., Dawson, K., Anderson, T. R., Murdoch, D., Chambers, S., Biggs, P., Cree, S., & Slow, S. (2020). Complete genome sequence of a Legionella longbeachae serogroup 2 isolate derived from a patient with Legionnaires’ disease. Microbiology Resource Announcements, 9(5), e01563-19. doi: 10.1128/MRA.01563-19
Conference Contribution - Poster Presentation (not in published proceedings)
Lian, X., Scott-Thomas, A., Chambers, S., Lewis, J., Aamir, R., & Bhatia, M. (2020, December). The application of MARS spectral CT in diagnosing invasive aspergillosis. Poster session presented at the 6th One Health Aotearoa (OHA) Symposium, [Online].
Working Paper; Discussion Paper; Technical Report
Carr, A. C., Spencer, E., Dixon, L., & Chambers, S. (2020). Patients with community acquired pneumonia exhibit depleted vitamin C status and elevated oxidative stress. PrePrints. doi: 10.20944/preprints202004.0243.v1
2019
Journal - Research Article
Panta, G., Richardson, A. K., Shaw, I. C., Chambers, S., & Coope, P. A. (2019). Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study. PLoS ONE, 14(11), e0225595. doi: 10.1371/journal.pone.0225595
Gilkison, C., Chambers, S., Blok, D. J., Richardus, J. H., Timeon, E., Rimon, E., & Priest, P. (2019). Predicting the impact of household contact and mass chemoprophylaxis on future new leprosy cases in South Tarawa, Kiribati: A modelling study. PLoS Neglected Tropical Diseases, 13(9), e0007646. doi: 10.1371/journal.pntd.0007646
Chambers, S. T., Basevi, A., Gallagher, K., Carswell-Moyna, A., Isenman, H., Pithie, A., Dalton, S., & Metcalf, S. C. L. (2019). Outpatient parenteral antimicrobial therapy (OPAT) in Christchurch: 18 years on. New Zealand Medical Journal, 132(1501), 21-32. Retrieved from https://www.nzma.org.nz/journal
Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191
Priest, P. C., Slow, S., Chambers, S. T., Cameron, C. M., Balm, M. N., Beale, M. W., Blackmore, T. K., … Ussher, J. E., van der Linden, A. J., … Murdoch, D. R. (2019). The burden of Legionnaires' disease in New Zealand (LegiNZ): A national surveillance study. Lancet Infectious Diseases, 19, 770-777. doi: 10.1016/S1473-3099(19)30113-6
Shahid, K., Alamri, Y., Scowcroft, H., Dixon, L., Creighton, J., Isenman, H., Metcalf, S., & Chambers, S. (2019). Urinalysis orders and yield among General Medicine patients: A single-centre's experience in New Zealand. New Zealand Medical Journal, 132(1488), 21-27. Retrieved from https://www.nzma.org.nz/journal
Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141
Journal - Research Other
Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2019). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents, 53, 401-407. doi: 10.1016/j.ijantimicag.2018.12.014
Conference Contribution - Published proceedings: Abstract
Drennan, P., Green, J., Gardiner, S., Metcalf, S., Kirkpatrick, C., Zhang, M., & Chambers, S. (2019). Clinical outcomes and pharmacokinetic-pharmacodynamic target attainment in patients treated with oral flucloxacillin plus probenecid for staphylococcal infections. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 22). Retrieved from https://www.asceptasm.com
Conference Contribution - Poster Presentation (not in published proceedings)
Dawson, K., Slow, S., Murdoch, D., Anderson, T., & Chambers, S. (2019, December). Characterising the relationship between Legionella longbeachae and their amoebal hosts: Implications for Legionnaires' disease prevention. Poster session presented at the 5th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.
Jun, H., Mohammadi, A., Slow, S., Murdoch, D., & Chambers, S. (2019, December). The development of low-risk potting mix products to protect gardeners from Legionnaires' disease. Poster session presented at the 5th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.
2018
Journal - Research Article
Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2
Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370
Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673
Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal
Scott, P., Priest, P. C., Chambers, S. T., Heijne, J. C. M., & Murdoch, D. R. (2018). Staphylococcus aureus carriage in a New Zealand primary school: A cohort study. Pediatric Infectious Disease Journal, 37(6), e172-e175. doi: 10.1097/inf.0000000000001796
Journal - Research Other
Isenman, H., Anderson, T. R., Chambers, S. T., Podmore, R. G., & Murdoch, D. R. (2018). Antimicrobial susceptibilities of clinical Legionella longbeachae isolates. Journal of Antimicrobial Chemotherapy, 73(4), 1102-1104. doi: 10.1093/jac/dkx484
Conference Contribution - Poster Presentation (not in published proceedings)
Mohammadi, A., Chambers, S., Slow, S., Scott-Thomas, A., Scott, P., Anderson, T., & Murdoch, D. (2018, December). Enhancing the culturability and qPCR efficiency for Legionella longbeachae in sputum specimens using immunomagnetic separation. Poster session presented at the 4th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.
Chambers, S., Withers, A., Mohammadi, A., Chim, M., Slow, S., Scott-Thomas, A., Scott, P., … Anderson, T., & Murdoch, D. (2018, December). Legionella longbeachae in bark from living P. radiata trees around Christchurch. Poster session presented at the 4th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Scott, P., Zhang, J., Anderson, T., Priest, P., Chambers, S., Murdoch, D., & Biggs, P. (2018, December). Whole-genome sequencing of Staphylococcus aureus isolates from a New Zealand primary school. Invited presentation at the 4th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.
2017
Journal - Research Article
Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017). Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Critical Care, 21, 300. doi: 10.1186/s13054-017-1891-y
Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005
Lever, M., McEntyre, C. J., George, P. M., & Chambers, S. T. (2017). Is N,N-dimethylglycine N-oxide a choline and betaine metabolite? Biological Chemistry, 398(7), 775-784. doi: 10.1515/hsz-2016-0261
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755
Journal - Research Other
Scott-Thomas, A., & Chambers, S. T. (2017). Volatile organic compounds: Upcoming role in diagnosis of invasive mould infections. Current Fungal Infection Reports, 11(3), 117-123. doi: 10.1007/s12281-017-0284-7
Conference Contribution - Published proceedings: Abstract
Chambers, S., & Bryan, M. (2017). Antimicrobial use in veterinary and medical practice: A view from each ivory tower. Proceedings of the 3rd One Health Aotearoa Symposium. Retrieved from https://onehealth.org.nz
Harun, S., Chambers, S., Hooper, G., Frampton, C., Chapman, P., Mohammed, R., … Haslett, J., Nolan, I., & Stamp, L. (2017). Prosthetic joint infections in Canterbury, New Zealand: A comparison of individuals with and without a rheumatic disease. Internal Medicine Journal, 47(Suppl. 2), (pp. 21). doi: 10.1111/imj.13426
Conference Contribution - Verbal presentation and other Conference outputs
Chambers, S. (2017, August). Better stewardship of antibiotics. Plenary presentation at the 8th South General Practice Conference & Medical Exhibition (GP CME), Christchurch, New Zealand.
2016
Journal - Research Article
Faatoese, A., Sikaleti, S., Priest, P., & Chambers, S. (2016). Knowledge and attitudes to leprosy of pacific people living in New Zealand. Leprosy Review, 87(3), 368-377.
