Principal Investigator
Email mark.hampton@otago.ac.nz
Tel +64 3 378 6225
Mark Hampton is a professor at the Department of Pathology and Biomedical Science on the University of Otago, Christchurch campus, and director of Mātai Hāora - Centre for Redox Biology and Medicine .
He completed his undergraduate and PhD studies in New Zealand before taking up postdoctoral positions at the Karolinksa Institute in Sweden and Harvard in the USA. He subsequently returned to the University of Otago where he was promoted to a professorial role in 2013.
Research interests
Oxidants (also called reactive oxygen species or free radicals) are continuously generated in our body, and we rely on sophisticated antioxidant systems to prevent them from causing damage. However, oxidants also have beneficial roles. They can act as signalling molecules that regulate a number of life and death pathways in cells. Oxidants are also generated by the immune system to destroy microbes. Prof Hampton's research is focused on understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease.
Professor Hampton's current projects include investigations of how disruption of redox homeostasis can promote the killing of cancer cells and pathogenic microbes, and how oxidative stress and mitochondrial dysfunction are associated with the biological processes underlying human ageing.
Affiliations
Publications
Publications
Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385 Journal - Research Article
Featherston, T., Helem, S., Smyth, L. C. D., Hampton, M. B., & Paumann-Page, M. (2024). Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability. Toxicology Mechanisms & Methods. Advance online publication. doi: 10.1080/15376516.2024.2360051 Journal - Research Article
Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032 Journal - Research Article
Seddon, A., Das, A., Hampton, M., & Stevens, A. (2024). Understanding how immune oxidants can drive epigenetic change. European Journal of Human Genetics, 32(Suppl. 1), (pp. 720). doi: 10.1038/s41431-023-01482-x Conference Contribution - Published proceedings: Abstract
Faville, S., Hampton, M. B., Pace, P., Goebl, C., & Helem, S. (2023). Chemoproteomic analyses of the anti-cancer effects of portimines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract
2024
Journal - Research Article
Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385
Featherston, T., Helem, S., Smyth, L. C. D., Hampton, M. B., & Paumann-Page, M. (2024). Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability. Toxicology Mechanisms & Methods. Advance online publication. doi: 10.1080/15376516.2024.2360051
Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032
Conference Contribution - Published proceedings: Abstract
Seddon, A., Das, A., Hampton, M., & Stevens, A. (2024). Understanding how immune oxidants can drive epigenetic change. European Journal of Human Genetics, 32(Suppl. 1), (pp. 720). doi: 10.1038/s41431-023-01482-x
2023
Journal - Research Article
Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23
Peeters, W. M., Gram, M., Dias, G. J., Vissers, M. C. M., Hampton, M. B., Dickerhof, N., Bekhit, A. E., … Bayer, S., … Sheard, P. W., Danielson, K. M., … Cornwall, J., & Rowlands, D. S. (2023). Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes. Redox Biology, 67, 102918. doi: 10.1016/j.redox.2023.102918
Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792
Shearer, H. L., Loi, V. V., Weiland, P., Bange, G., Altegoer, F., Hampton, M. B., … Dickerhof, N. (2023). MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus. Molecular Microbiology. Advance online publication. doi: 10.1111/mmi.15035
Taylor, M. F., Black, M. A., Hampton, M. B., & Ledgerwood, E. C. (2023). Insights into H2O2-induced signaling in Jurkat cells from analysis of gene expression. Free Radical Research. Advance online publication. doi: 10.1080/10715762.2023.2165073
Seddon, A. R., Das, A. B., Hampton, M. B., & Stevens, A. J. (2023). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Human Molecular Genetics, 32(4), 632-648. doi: 10.1093/hmg/ddac232
Journal - Research Other
Hampton, M. B., & Dickerhof, N. (2023). Inside the phagosome: A bacterial perspective. Immunological Reviews, 314, 197-209. doi: 10.1111/imr.13182
Conference Contribution - Published proceedings: Abstract
Faville, S., Hampton, M. B., Pace, P., Goebl, C., & Helem, S. (2023). Chemoproteomic analyses of the anti-cancer effects of portimines. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Helem, S., Pace, P., Seddon, A., Selwood, A., & Hampton, M. (2023). The anti-proliferative properties of the marine derived bioactive compound portimine. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Paumann-Page, M., Smith-Diaz, C., Kumar, A., Chitcholtan, K., Hampton, M., & Winterbourn, C. (2023). Peroxidasin: A novel modulator of melanoma cell invasion. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Smith-Diaz, C., Magon, N. J., McKenzie, J. L., Hore, T., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2023). Transcriptomics and epigenomics analysis of SKM-1 leukaemia response to Vitamin C. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Austad, S., Pace, P., Goebl, C., & Hampton, M. (2023). Unravelling the functional role of peroxiredoxin oligomeric conformations. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Featherston, T., Paumann-Page, M., & Hampton, M. (2023). Treating vemurafenib-resistant metastatic melanoma cells with thioredoxin reductase inhibitors. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Schwartfeger, A., Bozonet, S. M., Magon, N. J., Göbl, C., Morris, V. K., & Hampton, M. B. (2023). Oxidation triggered amyloid assembly of the cell death regulator caspase-8. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Shearer, H., Currie, M., Agnew, H., Trappetti, C., Stull, F., Pace, P., … Hampton, M., … Dickerhof, N. (2023). Sensitising Streptococcus pneumoniae to the immune-derived oxidant hypothiocyanous acid. Free Radical Biology & Medicine, 208(Suppl. 1), 96. doi: 10.1016/j.freeradbiomed.2023.10.110
Meotti, F., de Souza, L. F., Dempsey, B., Silva, R., Pinz, M., Cruz, L., Pace, P., Hampton, M., & Winterbourn, C. (2023). Peroxiredoxin 2 interacts with granule stress proteins in proliferative leukemic myeloid cells. Free Radical Biology & Medicine, 208(Suppl. 1), 38. doi: 10.1016/j.freeradbiomed.2023.10.053
Ledgerwood, E., King-Hudson, T.-R., Pearson, A., Dunstan-Harrison, C., & Hampton, M. (2023). Peroxiredoxins as markers of redox homeostasis in studies of human ageing. Free Radical Biology & Medicine, 208(Suppl. 1), 113. doi: 10.1016/j.freeradbiomed.2023.10.127
2022
Chapter in Book - Research
