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Centre for Free Radical Research

ProjectPrimary supervisor
The impact of mitochondrial dysfunction on stem cell differentiationDr Annika Seddon
Identifying molecular targets of the antineoplastic compound portimine AProfessor Mark Hampton
Investigation of p16INK4A Amyloids in Human Cancer CellsDr Christoph Goebl
Investigating the Streptococcus pneumoniae glutathione substrate binding protein as a potential drug target for antimicrobial therapyDr Nina Dickerhof
Investigating the Impact of Ascorbate on Macrophage Differentiation and FunctionDr Stephanie Bozonet
Characterising the role of peroxidasin in breast cancerDr Martina Paumann-Page
Identification of key peptide regions in the amyloid state of the tumour suppressor p16Dr Christoph Goebl
The interaction of neutrophils and amyloid-ß in Alzheimer's diseaseDr Leon Smyth
Vitamin C as an Epigenetic Therapeutic for Acute Myeloid LeukaemiaProfessor Margreet Vissers
Peroxiredoxins as biomarkers of oxidative stress in metastatic melanoma cellsProfessor Mark Hampton
Mycobacterial resistance to neutrophil oxidantsProfessor Mark Hampton
Intracellular redox changes during TNFα-mediated necroptosisProfessor Mark Hampton
Investigating the pro-apoptotic properties of portimineProfessor Mark Hampton
Inactivation of a thiol-dependent enzyme by urate hydroperoxide Professor Tony Kettle
Measurement of mitochondrial dysfunction in humansDr Andree Pearson
Involvement of mitochondria and peroxiredoxin in TNF-mediated necroptosisProfessor Mark Hampton
The effect of cell metabolism on epigenetic processes in cancer cells Professor Margreet Vissers
Functional consequences of lowering mitochondrial peroxiredoxin 3 expression Professor Mark Hampton
Neutrophil activation in inflammatory bowel diseaseProfessor Richard Gearry
Inhibiting the pro-inflammatory cytokine MIFProfessor Mark Hampton
Assessing a blood biomarker of lung infectionProfessor Christine Winterbourn

Gene Structure and Function Laboratory

ProjectPrimary supervisor
Nanopore sequencing of the pharmacogene CYP2C19 in a Ngāti Porou cohortProfessor Martin Kennedy
CRISPR-Cas detection of Legionella in clinical blood samplesProfessor Martin Kennedy
Allelic diversity of the pharmacogene CYP2D6 in Māori and PasifikaDr Simran Maggo
Targeted enrichment and Nanopore sequencing of RNA transcripts from breast cancer risk genesProfessor Martin Kennedy
Diagnostic applications of a Nanopore sequencing deviceProfessor Martin Kennedy
Impact of G-quadruplex structures and DNA methylation on allelic drop-out during in vitro amplification of imprinted genesProfessor Martin Kennedy
Establishment and validation of a telomere length assayProfessor Martin Kennedy
Does promoter variation in the USP46 gene influence antidepressant response?Professor Martin Kennedy

Inflammation Research Group

ProjectPrimary supervisor
Hydrogen sulfide: Investigation into the effects of different H2S donors on the upregulation of inflammatory cytokinesProfessor Madhav Bhatia

The Infection Group

ProjectPrimary supervisor
Development of a non-invasive “liquid biopsy” for Kingella kingae infections in children using cell-free DNADr Amy Scott-Thomas
Characterising the relationship between Legionella longbeachae and their amoebal hosts: Implications for Legionnaires' disease prevention  Dr Sandy Slow
A novel strategy to prevent bacterial biofilm formation using methylthioadenosine-nucleosidase inhibitorsProfessor Steve Chambers
Detecting 2-aminoacetophenone and pyocyanin from clinical strains of Pseudomonas aeruginosaDr Amy Scott-Thomas

Mackenzie Cancer Research Group

ProjectPrimary supervisor
In Vitro Liver Metabolism of Portimine; a New Anticancer Agent from Marine AlgaeProfessor Gabi Dachs
Adipocyte Markers as Predictors of Progression in Men with Prostate CancerDr Elisabeth Phillips
Investigating the relationship between ascorbate and the differentiation of monocytes in an in-vitro melanoma model Assoc Professor Margaret Currie
Gene modification of breast cancer cells for cancer imaging  Professor Gabi Dachs
Copy number variants and familial breast and ovarian cancer riskAssoc Prof Logan Walker
Can vitamin C reduce metastases in a mouse model of breast cancer?Professor Gabi Dachs
Measuring markers of immune response in patients treated with Nivolumab (Opdivo) or Pembrolizumab (Keytruda)Assoc Professor Margaret Currie
The influence of exercise and hyperlipidaemia on breast cancerProfessor Gabi Dachs
Development of a metabolic syndrome model of breast cancerProfessor Gabi Dachs
Does fat provide energy for breast tumour cell invasion and metastasis?Assoc Professor Margaret Currie
Exploring molecular links between obesity and breast cancerAssoc Professor Logan Walker
Evaluating molecular markers of breast tumour progression Assoc Professor Logan Walker
Gene transfer to restore vitamin C synthesis in human cell lineProfessor Gabi Dachs
Immune suppression and cutaneous squamous cell carcinoma tumour biology Assoc Professor Margaret Currie
Myeloid-serived suppressor cells, tumour angiogenesis and cancer progressionAssoc Professor Margaret Currie

Nutrition in Medicine Research Group

ProjectPrimary supervisor
Can we Attenuate Inflammation and Oxidative Stress in People with Metabolic SyndromeProfessor Anitra Carr

Molecular Pathology

ProjectPrimary supervisor
Development of an assay for interferon beta bioavailability in relapsing-remitting MS patientsProfessor Steve Brennan

Christchurch Heart Institute

ProjectPrimary supervisor
Evaluation of The Four-and-a-half LIM 2 (FHL2) Single Polypeptide As A Potential Biomarker of Cardio-Renal Syndrome (CRS)Professor Chris Pemberton

Surgery

ProjectPrimary supervisor
Nutritional immunity: Butyrate and colon carcinogenesisAssoc Professor Jacqui Keenan
Bacterial lipopolysaccharide and immune activation in colorectal cancerAssoc Professor Jacqui Keenan
Aspirin's role in preventing E-cadherin cleavage by the carcinogenic Bacteroides fragilis toxin  Assoc Professor Jacqui Keenan

Related Information

Otago Profile

Rebekah Crake in the lab_thumbnail
Exploring molecular links between obesity and breast cancer.
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Otago Profile

Teagan Hoskin in the lab_thumbnail
Neutrophil activation in inflammatory bowel disease.
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Otago Profile

Hannah Kennedy thumbnail
Development of an assay for interferon beta bioavailability in relapsing-remitting MS patients.
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Otago Profile

Annika Seddon in the lab -thumb
Immune suppression and cutaneous squamous cell carcinoma tumour biology.
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Regulations on this page are taken from the 2023 Calendar and supplementary material.

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