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521
Isenman, H. L., Chambers, S. T., Pithie, A. D., MacDonald, S. L. S., Hegarty, J. M., Fenwick, J. L., Maze, M. J., Metcalf, S. C. L., & Murdoch, D. R. (2016). Legionnaires' disease caused by Legionella longbeachae: Clinical features and outcomes of 107 cases from an endemic area. Respirology, 21(7), 1292-1299. doi: 10.1111/resp.12808
Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9
Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z
Conference Contribution - Published proceedings: Abstract
Everts, R., Chambers, S., Begg, E., Elvy, J., Gardiner, S., Mayer, H., & Turnidge, J. (2016). Pilot study of flucloxacillin and probenecid twice daily versus flucloxacillin four times daily for acute bacterial skin infections. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2016). Taking flucloxacillin with food does not compromise effective plasma concentrations in healthy volunteers. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/
2015
Journal - Research Article
Kennedy, N., Chambers, S. T., Nolan, I., Gallagher, K., Werno, A., Browne, M., & Stamp, L. K. (2015). Native joint septic arthritis: Epidemiology, clinical features, and microbiological causes in a New Zealand population. Journal of Rheumatology, 42(12), 2392-2397. doi: 10.3899/jrheum.150434
Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007
Dobinson, H. C., Anderson, T. P., Chambers, S. T., Doogue, M. P., Seaward, L., & Werno, A. M. (2015). Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. Journal of Clinical Microbiology, 53(9), 2895-2899. doi: 10.1128/jcm.00760-15
Arnold, C. J., Johnson, M., Bayer, A. S., Bradley, S., Giannitsioti, E., Miró, J. M., … for the ICE Investigators, including Chambers, S., Raymond, N., & Murdoch, D. R. (2015). Candida infective endocarditis: An observational cohort study with a focus on therapy. Antimicrobial Agents & Chemotherapy, 59(4), 2365-2373. doi: 10.1128/AAC.04867-14
McEntyre, C. J., Lever, M., Chambers, S. T., George, P. M., Slow, S., Elmslie, J. L., Florkowski, C. M., Lunt, H., & Krebs, J. D. (2015). Variation of betaine, N,N-dimethylglycine, choline, glycerophosphorylcholine, taurine, and trimethylamine-N-oxide in the plasma and urine of overweight people with type 2 diabetes over a two-year period. Annals of Clinical Biochemistry, 52(3), 352-360. doi: 10.1177/0004563214545346
Journal - Research Other
Chambers, S. T. (2015). Leprosy in New Zealand. New Zealand Medical Journal, 128(1414). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Kennedy, N., Chambers, S., Nolan, I., Gallagher, K., Browne, M., & Stamp, L. (2015). Native joint septic arthritis in a New Zealand population. Internal Medicine Journal, 45(Suppl. 2), (pp. 19). doi: 10.1111/imj.12752
Bhatia, M., Badiei, A., Gaddam, R., Fraser, R., & Chambers, S. (2015). Inhibition of hydrogen sulfide synthesis by gene silencing protects mice against caerulein-induced acute pancreatitis. Pancreatology, 15(3, Suppl.), (pp. S2). doi: 10.1016/j.pan.2015.05.048
Conference Contribution - Verbal presentation and other Conference outputs
Begg, E., Gardiner, S., Drennan, P., Green, J., Isenman, H., Begg, R., Chambers, S., Zhang, M., & Everts, R. (2015, September). Is it bad to take flucloxacillin with food? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
Kennedy, N., Stamp, L., Chambers, S., Nolan, I., Werno, A., & Brown, M. (2015, September). Native joint septic arthritis: Epidemiology, clinical features and microbiological causes in a New Zealand population. Verbal presentation at the New Zealand Rheumatology Association Annual Scientific Meeting, Queenstown, New Zealand.
2014
Journal - Research Article
Slow, S., Florkowski, C. M., Chambers, S. T., Priest, P. C., Stewart, A. W., Jennings, L. C., … Murdoch, D. R. (2014). Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: Randomised controlled trial. BMJ, 349, g7260. doi: 10.1136/bmj.g7260
Blyth, C. C., Gilroy, N. M., Guy, S. D., Chambers, S. T., Cheong, E. Y., Gottlieb, T., … Thursky, K. A. (2014). Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014. Internal Medicine Journal, 44(12b), 1333-1349. doi: 10.1111/imj.12598
Lever, M., George, P. M., Slow, S., Bellamy, D., Young, J. M., Ho, M., … Elmslie, J. L., … Troughton, R. W., Frampton, C. M., Richards, A. M., & Chambers, S. T. (2014). Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: An observational study. PLoS ONE, 9(12), e114969. doi: 10.1371/journal.pone.0114969
Lever, M., McEntyre, C. J., George, P. M., Slow, S., Elmslie, J. L., Lunt, H., Chambers, S. T., Parry-Strong, A., & Krebs, J. D. (2014). Extreme urinary betaine losses in type 2 diabetes combined with bezafibrate treatment are associated with losses of dimethylglycine and choline but not with increased losses of other osmolytes. Cardiovascular Drugs & Therapy, 28, 459-468. doi: 10.1007/s10557-014-6542-9
Scragg, R., Slow, S., Stewart, A. W., Jennings, L. C., Chambers, S. T., Priest, P. C., Florkowski, C. M., … Murdoch, D. R. (2014). Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: A randomized controlled trial. Hypertension, 64, 725-730. doi: 10.1161/hypertensionaha.114.03466
Yew, H. S., Chambers, S. T., Roberts, S. A., Holland, D. J., Julian, K. A., Raymond, N. J., … Murdoch, D. R. (2014). Association between HACEK bacteraemia and endocarditis. Journal of Medical Microbiology, 63(Part 6), 892-895. doi: 10.1099/jmm.0.070060-0
Lever, M., McEntyre, C. J., George, P. M., Slow, S., Chambers, S. T., & Foucher, C. (2014). Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults. Journal of Clinical Lipidology, 8(4), 433-440. doi: 10.1016/j.jacl.2014.04.001
Walls, G., McBride, S., Raymond, N., Read, K., Coomarasamy, C., Morris, A. J., Chambers, S., … Murdoch, D. R. (2014). Infective endocarditis in New Zealand: Data from the International Collaboration on Endocarditis Prospective Cohort Study. New Zealand Medical Journal, 127(1391). Retrieved from http://www.nzma.org.nz/journal
Palmer, B. R., Slow, S., Ellis, K. L., Pilbrow, A. P., Skelton, L., Frampton, C. M., Palmer, S. C., Troughton, R. W., Yandle, T. G., … Whalley, G. A., … Lever, M., George, P. M., Chambers, S. T., … Richards, A. M., & Cameron, V. A. (2014). Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients. PLoS ONE, 9(3), e89029. doi: 10.1371/journal.pone.0089029
Slow, S., Priest, P. C., Chambers, S. T., Stewart, A. W., Jennings, L. C., Florkowski, C. M., … Murdoch, D. R. (2014). Effect of vitamin D3 supplementation on Staphylococcus aureus nasal carriage: A randomized, double-blind, placebo-controlled trial in healthy adults. Clinical Microbiology & Infection, 20(5), 453-458. doi: 10.1111/1469-0691.12350
Journal - Research Other
Murdoch, D. R., Podmore, R. G., Anderson, T. P., Barratt, K., Maze, M. J., French, K. E., … Chambers, S. T., & Werno, A. M. (2014). Reply to Boethel et al. Clinical Infectious Diseases, 59(10), 1506. doi: 10.1093/cid/ciu608
Gaddam, R. R., Chambers, S., & Bhatia, M. (2014). ACE and ACE2 in inflammation: A tale of two enzymes. Inflammation & Allergy Drug Targets, 13(4), 224-234. [Review].
