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2024

  • Swaminathan A, Borichevsky GM, Frampton C, Kettle AJ, Peyrin-Biroulet L, Siegel CA, Day AS, Gearry RB. Development and investigation of a non-invasive disease severity index for inflammatory bowel disease. J Crohns Colitis. in press 2024.
  • Heath SG, Naughton JD, Magon NJ, Gray SG, Smith BR, Morris VK, Göbl C. Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach. J Biol Chem. In press 2024.
  • Featherston T, Paumann-Page M, Hampton MB. Melanoma redox biology and the emergence of drug resistance. Adv Cancer Res. 162:145-171, 2024.
  • Winterbourn CW and Kettle AJ, 2024, Peroxidases, In: Comprehensive Toxicology, 4th Edition, https://doi.org/10.1016/B978-0-323-95488-4.00031-0
  • Heath SG, Gray SG, Hamzah EM, O’Connor KM, Bozonet SM, Botha AD, de Cordovez P, Magon NJ, Naughton JD, Goldsmith DLW, Schwartfeger AJ, Sunde M, Buell AK, Morris VK, Göbl C. Amyloid formation and depolymerization of the tumour suppressor protein p16INK4a is strictly controlled by an oxidative thiol-based mechanism. Nature Communications, in press, 2024. DOI: 10.1038/s41467-024-49581-7
  • Seddon A.R., Damiano O.M., Hampton M.B. and Stevens A.J. Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics in press, 2024.
  • Featherston T, Helem S, Smyth LCD., Hampton MB and Paumann-Page M. Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability. Toxicol. Mech. Methods. in press, 2024.
  • Blake TL, Sly PD, Andersen I, Wainwright CE, Reid DW, Bell SC, Smith BR, Kettle AJ and Dickerhof N  2024. Changes in urinary glutathione sulfonamide (GSA) levels between admission and discharge of patients with cystic fibrosis  J Cystic Fibrosis 2024 Apr 23:S1569-1993(24)00054-7. DOI: 10.1016/j.jcf.2024.04.009. Online ahead of print.
  • Ashby L, Chan L, Winterbourn C, Woon ST, Keating P, Heller R, Ameratunga R, Chua I, Hsiao KC. Phenotypic spectrum in a family with a novel RAC2 p.I21S dominant-activating mutation. Clin Transl Immunology. 2024 Feb 26;13(2):e1493. doi: 10.1002/cti2.1493. eCollection 2024.
  • Topham B, de Vries M, Nonis M, van Berkel R, Pullar JM, Magon NJ, Vissers MCM, Currie MJ, Robinson BA, Gibbs D, Ang A, Dachs GU. Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes. 2024 Apr 30;8(2):17. doi: 10.3390/epigenomes8020017.
  • Shearer HL, Currie MJ, Agnew HN, Trappetti C, Stull F, Pace PE, Paton JC, Dobson RCJ, Dickerhof N, Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae. J Biol Chem. 300(5):107282. DOI: 10.1016/j.jcf.2024.04.009, 2024
  • Swaminathan, A., G.M. Borichevsky, C.M. Frampton, A.S. Day, M.B. Hampton, A.J. Kettle, and R.B. Gearry, Comparison of Fecal Calprotectin and Myeloperoxidase in Predicting Outcomes in Inflammatory Bowel Disease. Inflamm Bowel Dis. DOI: 10.1093/ibd/izae032, 2024
  • Fletcher, B.D., J.J. Haszard, M.C.M. Vissers, and T.S. Conner, Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention in adults with low vitamin C. Br J Nutr. 131(8): p. 1384-1396. DOI: 10.1017/s0007114523002787, 2024
  • Coker, S.J., M.J. Berry, M.C.M. Vissers, and R.M. Dyson, Maternal Vitamin C Intake during Pregnancy Influences Long-Term Offspring Growth with Timing- and Sex-Specific Effects in Guinea Pigs. Nutrients. 16(3). DOI: 10.3390/nu16030369, 2024

