Holdren, M., Richardson, M., Ritter, D., Young, C., Brannan, T., Pesaran, T., … Walker, L., … Couch, F. (2023). ATM and PALB2 variant curation guidelines progress update: ClinGen Hereditary Breast, Ovarian, and Pancreatic Cancer Variant Curation Expert Panel. Genetics in Medicine Open, 1(1, Suppl.), (pp. 11). doi: 10.1016/j.gimo.2023.100080
Conference Contribution - Published proceedings: Abstract
Parsons, M., Anderson, M., Berkofsky-Fessler, W., Caputo, S., Chan, R., Cline, M., … Walker, L., … Spurdle, A. (2023). The ClinGen ENIGMA BRCA1/2 expert panel: A dynamic framework for evidence-based recommendations to improve classification criteria for variants in BRCA1/2. Genetics in Medicine Open, 1(1, Suppl.), (pp. 19). doi: 10.1016/j.gimo.2023.100095
Conference Contribution - Published proceedings: Abstract
Morley-Bunker, A., Currie, M., Pearson, J., Mukundan, R., Gavruskin, A., Hemmings, C., Eglinton, T., & Walker, L. (2023, August). Utilisation of digital pathology and AI methods for the detection of MSI status in colorectal cancer. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6
Journal - Research Article
Thomassen, M., Mesman, R. L. S., Hansen, T. V. O., Menendez, M., Rossing, M., Esteban-Sánchez, A., … Walker, L. C., … Spurdle, A. B. (2022). Clinical, splicing and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach. Human Mutation, 43, 1921-1944. doi: 10.1002/humu.24449
Journal - Research Article
Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., … Easton, D. F. (2022). Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology, 5(1), 65. doi: 10.1038/s42003-021-02990-6
Journal - Research Article
Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765
Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y
Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5
Journal - Research Article
McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320
Journal - Research Article
Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202
Journal - Research Article
Lattimore, V., Parsons, M. T., Spurdle, A. B., Pearson, J., Lehnert, K., Sullivan, J., … Morrin, H., Robinson, B., & Walker, L. (2021). Under-ascertainment of breast cancer susceptibility gene carriers in a cohort of New Zealand female breast cancer patients. Breast Cancer Research & Treatment, 185, 583-590. doi: 10.1007/s10549-020-05986-8
Journal - Research Article
Dennis, J., Walker, L., Tyrer, J., Michailidou, K., & Easton, D. F. (2021). Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation of z-scores improves detection and reliability. Genetic Epidemiology, 45, 237-248. doi: 10.1002/gepi.22367
Journal - Research Article
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015
Journal - Research Other
Leman, R., Tubeuf, H., Raad, S., Tournier, I., Derambure, C., Lanos, R., … Walker, L. C., … Krieger, S. (2020). Assessment of branch point prediction tools to predict physiological branch points and their alteration by variants. BMC Genomics, 21, 86. doi: 10.1186/s12864-020-6484-5
Journal - Research Article
Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1
Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Journal - Research Article
Spurdle, A. B., Greville-Heygate, S., Antoniou, A. C., Brown, M., Burke, L., de la Hoya, M., … Walker, L. C., … Eccles, D. M. (2019). Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report. Journal of Medical Genetics, 56, 347-357. doi: 10.1136/jmedgenet-2018-105872
Journal - Research Other
Fischer, J., Walker, L. C., Robinson, B. A., Frizelle, F. A., Church, J. M., & Eglinton, T. W. (2019). Clinical implications of the genetics of sporadic colorectal cancer. ANZ Journal of Surgery, 89(10), 1224-1229. doi: 10.1111/ans.15074
Journal - Research Other
Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics, 56, 453-460. doi: 10.1136/jmedgenet-2018-105834
Journal - Research Article
Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693
Journal - Research Article
Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675
Journal - Research Article
Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer, 145, 401-414. doi: 10.1002/ijc.32114
Journal - Research Article