Chambers, S. T. (2014). Leprosy in the South Pacific. New Zealand Medical Journal, 127(1394). Retrieved from http://www.nzma.org.nz/journal
Maze, M. J., Slow, S., Cumins, A.-M., Boon, K., Goulter, P., Podmore, R. G., … Pithie, A. D., Epton, M. J., Werno, A. M., Chambers, S. T., & Murdoch, D. R. (2014). Enhanced detection of Legionnaires' disease by PCR testing of induced sputum and throat swabs. European Respiratory Journal, 43(2), 644-646. doi: 10.1183/09031936.00191913
Conference Contribution - Poster Presentation (not in published proceedings)
Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Inhibition of hydrogen sulfide production through gene silencing attenuates inflammation in LPS-activated macrophages via NF-κB pathway. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S., & Bhatia, M. (2014, September). Alteration of metalloprotease enzymes of the renin-angiotensin system in acute pancreatitis in a mouse model. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
2013
Chapter in Book - Other
Chambers, S. (2013). Microbiology and Iinfectious Diseases. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 122-126). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Murdoch, D. R., Podmore, R. G., Anderson, T. P., Barratt, K., Maze, M. J., French, K. E., … Chambers, S. T., & Werno, A. M. (2013). Impact of routine systematic polymerase chain reaction testing on case finding for Legionnaires' disease: A pre-post comparison study. Clinical Infectious Diseases, 57(9), 1275-1281. doi: 10.1093/cid/cit504
Scott-Thomas, A., Epton, M., & Chambers, S. (2013). Validating a breath collection and analysis system for the new tuberculosis breath test. Journal of Breath Research, 7(3), 037108. doi: 10.1088/1752-7155/7/3/037108
Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal
Chambers, S. T., Murdoch, D., Morris, A., Holland, D., Pappas, P., Almela, M., … Raymond, N., … and the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2013). HACEK infective endocarditis: Characteristics and outcomes from a large, multi-national cohort. PLoS ONE, 8(5), e63181. doi: 10.1371/journal.pone.0063181
Chang, C. L., Mills, G. D., Karalus, N. C., Jennings, L. C., Laing, R., Murdoch, D. R., Chambers, S. T., … Hancox, R. J. (2013). Biomarkers of cardiac dysfunction and mortality from community-acquired pneumonia in adults. PLoS ONE, 8(5), e62612. doi: 10.1371/journal.pone.0062612
Maze, M. J., Skea, S., Pithie, A., Metcalf, S., Pearson, J. F., & Chambers, S. T. (2013). Prevalence of concurrent deep vein thrombosis in patients with lower limb cellulitis: A prospective cohort study. BMC Infectious Diseases, 13, 141. doi: 10.1186/1471-2334-13-141
Dummer, J., Storer, M., Sturney, S., Scott-Thomas, A., Chambers, S., Swanney, M., & Epton, M. (2013). Quantification of hydrogen cyanide (HCN) in breath using selected ion flow tube mass spectrometry: HCN is not a biomarker of Pseudomonas in chronic suppurative lung disease. Journal of Breath Research, 7(1), 017105. doi: 10.1088/1752-7155/7/1/017105
Scott-Thomas, A., Syhre, M., Epton, M., Murdoch, D. R., & Chambers, S. T. (2013). Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test. Tuberculosis, 93(3), 312-317. doi: 10.1016/j.tube.2013.01.005
Maze, M. J., Laws, P., Buckenham, T., Pithie, A., Gallagher, K., Metcalf, S., Roake, J., & Chambers, S. T. (2013). Outcomes of infected abdominal aortic grafts managed with antimicrobial therapy and graft retention in an unselected cohort. European Journal of Vascular & Endovascular Surgery, 45(4), 373-380. doi: 10.1016/j.ejvs.2013.01.019
Chirouze, C., Athan, E., Alla, F., Chu, V. H., Corey, G. R., Selton-Suty, C., … on behalf of the International Collaboration on Endocarditis Study Group, including Chambers, S., & Murdoch, D. R. (2013). Enterococcal endocarditis in the beginning of the 21st century: Analysis from the International Collaboration on Endocarditis-Prospective Cohort Study. Clinical Microbiology & Infection, 19(12), 1140-1147. doi: 10.1111/1469-0691.12166
Conference Contribution - Published proceedings: Abstract
Chambers, S. (2013). New diagnostics for paediatric lung infections. Proceedings of the George Abbott Symposium. Retrieved from http://www.otago.ac.nz/george-abbott
Conference Contribution - Verbal presentation and other Conference outputs
Begg, E. J., Chambers, S. T., Zhang, M., & Everts, R. J. (2013, August). Pharmacokinetics of oral flucloxacillin alone without food, with probenecid without food, and with probenecid with food. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2012
Journal - Research Article
Lever, M., Slow, S., McGregor, D. O., Dellow, W. J., George, P. M., & Chambers, S. T. (2012). Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses. Cardiovascular Diabetology, 11, 34. doi: 10.1186/1475-2840-11-34
Lever, M., Storer, M. K., Lewis, J. G., George, P. M., & Chambers, S. T. (2012). Plasma betaine concentrations correlate with plasma cortisol but not with C-reactive protein in an elderly population. Clinical Chemistry & Laboratory Medicine, 50(9), 1635-1640. doi: 10.1515/cclm-2011-0844
Murdoch, D. R., Slow, S., Chambers, S. T., Jennings, L. C., Stewart, A. W., Priest, P. C., Florkowski, C. M., … Scragg, R. (2012). Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: The vidaris randomized controlled trial. JAMA, 308(13), 1333-1339. doi: 10.1001/jama.2012.12505
Lever, M., George, P. M., Elmslie, J. L., Atkinson, W., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). Betaine and secondary events in an acute coronary syndrome cohort. PLoS ONE, 7(5), e37883. doi: 10.1371/journal.pone.0037883
Lever, M., George, P. M., Atkinson, W., Elmslie, J. L., Slow, S., Molyneux, S. L., Troughton, R. W., Richards, A. M., Frampton, C. M., & Chambers, S. T. (2012). The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments. PLoS ONE, 7(3), e32460. doi: 10.1371/journal.pone.0032460
Cornelius, A. J., Chambers, S. T., Aitken, J., Brandt, S. M., Horn, B., & On, S. L. W. (2012). Epsilonproteobacteria in humans: New Zealand. Emerging Infectious Diseases, 18(3), 510-512. doi: 10.3201/eid1803.110875
Chambers, S. T., Scott-Thomas, A., & Epton, M. (2012). Developments in novel breath tests for bacterial and fungal pulmonary infection. Current Opinion in Pulmonary Medicine, 18(3), 228-232. doi: 10.1097/MCP.0b013e328351f98b
Mangin, D., Murdoch, D., Wells, J. E., Coughlan, E., Bagshaw, S., Corwin, P., Chambers, S., & Toop, L. (2012). Chlamydia trachomatis testing sensitivity in midstream compared with first-void urine specimens. Annals of Family Medicine, 10(1), 50-53. doi: 10.1370/afm.1323
Lever, M., Slow, S., George, P. M., & Chambers, S. T. (2012). Betaine excretion correlates with plasma homocysteine when plasma lipids are elevated. Clinical Biochemistry, 45(1-2), 154-156. doi: 10.1016/j.clinbiochem.2011.10.021
Conference Contribution - Published proceedings: Abstract
Chambers, S. T. (2012). Leprosy in the Pacific: Elimination, eradication or laissez faire? Proceedings of the 5th Annual Otago International Health Research Network (OIHRN) Conference. Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/programme.html
Scott-Thomas, A., Syhre, M., Epton, M., Murdoch, D. R., & Chambers, S. T. (2012). Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test. Proceedings of the 5th Annual Otago International Health Research Network (OIHRN) Conference. Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/programme.html
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M., Bayer, S., Moran, S., Maghzal, G., Stocker, R., Choe, C. F., Lunt, H., Chambers, S., Peskin, A., & Winterbourn, C. (2012, November). Peroxiredoxins as biomarkers of oxidative stress. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.
