Free Radical Research Publications 2014-2015

2015

• Peskin AV, Pace PE, Behring JB, Paton LN, Soethoudt M, Bachschmid MM, Winterbourn CC. Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin. J Biol Chem. 2015 Nov 24. pii: jbc.M115.692798. [Epub ahead of print] PMID:26601956
• Poynton RA, Peskin AV, Haynes AC, Lowther WT, Hampton MB, Winterbourn C. Kinetic Analysis of Structural Influences on the Susceptibility of Peroxiredoxins 2 and 3 to Hyperoxidation. Biochem J. 2015 Nov 27. pii: BJ20150572. [Epub ahead of print] PMID:26614766
• Newman TA, Carleton CR, Leeke B, Hampton MB, Horsfield JA. Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biol. 2015 Dec;6:648-55. doi: 10.1016/j.redox.2015.10.010. Epub 2015 Nov 4. PMID:26584358
• Balasubramanian D, Deng AX, Doudney K, Hampton MB, Kennedy MA. Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology. 2015 Jul 4. pii: S0028- 3908(15)30004-6. doi: 10.1016/j.neuropharm.2015.06.018. [Epub ahead of print] PMID: 26151765
• Radjainia M, Venugopal H, Desfosses A, Phillips AJ, Yewdall NA, Hampton MB, Gerrard JA, Mitra AK. Cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Structure. 2015 May 5;23(5):912-20. doi: 10.1016/j.str.2015.03.019. Epub 2015 Apr 23. PMID: 25914057
• Jodczyk S, Pearson JF, Aitchison A, Miller AL, Hampton MB, Kennedy MA. Telomere Length Measurement on the Roche LightCycler 480 Platform. Genet Test Mol Biomarkers. 2015 Feb;19(2):63-8. doi: 10.1089/gtmb.2014.0208. Epub 2014 Dec 23. PMID: 25535668
• Bayer SB, Hampton MB, Winterbourn CC. Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion. 2015 Feb 26. doi: 10.1111/trf.13039. [Epub ahead of print] PMID: 25720945
• Winterbourn CC, Hampton MB. Redox biology: Signaling via a peroxiredoxin sensor. Nat Chem Biol. 2015 Jan;11(1):5-6. doi: 10.1038/nchembio.1722. Epub 2014 Dec 17. PMID:25517384 [PubMed - in process]
• Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available. PMID: 25341790
• Winterbourn CC. Are free radicals involved in thiol-based redox signaling? Free Radic Biol Med. 2015 Mar;80:164-70. doi: 10.1016/j.freeradbiomed.2014.08.017. Epub 2014 Sep 30. PMID: 25277419
• Rees MD, Maiocchi SL, Kettle AJ, Thomas SR. Mechanism and Regulation of Peroxidase-Catalyzed Nitric Oxide Consumption in Physiological Fluids: Critical Protective Actions of Ascorbate and Thiocyanate.Free Radic Biol Med. 2014 Apr 3. pii: S0891-5849(14)00154-3. doi: 10.1016/j.freeradbiomed.2014.03.037. [Epub ahead of print] PMID:24704973
• Carr AC, Shaw GM, Fowler AA, Natarajan R. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock? Crit Care. 2015 Nov 27;19(1):418. doi: 10.1186/s13054-015-1131-2. PMID:26612352
• Dickerhof N, Schindler L, Bernhagen J, Kettle AJ, Hampton MB. Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radic Biol Med. 2015 Oct 7. pii: S0891-5849(15)00579-1. doi: 10.1016/j.freeradbiomed.2015.09.009. [Epub ahead of print]
• Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR, Holdsworth SR. Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.
  Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109. PMID: 25777776
• Magon NJ, Turner R, Gearry RB, Hampton MB, Sly PD, Kettle AJ. Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radic Biol Med. 2015 May 22. pii: S0891-5849(15)00233-6. doi: 10.1016/j.freeradbiomed.2015.05.022. [Epub ahead of print] PMID: 26006104
• Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD. Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD. Eur J Med Chem. 2015 Mar 26;93:501-10. doi: 10.1016/j.ejmech.2015.02.012. Epub 2015 Feb 24. PMID: 25743213
• Wilkie-Grantham RP, Magon NJ, Harwood DT, Kettle AJ, Vissers MC, Winterbourn CC, Hampton MB. Myeloperoxidase-Dependent Lipid Peroxidation Promotes the Oxidative Modification of Cytosolic Proteins in Phagocytic Neutrophils. J Biol Chem. 2015 Feb 19. pii: jbc.M114.613422. [Epub ahead of print] PMID: 25697357
• Campbell EJ, Vissers MC, Bozonet S, Dyer A, Robinson BA, Dachs GU. Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice. Cancer Med. 2015 Feb;4(2):303-14. doi: 10.1002/cam4.349. Epub 2014 Oct 30. PMID: 25354695
• Bozonet SM, Carr AC, Pullar JM, Vissers MC. Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit. Nutrients. 2015 Apr 9;7(4):2574-88. doi: 10.3390/nu7042574.

2014

• Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available. PMID: 25341790
• Winterbourn CC. Are free radicals involved in thiol-based redox signaling? Free Radic Biol Med. 2015 Mar;80:164-70. doi: 10.1016/j.freeradbiomed.2014.08.017. Epub 2014 Sep 30. PMID: 25277419
• Rees MD, Maiocchi SL, Kettle AJ, Thomas SR. Mechanism and Regulation of Peroxidase-Catalyzed Nitric Oxide Consumption in Physiological Fluids: Critical Protective Actions of Ascorbate and Thiocyanate.Free Radic Biol Med. 2014 Apr 3. pii: S0891-5849(14)00154-3. doi: 10.1016/j.freeradbiomed.2014.03.037. [Epub ahead of print] PMID:24704973
• Green JN, Kettle AJ, Winterbourn CC. Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radic Biol Med. 2014 Sep 16. pii: S0891-5849(14)00404-3. doi: 10.1016/j.freeradbiomed.2014.08.013. [Epub ahead of print]. PMID: 25236747
• Nedoboy PE, Morgan PE, Mocatta TJ, Richards AM, Winterbourn CC, Davies MJ.High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction.Free Radic Res. 2014 Oct;48(10):1256-66. doi: 10.3109/10715762.2014.947286. PMID: 25050609
• Kato Y, Ono S, Kitamoto N, Kettle AJCovalent modification of cytoskeletal proteins in neuronal cells by tryptamine-4,5-dione. Redox Biol. 2014, Vol 2 Pages 983-990.
• Seidel A, Parker H, Turner R, Dickerhof N, Khalilova IS, Wilbanks SM, Kettle AJ, Jameson GN. Uric Acid and Thiocyanate as Competing Substrates of Lactoperoxidase. J Biol Chem. 2014 Jun 13. pii: jbc.M113.544957. [Epub ahead of print] PMID:24928513
• Dickerhof N, Magon NJ, Tyndall JD, Kettle AJ, Hampton MB. Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase (MPO)-dependant oxidation of epicatechins. Biochem J. 2014 Jun 11. [Epub ahead of print] PMID: 24916123
• Stamp LK, Turner R, Khalilova IS, Zhang M, Drake J, Forbes LV, Kettle AJ. Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia. Rheumatology (Oxford). 2014 Jun 4. pii: keu218. [Epub ahead of print] PMID: 24899662
• Rees MD, Maiocchi SL, Kettle AJ, Thomas SR. Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: Critical protective actions of ascorbate and thiocyanate. Free Radic Biol Med. 2014 Jul;72:91-103. doi: 10.1016/j.freeradbiomed.2014.03.037. Epub 2014 Apr 4. PMID: 24704973
• Bekeschus S, Kolata J, Winterbourn C, Kramer A, Turner R, Weltmann KD, Bröker B, Masur K. Hydrogen peroxide: A central player in physical plasma-induced oxidative stress in human blood cells. Free Radic Res. 2014 May;48(5):542-9. doi: 10.3109/10715762.2014.892937. Epub 2014 Mar 6. PMID: 24528134
• Cheah FC, Peskin AV, Wong FL, Ithnin A, Othman A, Winterbourn CC. Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants. FASEB J. 2014 Mar 17. [Epub ahead of print] PMID: 24636884
• Stamp LK, Turner R, Khalilova IS, Zhang M, Drake J, Forbes LV, Kettle AJ. Myeloperoxidase and Oxidation of Uric Acid in Gout: Implications for the clinical consequences of hyperuricaemia. Rheumatology 2014, in press
• Kettle AJ, Turner RR, Gangell CL, Harwood DT, Khalilova IS, Chapman AL, Winterbourn CC, Sly PD.Oxidation contributes to low glutathione in the airways of children with cystic fibrosis. Eur Respir J, 2014, in press.