Shearer, H. L., Hampton, M. B., & Dickerhof, N. (2022). Bactericidal activity of the oxidants derived from mammilian heme peroxidases. In C. L. Hawkins & W. M. Nauseef (Eds.), Mammalian heme peroxidases: Diverse roles in health and disease. (pp. 171-188). Boca Raton, FL: CRC Press. doi: 10.1201/9781003212287
Journal - Research Article
Shearer, H. L., Pace, P. E., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. Journal of Biological Chemistry, 298(9), 102359. doi: 10.1016/j.jbc.2022.102359
Swaminathan, A., Borichevsky, G. M., Edwards, T. S., Hirschfeld, E., Mules, T. C., Frampton, C. M. A., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2022). Faecal myeloperoxidase as a biomarker of endoscopic activity in inflammatory bowel disease. Journal of Crohn's & Colitis, 16, 1862-1873. doi: 10.1093/ecco-jcc/jjac098
Ashby, L. V., Springer, R., Loi, V. V., Antelmann, H., Hampton, M. B., Kettle, A. J., & Dickerhof, N. (2022). Oxidation of bacillithiol during killing of Staphylococcus aureus USA300 inside neutrophil phagosomes. Journal of Leukocyte Biology, 112, 591-605. doi: 10.1002/jlb.4hi1021-538rr
Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologicca Communications, 10, 38. doi: 10.1186/s40478-022-01347-2
van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2022). Hypothiocyanous acid disrupts the barrier function of brain endothelial cells. Antioxidants, 11, 608. doi: 10.3390/antiox11040608
Shearer, H. L., Kaldor, C. D., Hua, H., Kettle, A. J., Parker, H. A., & Hampton, M. B. (2022). Resistance of Streptococcus pneumoniae to hypothiocyanous acid generated by host peroxidases. Infection & Immunity, 90(3), e00530-21. doi: 10.1128/iai.00530-21
Shearer, H. L., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). Glutathione utilization protects Streptococcus pneumoniae against lactoperoxidase-derived hypothiocyanous acid. Free Radical Biology & Medicine, 179, 24-33. doi: 10.1016/j.freeradbiomed.2021.12.261
Conference Contribution - Published proceedings: Abstract
Hampton, M. B. (2022). Redox signalling comes of age. Proceedings of the ComBio Conference. (pp. 86). Retrieved from https://combio.org.au/combio2022/
Conference Contribution - Poster Presentation (not in published proceedings)
Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Shearer, H. L., Parker, H. A., Pace, P. E., Hampton, M. B., & Dickerhof, N. (2022, August). Sensitising Streptococcus pneumoniae to oxidative stress. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Dickerhof, N., Parker, H. A., Hampton, M. B., & Kettle, A. J. (2022, August). Gauging the exposure of bacteria to toxic oxidants inside neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Pace, P. E., Peskin, A. V., Winterbourn, C. C., & Hampton, M. B. (2022, August). Disrupting the oligomeric structure of peroxiredoxins in cancer cells using CRISPR. Poster session presented at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M., Kettle, T., Gladyshev, V., & Sly, P. (2022, December). Where are oxidative footprints leading us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.
Hampton, M., Winterbourn, C., Dick, T., & Murphy, M. (2022, December). What are redox signals telling us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.
Featherston, T., Khor, C., Paumann-Page, M., & Hampton, M. (2022, August). Reprogrammed antioxidant defences in metastatic melanoma cells. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Hampton, M. (2022, July). Redox biology and immunology: Exploring new connections. Plenary presentation at the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference, Dunedin, New Zealand.
Other Research Output
Hampton, M. (2022, October). Redox biology comes of age. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2021
Journal - Research Article
Parker, H. A., Jones, H. M., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021). Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants, 10, 1791. doi: 10.3390/antiox10111791
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Frontiers in Oncology, 11, 709543. doi: 10.3389/fonc.2021.709543
Pearson, A. G., Pullar, J. M., Cook, J., Spencer, E. S., Vissers, M. C. M., Carr, A. C., & Hampton, M. B. (2021). Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration. Redox Biology, 43, 101980. doi: 10.1016/j.redox.2021.101980
Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6
Schindler, L., Smyth, L. C. D., Bernhagen, J., Hampton, M. B., & Dickerhof, N. (2021). Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils. Redox Biology, 41, 101946. doi: 10.1016/j.redox.2021.101946
Parker, H. A., Dickerhof, N., Forrester, L., Ryburn, H., Smyth, L., Messens, J., Aung, H. L., Cook, G. M., Kettle, A. J., & Hampton, M. B. (2021). Mycobacterium smegmatis resists the bactericidal activity of hypochlorous acid produced in neutrophil phagosomes. Journal of Immunology, 206, 1901-1912. doi: 10.4049/jimmunol.2001084
Schindler, L., Zwissler, L., Krammer, C., Hendgen-Cotta, U., Rassaf, T., Hampton, M. B., Dickerhof, N., & Bernhagen, J. (2021). Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. Journal of Leukocyte Biology, 110, 893-905. doi: 10.1002/JLB.3A0420-242RRR
Das, A. B., Seddon, A. R., O'Connor, K. M., & Hampton, M. B. (2021). Regulation of the epigenetic landscape by immune cell oxidants. Free Radical Biology & Medicine, 170, 131-149. doi: 10.1016/j.freeradbiomed.2020.12.453
Königstorfer, A., Ashby, L. V., Bollar, G. E., Billiot, C. E., Gray, M. J., Jakob, U., Hampton, M. B., & Winterbourn, C. C. (2021). Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease, 79, ftaa079. doi: 10.1093/femspd/ftaa079
Mayyas, I. M., Weeks, R. J., Day, R. C., Magrath, H. E., O’Connor, K. M., Kardailsky, O., Hore, T. A., Hampton, M. B., & Morison, I. M. (2021). Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics, 16(11), 1251-1259. doi: 10.1080/15592294.2020.1861169
Journal - Research Other
Parker, H. A., Forrester, L., Kaldor, C. D., Dickerhof, N., & Hampton, M. B. (2021). Antimicrobial activity of neutrophils against mycobacteria. Frontiers in Immunology, 12, 782495. doi: 10.3389/fimmu.2021.782495
Conference Contribution - Published proceedings: Abstract
Featherston, T., Paumann-Page, M., Dickerhof, N., Kaldor, C., Winterbourn, C. C., & Hampton, M. B. (2021). Measuring and exploiting oxidative stress in metastatic melanoma. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 281). Retrieved from https://www.faobmb2021.org
Borichevsky, G., Swaminathan, A., Edwards, T., Day, A., Hampton, M., Kettle, A., & Gearry, R. (2021). Faecal myeloperoxidase is a biomarker of endoscopically active inflammatory bowel disease. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 234). Retrieved from https://www.faobmb2021.org
Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org