Cline, M. S., Liao, R. G., Parsons, M. T., Paten, B., Alquaddoomi, F., Antoniou, A., … BRCA Challenge Authors, including Walker, L., … Spurdle, A. B. (2018). BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. PLoS Genetics, 14(12), e1007752. doi: 10.1371/journal.pgen.1007752
Journal - Research Other
Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140
Journal - Research Article
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Journal - Research Article
Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203
Journal - Research Article
Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6
Journal - Research Article
Shimelis, H., Mesman, R. L. S., Von Nicolai, C., Ehlen, A., Guidugli, L., Martin, C., … Walker, L., … Couch, F. J. (2017). BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Research, 77(11), 2789-2799. doi: 10.1158/0008-5472.can-16-2568
Journal - Research Article
de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094
Journal - Research Article
Fackenthal, J. D., Yoshimatsu, T., Zhang, B., de Garibay, G. R., Colombo, M., De Vecchi, G., … Walker, L. C., … de la Hoya, M. (2016). Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. Journal of Medical Genetics, 53, 548-558. doi: 10.1136/jmedgenet-2015-103570
Journal - Research Article
Walker, L. C., Nones, K., Patch, A.-M., & Waddell, N. (2016). Studying genomic and epigenetic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417.pub2
Chapter in Book - Research
Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334
Journal - Research Article
Gerring, Z., Pearson, J. F., Morrin, H. R., Robinson, B. A., Harris, G. C., & Walker, L. C. (2015). Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients. Histopathology, 67(4), 538-547. doi: 10.1111/his.12678
Journal - Research Article
Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407
Journal - Research Article
Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989
Journal - Research Article
Peterlongo, P., Chang-Claude, J., Moysich, K. B., Rudolph, A., Schmutzler, R. K., Simard, J., … Walker, L. C., … Friedman, E. (2015). Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 24(1), 308-316. doi: 10.1158/1055-9965.epi-14-0532
Journal - Research Article
Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Moir-Meyer, G. L., Pearson, J. F., Lose, F., The Australian National Endometrial Cancer Study Group, Scott, R. J., McEvoy, M., … Walker, L. C. (2015). Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition. Human Genetics, 134(3), 269-278. doi: 10.1007/s00439-014-1507-4
Journal - Research Article
Colombo, M., Blok, M. J., Whiley, P., Santamariña, M., Gutiérrez-Enríquez, S., Romero, A., … Walker, L., … de la Hoya, M. (2014). Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: A report from the ENIGMA consortium. Human Molecular Genetics, 23(14), 3666-3680. doi: 10.1093/hmg/ddu075
Journal - Research Article
Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658
Journal - Research Article
Walker, L. C., Whiley, P. J., Houdayer, C., Hansen, T. V. O., Vega, A., Santamarina, M., … on behalf of the ENIGMA consortium. (2013). Evaluation of a 5-tier scheme proposed for classification of sequence variants using bioinformatic and splicing assay data: Inter-reviewer variability and promotion of minimum reporting guidelines. Human Mutation, 34(10), 1424-1431. doi: 10.1002/humu.22388
Journal - Research Article
Walker, L. C., McDonald, M., Wells, J. E., Harris, G. C., Robinson, B. A., & Morris, C. M. (2013). Dual-color fluorescence in situ hybridization reveals an association of chromosome 8q22 but not 8p21 imbalance with high grade invasive breast carcinoma. PLoS ONE, 8(7), e70790. doi: 10.1371/journal.pone.0070790
Journal - Research Article
Walker, L. C., Krause, L., kConFab Investigators, Spurdle, A. B., & Waddell, N. (2012). Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours. Breast Cancer Research & Treatment, 134(3), 1005-1011. doi: 10.1007/s10549-012-2024-6
Journal - Research Article
Spurdle, A. B., Thompson, D. J., Ahmed, S., Ferguson, K., Healey, C. S., O'Mara, T., Walker, L. C., … The Australian National Endometrial Cancer Study Group, … National Study of Endometrial Cancer Genetics Group, … Easton, D. F. (2011). Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43(5), 451-454. doi: 10.1038/ng.812