• Kasperkiewicz P, Poreba M, Snipas S, Parker H, Winterbourn C, Salvesen G, Drag M. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. PNAS 2014, 111:2518-23.
• Parker HA, Magon NJ, Green JN, Hampton MB, Winterbourn CC. Analysis of neutrophil bactericidal activity. Methods Mol Biol. 2014;1124:291-306. doi: 10.1007/978-1-62703-845-4_19. PMID: 24504960
  Supplementary file (XLS)
• Maghzal GJ, Cergol KM, Shengule SR, Suarna C, Newington D, Kettle AJ, Payne RJ, Stocker R. Assessment of Myeloperoxidase Activity by the Conversion of Hydroethidine to 2-Chloroethidium. J Biol Chem. 2014 Jan 16. [Epub ahead of print]
• Kuiper C, Vissers MC. Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression. Front Oncol. 2014 Dec 10;4:359. doi: 10.3389/fonc.2014.00359. eCollection 2014. Review. PMID: 25540771
• Campbell EJ, Vissers MC, Bozonet S, Dyer A, Robinson BA, Dachs GU. Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo-/- mice. Cancer Med. 2014 Oct 30. doi: 10.1002/cam4.349. [Epub ahead of print]
• Kuiper C, Vissers MCM, Hicks K. Pharmacokinetic modelling of ascorbate diffusion through normal and tumour tissue. Free Radic Biol Med. 2014 In press. http://authors.elsevier.com/sd/article/S0891584914004420
• Vissers MC, Kuiper C, Dachs GU..Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer. Biochem Soc Trans. 2014 Aug 1;42(4):945-51. doi: 10.1042/BST20140118. PMID: 25109984
• Carr AC, Vissers MC, Cook J.(letter to the editor). Parenteral vitamin C for palliative care of terminal cancer patients. N Z Med J. 2014 Jun 20;127(1396):84-6. No abstract available. PMID: 24997468
• Carr AC, Vissers MCM, Cook JS (mini review). Effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Frontiers in Oncology, 2014, In press.
• Carr A, Pullar J, Forbes L, Rosengrave P. Working mothers are disadvantaged by limited funding for health research. N Z Med J. 2014 Jul 18;127(1398):138-40. No abstract available. PMID: 25146873
• Dachs GU, Munn DG, Carr AC, Vissers MCM, Robinson BA.Consumption of vitamin C is below recommended daily intake in many cancer patients and healthy volunteers in Christchurch. NZMJ 7 March 2014, Vol 127 No 1390; ISSN 1175 8716 Page 73-6. http://journal.nzma.org.nz/journal/127-1390/6025/
• Kuiper C, Dachs GU, Currie MJ, Vissers MC. Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radic Biol Med. 2014 Feb 1. pii: S0891-5849(14)00046-X. doi: 10.1016/j.freeradbiomed.2014.01.033. [Epub ahead of print]
• Carr, A.C., Vissers M.C.M., Cook J. (2014). Relief from cancer chemotherapy side effects with pharmacologic vitamin C. NZ Med J, 127 (1388), 1-5.
• Kuiper C, Dachs GU, Munn D, Currie MJ, Robinson BA, Pearson JF and Vissers MCM (2014) Increased tumor ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer. Front. Oncol.4:10. doi: 10.3389/fonc.2014.00010
• Edited book: Carr, A.C. and Vissers, M.C. (Eds). Vitamin C and Human Health. MDPI Open Access Publishing, 2014, in press.