Shearer, H. L., Parker, H. A., Paton, J., Camilli, A., Pace, P. E., Dickerhof, N., & Hampton, M. B. (2021). Sensitising Streptococcus pneumoniae to oxidative stress. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 145). Retrieved from https://www.faobmb2021.org
Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org
Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org
van Leeuwen, E., Smyth, L., Pace, P., & Hampton, M. (2021). Hypothiocyanous acid oxidizes collapsin response mediator protein 2 in brain pericytes. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 277). Retrieved from https://www.faobmb2021.org
Taylor, M., Black, M., Hampton, M., & Ledgerwood, L. (2021). Transcriptional response of Jurkat T lymphoma cells to hydrogen peroxide. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 276). Retrieved from https://www.faobmb2021.org
Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org
2020
Chapter in Book - Research
Magon, N. J., Parker, H. A., Ashby, L. V., Springer, R. J., & Hampton, M. B. (2020). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil: Methods and protocols: Methods in molecular biology (Vol. 2087). (3rd ed.) (pp. 149-164). New York, NY: Humana Press. doi: 10.1007/978-1-0716-0154-9_12
Journal - Research Article
Van Leeuwen, E., Hampton, M. B., & Smyth, L. C. D. (2020). Redox signalling and regulation of the blood-brain barrier. International Journal of Biochemistry & Cell Biology, 125, 105794. doi: 10.1016/j.biocel.2020.105794
Pearson, A. G., Zawari, M., Pearson, J. F., & Hampton, M. B. (2020). Quantifying mitochondrial respiration in human lymphocytes and monocytes challenged with hydrogen peroxide. Free Radical Research, 54(4), 271-279. doi: 10.1080/10715762.2020.1753722
O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092
Meng, Y., Sheen, C. R., Magon, N. J., Hampton, M. B., & Dobson, R. C. J. (2020). Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. Journal of Biological Chemistry, 295(10), 2984-2999. doi: 10.1074/jbc.RA119.012226
Journal - Research Other
Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033
2019
Journal - Research Article
Talla, U., Bozonet, S. M., Parker, H. A., Hampton, M. B., & Vissers, M. C. M. (2019). Prolonged exposure to hypoxia induces an autophagy-like cell survival program in human neutrophils. Journal of Leukocyte Biology, 106, 1367-1379. doi: 10.1002/jlb.4a0319-079rr
Dickerhof, N., Isles, V., Pattemore, P., Hampton, M. B., & Kettle, A. J. (2019). Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis. Journal of Biological Chemistry, 294(36), 13502-13514. doi: 10.1074/jbc.RA119.009934
de Souza, L. F., Pearson, A. G., Pace, P. E., Dafre, A. L., Hampton, M. B., Meotti, F. C., & Winterbourn, C. C. (2019). Peroxiredoxin expression and redox status in neutrophils and HL-60 cells. Free Radical Biology & Medicine, 135, 227-234. doi: 10.1016/j.freeradbiomed.2019.03.007
Conference Contribution - Published proceedings: Abstract
Fischer, J., Eglinton, T., Frizelle, F., Pace, P., Pearson, A., & Hampton, M. (2019). Marker of oxidative stress as a novel predictor of response to neoadjuvant chemoradiotherapy for rectal cancer. ANZ Journal of Surgery, 89(Suppl. 1), (pp. 25). doi: 10.1111/ans.15180
Conference Contribution - Verbal presentation and other Conference outputs
Das, A. B., Hampton, M. B., & Vissers, M. C. M. (2019, August-September). Creodes and cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Edited Book - Research
Vissers, M. C. M., Hampton, M. B., & Kettle, A. J. (Eds.). (2018). Hydrogen peroxide metabolism in health and disease. Boca Raton, FL: CRC Press, 456p.
Chapter in Book - Research
Hampton, M. B. (2018). Hydrogen peroxide-dependent redox signaling: Basic concepts and unanswered questions. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 353-364). Boca Raton, FL: CRC Press.
Journal - Research Article
Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407
Richards, S. J. G., Frizelle, F. A., Geddes, J. A., Eglinton, T. W., & Hampton, M. B. (2018). Frailty in surgical patients. International Journal of Colorectal Disease, 33(12), 1657-1666. doi: 10.1007/s00384-018-3163-y
Yewdall, N. A., Peskin, A. V., Hampton, M. B., Goldstone, D. C., Pearce, F. G., & Gerrard, J. A. (2018). Quaternary structure influences the peroxidase activity of peroxiredoxin 3. Biochemical & Biophysical Research Communications, 497(2), 558-563. doi: 10.1016/j.bbrc.2018.02.093
Hampton, M. B., Vick, K. A., Skoko, J. J., & Neumann, C. A. (2018). Peroxiredoxin involvement in the initiation and progression of human cancer. Antioxidants & Redox Signaling, 28(7), 591-608. doi: 10.1089/ars.2017.7422
Journal - Research Other
Fischer, J., Eglinton, T. W., Frizelle, F. A., & Hampton, M. B. (2018). Peroxiredoxins in colorectal cancer: Predictive biomarkers of radiation response and therapeutic targets to increase radiation sensitivity? Antioxidants, 7(10), 136. doi: 10.3390/antiox7100136
Conference Contribution - Published proceedings: Abstract
Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz
Kaldor, C. D., Parker, H. A., & Hampton, M. B. (2018). Oxidant production by Streptococcus pneumoniae associated with neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 108). Retrieved from https://www.nzmsconference.org.nz
Parker, H. A., Jones, M. G., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2018). Timing of reactive oxygen species involvement in formation of neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 100). Retrieved from https://www.nzmsconference.org.nz
Parker, H. A., Hampton, M. B., Rosado, L. A., Messens, J., & Kettle, A. J. (2018). Resistance of Mycobacterium smegmatis to oxygen-dependent killing by neutrophils. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 95-96). Retrieved from https://www.nzmsconference.org.nz
Vick, K., Kaur, G., Doroshow, J., Winterbourn, C., & Hampton, M. (2018). Peroxiredoxins as markers of oxidative stress in cancer cells. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Dagnell, M., Cheng, Q., Pace, P. E., Hampton, M. B., Winterbourn, C. C., & Arnér, E. S. J. (2018). Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S36). doi: 10.1016/j.freeradbiomed.2018.04.123
Conference Contribution - Poster Presentation (not in published proceedings)
Mayyas, I., Weeks, R., Hampton, M., Hore, T., & Morison, I. (2018, August). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Swan, J., Aitchison, A., Hampton, M., & Keenan, J. (2018, September). Asprin's role in preventing e-cadherin cleavage by the carcinogenic Bacteroides Fragilis toxin. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Kaldor, C., Parker, H., Cook, G., & Hampton, M. (2018, September). Streptococcus Pneumoniae adhered to neutrophil extracellular traps produce hydrogen peroxide which is converted into hypochlorous acid. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.