Journal - Research Article
Whiley, P. J., Guidugli, L., Walker, L. C., Healey, S., Thompson, B. A., Lakhani, S. R., … Spurdle, A. B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32(6), 678-687. doi: 10.1002/humu.21495
Journal - Research Article
Walker, L. C., Thompson, B. A., Waddell, N., kConFab Investigators, Grimmond, S. M., & Spurdle, A. B. (2010). Use of DNA–damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and
BRCA2 mutation status in familial breast cancer patients. PLoS Genetics, 6(2), e1000850. doi: 10.1371/journal.pgen.1000850
Journal - Research Article
Walker, L. C., Whiley, P., Couch, F. J., Farrugia, D. J., Healey, S., Eccles, D. M., … kConFab Investigators, … Spurdle, A. B. (2010). Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: Implications for prediction of pathogenicity. Human Mutation, 31(6), E1484-E1505. doi: 10.1002/humu.21267
Journal - Research Article
Walker, L. C., Fredericksen, Z. S., Wang, X., Tarrell, R., Pankratz, V. S., Lindor, N. M., … Couch, F. J. (2010). Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research, 12(6), R102. doi: 10.1186/bcr2785
Journal - Research Article
Walker, L. C., & Spurdle, A. B. (2010). Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer. In M. Webb (Ed.), Cancer susceptibility: Methods and protocols (Methods in molecular biology, Vol. 653). (pp. 23-34). New York: Springer. doi: 10.1007/978-1-60761-759-4
Chapter in Book - Research
Walker, L. C., & Waddell, N. (2010). Studying genomic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417
Chapter in Book - Research
Walker, L. C., Waddell, N., Ten Haaf, A., kConFab Investigators, Grimmond, S., & Spurdle, A. B. (2008). Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. Breast Cancer Research & Treatment, 112(2), 229-236. doi: 10.1007/s10549-007-9848-5
Journal - Research Article
Whiley, P., Pettigrew, C. A., Brewster, B. L., Walker, L. C., for kConFab Investigators, Spurdle, A. B., & Brown, M. A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11, 80. doi: 10.1186/1471-2350-11-80
Journal - Research Article
Walker, L. C. (2009). Toward understanding the molecular basis of ovarian cancer. Human Mutation, 30(12), v. doi: 10.1002/humu.21162
Journal - Research Other
Walker, L. C., Harris, G. C., Wells, J. E., Robinson, B. A., & Morris, C. M. (2008). Association of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes Chromosomes & Cancer, 47(5), 405-417. doi: 10.1002/gcc.20545
Journal - Research Article
Waddell, N., Ten Haaf, A., Marsh, A., Johnson, J., Walker, L. C., kConFab Investigators, … Spurdle, A. B. (2008). BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression. PLoS Genetics, 4(5), e1000080. doi: 10.1371/journal.pgen.1000080
Journal - Research Article
Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics & Cytogenetics, 178, 94-103.
Journal - Research Article
Ganly, P. S., Walker, L. C., & Morris, C. M. (2004). Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia. Leukemia & Lymphoma, 45(1), 1-10.
Journal - Research Article
Walker, L. C., Campbell, H. J., Corbett, R., Spearing, R. L., Heaton, D. C., Macdonald, D. H., Morris, C. M., & Ganly, P. S. (2002). A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia. British Journal of Haematology, 117(4), 878-881. doi: 10.1046/j.1365-2141.2002.03512.x
Journal - Research Article
Walker, L. C., Morrison, M. J., Parfitt, R., & Crossen, P. E. (2001). Translocation (2;14) associated with complex rearrangements of the Ig heavy chain in non-Hodgkin lymphoma. Cancer Genetics & Cytogenetics, 128, 137-140.
Journal - Research Article
Sin, F. T. Y., Mukherjee, U. K., Walker, L. C., & Sin, I. L. (1997). The application of gene transfer techniques to marine resource mangement: Recent advances, problems and future directions. Hydrobiologia, 352, 263-278.
Journal - Research Article
Walker, L. (2017, October). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-currence of known exon skipping events. Poster session presented at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Walker, L. (2007). Genetic aberrations in breast cancer (PhD). University of Otago, Dunedin, New Zealand. 229p.
Awarded Doctoral Degree