2011
Journal - Research Article
Bhandari, S., Chambers, S., Pearson, J., Syhre, M., Epton, M., & Scott-Thomas, A. (2011). Determining the limits and confounders for the 2-pentyl furan breath test by gas chromatography/mass spectrometry. Journal of Chromatography B, 879(26), 2815-2820. doi: 10.1016/j.jchromb.2011.08.010
Lever, M., George, P. M., Atkinson, W., Molyneux, S. L., Elmslie, J. L., Slow, S., Richards, A. M., & Chambers, S. T. (2011). Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS ONE, 6(7), e21666. doi: 10.1371/journal.pone.0021666
Scott-Thomas, A., Pearson, J., & Chambers, S. (2011). Potential sources of 2-aminoacetophenone to confound the Pseudomonas aeruginosa breath test, including analysis of a food challenge study. Journal of Breath Research, 5(4), 046002. doi: 10.1088/1752-7155/5/4/046002
Love, R. L., Allison, R., & Chambers, S. T. (2011). Peritonsillar infection in Christchurch 2006-2008: Epidemiology and microbiology. New Zealand Medical Journal, 124(1337). Retrieved from http://journal.nzma.org.nz/journal/124-1337/4732/content.pdf
Dummer, J., Storer, M., Swanney, M., McEwan, M., Scott-Thomas, A., Bhandari, S., Chambers, S., … Epton, M. (2011). Analysis of biogenic volatile organic compounds in human health and disease. Trends in Analytical Chemistry, 30(7), 960-967. doi: 10.1016/j.trac.2011.03.011
Maze, M. J., Pithie, A., Dawes, T., & Chambers, S. T. (2011). An audit of venous duplex ultrasonography in patients with lower limb cellulitis. New Zealand Medical Journal, 124(1329). Retrieved from http://journal.nzma.org.nz/journal/124-1329/4538/content.pdf
Chambers, S. T., Bhandari, S., Scott-Thomas, A., & Syhre, M. (2011). Novel diagnostics: Progress toward a breath test for invasive Aspergillus fumigatus. Medical Mycology, 49(Suppl. 1), S54-S61. doi: 10.3109/13693786.2010.508187
Journal - Research Other
Chambers, S. T., & Dickson, N. (2011). Global polio eradication: Progress, but determination and vigilance still needed [Viewpoint]. New Zealand Medical Journal, 124(1337). Retrieved from http://journal.nzma.org.nz/journal/124-1337/4742/content.pdf
Journal - Professional & Other Non-Research Articles
Chambers, S. T. (2011). [Review of the book Control of the Leishmaniases: Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases. WHO Technical Report Series, No. 949]. New Zealand Medical Journal, 124(1339). Retrieved from http://journal.nzma.org.nz/journal/124-1339/4804/content.pdf
Conference Contribution - Published proceedings: Abstract
Locker, J., Hooper, G., & Chambers, S. (2011). What is the best treatment for infected arthroplasty: Debridement versus 2 stage revision? Proceedings of the New Zealand Orthopaedic Association (NZOA) and Australian Orthopaedic Association (AOA) Combined Annual Scientific Meeting: Orthopaedic Education: The E-future. Retrieved from http://www.aoanzoa2011.co.nz/
Conference Contribution - Verbal presentation and other Conference outputs
Palmer, B. R., Ellis, K. L., Pilbrow, A. P., Slow, S., Lever, M., Palmer, S. C., Skelton, L., Frampton, C. M., Troughton, R. W., Yandle, T. G., … Chambers, S. T., George, P. M., Richards, A. M., & Cameron, V. A. (2011, September). Folate pathway genetics, homocysteine and survival in coronary heart patients. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2010
Journal - Research Article
The International HIV Controllers Study, including Chambers, S. T. (2010). The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science, 330(6010), 1551-1557. doi: 10.1126/science.1195271
Scott-Thomas, A. J., Syhre, M., Pattemore, P. K., Epton, M., Laing, R., Pearson, J., & Chambers, S. T. (2010). 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulmonary Medicine, 10, 56. doi: 10.1186/1471-2466-10-56
Lever, M., George, P. M., Slow, S., Elmslie, J. L., Shand, B. I., Scott, R. S., & Chambers, S. T. (2010). Fibrates plus betaine: A winning combination? [Viewpoint]. New Zealand Medical Journal, 123(1324). Retrieved from http://journal.nzma.org.nz/journal/123-1324/4389/content.pdf
Huggan, P. J., Wells, J. E., Browne, M., Richardson, A., Murdoch, D. R., & Chambers, S. T. (2010). Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Internal Medicine Journal, 40(2), 117-125. doi: 10.1111/j.1445-5994.2009.01910.x
Conference Contribution - Poster Presentation (not in published proceedings)
Bhandari, S., Charles, C. J., Miller, A. P., Scott-Thomas, A., Syhre, M., & Chambers, S. T. (2010, September). Cyclophosphamide pulmonary toxicity limiting sheep model of immunosuppression. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.
2009
Journal - Research Article
Amodeo, M. R., Clulow, T., Lainchbury, J., Murdoch, D. R., Gallagher, K., Dyer, A., Metcalf, S. C. L., Pithie, A. D., & Chambers, S. T. (2009). Outpatient intravenous treatment for infective endocarditis: Safety, effectiveness and one-year outcomes. Journal of Infection, 59(6), 387-393. doi: 10.1016/j.jinf.2009.09.009
Lever, M., George, P. M., Slow, S., Elmslie, J. L., Scott, R. S., Richards, A. M., Fink, J. N., & Chambers, S. T. (2009). Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovascular Drugs & Therapy, 23(5), 395-401. doi: 10.1007/s10557-009-6188-1
Dalton, S. C., & Chambers, S. T. (2009). Cutaneous myiasis due to Dermatobia hominis (the human botfly) in a New Zealand traveller returned from South America [Clinical correspondence]. New Zealand Medical Journal, 122(1302). Retrieved from http://journal.nzma.org.nz/journal/122-1302/3778/content.pdf
Atkinson, W., Slow, S., Elmslie, J., Lever, M., Chambers, S. T., & George, P. M. (2009). Dietary and supplementary betaine: Effects on betaine and homocysteine concentrations in males. Nutrition, Metabolism & Cardiovascular Diseases, 19(11), 767-776. doi: 10.1016/j.numecd.2009.01.004
Slow, S., Lever, M., Chambers, S. T., & George, P. M. (2009). Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiological Research, 58(3), 403-410.
Murdoch, D. R., Corey, G. R., Hoen, B., Miró, J. M., Fowler, Jr, V. G., Bayer, A. S., … Chambers, S. T., … Raymond, N. J., … for the International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators. (2009). Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The International Collaboration on Endocarditis-Prospective Cohort Study. Archives of Internal Medicine, 169(5), 463-473.
Lever, M., Atkinson, W., Slow, S., Chambers, S. T., & George, P. M. (2009). Plasma and urine betaine and dimethylglycine variation in healthy young male subjects. Clinical Biochemistry, 42(7-8), 706-712. doi: 10.1016/j.clinbiochem.2009.02.001
Khashram, M., Huggan, P., Ikram, R., Chambers, S., Roake, J. A., & Lewis, D. R. (2009). Effect of TNP on the microbiology of venous leg ulcers: A pilot study. Journal of Wound Care, 18(4), 164-167.
Syhre, M., Manning, L., Phuanukoonnon, S., Harino, P., & Chambers, S. T. (2009). The scent of Mycobacterium tuberculosis: Part II breath. Tuberculosis, 89, 263-266. doi: 10.1016/j.tube.2009.04.003
Wong, J. S. J., Anderson, T. P., Chambers, S. T., On, S. L. W., & Murdoch, D. R. (2009). Campylobacter fetus-associated epidural abscess and bacteremia. Journal of Clinical Microbiology, 47(3), 857-858. doi: 10.1128/JCM.00725-08
Chambers, S. T., Syhre, M., Murdoch, D. R., McCartin, F. J., & Epton, M. J. (2009). Detection of 2-Pentylfuran in the breath of patients with Aspergillus fumigatus. Medical Mycology, 47(5), 468-476. doi: 10.1080/13693780802475212
Journal - Research Other
Murdoch, D. R., & Chambers, S. T. (2009). Atypical pneumonia: Time to breathe new life into a useful term? Lancet Infectious Diseases, 9(8), 512-519. doi: 10.1016/S1473-3099(09)70148-3
Conference Contribution - Published proceedings: Abstract
Chambers, S., Syhre, M., & Manning, L. (2009). The scent of Mycobacterium tuberculosis: Part II. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Chambers, S. T., Syhre, M., Manning, L., & Harino, P. (2009, November). A breath test for tuberculosis. Verbal presentation at the 2nd Otago International Health Research Network Conference, Dunedin, New Zealand.