2017
Journal - Research Article
Schindler, L., Dickerhof, N., Hampton, M. B., & Bernhagen, J. (2017). Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning. Redox Biology, 15, 135-142. doi: 10.1016/j.redox.2017.11.028
Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745
Conference Contribution - Published proceedings: Abstract
Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017). Mechanisms of active DNA demethylation in somatic cells. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 770. Retrieved from http://gen2017.w.events4you.currinda.com
Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185
Conference Contribution - Poster Presentation (not in published proceedings)
Bozonet, S., Hampton, M., & Vissers, M. (2017, September). Hypothiocyanous acid protects endothelial cells from hypochlorous acid-mediated death. Poster session presented at the European Cell Death Organisation (ECDO)25gth Conference: Cell Death and Immunity in Disease: From Molecules to Translational Medicine, Leuven, Belgium.
Mayyas, I., Weeks, R., Hampton, M., & Morison, I. (2017, September). Mechanisms of active DNA demethylation in somatic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Pearson, A. G., Zawari, M., & Hampton, M. B. (2017, September). Assessing mitochondrial activity and response to oxidative stress in human monocyte and lymphocytes. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Talla, U. R., Parker, H., Bozonet, S., Hampton, M., & Vissers, M. (2017, July). An altered cell death pathway for neutrophils in a hypoxic environment. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Hampton, M. B., Dickerhof, N., Pace, P. E., & Bozonet, S. M. (2017, July). Redox signalling and the regulation of immune cell life and death. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Pearson, A., Zawari, M., & Hampton, M. B. (2017, July). Assessment of mitochondrial metabolism in immune cells. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Hoskin, T. S., Dickerhof, N., Hampton, M. B., & Kettle, A. J. (2017, July). Calprotectin is sensitive to oxidants generated by myeloperoxidase. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
Parker, H., Jones, M., Hampton, M., & Winterbourn, C. (2017, July). Oxidant-dependent steps in the formation of neutrophil extracellular traps. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.
2016
Journal - Research Article
Cuddihy, S. L., Drake, S., Harwood, T., Selwood, A. I., McNabb, P. S., & Hampton, M. B. (2016). The marine cytotoxin portimine is a potent and selective inducer of apoptosis. Apoptosis, 21(12), 1447-1452. doi: 10.1007/s10495-016-1302-x
Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995
Yewdall, N. A., Venugopal, H., Desfosses, A., Abrishami, V., Yosaatmadja, Y., Hampton, M. B., … Radjainia, M. (2016). Structures of human peroxiredoxin 3 suggest self-chaperoning assembly that maintains catalytic state. Structure, 24(7), 1120-1129. doi: 10.1016/j.str.2016.04.013
Poynton, R. A., Peskin, A. V., Haynes, A. C., Lowther, W. T., Hampton, M. B., & Winterbourn, C. C. (2016). Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochemical Journal, 473, 411-421. doi: 10.1042/bj20150572
Journal - Research Other
Bolaños, J. P., Cadenas, E., Duchen, M. R., Hampton, M. B., Mann, G. E., & Murphy, M. P. (2016). Introduction to special issue on mitochondrial redox signaling in health and disease. Free Radical Biology & Medicine, 100, 1-4. doi: 10.1016/j.freeradbiomed.2016.08.004
Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442
Hampton, M. B., & O'Connor, K. M. (2016). Peroxiredoxins and the regulation of cell death. Molecules & Cells, 39(1), 72-76. doi: 10.14348/molcells.2016.2351
Conference Contribution - Published proceedings: Abstract
Pearson, A. G., Moran, S. M., Zawari, M., & Hampton, M. B. (2016). Peroxiredoxins as markers of oxidative stress in circulating blood cells. Free Radical Biology & Medicine, 100(Suppl.), (pp. S106). doi: 10.1016/j.freeradbiomed.2016.10.270
Talla, U. R., Bozonet, S., Parker, H., Hampton, M., & Vissers, M. (2016). Inhibition of neutrophil apoptosis and initiation of an autophagy-like process in hypoxia and effects on neutrophil function. Free Radical Biology & Medicine, 100(Suppl.), (pp. S63). doi: 10.1016/j.freeradbiomed.2016.10.166
Pace, P., Peskin, A. V., Jasoni, C. L., Winterbourn, C., & Hampton, M. (2016). Interaction of peroxiredoxin 2 with collapsin response mediator protein 2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.126
Dagnell, M., Pace, P., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E., Hampton, M., & Winterbourn, C. (2016). Thioredoxin reductase 1 directly protects protein tyrosine phosphatase 1B from inactivation by H2O2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.125
Newman, T., Leeke, B., Carleton, C., Leask, M., Hampton, M., & Horsfield, J. (2016). How zebrafish can help understand craniofacial biology. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 16-17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026
2015
Journal - Research Article
Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology, 6, 648-655. doi: 10.1016/j.redox.2015.10.010
Dickerhof, N., Schindler, L., Bernhagen, J., Kettle, A. J., & Hampton, M. B. (2015). Macrophage migration inhibitory factor (MIF) Is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function. Free Radical Biology & Medicine, 89, 498-511. doi: 10.1016/j.freeradbiomed.2015.09.009
Balasubramanain, D., Deng, A. X., Doudney, K., Hampton, M. B., & Kennedy, M. A. (2015). Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology, 99, 79-88. doi: 10.1016/j.neuropharm.2015.06.018
Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022
Radjainia, M., Venugopal, H., Desfosses, A., Phillips, A. M., Yewdall, N. A., Hampton, M. B., … Mitra, A. K. (2015). Cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Structure, 23(5), 912-920. doi: 10.1016/j.str.2015.03.019
Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012
Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422
Bayer, S. B., Hampton, M. B., & Winterbourn, C. C. (2015). Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion, 55(8), 1909-1918. doi: 10.1111/trf.13039
Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208
Journal - Research Other
Winterbourn, C. C., & Hampton, M. B. (2015). Signaling via a peroxiredoxin sensor. Nature Chemical Biology, 11(1), 5-6. doi: 10.1038/nchembio.1722
Conference Contribution - Published proceedings: Abstract
Spencer, E., Dickerhof, N., Tyndall, J., Bernhagen, J., Kettle, A., & Hampton, M. (2015). Assessing inhibition of macrophage migration inhibitory factor by isothiocyanates. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S42-S43). doi: 10.1016/j.freeradbiomed.2015.07.145
Conference Contribution - Verbal presentation and other Conference outputs
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2015, September). Myeloperoxidase-derived oxidants render macrophage migration inhibitory factor (MIF) enzymatically inactive while retaining its immunologic function. Verbal presentation at the 9th International Human Peroxidase Meeting, Cologne, USA.
