Ang AD, Vissers MCM, Burgess ER, Currie MJ, Dachs GU. Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions. Antioxidants (Basel, Switzerland). 2021;10(3).
Crake R, Burgess E, Royds JA, Phillips E, Vissers MCM, Dachs GU. The role of 2-oxoglutarate dependent dioxygenases in gliomas and glioblastomas: a review of epigenetic reprogramming and hypoxic response. Frontiers in Oncology 2021; 11, 313.
Dachs GU, Gandhi J, Wohlrab C, Carr AC, Morrin HR, Pullar JM, Bayer SB, Eglinton TW, Robinson BA, Vissers MCM. Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study. Frontiers in Oncology. 2021;10:600715.
Das A.B., Seddon A.R., O'Connor K.M. and Hampton M.B. Regulation of the epigenetic landscape by immune cell oxidants. Free Rad. Biol. Med. 170:131-149, 2021.
Das AB, Smith-Diaz CC, Vissers MCM. Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate. Haematologica. 2021;106(1):14-25.
Fletcher BD, Flett JAM, Wickham SR, Pullar JM, Vissers MCM, Conner TS. Initial Evidence of Variation by Ethnicity in the Relationship between Vitamin C Status and Mental States in Young Adults. Nutrients. 2021;13(3).
Jansson D, Dieriks VB, Rustenhoven J, Smyth LCD, Scotter E, Aalderink M, Feng S, Johnson R, Schweder P, Mee E, Heppner P, Turner C, Curtis M, Faull R, Dragunow M. Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus. Commun Biol. 2021 Feb 26;4(1):260. doi: 10.1038/s42003-021-01787-x.
Konigstorfer A, Ashby LV, Bollar GE, Billiot CE, Gray MJ, Jakob U, Hampton, MB, Winterbourn, CC. (2021)Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease 79(1).
Mayyas I.M., Weeks R.J., Day R.C., Magrath H.E., O'Connor K.M., Kardailsky O., Hore T.A., Hampton M.B. and Morison I.M. Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics 16:1251-1259, 2021.
Parker H.A., Dickerhof N., Forrester L., Ryburn H., Smyth L., Messens J., Aung H.L., Cook G.M., Kettle A.J. and Hampton M.B. Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. J. Immunol. 206:1901-1912, 2021.
Parker H.A., Forrester, L., Kaldor, C.D., Dickerhof, N. and Hampton M.B. Antimicrobial activity of neutrophils against mycobacteria. Front. Immunol. 12:782495, 2021.
Parker H.A., Jones H.M., Kaldor C.D., Hampton M.B. and Winterbourn C.C. Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants 10:1791, 2021.
Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., Sevcnikar, B., Furtmuller, P. G., Traxlmayr, M. W., Obinger, C., Eccles, M. R., and Winterbourn, C. C. (2021) Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biol 46, 102090
Pearson A.G., Pullar J.M., Cook J., Spencer E.S., Vissers M.C.M., Carr A.C. and Hampton M.B. Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration. Redox Biol. 43:101980, 2021.
Peskin, A. V., and Winterbourn, C. C. (2021) The Enigma of 2-Cys Peroxiredoxins: What Are Their Roles? Biochemistry (Mosc.) 86, 84-91
Peskin, A. V., Meotti, F. C., Kean, K. M., Gobl, C., Peixoto, A. S., Pace, P. E., Horne, C. R., Heath, S. G., Crowther, J. M., Dobson, R. C. J., Karplus, P. A., and Winterbourn, C. C. (2021) Modifying the resolving cysteine affects the structure and hydrogen peroxide. Journal of Biological Chemistry 296:100494-
Pullar JM, Vissers MCM. Re: "Micronutrient Status in Diabetic Patients with Foot Ulcers" by Pena et al. Advances in wound care. 2021;10(1):49-50.
Queiroz, R. F., Stanley, C. P., Wolhuter, K., Kong, S. M. Y., Rajivan, R., McKinnon, N., Nguyen, G. T. H., Roveri, A., Guttzeit, S., Eaton, P., Donald, W. A., Ursini, F., Winterbourn, C. C., Ayer, A., and Stocker, R. (2021) Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation. Nature Communications 12, 6626
Schindler L, Smyth LCD, Bernhagen J, Hampton MB, Dickerhof N, Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils, Redox Biology 41:101946; 2021; IF: 9.9
Seddon A.R., Liau Y., Pace P.E., Miller A.L., Das A.B., Kennedy M.A., Hampton M.B. and Stevens A.J. Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics Chromatin 14:17, 2021.