Film/Video/CD Rom
Fraser, R., Chambers, S., Fellows, A., Brennan, S., Vissers, M., Fu, R., & Scott-Thomas, A. (2009). The Body, the Research, the Professor: Respiratory Research and Cystic Fibrosis [Episode 5] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
2008
Journal - Research Article
Syhre, M., & Chambers, S. T. (2008). The scent of Mycobacterium tuberculosis. Tuberculosis, 88(4), 317-323.
Sanders, J., Pithie, A., Ganly, P., Surgenor, L., Wilson, R., Merriman, E., … Chambers, S. (2008). A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. Journal of Antimicrobial Chemotherapy, 62(4), 809-815. doi: 10.1093/jac/dkn284
Atkinson, W., Elmslie, J., Lever, M., Chambers, S. T., & George, P. M. (2008). Dietary and supplementary betaine: Acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. American Journal of Clinical Nutrition, 87(3), 577-585.
Jennings, L. C., Anderson, T. P., Beynon, K. A., Chua, A., Laing, R. T. R., Werno, A. M., … Chambers, S. T., & Murdoch, D. R. (2008). Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax, 63(1), 42-48. doi: 10.1136/thx.2006.075077
Huggan, P. J., Murdoch, D. R., Gallagher, K., & Chambers, S. T. (2008). Concomitant Staphylococcus aureus bacteriuria is associated with poor clinical outcome in adults with S. aureus bacteraemia. Journal of Hospital Infection, 69(4), 345-349. doi: 10.1016/j.jhin.2008.04.027
Syhre, M., Scotter, J. M., & Chambers, S. T. (2008). Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Medical Mycology, 46(3), 209-215. doi: 10.1080/13693780701753800
2007
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Cameron, C., Jeffery, M., … Pithie, A., … Sainsbury, R. (2007). Management guidelines for common medical conditions (12th ed.). Christchurch, New Zealand: Canterbury District Health Board, 288p.
Journal - Research Article
Vella-Brincat, J. W. A., Begg, E. J., Kirkpatrick, C. M. J., Zhang, M., Chambers, S. T., & Gallagher, K. (2007). Protein binding of cefazolin is saturable in vivo both between and within patients. British Journal of Clinical Pharmacology, 63(6), 753-757.
Chambers, S. T., Pithie, A., Gallagher, K., Liu, T., Charles, C. J., & Seaward, L. (2007). Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: Efficacy in a sheep model. Journal of Antimicrobial Chemotherapy, 59, 779-782.
Slow, S., Vasudevamurthy, M., Fraser, R., McEntyre, C., Lever, M., Chambers, S., & George, P. (2007). Dimethylthetin treatment causes diffuse alveolar lung damage: A pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). Experimental & Toxicologic Pathology, 58, 285-290.
Atkinson, W., Downer, P., Lever, M., Chambers, S. T., & George, P. M. (2007). Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects. European Journal of Nutrition, 46, 446-452. doi: 10.1007/s00394-007-0684-5
Lever, M., Atkinson, W., George, P. M., & Chambers, S. T. (2007). Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Clinical Biochemistry, 40, 1225-1231.
Lever, M., Atkinson, W., Sizeland, P. C. B., Chambers, S. T., & George, P. M. (2007). Inter- and intra-individual variations in normal urinary glycine betaine excretion. Clinical Biochemistry, 40, 447-453.
Lever, M., Atkinson, W., George, P. M., & Chambers, S. T. (2007). An abnormal urinary excretion of glycine betaine may persist for years. Clinical Biochemistry, 40, 798-801.
Conference Contribution - Published proceedings: Abstract
Elmslie, J., Atkinson, W., Slow, S., Lever, M., George, P., & Chambers, S. (2007). Development of a high betaine diet for use in studies of glycine betaine homeostasis. Nutrition & Dietetics. 64(Suppl. 3), (pp. S81-S82). doi: 10.1111/j.1747-0080.2007.00216.x
Conference Contribution - Verbal presentation and other Conference outputs
Sanders, J., Pithie, A., Ganly, P., Wilson, R., Merriman, E., Loudon, G., … Chambers, S. (2007, May). A prospective double blind randomised trial comparing intraluminal ethanol with heparinised saline for the prevention of catheter related bacteraemia in immunosuppressed haematology patients. Verbal presentation at the Haematology Society of Australia and New Zealand and New Zealand Flow Cytometry Group Annual New Zealand Branch Meeting, Christchurch, New Zealand.
2006
Authored Book - Research
Ministry of Health, including Chambers, S., Jennings, L., & Tatley, M. (2006). Immunisation Handbook 2006. Wellington, New Zealand: Ministry of Health, 455p.
Journal - Research Article
Vella-Brincat, J., Begg, E., Zhang, M., & Chambers, S. (2006). Cooling enhances benzylpenicillin stability during continuous home intravenous administration. Hospital Pharmacist, 13, 56-57.
Morpeth, S. C., Chambers, S. T., Gallagher, K., Frampton, C., & Pithie, A. D. (2006). Lower limb cellulitis: Features associated with length of hospital stay. Journal of Infection, 52, 23-29.
Chambers, S., Laing, R., Murdoch, D., Frampton, C., Jennings, L., Karalus, N., … Town, I. (2006). Māori have a much higher incidence of community-acquired pneumonia and pneumococcal pneumonia than non-Māori: Findings from two New Zealand hospitals. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1978/content.pdf
Manning, L., Chambers, S., Paltridge, G., & Maurice, P. (2006). Cutaneous larva migrans (hookworm) acquired in Christchurch, New Zealand [Case report]. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1910/content.pdf
Chambers, S. T., Peddie, B., & Pithie, A. (2006). Ethanol disinfection of plastic-adherent micro-organisms. Journal of Hospital Infection, 63, 193-196.
Baker, M., Wilson, N., Ikram, R., Chambers, S., Shoemack, P., & Cook, G. (2006). Regulation of chicken contamination urgently needed to control New Zealand's serious campylobacteriosis epidemic. New Zealand Medical Journal, 119(1243). Retrieved from http://journal.nzma.org.nz/journal/119-1243/2264/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Atkinson, W., Elmslie, J., Lever, M., Chambers, S., & George, P. (2006, August). The bioavailability of dietary versus supplementary glycine betaine: Acute effects on normal and post-methionine load, plasma homocysteine concentrations in healthy individuals. Poster session presented at the Federation of American Societies for Experimental Biology Summer Research Conference, California, USA.
2005
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Doogue, M., Jeffery, M., … Pithie, A., … Sainsbury, R. (2005). Management guidelines for common medical conditions (11th ed.). Christchurch, NZ: Canterbury District Health Board, 271p.
Journal - Research Article
Scotter, J. M., Langford, V. S., Wilson, P. F., McEwan, M. J., & Chambers, S. T. (2005). Real-time detection of common microbial volatile organic compounds from medically important fungi by Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS). Journal of Microbiological Methods, 63, 127-134.
Corwin, P., Toop, L., McGeoch, G., Than, M., Wynn-Thomas, S., Wells, J. E., Dawson, R., … Pithie, A., Chambers, S., Fletcher, L., & Richards, D. (2005). Randomised controlled trial of intravenous antibiotic treatment for cellulitis at home compared with hospital. British Medical Journal, 330(7483). Retrieved from http://www.bmj.com/cgi/reprint/330/7483/129
Lever, M., George, P. M., Dellow, W. J., Scott, R. S., & Chambers, S. T. (2005). Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic. Metabolism, 54, 1-14.
Scotter, J. M., & Chambers, S. T. (2005). Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive Aspergillosis in a neutropenic rat model and effect of caspofungin acetate. Clinical & Diagnostic Laboratory Immunology, 12(11), 1322-1327.