Venugopal, H., Radjainia, M., Desfosses, A., Phillips, A. J., Yewdall, A. J., Hampton, M. B., … Mitra, A. K. (2015, August-September). High resolution cryo-electron microscopy structure of human peroxiredoxin-3 filament reveals the assembly of a putative chaperone. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Chapter in Book - Research
Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19
Journal - Research Article
Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612
Poynton, R. A., & Hampton, M. B. (2014). Peroxiredoxins as biomarkers of oxidative stress. Biochimica et Biophysica Acta: General Subjects, 1840(2), 906-912. doi: 10.1016/j.bbagen.2013.08.001
Conference Contribution - Published proceedings: Abstract
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). No association between telomere length and exposure to life course stress or adversity in two longitudinal New Zealand cohorts. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 1325M. Retrieved from http://www.ashg.org/
Jodczyk, S., Pearson, J. F., Fergusson, D. M., Horwood, L. J., Spittlehouse, J. K., Joyce, P. R., Hampton, M. B., & Kennedy, M. A. (2014). Association between telomere length and life stress in two New Zealand cohorts. New Zealand Medical Journal, 127(1396). Retrieved from http://www.nzma.org.nz/journal
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define structure activity relationships. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 88). Retrieved from http://www.crystal29.com/
Conference Contribution - Poster Presentation (not in published proceedings)
Tyndall, J. D. A., Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., & Hampton, M. B. (2014, August). Multiple binding modes of isothiocyanate inhibitors of macrophage migration inhibitory factor define design strategies. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Jodczyk, S., Pearson, J., Fergusson, D., Horwood, J., Spittlehouse, J., Joyce, P., Hampton, M., & Kennedy, M. (2014, September). No association between telomere length and exposure to life course stress in two longitudinal New Zealand cohorts. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. (2014, December). Mitochondrial redox changes during TNF-mediated necroptosis. Verbal presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.
2013
Journal - Research Article
Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2013). Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis. World Journal of Gastroenterology, 19(39), 6656-6664. doi: 10.3748/wjg.v19.i39.6656
Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030
Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB Journal, 27(8), 3315-3322. doi: 10.1096/fj.13-227298
Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881
Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2013). Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biology & Medicine, 58, 109-117. doi: 10.1016/j.freeradbiomed.2013.01.021
Conference Contribution - Published proceedings: Abstract
Hampton, M. (2013). New ways of thinking about and measuring oxidative stress. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/
Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S35-S36). doi: 10.1016/j.freeradbiomed.2013.10.470
Conference Contribution - Poster Presentation (not in published proceedings)
Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
O'Connor, K. M., & Hampton, M. B. (2013, August). Using the Seahorse Bioscience Extracellular Flux Analyzer to measure the consequences of oxidative stress on mitochondrial function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Ejje, N., Deuss, F. A., Puskar, L., Hampton, M. B., & Giles, G. I. (2013, August). Analysis of the intracellular targets of auranofin drug action by Synchrotron Radiation Fourier Transform Infrared Spectroscopy. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Covalent modification of the pro-inflammatory cytokine MIF by dietary and endogenous electrophiles. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Vick, K. A., Betz, A., O'Connor, K. M., Hughes, S. M., Ledgerwood, E. C., & Hampton, M. B. (2013, August). Functional consequences of lowering mitochondrial peroxiredoxin 3 expression. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Spencer, E. S., Dale, E., Smith, R. A. J., Gamble, A. B., Tyndall, J. D. A., Rutledge, M. T., Wilbanks, S. M., Dickerhof, N., Kettle, A. J., & Hampton, M. B. (2013, August). Assessing inhibition of macrophage migration inhibitory factor by novel isothiocyanates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Pujary, U. R., Hampton, M., Parker, H., & Vissers, M. (2013, August). Effect of hypoxia on neutrophil survival and function. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Poynton, R. A., Peskin, A. V., Dickerhof, N., Lowther, T. W., Betz, A., Winterbourn, C. C., & Hampton, M. B. (2013, August). Kinetics and biochemical properties of peroxiredoxin 3 hyperoxidation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Newman, T. A. C., Hampton, M. B., & Horsfield, J. A. (2013, August). The developmental consequences of oxidative stress. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013, August). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Gommans, A., Hampton, M. B., Tyndall, J. D. A., & Wilbanks, S. M. (2013, August). Improved-resolution structure of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Gommans, A. L., Tyndall, J. D. A., Hampton, M. B., & Wilbanks, S. M. (2013, February). Improved resolution of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate. Verbal presentation at the 38th Lorne Conference on Protein Structure and Function, Lorne, Australia.
Hampton, M. (2013, February). Exploring nature's medicine chest. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand.