2023

  • Major G, Longoni A, Simcock J, Magon NJ, Harte J, Bathish B, Kemp R, Woodfield T, Lim KS. Clinical Applicability of Visible Light-Mediated Cross-linking for Structural Soft Tissue Reconstruction. Adv Sci (Weinh). 2023 Sep;10(26):e2300538. doi: 10.1002/advs.202300538. Epub 2023 Jul 9.
  • Pulido S, Rückert H, Falsone SF, Göbl C, Meyer NH, Zangger K. The membrane-binding bacterial toxin long direct repeat D inhibits protein translation. Biophys Chem. 2023 Jul;298:107040. doi: 10.1016/j.bpc.2023.107040.
  • Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan GS, Zheng C, Göbl C, Gill KT, Haight J, Wakeham AC, Snow BE, Bradaschia-Correa V, Ganguly M, Lu Z, Saunders ME, Flavell RA, Mak TW. Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis. Cell Death Differ. 2023 Feb;30(2):407-416. doi: 10.1038/s41418-022-01092-y.
  • Winterbourn, C.C., A.V. Peskin, T. Kleffmann, R. Radi, and P.E. Pace, Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide. Proc Natl Acad Sci U S A. 120(18): p. e2221047120. DOI: 10.1073/pnas.2221047120, 2023
  • Swaminathan, A., C.M. Frampton, G.M. Borichevsky, A.J. Kettle, and R.B. Gearry, Response to: Evaluating Discriminative Accuracy of Biomarkers in Relation to Binary Study Outcomes: First Validate, Then Celebrate? J Crohns Colitis. 17(1): p. 147-148. DOI: 10.1093/ecco-jcc/jjac126, 2023
  • Shearer, H.L., P.E. Pace, L.M. Smith, P.C. Fineran, A.J. Matthews, A. Camilli, N. Dickerhof, and M.B. Hampton, Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. J Bacteriol. 205(10): p. e0020823. DOI: 10.1128/jb.00208-23, 2023
  • Shearer, H.L., V.V. Loi, P. Weiland, G. Bange, F. Altegoer, M.B. Hampton, H. Antelmann, and N. Dickerhof, MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Mol Microbiol. 119(4): p. 456-470. DOI: 10.1111/mmi.15035, 2023
  • Seddon, A.R., A.B. Das, M.B. Hampton, and A.J. Stevens, Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Hum Mol Genet. 32(4): p. 632-648. DOI: 10.1093/hmg/ddac232, 2023
  • Praditi, C., S.M. Bozonet, G.U. Dachs, and M.C.M. Vissers, Ascorbate Uptake and Retention by Breast Cancer Cell Lines and the Intracellular Distribution of Sodium-Dependent Vitamin C Transporter 2. Antioxidants (Basel). 12(11). DOI: 10.3390/antiox12111929, 2023
  • Peeters, W.M., M. Gram, G.J. Dias, M.C.M. Vissers, M.B. Hampton, N. Dickerhof, A.E. Bekhit, M.J. Black, J. Oxbøll, S. Bayer, M. Dickens, K. Vitzel, P.W. Sheard, K.M. Danielson, L.D. Hodges, J.C. Brønd, J. Bond, B.G. Perry, L. Stoner, J. Cornwall, and D.S. Rowlands, Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biol. 67: p. 102918. DOI: 10.1016/j.redox.2023.102918, 2023
  • Paumann-Page, M., C. Obinger, C.C. Winterbourn, and P.G. Furtmüller, Peroxidasin Inhibition by Phloroglucinol and Other Peroxidase Inhibitors. Antioxidants (Basel). 13(1). DOI: 10.3390/antiox13010023, 2023
  • Pace, P.E. and C.C. Winterbourn, Letter to the Editor: A Cautionary Note on Using Phosphatase Inhibitors with Hydrogen Peroxide. Antioxid Redox Signal. 38(4-6): p. 316-317. DOI: 10.1089/ars.2022.0092, 2023
  • Kettle, A.J., L.V. Ashby, C.C. Winterbourn, and N. Dickerhof, Superoxide: The enigmatic chemical chameleon in neutrophil biology. Immunol Rev. 314(1): p. 181-196. DOI: 10.1111/imr.13183, 2023
  • Hampton, M.B. and N. Dickerhof, Inside the phagosome: A bacterial perspective. Immunol Rev. 314(1): p. 197-209. DOI: 10.1111/imr.13182, 2023
  • Coker, S.J., R.M. Dyson, C.C. Smith-Díaz, M.C.M. Vissers, and M.J. Berry, Effects of Low Vitamin C Intake on Fertility Parameters and Pregnancy Outcomes in Guinea Pigs. Nutrients. 15(19). DOI: 10.3390/nu15194107, 2023
  • Bozonet, S.M., N.J. Magon, A.J. Schwartfeger, A. Konigstorfer, S.G. Heath, M.C.M. Vissers, V.K. Morris, C. Göbl, J.M. Murphy, G.S. Salvesen, and M.B. Hampton, Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. J Biol Chem. 299(6): p. 104792. DOI: 10.1016/j.jbc.2023.104792, 2023