Slow, S., Donaggio, M., Cressey, P. J., Lever, M., George, P. M., & Chambers, S. T. (2005). The betaine content of New Zealand foods and estimated intake in the New Zealand diet. Journal of Food Composition & Analysis, 18, 473-485.
Chambers, S. T., Sanders, J., Patton, W. N., Ganly, P., Birch, M., Crump, J. A., & Spearing, R. L. (2005). Reduction of exit-site infections of tunnelled intravascular catheters among neutropenic patients by sustained-release chlorhexidine dressings: Results from a prospective randomized controlled trial. Journal of Hospital Infection, 61, 53-61.
Chambers, S. T., Morpeth, S. C., & Laird, H. M. (2005). Campylobacter fetus prosthetic hip joint infection: Successful management with device retention and review. Journal of Infection, 50, 258-261.
Werno, A. M., Anderson, T. P., Chambers, S. T., Laird, H. M., & Murdoch, D. R. (2005). Recurrent breast abscess caused by Gordonia bronchialis in an immunocompetent patient. Journal of Clinical Microbiology, 43(6), 3009-3010.
Scotter, J. M., Campbell, P., Anderson, T. P., Murdoch, D. R., Chambers, S. T., & Patton, W. N. (2005). Comparison of PCR-ELISA and galactomannan detection for the diagnosis of invasive aspergillosis. Pathology, 37(3), 246-253.
Richards, D., Toop, L., Chambers, S., & Fletcher, L. (2005). Response to antibiotics of women with symptoms of urinary tract infection but negative dipstick urine test results: Double blind randomised controlled trial. British Medical Journal, 331(7509). Retrieved from http://bmj.bmjjournals.com/cgi/content/abstract/331/7509/143
Mangin, D., Toop, L., Chambers, S., Ikram, R., & Harris, B. (2005). Increased rates of trimethoprim resistance in uncomplicated urinary tract infection: Cause for concern? New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1726/content.pdf
Journal - Professional & Other Non-Research Articles
Chambers, S. T. (2005). Diagnosis and management of staphylococcal infections of pacemakers and cardiac defibrillators. Internal Medicine Journal, 35, S63-S71.
Chambers, S. T. (2005). Diagnosis and management of staphylococcal infections of vascular grafts and stents. Internal Medicine Journal, 35, S72-S78.
Roberts, S., & Chambers, S. (2005). Diagnosis and management of Staphylococcus aureus infections of the skin and soft tissue. Internal Medicine Journal, 35(Suppl. S2), S97-S105. doi: 10.1111/j.1444-0903.2005.00983.x
Conference Contribution - Verbal presentation and other Conference outputs
Vella-Brincat, J. W. A., Begg, E. J., & Chambers, S. T. (2005, August). Stability of cooled benzylpenicillin during continuous home intravenous administration. Verbal presentation at the Ascept New Zealand Scientific Meeting, Wellington, New Zealand.
2004
Edited Book - Other
Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.
Journal - Research Article
Lever, M., Sizeland, P. C. M., Frampton, C. M., & Chambers, S. T. (2004). Short and long-term variation of plasma glycine betaine concentrations in humans. Clinical Biochemistry, 37, 184-190.
Slow, S., Miller, W. E., McGregor, D. O., Lee, M. B., Lever, M., George, P. M., & Chambers, S. T. (2004). Trigonelline is not responsible for the acute increase in plasma homocysteine following ingestion of instant coffee. European Journal of Clinical Nutrition, 58, 1253-1256.
Slow, S., Lever, M., Lee, M. B., George, P. M., & Chambers, S. T. (2004). Betaine analogues alter homocysteine metabolism in rats. International Journal of Biochemistry & Cell Biology, 36, 870-880.
Slow, S., McGregor, D. O., Lever, M., Lee, M. B., George, P. M., & Chambers, S. T. (2004). Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients. Clinical Biochemistry, 37, 974-976. doi: 10.1016/j.clinbiochem.2004.07.005
Everts, R. J., Chambers, S. T., Murdoch, D. R., Rothwell, A. G., & McKie, J. (2004). Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints. ANZ Journal of Surgery, 74, 210-214.
Vella-Brincat, J. W. A., Begg, E. J., Gallagher, K., Kirkpatrick, C. M. J., Zhang, M., Frampton, C., & Chambers, S. T. (2004). Stability of benzylpenicillin during continuous home intravenous therapy. Journal of Antimicrobial Chemotherapy, 53(4), 675-677. British Society for Antimicrobial Chemotherapy.
Laing, R., Coles, C., Chambers, S. T., Frampton, C., Jennings, L., Karalus, N., … Town, G. I. (2004). Community-acquired pneumonia: Influence of management practices on length of hospital stay. Internal Medicine Journal, 34, 91-97.
Journal - Research Other
Chambers, S., Gallagher, K., & Pithie, A. (2004). Patient acceptability of home intravenous antibiotic therapy [Letter]. New Zealand Medical Journal, 117(1192). Retrieved from http://journal.nzma.org.nz/journal/117-1192/865/content.pdf
Metcalf, S. C. L., Chambers, S. T., & Pithie, A. D. (2004). Use of ethanol locks to prevent recurrent central line sepsis. Journal of Infection, 49(1), 20-22. doi: 10.1016/j.jinf.2003.08.010
Chambers, S., & Baker, M. (2004). Infectious diseases: Far from defeated [Editorial]. New Zealand Medical Journal, 117(1200). Retrieved from http://journal.nzma.org.nz/journal/117-1200/1013/content.pdf
Scotter, J. M., Stevens, J. M., Chambers, S. T., Lynn, K. L., & Patton, W. N. (2004). Diagnosis of aspergillus peritonitis in a renal dialysis patient by PCR and galactomannan detection. Journal of Clinical Pathology, 57, 662-664.
Journal - Professional & Other Non-Research Articles
Morpeth, S., Chambers, S., & Heckert, K. (2004). AIDS in New Zealand [Letter]. New Zealand Medical Journal, 117(1191). Retrieved from http://journal.nzma.org.nz/journal/117-1191/830/content.pdf
2003
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Begg, E. J., Chambers, S., Colls, B. M., Jeffery, G. M., … Pithie, A., … Sainsbury, R., & Young, C. (2003). Management guidelines for common medical conditions (10th ed.). Christchurch, NZ: Canterbury District Health Board, 299p.
Journal - Research Article
Evans, G. E., Murdoch, D. R., Anderson, T. P., Potter, H. C., George, P. M., & Chambers, S. (2003). Contamination of Qiagen DNA extraction kits with Legionella DNA [Letter to the editor]. Journal of Clinical Microbiology, 41(7), 3452-3453. doi: 10.1128/JCM.41.7.3452-3453.2003
de Zwart, F., Slow, S., Payne, R. J., Lever, M., George, P. M., Gerrard, J. A., & Chambers, S. (2003). Glycine betaine and glycine betaine analogues in common foods. Food Chemistry, 83, 197-204.
Murdoch, D. R., Anderson, T. P., Beynon, K. A., Chua, A., Fleming, A. M., La, R. T., Town, G. I., … Chambers, S., & Jennings, L. C. (2003). Evaluation of a PCR assay for detection of Streptococcus pneumoniae in respiratory and nonrespiratory samples from adults with community-acquired pneumonia. Journal of Clinical Microbiology, 41(1), 63-66.
Peddie, B. A., Wood, J. E., Lever, M., Happer, D. A., de Zwart, F., & Chambers, S. (2003). Assessment of antimicrobial activity of hydrophilic betaines in osmotically stressed bacteria. Antonie van Leeuwenhoek, 83(2), 175-181.
Conference Contribution - Poster Presentation (not in published proceedings)
Chambers, S., Sanders, J., Patton, W. N., Ganly, P. S., Birch, M., Crump, J., & Spearing, R. L. (2003). Reduction of intravascular catheter exit site infections among neutropenic patients by sustained release chlorhexidine dressings: Results from a prospective randomized controlled trial. Poster session presented at the Haematology Society of Australia and New Zealand Annual Scientific Meeting 2003, Christchurch, New Zealand.