Shearer H.L., Hampton M.B. and Dickerhof N. Bactericidal activity of the oxidants derived from mammalian heme peroxidases. In: Mammalian Peroxidases in Health and Disease, Hawkins C. and Nauseef W. eds, 2021.
Smith-Díaz C.C., Magon N.J., McKenzie J.L., Hampton M.B., Vissers M.C.M. and Das A.B. Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Front. Oncol. 11:709543, 2021.
Wohlrab C, Vissers MCM, Burgess ER, Nonis M, Phillips E, Robinson BA, Dachs GU. Limited Association Between Ascorbate Concentrations and Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical Samples. Cell Physiol Biochem 2021;55:553-56
Gubensäk N, Schrank E, Hartlmüller C, Göbl C, Falsone FS, Becker W, Wagner GE, Pulido S, Meyer NH, Pavkov-Keller T, Madl T, Reidl J, Zangger K.J Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR. Biol Chem. 2021 Oct;297(4):101167.
Crowther JM, Gilmour LH, Porebski BT, Heath SG, Pattinson NR, Owen MC, Fredericks R, Buckle AM, Fee CJ, Göbl C, Dobson RCJ. Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen. Biochem J. 2021 Sep 17;478(17):3319-3330. doi: 10.1042/BCJ20210476.
2020
Mohammad A, Saini RV, Kumar R, Sharma D, Saini NK, Gupta A, Thakur P, Winterbourn CC, Saini AK. A curious case of cysteines in human peroxiredoxin I. Redox Biol. 2020 Oct;37:101738. doi: 10.1016/j.redox.2020.101738. Epub 2020 Sep 24. PMID: 33011678 Free PMC article.
Conner TS, Fletcher BD, Pullar JM, Spencer E, Mainvil LA, Vissers MCM. KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Tablets on Vitality in Adults with Low Vitamin C Levels. Nutrients. 2020 Sep 22;12(9):2898. doi: 10.3390/nu12092898. PMID: 32971991 Free PMC article.
White R, Nonis M, Pearson JF, Burgess E, Morrin HR, Pullar JM, Spencer E, Vissers MCM, Robinson BA, Dachs GU. Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics. Nutrients. 2020 Aug 5;12(8):2338. doi: 10.3390/nu12082338. PMID: 32764253 Free PMC article.
Ashby LV, Springer R, Hampton MB, Kettle AJ, Winterbourn CC. Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radic Biol Med. 2020 Nov 1;159:119-124. doi: 10.1016/j.freeradbiomed.2020.07.033. Epub 2020 Jul 30. PMID: 32739594
Peskin AV, Meotti FC, de Souza LF, Anderson RF, Winterbourn CC, Salvador A. Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2. Free Radic Biol Med. 2020 Oct;158:115-125. doi: 10.1016/j.freeradbiomed.2020.07.007. Epub 2020 Jul 20. PMID: 32702382
Bathish B, Paumann-Page M, Paton LN, Kettle AJ, Winterbourn CC. Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. J Biol Chem. 2020 Sep 4;295(36):12697-12705. doi: 10.1074/jbc.RA120.014504. Epub 2020 Jul 16. PMID: 32675287
Dickerhof N, Paton L, Kettle AJ. Oxidation of bacillithiol by myeloperoxidase-derived oxidants. Free Radic Biol Med. 2020 Oct;158:74-83. doi: 10.1016/j.freeradbiomed.2020.06.009. Epub 2020 Jul 3. PMID: 32629107
van Leeuwen E, Hampton MB, Smyth LCD. Redox signalling and regulation of the blood-brain barrier. Int J Biochem Cell Biol. 2020 Aug;125:105794. doi: 10.1016/j.biocel.2020.105794. Epub 2020 Jun 17. PMID: 32562769 Review.
