Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6
Journal - Research Article
Thomassen, M., Mesman, R. L. S., Hansen, T. V. O., Menendez, M., Rossing, M., Esteban-Sánchez, A., … Walker, L. C., … Spurdle, A. B. (2022). Clinical, splicing and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach. Human Mutation, 43, 1921-1944. doi: 10.1002/humu.24449
Journal - Research Article
Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., … Easton, D. F. (2022). Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology, 5(1), 65. doi: 10.1038/s42003-021-02990-6
Journal - Research Article
Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765
Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y
Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5
Journal - Research Article
McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320
Journal - Research Article
Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202
Journal - Research Article
Lattimore, V., Parsons, M. T., Spurdle, A. B., Pearson, J., Lehnert, K., Sullivan, J., … Morrin, H., Robinson, B., & Walker, L. (2021). Under-ascertainment of breast cancer susceptibility gene carriers in a cohort of New Zealand female breast cancer patients. Breast Cancer Research & Treatment, 185, 583-590. doi: 10.1007/s10549-020-05986-8
Journal - Research Article
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015
Journal - Research Other
Dennis, J., Walker, L., Tyrer, J., Michailidou, K., & Easton, D. F. (2021). Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation of z-scores improves detection and reliability. Genetic Epidemiology, 45, 237-248. doi: 10.1002/gepi.22367
Journal - Research Article
Leman, R., Tubeuf, H., Raad, S., Tournier, I., Derambure, C., Lanos, R., … Walker, L. C., … Krieger, S. (2020). Assessment of branch point prediction tools to predict physiological branch points and their alteration by variants. BMC Genomics, 21, 86. doi: 10.1186/s12864-020-6484-5
Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139
Journal - Research Article
Spurdle, A. B., Greville-Heygate, S., Antoniou, A. C., Brown, M., Burke, L., de la Hoya, M., … Walker, L. C., … Eccles, D. M. (2019). Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report. Journal of Medical Genetics, 56, 347-357. doi: 10.1136/jmedgenet-2018-105872
Journal - Research Other
Fischer, J., Walker, L. C., Robinson, B. A., Frizelle, F. A., Church, J. M., & Eglinton, T. W. (2019). Clinical implications of the genetics of sporadic colorectal cancer. ANZ Journal of Surgery, 89(10), 1224-1229. doi: 10.1111/ans.15074
Journal - Research Other
Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics, 56, 453-460. doi: 10.1136/jmedgenet-2018-105834
Journal - Research Article
Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693
Journal - Research Article
Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675
Journal - Research Article
Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1
Journal - Research Article
Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer, 145, 401-414. doi: 10.1002/ijc.32114
Journal - Research Article
Cline, M. S., Liao, R. G., Parsons, M. T., Paten, B., Alquaddoomi, F., Antoniou, A., … BRCA Challenge Authors, including Walker, L., … Spurdle, A. B. (2018). BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. PLoS Genetics, 14(12), e1007752. doi: 10.1371/journal.pgen.1007752
Journal - Research Other
Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140
Journal - Research Article
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1
Journal - Research Article
Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203
Journal - Research Article
Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6
Journal - Research Article
Shimelis, H., Mesman, R. L. S., Von Nicolai, C., Ehlen, A., Guidugli, L., Martin, C., … Walker, L., … Couch, F. J. (2017). BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Research, 77(11), 2789-2799. doi: 10.1158/0008-5472.can-16-2568
Journal - Research Article
de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094
Journal - Research Article
Fackenthal, J. D., Yoshimatsu, T., Zhang, B., de Garibay, G. R., Colombo, M., De Vecchi, G., … Walker, L. C., … de la Hoya, M. (2016). Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. Journal of Medical Genetics, 53, 548-558. doi: 10.1136/jmedgenet-2015-103570
Journal - Research Article
Walker, L. C., Nones, K., Patch, A.-M., & Waddell, N. (2016). Studying genomic and epigenetic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417.pub2
Chapter in Book - Research
Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334
Journal - Research Article
Gerring, Z., Pearson, J. F., Morrin, H. R., Robinson, B. A., Harris, G. C., & Walker, L. C. (2015). Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients. Histopathology, 67(4), 538-547. doi: 10.1111/his.12678
Journal - Research Article
Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407
Journal - Research Article
Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989
Journal - Research Article
Peterlongo, P., Chang-Claude, J., Moysich, K. B., Rudolph, A., Schmutzler, R. K., Simard, J., … Walker, L. C., … Friedman, E. (2015). Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 24(1), 308-316. doi: 10.1158/1055-9965.epi-14-0532
Journal - Research Article
Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Moir-Meyer, G. L., Pearson, J. F., Lose, F., The Australian National Endometrial Cancer Study Group, Scott, R. J., McEvoy, M., … Walker, L. C. (2015). Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition. Human Genetics, 134(3), 269-278. doi: 10.1007/s00439-014-1507-4
Journal - Research Article