2012
Journal - Research Article
Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004
Tyndall, J. D. A., Lue, H., Rutledge, M. T., Bernhagen, J., Hampton, M. B., & Wilbanks, S. M. (2012). Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate. Acta Crystallographica Section F, 68(9), 999-1002. doi: 10.1107/s1744309112030552
Stacey, M. M., Cuddihy, S. L., Hampton, M. B., & Winterbourn, C. C. (2012). Protein thiol oxidation and formation of S-glutathionylated cyclophilin A in cells exposed to chloramines and hypochlorous acid. Archives of Biochemistry & Biophysics, 527(1), 45-54. doi: 10.1016/j.abb.2012.07.011
Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601
Keenan, J. I., Salm, N., Wallace, A. J., & Hampton, M. B. (2012). Using food to reduce H. pylori-associated inflammation. Phytotherapy Research, 26(11), 1620-1625. doi: 10.1002/ptr.4618
Conference Contribution - Published proceedings: Abstract
Pujary, U. R., Hampton, M., Winterbourn, C., & Vissers, M. (2012). Hypoxia extends neutrophil survival but does not necessarily retain cell function. Proceedings of the Oxygen Theme Meeting. (pp. 35). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Pace, P., Peskin, A., Hampton, M., & Winterbourn, C. (2012). Hydrogen peroxide-dependent interaction of peroxiredoxin 2 with ERp46. Proceedings of the Oxygen Theme Meeting. (pp. 32). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Spencer, E., Tyndall, J., Smith, R. A. J., & Hampton, M. (2012). Biological properties of isothiocyanates. Proceedings of the Oxygen Theme Meeting. (pp. 21). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Newman, T., Hampton, M., & Horsfield, J. (2012). A developmental role for Peroxiredoxin 3. Proceedings of the Oxygen Theme Meeting. (pp. 15). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Poynton, R., Peskin, A., Dickerhof, N., Paton, L., Winterbourn, C., & Hampton, M. (2012). Kinetics of peroxiredoxin 2 and 3 hyperoxidation. Proceedings of the Oxygen Theme Meeting. (pp. 14). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Hampton, M. (2012). Peroxiredoxin 3 as a mitochondrial antioxidant and sensor and marker of mitochondrial oxidative stress. Proceedings of the Oxygen Theme Meeting. (pp. 13). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Ulcerative Colitis (UC): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Falvey, J. D., Munday, J. S., Keenan, J. I., Dyer, A. E., Gearry, R. B., & Hampton, M. B. (2012). Clinical assessment of murine Dextran Sodium Sulphate (DSS) colitis: Prospective validation of a novel scoring tool. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Falvey, J. D., Hoskin, T., Meijer, B., Ashcroft, A., Hampton, M. B., Day, A. S., & Gearry, R. B. (2012). Disease assessment in Crohn's disease (CD): Data from the Novel Biomarkers in Inflammatory Bowel Disease (NBIBD) project cohort. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal
Pace, P. E., Peskin, A. V., Hampton, M. B., & Winterbourn, C. C. (2012). Hydrogen peroxide dependent interaction of peroxiredoxin 2 with ERp46. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2012.08.440
Peskin, A. V., Dickerhof, N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2012). Kinetics of hyperoxidation of human peroxiredoxin 2. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210-S211). doi: 10.1016/j.freeradbiomed.2012.08.441
Conference Contribution - Poster Presentation (not in published proceedings)
Newman, T., Hampton, M., & Horsfield, J. (2012, September). Peroxiredoxin 3 protects zebrafish development against mitochondrial oxidative stress. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M., Bayer, S., Moran, S., Maghzal, G., Stocker, R., Choe, C. F., Lunt, H., Chambers, S., Peskin, A., & Winterbourn, C. (2012, November). Peroxiredoxins as biomarkers of oxidative stress. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.
Balasubramanain, D., Hampton, M., & Kennedy, M. (2012, November). Effect of valproate on SPR gene expression in a serotonergic cell line. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
2011
Journal - Research Article
Brown, K. K., & Hampton, M. B. (2011). Biological targets of isothiocyanates. Biochimica et Biophysica Acta: General Subjects, 1810(9), 888-894. doi: 10.1016/j.bbagen.2011.06.004
Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355
Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2011). Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling. Antioxidants & Redox Signaling, 15(1), 167-174. doi: 10.1089/ars.2010.3843
Conference Contribution - Published proceedings: Abstract
Falvey, J. D., Munday, J. S., Keenan, J. I., Gearry, R. B., & Hampton, M. B. (2011). Assessing the efficacy of isothiocyanates in experimental colitis. New Zealand Medical Journal, 124(1347). Retrieved from http://journal.nzma.org.nz/journal/124-1347/5015/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. (2011, September). Peroxiredoxins as redox sensors and signalling proteins. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Tyndall, J. D. A., Dale, E. J., Spencer, E. S., Falvey, J. D., Smith, R. A. J., & Hampton, M. B. (2011, November-December). Isothiocyanate inhibitors of the proinflammatory cytokine macrophage migration inhibitory factor. Verbal presentation at the New Zealand Institute of Chemistry (NZIC) Conference, Hamilton, New Zealand.
2010
Chapter in Book - Research
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0
Requejo, R., Chouchani, E. T., Hurd, T. R., Menger, K. E., Hampton, M. B., & Murphy, M. P. (2010). Measuring mitochondrial protein thiol redox state. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 123-147). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0
Journal - Research Article
Bernal, A. B., Vickers, M. H., Hampton, M. B., Poynton, R. A., & Sloboda, D. M. (2010). Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS ONE, 5(12), e15558. doi: 10.1371/journal.pone.0015558
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313-321. doi: 10.1042/BJ20101156
Parker, H., Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2010). Uptake of Helicobacter pylori outer membrane vesicles by gastric epithelial cells. Infection & Immunity, 78(12), 5054-5061. doi: 10.1128/IAI.00299-10
Keenan, J. I., Salm, N., Hampton, M. B., & Wallace, A. J. (2010). Individual and combined effects of foods on Helicobacter pylori growth. Phytotherapy Research, 24(8), 1229-1233. doi: 10.1002/ptr.3167
Brown, K. K., Cox, A. G., & Hampton, M. B. (2010). Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Letters, 584, 1257-1262. doi: 10.1016/j.febslet.2010.02.042
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541
Conference Contribution - Published proceedings: Abstract
Falvey, J. D., Bentley, R. W., Merriman, T. R., Hampton, M. B., Barclay, M. L., Gearry, R. B., & Roberts, R. L. (2010). Gene-gene interaction between Macrophage Migration Inhibitory Factor (MIF) and NOD2 alters susceptibility to ileal Crohn's disease. New Zealand Medical Journal, 123(1327). Retrieved from http://journal.nzma.org.nz/journal/123-1327/4492/content.pdf
Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479
Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2010). Redox proteomics of EGF signaling. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S128). doi: 10.1016/j.freeradbiomed.2010.10.350
Brown, K. K., & Hampton, M. B. (2010). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2010.10.468
Conference Contribution - Poster Presentation (not in published proceedings)
Poynton, R. A., Sloboda, D. M., Vickers, M. H., Winterbourn, C. C., & Hampton, M. B. (2010, September). Peroxiredoxin 3 and oxidative stress in mitochondria. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2010, November-December). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Davies, M. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Removal of amino acid, peptide and protein peroxide by reaction with peroxiredoxin 2 and peroxiredoxin 3. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Cellular interactions of peroxiredoxin 2. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.
