Antimicrobial Pharmacist
BPharm(Hons), MClinPharm, PhDEmail sharon.gardiner@cdhb.health.nz
Sharon Gardiner is the antimicrobial pharmacist for CDHB, in a joint position between the departments of Clinical Pharmacology, Infectious Diseases and Pharmacy.
Her research interests include drug safety in breastfeeding, antibiotic dosing regimens and pharmacogenetics.
Publications
Pairman, L., Chin, P., Gardiner, S. J., & Doogue, M. (2024). Compulsory indications in hospital prescribing software tested with antibacterial prescriptions. AMIA Summits on Translational Science Proceedings, 2024, (pp. 632-641). [Full Paper] Conference Contribution - Published proceedings: Full paper
Harwood, A., Pearson, S., Howard, J., Jones, N., Greenlees, R., Broms, C., Gardiner, S. J., & Dalton, S. C. (2024). Pre-hospital, pre-antibiotic blood cultures for patients with suspected sepsis: A feasibility study [Research letter]. New Zealand Medical Journal/Te ara tika o te hauora hapori, 137(1592), 108-112. Retrieved from https://www.nzmj.org.nz/ Journal - Research Other
Hagedoorn, N. N., Al-Busaidi, I., Bridgford, P., Gardiner, S. J., Walls, T., & Hudson, B. (2023). Longitudinal trends in community antibiotic consumption in the Waitaha Canterbury Region of Aotearoa New Zealand over 10 years (2012-2021): An observational study. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1571), 49-64. Retrieved from https://journal.nzma.org.nz/ Journal - Research Article
Morahan, M.-C., Campbell, V., Selagan, N., Houghton, K., Gardiner, S., & Chin, P. (2022). Vanquish the vancomycin trough: The AUC strikes back. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 543. Retrieved from https://www.asceptasm.com Conference Contribution - Published proceedings: Abstract
Pairman, L., Chin, P., Gardiner, S., & Doogue, M. (2022, August-September). The effect of mandatory prescription indications for antibacterials. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
2024
Journal - Research Other
Harwood, A., Pearson, S., Howard, J., Jones, N., Greenlees, R., Broms, C., Gardiner, S. J., & Dalton, S. C. (2024). Pre-hospital, pre-antibiotic blood cultures for patients with suspected sepsis: A feasibility study [Research letter]. New Zealand Medical Journal/Te ara tika o te hauora hapori, 137(1592), 108-112. Retrieved from https://www.nzmj.org.nz/
Conference Contribution - Published proceedings: Full paper
Pairman, L., Chin, P., Gardiner, S. J., & Doogue, M. (2024). Compulsory indications in hospital prescribing software tested with antibacterial prescriptions. AMIA Summits on Translational Science Proceedings, 2024, (pp. 632-641). [Full Paper]
2023
Journal - Research Article
Hagedoorn, N. N., Al-Busaidi, I., Bridgford, P., Gardiner, S. J., Walls, T., & Hudson, B. (2023). Longitudinal trends in community antibiotic consumption in the Waitaha Canterbury Region of Aotearoa New Zealand over 10 years (2012-2021): An observational study. New Zealand Medical Journal/Te ara tika o te hauora hapori, 136(1571), 49-64. Retrieved from https://journal.nzma.org.nz/
2022
Conference Contribution - Published proceedings: Abstract
Morahan, M.-C., Campbell, V., Selagan, N., Houghton, K., Gardiner, S., & Chin, P. (2022). Vanquish the vancomycin trough: The AUC strikes back. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 543. Retrieved from https://www.asceptasm.com
Conference Contribution - Verbal presentation and other Conference outputs
Pairman, L., Chin, P., Gardiner, S., & Doogue, M. (2022, August-September). The effect of mandatory prescription indications for antibacterials. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
2021
Journal - Research Article
Everts, R. J., Gardiner, S. J., Zhang, M., Begg, R., Chambers, S. T., Turnidge, J., & Begg, E. J. (2021). Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 83, 182-189. doi: 10.1016/j.jinf.2021.05.037
Drennan, P. G., Green, J. K., Gardiner, S. J., Metcalf, S. C. L., Kirkpatrick, C. M. J., Everts, R. J., Zhang, M., & Chambers, S. T. (2021). Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid. British Journal of Clinical Pharmacology, 87, 4684-4693. doi: 10.1111/bcp.14887
Journal - Research Other
Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal
Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972
Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal
Everts, R. J., Begg, R., Gardiner, S. J., Zhang, M., Turnidge, J., Chambers, S. T., & Begg, E. J. (2020). Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. Journal of Infection, 80, 42-53. doi: 10.1016/j.jinf.2019.09.004
Conference Contribution - Verbal presentation and other Conference outputs
Gardiner, S. J. (2020, December). Antimicrobial stewardship in Canterbury and beyond [Invited]. Verbal presentation at the 6th One Health Aotearoa (OHA) Symposium, [Online].