Sevcnikar B, Schaffner I, Chuang CY, Gamon L, Paumann-Page M, Hofbauer S, Davies MJ, Furtmüller PG, Obinger C. The leucine-rich repeat domain of human peroxidasin 1 promotes binding to laminin in basement membranes. Arch Biochem Biophys. 2020 Aug 15;689:108443. doi: 10.1016/j.abb.2020.108443. Epub 2020 May 30. PMID: 32485152
Winterbourn CC. Hydrogen peroxide reactivity and specificity in thiol-based cell signalling. Biochem Soc Trans. 2020 Jun 30;48(3):745-754. doi: 10.1042/BST20190049. PMID: 32412042
Pearson AG, Zawari M, Pearson JF, Hampton MB. Quantifying mitochondrial respiration in human lymphocytes and monocytes challenged with hydrogen peroxide. Free Radic Res. 2020 Apr;54(4):271-279. doi: 10.1080/10715762.2020.1753722. Epub 2020 Apr 24. PMID: 32326774
O'Connor KM, Das AB, Winterbourn CC, Hampton MB. Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. J Biol Chem. 2020 Jun 5;295(23):7839-7848. doi: 10.1074/jbc.RA120.013092. Epub 2020 Apr 20. PMID: 32312750
Dickerhof N, Huang J, Min E, Michaëlsson E, Lindstedt EL, Pearson JF, Kettle AJ, Day BJ. Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation. Free Radic Biol Med. 2020 May 20;152:91-99. doi: 10.1016/j.freeradbiomed.2020.03.001. Epub 2020 Mar 4. PMID: 32142878
Ahuie GK, Gagnon H, Pace PE, Peskin AV, Wagner RJ, Naylor S, Klarskov K. Investigating protein thiol chemistry associated with dehydroascorbate, homocysteine and glutathione using mass spectrometry. Rapid Commun Mass Spectrom. 2020 Jun 15;34(11):e8774. doi: 10.1002/rcm.8774. PMID: 32119756
Kader T, Porteous CM, Jones GT, Dickerhof N, Narayana VK, Tull D, Taraknath S, McCormick SPA. Ribose-cysteine protects against the development of atherosclerosis in apoE-deficient mice. PLoS One. 2020 Feb 21;15(2):e0228415. doi: 10.1371/journal.pone.0228415. eCollection 2020. PMID: 32084149 Free PMC article.
Pullar JM, Dunham S, Dachs GU, Vissers MCM, Carr AC. Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals. Nutrients. 2020 Feb 6;12(2):418. doi: 10.3390/nu12020418. PMID: 32041092 Free PMC article.
Meng Y, Sheen CR, Magon NJ, Hampton MB, Dobson RCJ. Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. J Biol Chem. 2020 Mar 6;295(10):2984-2999. doi: 10.1074/jbc.RA119.012226. Epub 2020 Jan 23. PMID: 31974167
Sevcnikar B, Paumann-Page M, Hofbauer S, Pfanzagl V, Furtmüller PG, Obinger C. Reaction of human peroxidasin 1 compound I and compound II with one-electron donors. Arch Biochem Biophys. 2020 Mar 15;681:108267. doi: 10.1016/j.abb.2020.108267. Epub 2020 Jan 15. PMID: 31953133
Schneider M, Hannaway RF, Lamichhane R, de la Harpe SM, Tyndall JDA, Vernall AJ, Kettle AJ, Ussher JE. Neutrophils suppress mucosal-associated invariant T cells in humans. Eur J Immunol. 2020 May;50(5):643-655. doi: 10.1002/eji.201948394. Epub 2020 Feb 3. PMID: 31944287
Carr AC, Spencer E, Hoskin TS, Rosengrave P, Kettle AJ, Shaw G. Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients. Free Radic Biol Med. 2020 May 20;152:462-468. doi: 10.1016/j.freeradbiomed.2019.11.004. Epub 2019 Nov 5. PMID: 31698081
Chami B, San Gabriel PT, Kum-Jew S, Wang X, Dickerhof N, Dennis JM, Witting PK. The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis. Redox Biol. 2020 Jan;28:101333. doi: 10.1016/j.redox.2019.101333. Epub 2019 Sep 28. PMID: 31593888 Free PMC article.