2009
Journal - Research Article
Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092
Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242
Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g
Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23
Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j.febslet.2009.02.018
Conference Contribution - Published proceedings: Abstract
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009). Peroxiredoxin 3 is a key regulator of mitochondrial hydrogen peroxide. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]
Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2009). Rapid removal of amino acid, peptide and protein peroxides. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S150-S151). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Pace, P., Hampton, M., & Winterbourn, C. (2009, December). Cellular interactions of peroxiredoxins. Poster session presented at the 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.
2008
Journal - Research Article
Chitcholtan, K., Hampton, M. B., & Keenan, J. I. (2008). Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis, 29(12), 2400-2405. doi: 10.1093/carcin/bgn218
Cox, A. G., Brown, K. K., Arner, E. S. J., & Hampton, M. B. (2008). The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochemical Pharmacology, 76(9), 1097-1109. doi: 10.1016/j.bcp.2008.08.021
Winterbourn, C. C., & Hampton, M. B. (2008). Thiol chemistry and specificity in redox signaling. Free Radical Biology & Medicine, 45(5), 549-561. doi: 10.1016/j.freeradbiomed.2008.05.004
Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2008). Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxidants & Redox Signaling, 10(9), 1621-1629. doi: 10.1089/ars.2008.2081
Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology & Medicine, 44(6), 1001-1009. doi: 10.1016/j.freeradbiomed.2007.11.017
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229
Thomson, S. J., Cox, A. G., Cuddihy, S. L., Pullar, J. M., & Hampton, M. B. (2008). Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochemical & Biophysical Research Communications, 375(1), 145-150. doi: 10.1016/j.bbrc.2008.07.133
Brown, K. K., Eriksson, S. E., Arnér, E. S. J., & Hampton, M. B. (2008). Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radical Biology & Medicine, 45(4), 494-502. doi: 10.1016/j.freeradbiomed.2008.04.030
Cuddihy, S. L., Brown, K. K., Thomson, S. J., & Hampton, M. B. (2008). Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL. Cancer Letters, 271(2), 215-221. doi: 10.1016/j.canlet.2008.06.002
Conference Contribution - Published proceedings: Abstract
Cox, A. G., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. New Zealand Medical Journal, 121(1271). Retrieved from Oxidation of mitochondrial peroxiredoxin 3 during the initiation of http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2008). Impact of oxidative stress on DNA methylation. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Wilkie, R., Vissers, M. C. M., & Hampton, M. B. (2008). A functional NADPH oxidase promotes neutrophil apoptosis by a caspase-independent mechanism. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Chitcholtan, K., Hampton, M., & Keenan, J. (2008). Outer membrane vesicles (OMVs) of Helicobacter pylori alter cellular signalling pathways in human gastric epithelial cells. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Brown, K. K., & Hampton, M. B. (2008). Pro-apoptotic isothiocyanates inactivate proteins involved in maintaining mitochondrial redox homeostasis. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Poster session presented at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Hampton, M. (2008, November). Mitochondrial peroxiredoxin 3 and the regulation of apoptosis. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.
Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.
2007
Chapter in Book - Research
Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Neutrophil methods and protocols. (pp. 319-332). Totowa, USA: Humana Press.
Journal - Research Article
Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897.
Wilkie, R. P., Vissers, M. C. M., Dragunow, M., & Hampton, M. B. (2007). A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection & Immunity, 75(7), 3256-3263.
Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617.
Cox, A. G., & Hampton, M. B. (2007). Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide. Carcinogenesis, 28(10), 2166-2171.
Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892.
Conference Contribution - Published proceedings: Abstract
Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2007). Mitochondrial peroxiredoxin 3 is oxidized during Fas and TNF-a mediated apoptosis. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/
Chitcholtan, K., Hampton, M., & Keenan, J. (2007). H. pylori outer membrane vesicles induce DNA damage in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 155). [Abstract]
Salm, N., Hampton, M., Wallace, A. J., & Keenan, J. (2007). Broccoli sprouts inhibit the release of interleukin-8 from AGS cells co-cultured with Helicobacter pylori. Zoonoses and Public Health. 54(Suppl. 1), (pp. 97-98). [Abstract]
Davis, K. A., Chitcholtan, K., Hampton, M., & Keenan, J. I. (2007). Helicobacter pylori outer membrane vesicles induce cytoskeletal rearrangements and cell signaling events in gastric epithelial cells. Zoonoses and Public Health. 54(Suppl. 1), (pp. 151). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2007, August). Impact of oxidative stress on DNA methylation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2006
Chapter in Book - Research
Hampton, M. B., Baty, J. W., & Winterbourn, C. C. (2006). Use of a proteomic technique to identify oxidant-sensitive thiol proteins in cultured cells. In I. Dalle-Donne, A. Scaloni & D. A. Butterfield (Eds.), Redox Proteomics: From protein modifications to cellular dysfunction and diseases. (pp. 253-265). Hoboken, NJ: John Wiley & Sons.
Journal - Research Article
Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869.
Thomson, S. J., Brown, K. K., Pullar, J. M., & Hampton, M. B. (2006). Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Research, 66(13), 6772-6777.
Conference Contribution - Published proceedings: Abstract
Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract]
Wilkie, R., Vissers, M., & Hampton, M. (2006). Role of NADPH oxidase: Derived oxidants in neutrophil apoptosis. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
2005
Journal - Research Article
Baird, S. K., Reid, L., Hampton, M. B., & Gieseg, S. P. (2005). OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta: Molecular Cell Research, 1745, 361-369. doi: 10.1016/j.bbamcr.2005.07.001
Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-KB activation. Journal of Leukocyte Biology, 77, 432-437.
Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2005). Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochemical Journal, 390(3), 785-795.
Keenan, J. I., Peterson, II, R. A., & Hampton, M. B. (2005). NADPH oxidase involvement in the pathology of Helicobacter pylori infection. Free Radical Biology & Medicine, 38, 1188-1196.
Conference Contribution - Published proceedings: Abstract
Parker, H., Ismail, S., Neal, S., Hampton, M., & Keenan, J. (2005). Association of Helicobacter pylori outer membrane vesicles with gastric epithelial cells. In V. Korolik, A. Lee, H. Mitchell, G. Mendz, B. Fry & P. Coloe (Eds.), Proceedings of the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms. (pp. 72). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Pullar, J. M., Baty, J. W., Csordas, A., Winterbourn, C. C., & Hampton, M. B. (2005, December). Oxidation of thiol proteins in cultured cells: Comparison of H2O2 with receptor-mediated signalling. Verbal presentation at the 3rd Joint Meeting of the Society for Free Radical Research Australasia and Japan, Queensland, Australia.