2019
Journal - Research Other
Drennan, P. G., Begg, E. J., Gardiner, S. J., Kirkpatrick, C. M. J., & Chambers, S. T. (2019). The dosing and monitoring of vancomycin: What is the best way forward? International Journal of Antimicrobial Agents, 53, 401-407. doi: 10.1016/j.ijantimicag.2018.12.014
Conference Contribution - Published proceedings: Abstract
Drennan, P., Green, J., Gardiner, S., Metcalf, S., Kirkpatrick, C., Zhang, M., & Chambers, S. (2019). Clinical outcomes and pharmacokinetic-pharmacodynamic target attainment in patients treated with oral flucloxacillin plus probenecid for staphylococcal infections. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 22). Retrieved from https://www.asceptasm.com
2018
Journal - Research Article
Green, J. K., Gardiner, S. J., Clarke, S. L., Thompson, L., Metcalf, S. C. L., & Chambers, S. T. (2018). Antimicrobial stewardship practice in New Zealand's rural hospitals. New Zealand Medical Journal, 131(1481), 16-26. Retrieved from https://www.nzma.org.nz/journal
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2018). In healthy volunteers, taking flucloxacillin with food does not compromise effective plasma concentrations in most circumstances. PLoS ONE, 13(7), e0199370. doi: 10.1371/journal.pone.0199370
Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673
Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal
2017
Journal - Research Article
Gardiner, S. J., Pryer, J. A., & Duffy, E. J. (2017). Survey of antimicrobial stewardship practices in public hospitals in New Zealand district health boards. New Zealand Medical Journal, 130(1458), 27-41. Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Hamilton, N., Chuah, Q., Chin, P., & Gardiner, S. (2017). Real-time review of electronic prescribing of restricted antimicrobials: A pilot of a new antimicrobial stewardship initiative for Christchurch Hospital. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 79). Retrieved from http://www.asceptasm.com/
Chuah, Q., Chin, P., Hamilton, N., Gardiner, S., Strother, M., Dalton, S., Metcalf, S., & Doogue, M. (2017). Using electronic prescribing data to direct antimicrobial stewardship. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 107). Retrieved from http://www.hinz.org.nz/
2016
Conference Contribution - Published proceedings: Abstract
Everts, R., Chambers, S., Begg, E., Elvy, J., Gardiner, S., Mayer, H., & Turnidge, J. (2016). Pilot study of flucloxacillin and probenecid twice daily versus flucloxacillin four times daily for acute bacterial skin infections. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/
Gardiner, S. J., Drennan, P. G., Begg, R., Zhang, M., Green, J. K., Isenman, H. L., Everts, R. J., Chambers, S. T., & Begg, E. J. (2016). Taking flucloxacillin with food does not compromise effective plasma concentrations in healthy volunteers. Proceedings of the Australasian Society for Infectious Diseases New Zealand Branch Annual Scientific Meeting. Retrieved from https://www.asid.net.au/
Ghoreishi, N., Graham, T., Gardiner, S., & Walls, T. (2016). Antimicrobial use in children at a tertiary teaching hospital in New Zealand. International Journal of Infectious Diseases, 45(Suppl. 1), (pp. 120-121). doi: 10.1016/j.ijid.2016.02.302
2015
Chapter in Book - Research
Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1
Conference Contribution - Verbal presentation and other Conference outputs
Begg, E., Gardiner, S., Drennan, P., Green, J., Isenman, H., Begg, R., Chambers, S., Zhang, M., & Everts, R. (2015, September). Is it bad to take flucloxacillin with food? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2011
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., Ross, A. G., Stedman, C. A. M., … Barclay, M. L. (2011). Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology & Hepatology, 26(1), 49-54. doi: 10.1111/j.1440-1746.2010.06489.x
2010
Chapter in Book - Research
Begg, E. J., Gardiner, S. J., & Kirkpatrick, C. M. J. (2010). Lactation and contamination of breast milk with xenobiotics. In C. A. McQueen (Ed.), Comprehensive toxicology. (2nd ed.) (pp. 445-455). Oxford, UK: Elsevier.