2022

  • Smyth L.C.D., Murray H.C., Hill M., van Leeuwen E., Highet B., Magon N.J., Osanlouy M., Mathiesen S.N., Mockett B., Singh-Bains M.K., Morris V.K., Clarkson A.N., Curtis M.A., Abraham W.C., Hughes S.M., Faull R.L.M., Kettle A.J., Dragunow M. and Hampton M.B. Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease. Acta Neuropathol. Commun. 10:38, 2022.
  • van Leeuwen E., Hampton M.B. and Smyth L.C.D. Hypothiocyanous acid disrupts the barrier function of brain endothelial cells. Antioxidants 11:608, 2022.
  • Shearer H.L., Kaldor C.D., Hua H., Kettle A.J., Parker H.A. and Hampton M.B. Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infect. Immun. 90:e0053021, 2022.
  • Shearer H.L., Paton J.C., Hampton M.B. and Dickerhof N. Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid. Free Radic. Biol. Med. 179:24-33, 2022.
  • Smyth LCD, Highet B, Jansson D, Wu J, Rustenhoven J, Aalderink M, Tan A, Li S, Johnson R, Coppieters N, Handley R, Narayan P, Singh-Bains MK, Schweder P, Turner C, Mee EW, Heppner P, Correia J, Park TI, Curtis MA, Faull RLM, Dragunow M. Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease. Commun Biol. 2022 Mar 17;5(1):235. doi: 10.1038/s42003-022-03180-8.
  • Park TI, Smyth LCD, Aalderink M, Woolf ZR, Rustenhoven J, Lee K, Jansson D, Smith A, Feng S, Correia J, Heppner P, Schweder P, Mee E, Dragunow M. Routine culture and study of adult human brain cells from neurosurgical specimens. Nat Protoc. 2022 Feb;17(2):190-221. doi: 10.1038/s41596-021-00637-8. Epub 2022 Jan 12.
  • Vissers MCM, Pullar JM. Re-opening old wounds-vitamin C and wound healing deserve a re-examination. Am J Clin Nutr. 2022 Jan 11;115(1):1-2. doi: 10.1093/ajcn/nqab300.
  • Taylor, M.F., M.A. Black, M.B. Hampton, and E.C. Ledgerwood, Insights into H(2)O(2)-induced signaling in Jurkat cells from analysis of gene expression. Free Radic Res. 56(9-10): p. 666-676. DOI: 10.1080/10715762.2023.2165073, 2022
  • Swaminathan, A., G.M. Borichevsky, T.S. Edwards, E. Hirschfeld, T.C. Mules, C.M.A. Frampton, A.S. Day, M.B. Hampton, A.J. Kettle, and R.B. Gearry, Faecal Myeloperoxidase as a Biomarker of Endoscopic Activity in Inflammatory Bowel Disease. J Crohns Colitis. 16(12): p. 1862-1873. DOI: 10.1093/ecco-jcc/jjac098, 2022
  • Shearer, H.L., P.E. Pace, J.C. Paton, M.B. Hampton, and N. Dickerhof, A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. J Biol Chem. 298(9): p. 102359. DOI: 10.1016/j.jbc.2022.102359, 2022
  • Murphy, M.P., H. Bayir, V. Belousov, C.J. Chang, K.J.A. Davies, M.J. Davies, T.P. Dick, T. Finkel, H.J. Forman, Y. Janssen-Heininger, D. Gems, V.E. Kagan, B. Kalyanaraman, N.G. Larsson, G.L. Milne, T. Nyström, H.E. Poulsen, R. Radi, H. Van Remmen, P.T. Schumacker, P.J. Thornalley, S. Toyokuni, C.C. Winterbourn, H. Yin, and B. Halliwell, Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metab. 4(6): p. 651-662. DOI: 10.1038/s42255-022-00591-z, 2022
  • Edwards, T.S., N. Dickerhof, N.J. Magon, L.N. Paton, P.D. Sly, and A.J. Kettle, Formation of Calprotectin-Derived Peptides in the Airways of Children with Cystic Fibrosis. J Immunol. 208(4): p. 979-990. DOI: 10.4049/jimmunol.2001017, 2022
  • Crake, R.L.I., E.R. Burgess, G.A.R. Wiggins, N.J. Magon, A.B. Das, M.C.M. Vissers, H.R. Morrin, J.A. Royds, T.L. Slatter, B.A. Robinson, E. Phillips, and G.U. Dachs, Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Sci Rep. 12(1): p. 14845. DOI: 10.1038/s41598-022-19032-8, 2022
  • Conner, T.S., B.D. Fletcher, J.J. Haszard, J.M. Pullar, E. Spencer, L.A. Mainvil, and M.C.M. Vissers, Reply to Vorland et al. Mixed Random and Nonrandom Allocation, and Group Randomization Have Been Mislabeled and Misanalysed, Necessitating Reanalysis. Comment on "Conner et al. KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Tablets on Vitality in Adults with Low Vitamin C Levels. Nutrients 2020, 12, 2898". Nutrients. 14(19). DOI: 10.3390/nu14194065, 2022
  • Conner, T.S., B.D. Fletcher, J.J. Haszard, J.M. Pullar, E. Spencer, L.A. Mainvil, and M.C.M. Vissers, Correction: Conner et al. KiwiC for Vitality: Results of a Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Tablets on Vitality in Adults with Low Vitamin C Levels. Nutrients 2020, 12, 2898. Nutrients. 14(19). DOI: 10.3390/nu14194063, 2022
  • Burgess, E.R., R.L.I. Crake, E. Phillips, H.R. Morrin, J.A. Royds, T.L. Slatter, G.A.R. Wiggins, M.C.M. Vissers, B.A. Robinson, and G.U. Dachs, Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival. Front Oncol. 12: p. 829524. DOI: 10.3389/fonc.2022.829524, 2022
  • Ashby, L.V., R. Springer, V.V. Loi, H. Antelmann, M.B. Hampton, A.J. Kettle, and N. Dickerhof, Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. J Leukoc Biol. 112(4): p. 591-605. DOI: 10.1002/jlb.4hi1021-538rr, 2022

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