Colombo, M., Blok, M. J., Whiley, P., Santamariña, M., Gutiérrez-Enríquez, S., Romero, A., … Walker, L., … de la Hoya, M. (2014). Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: A report from the ENIGMA consortium. Human Molecular Genetics, 23(14), 3666-3680. doi: 10.1093/hmg/ddu075
Journal - Research Article
Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658
Journal - Research Article
Walker, L. C., Whiley, P. J., Houdayer, C., Hansen, T. V. O., Vega, A., Santamarina, M., … on behalf of the ENIGMA consortium. (2013). Evaluation of a 5-tier scheme proposed for classification of sequence variants using bioinformatic and splicing assay data: Inter-reviewer variability and promotion of minimum reporting guidelines. Human Mutation, 34(10), 1424-1431. doi: 10.1002/humu.22388
Journal - Research Article
Walker, L. C., McDonald, M., Wells, J. E., Harris, G. C., Robinson, B. A., & Morris, C. M. (2013). Dual-color fluorescence in situ hybridization reveals an association of chromosome 8q22 but not 8p21 imbalance with high grade invasive breast carcinoma. PLoS ONE, 8(7), e70790. doi: 10.1371/journal.pone.0070790
Journal - Research Article
Walker, L. C., Krause, L., kConFab Investigators, Spurdle, A. B., & Waddell, N. (2012). Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours. Breast Cancer Research & Treatment, 134(3), 1005-1011. doi: 10.1007/s10549-012-2024-6
Journal - Research Article
Spurdle, A. B., Thompson, D. J., Ahmed, S., Ferguson, K., Healey, C. S., O'Mara, T., Walker, L. C., … The Australian National Endometrial Cancer Study Group, … National Study of Endometrial Cancer Genetics Group, … Easton, D. F. (2011). Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43(5), 451-454. doi: 10.1038/ng.812
Journal - Research Article
Whiley, P. J., Guidugli, L., Walker, L. C., Healey, S., Thompson, B. A., Lakhani, S. R., … Spurdle, A. B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32(6), 678-687. doi: 10.1002/humu.21495
Journal - Research Article
Walker, L. C., Thompson, B. A., Waddell, N., kConFab Investigators, Grimmond, S. M., & Spurdle, A. B. (2010). Use of DNA–damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and
BRCA2 mutation status in familial breast cancer patients. PLoS Genetics, 6(2), e1000850. doi: 10.1371/journal.pgen.1000850
Journal - Research Article
Walker, L. C., Whiley, P., Couch, F. J., Farrugia, D. J., Healey, S., Eccles, D. M., … kConFab Investigators, … Spurdle, A. B. (2010). Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: Implications for prediction of pathogenicity. Human Mutation, 31(6), E1484-E1505. doi: 10.1002/humu.21267
Journal - Research Article
Walker, L. C., Fredericksen, Z. S., Wang, X., Tarrell, R., Pankratz, V. S., Lindor, N. M., … Couch, F. J. (2010). Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research, 12(6), R102. doi: 10.1186/bcr2785
Journal - Research Article
Walker, L. C., & Spurdle, A. B. (2010). Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer. In M. Webb (Ed.), Cancer susceptibility: Methods and protocols (Methods in molecular biology, Vol. 653). (pp. 23-34). New York: Springer. doi: 10.1007/978-1-60761-759-4
Chapter in Book - Research
Walker, L. C., & Waddell, N. (2010). Studying genomic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417
Chapter in Book - Research
Walker, L. C., Waddell, N., Ten Haaf, A., kConFab Investigators, Grimmond, S., & Spurdle, A. B. (2008). Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. Breast Cancer Research & Treatment, 112(2), 229-236. doi: 10.1007/s10549-007-9848-5
Journal - Research Article
Whiley, P., Pettigrew, C. A., Brewster, B. L., Walker, L. C., for kConFab Investigators, Spurdle, A. B., & Brown, M. A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11, 80. doi: 10.1186/1471-2350-11-80
Journal - Research Article
Walker, L. C. (2009). Toward understanding the molecular basis of ovarian cancer. Human Mutation, 30(12), v. doi: 10.1002/humu.21162
Journal - Research Other
Walker, L. C., Harris, G. C., Wells, J. E., Robinson, B. A., & Morris, C. M. (2008). Association of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes Chromosomes & Cancer, 47(5), 405-417. doi: 10.1002/gcc.20545
Journal - Research Article
Waddell, N., Ten Haaf, A., Marsh, A., Johnson, J., Walker, L. C., kConFab Investigators, … Spurdle, A. B. (2008). BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression. PLoS Genetics, 4(5), e1000080. doi: 10.1371/journal.pgen.1000080
Journal - Research Article
Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics & Cytogenetics, 178, 94-103.
Journal - Research Article
Ganly, P. S., Walker, L. C., & Morris, C. M. (2004). Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia. Leukemia & Lymphoma, 45(1), 1-10.
Journal - Research Article
Walker, L. C., Campbell, H. J., Corbett, R., Spearing, R. L., Heaton, D. C., Macdonald, D. H., Morris, C. M., & Ganly, P. S. (2002). A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia. British Journal of Haematology, 117(4), 878-881. doi: 10.1046/j.1365-2141.2002.03512.x
Journal - Research Article
Walker, L. C., Morrison, M. J., Parfitt, R., & Crossen, P. E. (2001). Translocation (2;14) associated with complex rearrangements of the Ig heavy chain in non-Hodgkin lymphoma. Cancer Genetics & Cytogenetics, 128, 137-140.
Journal - Research Article
Sin, F. T. Y., Mukherjee, U. K., Walker, L. C., & Sin, I. L. (1997). The application of gene transfer techniques to marine resource mangement: Recent advances, problems and future directions. Hydrobiologia, 352, 263-278.
Journal - Research Article
Walker, L. (2017, October). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-currence of known exon skipping events. Poster session presented at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Walker, L. (2007). Genetic aberrations in breast cancer (PhD). University of Otago, Dunedin, New Zealand. 229p.
Awarded Doctoral Degree