2009
Journal - Research Article
Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9
2008
Journal - Research Article
Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032
Gardiner, S. J., Gearry, R. B., Burt, M. J., Ding, S. L., & Barclay, M. L. (2008). Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. European Journal of Gastroenterology & Hepatology, 20(12), 1238-1242. doi: 10.1097/MEG.0b013e3282ffda37
Jensen, B. P., Sharp, C. F., Gardiner, S. J., & Begg, E. J. (2008). Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B, 865(1-2), 48-54. doi: 10.1016/j.jchromb.2008.02.006
Journal - Research Other
Gardiner, S. J., Kirkpatrick, C. M. J., Zhang, M., & Begg, E. J. (2008). Cimetidine does not appear to influence the distribution of metformin into human milk [Letter to the editor]. British Journal of Clinical Pharmacology, 66(4), 564-565. doi: 10.1111/j.1365-2125.2008.03190.x
Conference Contribution - Published proceedings: Abstract
Barclay, M. L., Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., … Stedman, C. A. M. (2008). Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio. Journal of Gastroenterology and Hepatology. 23(Suppl. 4), (pp. A194). [Abstract]
Barclay, M. L., Gardiner, S. J., Gearry, R. B., Burt, M. J., Chalmers-Watson, T., Chapman, B. A., … Stedman, C. A. M. (2008). Allopurinol may improve response to azathioprine and 6-mercaptopurine by correcting an unfavourable metabolite ratio. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
2007
Chapter in Book - Other
Gardiner, S. J., & Woods, D. J. (2007). Drugs in pregnancy and lactation. In R. Walker & C. Whittlesea (Eds.), Clinical pharmacy and therapeutics. (4th ed.) (pp. 681-690). Edinburgh, Scotland: Churchill Livingstone.
Journal - Research Other
Gardiner, S. J., Begg, E. J., Sau, A., Marinaki, A., Gearry, R. B., & Barclay, M. L. (2007). Thiopurine treatment in inflammatory bowel disease [Letter to the editor]. Clinical Pharmacokinetics, 46(9), 803-804.
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Breast-feeding during maternal use of azathioprine [Comment]. Annals of Pharmacotherapy, 41(4), 719-720.
Conference Contribution - Published proceedings: Abstract
Jensen, B. P., Sharp, C. F., Gardiner, S. J., Begg, E. J., Lainchbury, J. G., & Troughton, R. W. (2007). Stereoselective LC-MS assay of S- and R-metoprolol in plasma for correlation with CYP2D6 genotype in patients with systolic heart failure. In C. G. Sobey & S. Smid (Eds.), Proceedings of the 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists Combined Conference. Victoria, Australia: ASCEPT. [Abstract]
Gardiner, S. J., Gearry, R. B., Begg, E. J., & Barclay, M. L. (2007). Thiopurine methyltransferase (TPMT) and thiopurine dose in inflammatory bowel disease (IBD). Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Sharp, C. F., Begg, E. J., Gardiner, S. J., Roberts, R. L., Jensen, B. P., Lainchbury, J. G., & Troughton, R. W. (2007). CYP2D6 genotype and its relation to metoprolol dose, concentrations and effects in patients with systolic heart failure. Proceedings of the 3rd Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.chmeds.ac.nz/research/carneycentre/symposium.htm
Conference Contribution - Verbal presentation and other Conference outputs
Gardiner, S. J. (2007, December). Pharmacogenetics, drug metabolism and clinical practice. Verbal presentation at the 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists and the 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Joint Meeting, Adelaide, South Australia.
