Multiple countries
Advancing a GMMA-based vaccine against invasive non-typhoidal salmonellosis through Phase 1 trial in Europe and sub-Saharan Africa (Vacc-iNTS)
Location: Multiple in Europe, Africa, and New Zealand
Co-investigator:Professor John Crump
Funder: European Union Horizon 2020
Status: Current
Abstract
To bridge the gap between preclinical and early clinical development of a novel vaccine against invasive nontyphoidal Salmonella using Generalized Modules for Membrane Antigens from the most common African serotypes
Students involved
- Christian Marchello, Postdoctoral Fellow
Febrile illness evaluation in a broad range of endemicities (FIEBRE)
Location: Malawi, Mozambique, Laos, Zimbabwe, United Kingdom, New Zealand
Co-investigator:Professor John Crump
Funder: UK Department for International Development
Status: Current
Abstract
To conduct standardized research on the causes of severe and outpatient fever among children and adults at multiple sites in Asia and Africa
Randomised controlled trial of preventive treatment of latent tuberculosis infection in patients with diabetes mellitus
Location: Tanzania and Uganda
Co-investigator: Professor Philip Hill
Funder: EDCTP. 4,844,699.25 Euros over 5 years.
Status: Current (commenced 2019)
Abstract
This world-first large randomized trial of preventive treatment of latent tuberculosis infection in people with diabetes, was designed by Otago researchers and is led by Prof Reinout van Crevel at Radboud University in the Netherlands. It is being conducted in Tanzania and Uganda.
Study for non-typhoidal Salmonella invasive disease prevention (StrIDENT) planning grant
Location: Democratic Republic of the Congo, Kenya, New Zealand
Principal Investigator:Professor John Crump
Other investigators: Octavie Lunguya, Institut National de Recherche Biomédicale; Samuel Kariuki, Kenya Medical Research Institute; Katrina Sharples, University of Otago; Nigel French, Massey University
Funder: Bill & Melinda Gates Foundation
Status: Current
Abstract
To develop a single comprehensive epidemiologic study that will fully or largely address critical data gaps on non-typhoidal Salmonella transmission.
Typhoid vaccine acceleration consortium 2.0 (TyVAC 2.0)
Location: Multiple Low-Income typhoid endemic countries
Co-Investigator:Professor John Crump (lead on epidemiology)
Funder: Bill & Melinda Gates Foundation
Status: Current
Abstract
To accelerate the introduction of new typhoid conjugate vaccines as part of an integrated approach to reducing the burden of morbidity and mortality from typhoid in countries eligible for support from Gavi, the Vaccine Alliance.
Tanzania
Intestinal perforations in Tanzania (IPET)
Location: Moshi, Tanzania
Principal Investigator: Professor John Crump
Funder: Bill & Melinda Gates Foundation
Status: Current
Abstract
Describe the etiology of intestinal perforations in northern Tanzania using infectious diseases pathology
Students involved
Dr Cristina Costales
Investigating febrile deaths in Tanzania (INDITe)
Location: Moshi, Tanzania
Principal Investigator:Professor John Crump
Funder: US National Institutes of Health
Status: Current
Abstract
To understand the biomedical and health systems causes of death among patients with severe febrile illness northern Tanzania
Students involved
- Cristina Costales
- Deng Madut
- John Bonnewell
Operationalising One Health interventions in Tanzania (OOHTZ)
Location: Northern Tanzania
Co-investigator: Professor John Crump
Funder: UK Biotechnology and Biological Sciences Research Council
Status: Current
Abstract
Address gaps in knowledge and implementation capacity to reduce the impact of zoonoses in livestock keeping communities in Tanzania
Sepsis characterization in Kilimanjaro (SICK)
Location: Moshi, Tanzania
Principal Investigator: Associate Professor Matthew P Rubach, Duke University
Co-investigators: Professor John Crump, Professor Venance P Maro, Kilimanjaro Christian Medical Centre
Funder: US National Institutes of Health
Status: Current
Abstract
To identify sepsis subtypes that are specific to the infectious disease epidemiology and population sub-structures of sub-Saharan Africa
Severe typhoid in Tanzania (STT)
Location: Moshi, Tanzania
Principal Investigator:Professor John Crump
Funder: Bill & Melinda Gates Foundation
Status: Current
Abstract
To estimate the incidence and severity of invasive salmonellosis in northern Tanzania
Students involved
- Dr Elena Cutting
- Dr Cristina Costales
Working Group on Ethics Guidelines for Global Health Training (WEIGHT)
Principal Investigator: Professor John Crump
Funder: Wellcome Trust
Abstract
Many universities in high-income countries have established global health institutes; students increasingly request training experiences in low- and middle-income countries. Such experiences raise a range of ethical concerns.
The Working Group on Ethics Guidelines for Global Health Training (WEIGHT) identifies ethics concerns and develops guidelines for mitigation of these concerns.