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Mark Hampton imagePrincipal Investigator

PhD (Otago) MSc(Hons) (Canterbury)

Email mark.hampton@otago.ac.nz
Tel +64 3 372 6770

Mark Hampton is a professor at the Department of Pathology and Biomedical Science on the University of Otago, Christchurch campus, and director of Mātai Hāora - Centre for Redox Biology and Medicine .

He completed his undergraduate and PhD studies in New Zealand before taking up postdoctoral positions at the Karolinksa Institute in Sweden and Harvard in the USA. He subsequently returned to the University of Otago where he was promoted to a professorial role in 2013.

Research interests

Oxidants (also called reactive oxygen species or free radicals) are continuously generated in our body, and we rely on sophisticated antioxidant systems to prevent them from causing damage. However, oxidants also have beneficial roles. They can act as signalling molecules that regulate a number of life and death pathways in cells. Oxidants are also generated by the immune system to destroy microbes. Prof Hampton's research is focused on understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease.

Professor Hampton's current projects include investigations of how disruption of redox homeostasis can promote the killing of cancer cells and pathogenic microbes, and how oxidative stress and mitochondrial dysfunction are associated with the biological processes underlying human ageing.

Publications

Stevens, A., Seddon, A., Hampton, M., & Andrew, D. (2024). Oxidative stress induced changes in DNA methylation. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Redox proteomic analysis of H2O2 -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radical Biology & Medicine. Advance online publication. doi: 10.1016/j.freeradbiomed.2024.10.314 Journal - Research Article

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Effect of peroxiredoxin 1 or peroxiredoxin 2 knockout on the thiol proteome of Jurkat cells. Free Radical Biology & Medicine, 225, 595-604. doi: 10.1016/j.freeradbiomed.2024.10.293 Journal - Research Article

Featherston, T., Paumann-Page, M., & Hampton, M. B. (2024). Melanoma redox biology and the emergence of drug resistance. In Advances in cancer research. Elsevier. doi: 10.1016/bs.acr.2024.06.004 Chapter in Book - Research

Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385 Journal - Research Article

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