Jensen, B. P., Sharp, C. F., Gardiner, S. J., Begg, E. J., Lainchbury, J. G., & Troughton, R. W. (2007, December). Stereoselective LC-MS assay of S- and R-metoprolol in plasma for corrrelation with CYP2D6 genotype in patients with systolic heart failure. Verbal presentation at the 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists and the 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Joint Meeting, Adelaide, South Australia.
Sharp, C. F., Begg, E. J., Gardiner, S. J., Roberts, R. L., Jensen, B. P., Lainchbury, J. G., & Troughton, R. W. (2007, September). CYP2D6 genotype and its relation to metoprolol dose, concentrations and effects in patients with systolic heart failure. Verbal presentation at the 3rd Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Begg, E. J., Sharp, C. F., Gardiner, S. J., Roberts, R. L., Jensen, B. P., Lainchbury, J. G., & Troughton, R. W. (2007, August). CYP2D6 genotype and its relation to metoprolol dose, concentrations and effects in patients with systolic heart failure. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Gardiner, S. J., & Begg, E. J. (2007, August). Pharmacogenetics, drug metabolism and clinical practice. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Gardiner, S. J., Gearry, R. B., Begg, E. J., & Barclay, M. L. (2007, September). Thiopurine methyltransferase (TPMT) and thiopurine dose in inflammatory bowel disease (IBD). Verbal presentation at the 3rd Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
2006
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521-590.
Gardiner, S. J., & Begg, E. J. (2006). Breastfeeding during tacrolimus therapy. Obstetrics & Gynecology, 107(2, Part 2, Suppl.), 453-455.
Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.
Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M., Gearry, R. B., Barclay, M. L., Clark, D. W., & Hansen, P. (2006). Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics, 24(8), 767-781.
Gardiner, S. J., Gearry, R. B., Barclay, M. L., & Begg, E. J. (2006). Two cases of thiopurine methyltransferase (TPMT) deficiency: A lucky save and a near miss with azathioprine. British Journal of Clinical Pharmacology, 62(4), 473-476. doi: 10.1111/j.1365-2125.2005.02474.x
Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048
Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., Gearry, R. B., Begg, E. J., & Barclay, M. L. (2006). Thiopurine methyltransferase (TPMT) and thiopurine dose in inflammatory bowel disease (IBD). Proceedings of the Australian Health and Medical Research Congress. (pp. 247). Sydney, Australia: Australian Health and Medical Research Congress. [Abstract]
Barclay, M. L., Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. Journal of Gastroenterology & Hepatology, 21(Suppl. 4), (pp. A252). doi: 10.1111/j.1440-1746.2006.04686.x
Conference Contribution - Verbal presentation and other Conference outputs
Gardiner, S. J., Gearry, R. B., Begg, E. J., & Barclay, M. L. (2006, August-September). Thiopurine methyltransferase (TPMT) and thiopurine dose in inflammatory bowel disease (IBD). Verbal presentation at the Australasian Society of Clinical Experimental Pharmacologists & Toxicologists (New Zealand) Annual Scientific Meeting, Auckland, New Zealand.
Roberts, R., Gardiner, S. J., Gearry, R. B., Bockett, N., & Barclay, M. L. (2006, August-September). Do mutations within inosine triphosphatase predict early intolerance to azathioprine? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (New Zealand) Annual Scientific Meeting, Auckland, New Zealand.
2005
Journal - Research Article
Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.
Gardiner, S. J., & Begg, E. J. (2005). Pharmacogenetic testing for drug metabolizing enzymes: Is it happening in practice? Pharmacogenetics & Genomics, 15, 365-369.
Conference Contribution - Verbal presentation and other Conference outputs
Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M. A., Gearry, R. B., Barclay, M. L., & Clark, D. W. J. (2005, August). Cost-efficacy of TPMT testing prior to azathioprine therapy. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Scientific Meeting, Wellington, New Zealand.
Gardiner, S. J., Begg, E. J., Gearry, R. B., & Barclay, M. L. (2005, August). Tacrolimus and azathioprine in breastfeeding: Are they safe? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Scientific Meeting, Wellington, New Zealand.
2004
Edited Book - Other
Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.
Journal - Research Article
Gardiner, S. J., & Begg, E. J. (2004). Genotyping for drug-metabolizing enzymes: Does the promise meet the reality? Pharmacogenomics, 5(8), 1033-1036. Future Medicine.
Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K. S., Gardiner, S. J., & Begg, E. J. (2004). Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy, 38, 273-276.
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.
Journal - Research Other
Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs. Annals of Pharmacotherapy, 38(1), 174-175.
Gardiner, S. J., Begg, E. J., Kirkpatrick, C. M. J., & Buckham, R. B. (2004). Metformin therapy and diabetes in pregnancy [Letter to the editor]. Medical Journal of Australia, 181(3), 174-175.
Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs [Letter]. Annals of Pharmacotherapy, 38, 174-175.
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., & Begg, E. J. (2004). Pharmacogenetics ″down under″: Is it happening? Proceedings of the 8th World Congress on Clinical Pharmacology and Therapeutics: Addendum. (PO-347). [Abstract]
2003
Journal - Research Article
Gardiner, S. J., Kristensen, J. H., Begg, E. J., Hackett, L. P., Wilson, D. A., Ilett, K., … Rampono, J. (2003). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. American Journal of Psychiatry, 160, 1428-1431.
Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.
Journal - Research Other
Gearry, R., Barclay, M., Gardiner, S., & Zhang, M. (2003). 6-thioguanine nucleotides and thiopurine methyltransferase activity: Important factors determining response to treatment and incidence of adverse effects from azathioprine and 6-MP [Letter]. New Zealand Medical Journal, 116(1178). Retrieved from http://journal.nzma.org.nz/journal/116-1178/531/content.pdf
Journal - Professional & Other Non-Research Articles
Begg, E., Sidwell, A., Gardiner, S., Nicholls, G., & Scott, R. (2003). The sorry saga of the statins in New Zealand: Pharmacopolitics versus patient care [Viewpoint]. New Zealand Medical Journal, 116(1170). Retrieved from http://journal.nzma.org.nz/journal/116-1170/360/content.pdf
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K., & Begg, E. J. (2003). Transfer of risperidone and its metabolite into human milk. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 10. Australia: ASCEPT. [Abstract]
Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2003). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 10, (pp. 77). [Abstract]
Barclay, M. L., Gearry, R. B., Zhang, M., Roberts, R. L., Harraway, J., Pike, L., & Gardiner, S. J. (2003). Early New Zealand experience of monitoring TPMT activity and RBC 6-thioguanine nucleotides in patients on azathioprine or 6-MP. In E. A. Davis & C. G. Sobey (Eds.), Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists. 10. Victoria, Australia: ASCEPT. [Abstract]
2002
Journal - Research Article
Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.
Gardiner, S. J., Begg, E. J., & Robinson, B. A. (2002). The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. Adverse Drug Reactions & Toxicological Reviews, 21(1-2), 1-16.
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., Kirkpatrick, C. M. J., Begg, E. J., Zhang, M., & Moore, M. P. (2002). Metformin and human milk: Unexpectedly low transfer and infant dose. Australian Health and Medical Research Congress. (A1162). [Abstract]
Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2002). Restricted penetration of metformin into human milk. Proceedings of the Australasian Society of Clinical and Experiemental Pharmacologists and Toxicologists. [Abstract]
2001
Journal - Research Article
Begg, E. J., Robson, R. A., Gardiner, S. J., Hudson, L. J., Reece, P. A., Olson, S. C., … Sedman, A. J. (2001). Quinapril and its metabolite quinaprilat in human milk. British Journal of Clinical Pharmacology, 51, 478-481.
Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Fifteen years of drug information in Christchurch Hospital. New Zealand Medical Journal, 114, 393-395.
Conference Contribution - Published proceedings: Abstract
Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Rapid and simple high-performance liqid chromatographic assay for the determination of metformin in human plasma and breast milk. Proceedings of Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. 9. [Abstract]
2000
Journal - Research Article
Gardiner, S. J., Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2000). Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. Adverse Drug Reactions & Toxicological Reviews, 19(4), 293-312.
Conference Contribution - Published proceedings: Abstract
Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2000). Fifteen years of drug information at Christchurch hospital. Proceedings of ASCEPT. 8, (pp. 149). [Abstract]
1998
Journal - Research Article
Gardiner, S. J., Kirkpatrick, C., & Begg, E. J. (1998). An audit of the drug information service at Christchurch Hospital. Proceedings of ASCEPT, 5, 113.