Scotter, J. M., Patton, W. N., Campbell, P., Anderson, T. P., Murdoch, D. R., Jennings, L. C., Chambers, S., Ganly, P. S., & Spearing, R. L. (2003, October). Comparison of PCR v galactomannan for the diagnosis of invasive aspergillosis. Poster session presented at the Haematology Society of Australia and New Zealand Annual Scientific Meeting 2003, Christchurch.
2002
Journal - Research Article
Howard, G. W., Begg, E. J., Chambers, S. T., Vella-Brincat, J., Zhang, M., & Kirkpatrick, C. M. J. (2002). Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion. Journal of Antimicrobial Chemotherapy, 50, 429-432.
Chambers, S., Gallagher, K., Metcalf, S., & Pithie, A. (2002). Home intravenous antimicrobial service: Twelve months experience in Christchurch. New Zealand Medical Journal, 115(1153), 216-218.
Richards, D. A., Toop, L. J., Chambers, S., Sutherland, M. G., Harris, B., Ikram, R., … Peddie, B. A. (2002). Antibiotic resistance in uncomplicated urinary tract infection: Problems with interpreting cumulative resistance rates from local community laboratories. New Zealand Medical Journal, 115(1146), 12-14.
McGregor, D. O., Dellow, W., Robson, R. A., Lever, M., George, P. M., & Chambers, S. (2002). Betaine supplementation decreases postmethionine hyperhomocysteinemia in chronic renal failure. Kidney International, 61(3), 1040-1046.
Conference Contribution - Published proceedings: Abstract
de Zoysa, J. R., Chambers, S., Lynn, K., Robson, R. A., & Searle, M. (2002). Oral flucloxacillin for staphylococcus aureus infection in dialysis dependent patients. Abstracts from ANZSN 37th Annual Scientific Meeting 2001. 7(1), (pp. A13). Australia: Nephrology. [Abstract]
2001
Authored Book - Other
Beard, M. E. J., Thwaites, J. H., Begg, E. J., Chambers, S., Jeffery, G. M., King, S., Pithie, A., … Sainsbury, R., & Young, C. (2001). Management Guidelines for Common Medical Conditions (9th ed.). Christchurch: Canterbury District Health Board.
Journal - Research Article
Hill, P. C., Birch, M., Chambers, S., Drinkovic, D., Ellis-Pegler, R. B., Everts, R., Murdoch, D. R., … Morris, A. J. (2001). Prospective study of 424 cases of Staphylococcus aureus bacteraemia: Determination of factors affecting incidence and mortality. Internal Medicine Journal, 31(2), 97-103.
Chambers, S., Heckert, K. A., Bagshaw, S., Ussher, J., Birch, M., & Wilson, M. A. (2001). Maternity care providers' attitudes and practices concerning HIV testing during pregnancy: Results of a survey of the Canterbury and upper South Island region. New Zealand Medical Journal, 114(1144), 513-516.
Laing, R., Slater, W., Coles, C., Chambers, S., Frampton, C. M., Jackson, R., Jennings, L. C., … Murdoch, D. R., & Town, G. I. (2001). Community-acquired pneumonia in Christchurch and Waikato 1999-2000: Microbiology and epidemiology. New Zealand Medical Journal, 114, 488-492.
McGregor, D. O., Dellow, W. J., Lever, M., George, P. M., Robson, R. A., & Chambers, S. T. (2001). Dimethylglycine accumulates in uremia and predicts elevated plasman homocysteine concentrations. Kidney International, 59(6), 2267-2272.
Dellow, W. J., Chambers, S., Barrell, G. K., Lever, M., & Robson, R. A. (2001). Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia. Diabetes Research & Clinical Practice, Supplement(3), 165-169.
Ronald, A. R., Nicolle, L. E., Stamm, E., Krieger, J., Warren, J., Schaeffer, A., … Chambers, S., & Andriole, V. (2001). Urinary tract infection in adults: Research priorities and strategies. International Journal of Antimicrobial Agents, 17(4), 343-348.
Conference Contribution - Published proceedings: Abstract
Begg, E. J., Howard, G. W., Vella-Brincat, J., Zhang, M., Kirkpatrick, C. M. J., & Chambers, S. T. (2001). Free concentrations of cephazolin in plasma and tissue fluid during continuous intravenous infusion. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 9, (pp. 99). [Abstract]
2000
Authored Book - Other
Beard, M. E. J., Town, G. I., Ardagh, M. W., Begg, E. J., Chambers, S., Jeffery, G. M., & Laing, R. T. R. (2000). Management Guidelines for Common Medical Conditions (8th ed.). Christchurch, New Zealand: Internal Medicine Services, Canterbury Health, 284p.
Journal - Research Article
Robinson, C., Cole, D. M., & Chambers, S. (2000). An unusual case of recurrent septicaemia. Hospital Medicine, 61(11).
Murdoch, D. R., & Chambers, S. (2000). Detection of Legionella DNA in peripheral leukocytes, serum, and urine from a patient with pneumonia caused by Legionella dumoffii. Clinical Infectious Diseases, 30(2), 382-383.
Crump, J. A., Murdoch, D. R., Chambers, S. T., Aickin, D. R., & Hunter, L. A. (2000). Female genital schistosomiasis. Journal of Travel Medicine, 7(1), 30-32.
Chambers, S. (2000). Resistance to antimicrobial agents: can we make a difference? Adverse Drug Reactions & Toxicological Reviews, 19(3), 207-221.
Chambers, S. T., Teele, D., Aickin, D. R., & Grimwood, K. (2000). Preventing neonatal HIV infection. New Zealand Medical Journal, 113, 1-2.
Everts, R. J., Murdoch, D. R., Chambers, S. T., Town, G. I., Withington, S. G., Martin, I. R., Epton, M. J., Frampton, C. M., … Schousboe, M. (2000). Nosocomial pneumonia in adult general medical and surgical patients at Christchurch Hospital. New Zealand Medical Journal, 113, 221-224.
Conference Contribution - Published proceedings: Abstract
Laing, R., Coles, C., McWha, J., Karalus, N., Chambers, S., Jennings, L. C., … Town, G. I. (2000). Development of molecular diagnosis in community acquired pneumonia (CAP). Respirology, 5(Supplement), (pp. A11). Melbourne. [Abstract]
1999
Journal - Research Article
Chambers, S., Town, G. I., Neill, A., Frampton, C. M., & Murdoch, D. R. (1999). Legionella, chlamydia pneumoniae and mycoplasma infection in patients admitted to Christchurch Hospital with pneumonia. New Zealand Medical Journal, 112(1090), 222-224.
Peddie, B. A., Lever, M., Randall, K., & Chambers, S. (1999). Osmoprotective activity, urea protection, and accumulation of hydrophilic betaines in Escheria coli and Staphylococcus aureus. Antonie van Leeuwenhoek, 75(3), 183-189.
Murdoch, D. R., Light, G. J., Jennings, L. C., & Chambers, S. (1999). Sequence-based classification scheme for the genus legionella targeting the 5S rRNA gene. Journal of Clinical Microbiology, 37(1), 281.
Murdoch, D. R., Jennings, L. C., Light, G. J., & Chambers, S. (1999). Detection of Legionella DNA in guinea pig peripheral leukocytes, urine and plasma by the polymerase chain reaction. European Journal of Clinical Microbiology & Infectious Diseases, 18(6), 445-447.
Elliot, N., Crump, J., McGuire, A., Bagshaw, S., & Chambers, S. (1999). Knowledge, attitudes and behaviour towards HIV infection among family planning clinic attendees: changes between 1991 and 1997. New Zealand Medical Journal, 112(1085), 121-123.
Dellow, W. J., Chambers, S., Lever, M., Lunt, H., & Robson, R. A. (1999). Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Research & Clinical Practice, 43(2), 91-99.