Keenan, J., Peterson, R., Ismail, S., Hock, B., Frampton, C., & Hampton, M. (2005, September). Host iron deficiency alters the outcome of infection in Helicobacter pylori-infected mice. Verbal presentation at the 13th International Workshop on Campylobacter, Helicobacter and Related Organisms, Gold Coast, Australia.
2004
Journal - Research Article
Baird, S. K., Hampton, M. B., & Gieseg, S. P. (2004). Oxidized LDL triggers phosphatidylserine exposure in human monocyte cell lines by both caspase-dependent and -independent mechanisms. FEBS Letters, 578, 169-174.
Pullar, J. M., Thomson, S. J., King, M. J., Turnbull, C. I., Midwinter, R. G., & Hampton, M. B. (2004). The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis. Carcinogenesis, 25(5), 765-772.
Conference Contribution - Published proceedings: Full paper
Vissers, M. C. M., & Hampton, M. B. (2004). The role of oxidants and vitamin C on neutrophil apoptosis and clearance. Biochemical Society Transactions. 32(3), (pp. 499-501). [Full Paper]
Conference Contribution - Published proceedings: Abstract
Keenan, J. I., Peterson, R. A., & Hampton, M. B. (2004). Role of neutrophil oxidants in the gastric pathology associated with Helicobacter pylori infection. Helicobacter. 9(5), (pp. 591-592). [Abstract]
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. M. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Proceedings of the Perinatal Society of Australia and New Zealand: 8th Annual Congress. (pp. P133). Sydney, Australia: PSANZ. [Abstract]
Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Pediatric Research. 56(3), (pp. 474). [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Thomson, S. J., Pullar, J. M., & Hampton, M. B. (2004, December). Phenethyl isothiocyanate triggers apoptosis in cells over-expressing Bcl-2. Poster session presented at the 13th Annual Conference of the Society for Free Radical Research (Australasia), Christchurch, New Zealand.
Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris.
2003
Journal - Research Article
Ismail, S., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and interleukin-8 production by gastric epithelial cells. Infection & Immunity, 71(10), 5670-5675.
Conference Contribution - Published proceedings: Abstract
Ismail, S., Parker, H., Hampton, M. B., & Keenan, J. I. (2003). Helicobacter pylori outer membrane vesicles modulate proliferation and IL-8 production by gastric epithelial cells. International Journal of Medical Microbiology, 293(Suppl. 35), (pp. 116). [Abstract]
2002
Journal - Research Article
Hampton, M. B., & Winterbourn, C. C. (2002). Redox regulation of neutrophil function. Antioxidants & Redox Signaling, 4(1), 1-3.
Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762.
Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Journal of Biological Chemistry, 277(22), 19402-19407.
Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781.
Hampton, M. B., Stamenkovic, G., & Winterbourn, C. C. (2002). Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Letters, 517, 229-232.
Hampton, M. B., Morgan, P., & Davies, M. (2002). Inactivation of cellular caspases by peptide-derived tryptophan and tyrosine peroxides. FEBS Letters, 527, 289-292.
Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2002). Detection of oxidant-sensitive thiol proteins by fluorescent labeling and two dimensional electrophoresis. Proteomics, 2, 1261-1266.
Conference Contribution - Published proceedings: Abstract
Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Free Radical Biology and Medicine. 33(Suppl. 1), (pp. S91-S92). [Abstract]
2001
Journal - Research Article
Vissers, M. C. M., Lee, W. G., & Hampton, M. B. (2001). Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants. Journal of Biological Chemistry, 276(50), 46835-46840. doi: 10.1074/jbc.M107664200
2000
Chapter in Book - Research
Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer.
Conference Contribution - Published proceedings: Abstract
Keenan, J. I., Hampton, M. B., & Allardyce, R. A. (2000). H. pylori proteases and the develpoment of gastric cancer. Gut. 47(Suppl. 1), (pp. A27). [Abstract]
1999
Journal - Research Article
Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999). Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochemical Journal, 344, 443-449.
Hampton, M. B., & Winterbourn, C. C. (1999). Methods for quantifying phagocytosis and bacterial killing by human neutrophils. Journal of Immunological Methods, 232, 15-22.
Stridh, H., Orrenius, S., & Hampton, M. B. (1999). Caspase involvement in the induction of apoptosis by the environmental toxicants tributylin and triphenyltin. Toxicology & Applied Pharmacology, 156, 141-146.
Journal - Professional & Other Non-Research Articles
Hampton, M. B. (1999). Mitochondria: unravelling the secrets of life and death. Redox Report, 4, 137-139.
1998
Journal - Research Article
Hampton, M. B., Zhivotovsky, B., Burgess, D. H., Slater, A. F. G., & Orrenius, S. (1998). Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts. Biochemical Journal, 329, 95-99.
Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death. BioFactors, 8, 1-5.
Stridh, H., Kimland, M., Jones, D. P., Orrenius, S., & Hampton, M. B. (1998). Cytochrome c release a cascade activation in hydrogen peroxide and tributyltin induced apoptosis. FEBS Letters, 429, 351-355.
Hampton, M. B., Fadeel, B., & Orrenius, S. (1998). Redox regulation of the caspases during apoptosis. Annals of the New York Academy of Sciences, 854, 328-335.
Fadeel, B., Ahlin, A., Henter, J., Orrenius, S., & Hampton, M. B. (1998). Involvement of caspases in neutrophil apoptosis: Evidence for a regulatory role of reactive oxygen species. Blood, 92, 4808-4818.
Hampton, M. B., & Orrenius, S. (1998). Redox regulation of apoptotic cell death in the immune system. Toxicology Letters, 102-103, 355-358.
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017.
Vollebregt, M., Hampton, M. B., & Winterbourn, C. C. (1998). Activation of NF-KB in human neutrophils during phagocytosis of bacteria independently of oxidant generation. FEBS Letters, 432, 40-44.
1997
Journal - Research Article
Hampton, M. B., & Orrenius, S. (1997). Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis. FEBS Letters, 414, 552-556.
Journal - Research Other
Orrenius, S., Burgess, D. H., & Hampton, M. B. (1997). Mitochondria as the focus of apoptosis research. Cell Death & Differentiation, 4, 427-428.
1996
Journal - Research Article
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517.