Crump, J. A., McLay, C. L., & Chambers, S. (1999). Ciguatera fish poisoning. New Zealand Medical Journal, 112(1092), 282-283.
Chambers, S., Peddie, B. A., Randall, K., & Lever, M. (1999). Inhibitors of bacterial growth in urine: what is the role of betaines? International Journal of Antimicrobial Agents, 11(3-4), 293-296.
Journal - Professional & Other Non-Research Articles
Crump, J. A., Chambers, S., Acland, R. H., McKinney, M. R., Murdoch, D. R., & MacFarlane, M. R. (1999). Successful management of pain syndrome due to Angiostrongylus cantonensis by implantable spinal cord stimulator. Australian & New Zealand Journal of Medicine, 29(4), 565.
Patton, N., Chambers, S., & Chapman, B. A. (1999). Management of activated HBV infection following intensive chemotherapy. Annals of Oncology, 10(4), 484.
1998
Journal - Research Article
Clark, F. L., Drummond, M. W., Chambers, S., Chapman, B. A., & Patton, W. N. (1998). Successful treatment with lamivudine for fulminant reactivated hepatitis B infection following intensive therapy for high-grade non-Hodgkin's lymphoma. Annals of Oncology, 9(4), 385-387.
Withington, S., Chambers, S. T., Beard, M. E., Inder, A., Ikram, R. B., Schousboe, M. I., … Spearing, R. L., & Hart, D. N. J. (1998). Invasive aspergillosis in severely neutropenic patients over 18 years: Impact of intranasal amphotericin B and HEPA filtration. Journal of Hospital Infection, 38(1), 11-18.
Randall, K., Lever, M., Blunt, J. W. W., & Chambers, S. (1998). Counteraction of urea denaturation by glycine betaine and other kosmotropes. Journal of Biochemistry, Molecular Biology & Biophysics, 2, 51-58.
Randall, K., Lever, M., Happer, D. A. R., Peddie, B. A., & Chambers, S. (1998). Protective effects of homarine, trigonilline and isomeric pyridinium betaines. Journal of Biochemistry, Molecular Biology & Biophysics, 1, 205-212.
Peddie, B. A., Wong-She, A., Randall, K., Lever, M., & Chambers, S. (1998). Osmoprotective properties and accumulation of betaine analogues by Staphylococcus aureus. FEMS Microbiology Letters, 160, 25-30.
1997
Journal - Research Article
Town, G. I., Chambers, S., & Neill, A. (1997). The hospital management of community acquired pneumonia in adults. New Zealand Medical Journal, 110(1048), 263-265.
Withington, S. G., & Chambers, S. T. (1997). The cost of campylobacteriosis in New Zealand in 1995. New Zealand Medical Journal, 110(1046), 222-224.
Randall, K., Peddie, B. A. A., Lever, M., & Chambers, S. (1997). Accumulation of betaine analogues during osmotic stress and anaerobiosis. Letters in Applied Microbiology, 24(4), 316.
Meyer, R. J., Town, G. I., Harre, E., Koning, M. M., Hurrell, M., Beard, M. E., & Chambers, S. T. (1997). An audit of the assessment and management of adults admitted to Christchurch Hospital with community acquired pneumonia. New Zealand Medical Journal, 110(1052), 349-352.
Journal - Professional & Other Non-Research Articles
Chambers, S., & Murdoch, D. R. (1997). Which tests are useful in the diagnosis of pneumonia? Patient Management, 26(4), 15-17.
Lester, W. A., Schousboe, M., Chambers, S., & Patton, W. N. (1997). A second case of Corynebacterium pseudotuberculosis in New Zealand. New Zealand Medical Journal, 110(1057), 463-470.
Everts, R., Chambers, S., Paltridge, G., & Newhook, C. J. (1997). Microsporidiosis in New Zealand. New Zealand Medical Journal, March 14;(1039), 83.
1996
Authored Book - Other
Beard, M. E. J., Begg, E. J., Ardagh, M. W., Chambers, S. T., Fink, J. N., Lim, V., & Town, G. I. (1996). Management Guidelines for Common Medical Conditions. (6th ed.). Christchurch: Internal Medicine Services, Canterbury Health Ltd.
Journal - Research Article
Peddie, B. A. A., Phillips, A., & Chambers, S. (1996). The effect of betaine accumulation by Escherichia coli K-12 on aminoglycoside activity. Journal of Antimicrobial Chemotherapy, 37, 396-397.
Bailey, R. R., Begg, E. J., Smith, A. H., Robson, R. A., Lynn, K. L., Chambers, S., Barclay, M. L., & Hornibrook, J. (1996). Prospective, randomised, controlled study comparing two dosing regimens of gentamicin/oral ciprofloxacin switch therapy for acute pyelonephritis. Clinical Nephrology, 46, 183-186.
Barclay, M. L., Begg, E. J., Chambers, S., Thornley, P. E., Pattemore, P. K., & Grimwood, K. (1996). Adaptive resistance to tobramycin in Pseudomonas aeruginosa lung infection in cystic fibrosis. Journal of Antimicrobial Chemotherapy, 37, 1155-1164.
Randall, K., Lever, M., Peddie, B. A., & Chambers, S. T. (1996). Natural and synthetic betaines counter the effects of high NaCl and urea concentrations. Biochimica et Biophysica Acta: General Subjects, 1291(3), 189-194.
Chambers, S., & Lever, M. (1996). Betaines and urinary tract infections. Nephron, 74, 1-10.
Randall, K., Lever, M., Peddie, B. A. A., & Chambers, S. (1996). Accumulation of natural and syntheic betaines by a mammalian renal cell line. Biochemistry & Cell Biology, 74, 283-287.
O'Brien, G. J., Chambers, S., Peddie, B. A. A., & Mahanty, H. K. (1996). The association between colicinogenicity and pathogenesis among uropathogenic isolates of Escherichia coli. Microbial Pathogenesis, 20, 185-190.
Murdoch, D. R., Walford, E. J., Jennings, L. C., Light, G. J., Schousboe, M., Chereshsky, A. Y., Chambers, S., & Town, G. I. (1996). Use of polymerase chain reaction to detect legionella DNA in urine and serum samples from patients with pneumonia. Clinical Infectious Diseases, 23, 475-480.
Murdoch, D. R., Everts, R., Chambers, S., & Cowan, I. A. (1996). Vertebral osteomyelitis due to Staphylococcus lugdunensis. Journal of Clinical Microbiology, 34, 993-994.
McKenna, G., Lyttle, H., Withington, S., Stoker, M., Morton, A., Paltridge, G., Murdoch, D., & Chambers, S. (1996). Schistosomiasis at Christchurch Hospital 1989-94. Australian & New Zealand Journal of Medicine, 26, 226-227.
Burt, M. J., Ross, A. G., Schroeder, B. A., Chambers, S., & Chapman, B. A. (1996). Evaluation of alpha inferferon for the treatment of chronic hepatitis B infection in Christchurch. New Zealand Medical Journal, 109, 162-164.
Barclay, M. L., Begg, E. J., Chambers, S. T., & Peddie, B. A. (1996). The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas Aeruginosa in vitro. Journal of Antimicrobial Chemotherapy, 38(5), 853-858.
Neill, A. M., Martin, I. R., Weir, R., Anderson, R., Chereshsky, A. Y., Epton, M. J., … Schousboe, M., Frampton, C. M., … Chambers, S. T., & Town, G. I. (1996). Community acquired pneumonia: aetiology and usefulness of severity criteria on admission. Thorax, 51(10), 1010-1016.
1995
Journal - Research Article
Sizeland, P. C. B., Chambers, S. T., Lever, M., Bason, L. M., & Robson, R. A. (1995). Short term response of nonurea organic osmolytes in human kidney to a water load and water deprivation. American Journal of Physiology: Renal Physiology, 268, F227-F233.