Associate Professor Joanna Kirman

Immunologist
Head of Department

BSc(Hons) (Otago), PhD (Otago)

Appointed: 2012

Email jo.kirman@otago.ac.nz
Tel +64 3 479 7714

Teaching roles

HUBS 191 Human Body Systems 1
MICR 223 Infection and Immunity (Convenor)
MICR 334 Advanced Immunology
MICR 464 Medical Microbiology and Immunology

Previous academic positions

Infectious Diseases Group Leader, Malaghan Institute of Medical Research, Wellington (2002-2012)

Research interests

Applied, cellular and molecular immunology, medical microbiology, vaccine immunology and technology.

Current research

Tuberculosis (TB) is a deadly lung disease caused by Mycobacterium tuberculosis (Mtb) that kills more people every year than any other bacterial infection. One third of the world's population is estimated to be infected, and New Zealand is not exempt. We believe the best way to control the global TB epidemic is through vaccination. Our lab's research is focused on understanding the generation and maintenance of immunological memory in order to improve vaccination against TB.

Find out more about the global TB epidemic

Lab group

Kirman Lab 2020

Staff

A profile photo of Kathy Sircombe Kathy Sircombe
Assistant Research Fellow

A profile photo of Dr Naomi Daniels Dr Naomi Daniels
Postdoctoral Fellow

Postgraduate students

A profile photo of Brin Ryder Brin Ryder
Postgraduate Writing Scholar

Reshvinder Kaur Bedi
PGDip BMLSc

Mitchell Foster
PhD Student

Natasha Nair
BSc (Hons)

Research projects

1. Dodging bullets: how the Beijing TB strain evades and subverts BCG-mediated trained innate immunity

Not all Mtb strains are equal. Beijing genotype Mtb strains display selective advantages over other genotypes including: greater virulence in animal studies; a higher capacity to withstand tuberculosis treatment; and increased relapse after treatment. The existing TB vaccine, bacillus Calmette–Guérin (BCG), is protective in ~50% of cases when delivered intradermally; however, BCG does not protect equally against all Mtb strains. In a case contact study of over 400 TB case households and over 1400 contacts in Indonesia (in which 1/3 of isolates were Beijing genotype), we found that although BCG vaccination was associated with protection in contacts exposed to non-Beijing strains there was no evidence of BCG protection against IGRA conversion in contacts exposed to a Beijing strain. In this project, we test the hypothesis that the Beijing TB strain evades and subverts BCG-mediated trained innate immunity using a mouse model of BCG vaccination and TB challenge.

Collaborators: Marcela Henao-Tamayo (Colorado State University), Philip Hill (University of Otago)

Funding: Marsden Fund of New Zealand

2. Role of Phagocytic Cells in the Induction of Immunity against Mycobacteria

There are many different subsets of macrophages and DCs that can be distinguished by phenotype and function; the role that each subset plays during early TB infection is unclear. In this project we are assessing the ability of the different DC subsets to control early infection, using molecular and cellular methods (RNA-Seq, qRT-CPR, flow cytometry).

Collaborators: Marcela Henao-Tamayo (Colorado State University), Siouxsie Wiles (University of Auckland)

Funding: Otago Medical Research Foundation (grant completed)

3. Novel Design of TB Vaccines

One way to improve the TB vaccine is through the use of novel vaccine formulations, designed to protect the immune-stimulating protein (antigen) from destruction or to enable its persistence in the body. If more antigen reaches the appropriate immune cells, this may lead to a stronger immune response; and if antigen is able to persist in the body this may reduce the number of booster shots required, which would improve immunisation completion rates.

Collaborators: Thomas Proft (University of Auckland)

Funding: Marsden Fund (grant completed)

4. The effect of BCG-induced trained innate immunity against abscess formation

The BCG vaccination can train innate immune cells to exhibit features of immunological memory, without the specificity of the adaptive immune response. In this study, we investigate the ability of the BCG vaccine to protect against polymicrobial skin abscess formation.

Collaborators: Daniel Pletzer (University of Otago)

Funding: BMS-Dean's Bequest

Opportunities

** We are currently seeking a highly motivated, excellent PhD candidate with an excellent academic record **

Public outreach on the COVID-19 epidemic

Radio New Zealand 2020 Our immune system vs coronavirus: ‘I think of it as an orchestra' (28 mins, produced by Allison Balance)

Stuff Podcast 2020 Claiming immunity: should COVID-19 survivors get better treatment? (26 mins, produced by Adam Dudding and Eugene Bingham)

ABC Radio National (Australia) How long will a COVID-19 vaccine take (42 mins, presented by Rod Quinn)

Otago Daily Times Therapeutic Drugs Needed (2020)

South China Morning Post Coronavirus vaccine will not be a magic bullet, scientists warn (by Simone McCarthy, 2020)

The Conversation, Stuff Could BCG, a 100-year-old vaccine for tuberculosis, protect against Covid-19? by Kylie Quinn, Jo Kirman, Katie Louise Flanagan and Magdalena Plebanski

Ten common misconceptions about the COVID-19 vaccine, debunked (by Emily Writes, 2021)

Radio New Zealand 2021 COVID vaccine could soon be approved (9 minutes, produced by the The Panel)

Newstalk ZB Experts hopeful 35% of New Zealanders against jab will change their minds (Mike Hosking Breakfast, 2021)

Past Honours and Masters candidates (Otago)

Mariana Traslosheros-Reyes BSc Honours 2020
Nicole Krotky Masters 2020 (University of Veterinary Medicine Vienna, Austria)
Stephanie Waller BBiomedSci 2019
Mitchell Foster BSc Honours 2019
Likhit Dukkipati BSc Honours 2019
Laura Hughes BBiomedSc Honours 2018 – David T Jones Prize (1st= BBioMedSci(Hons) student)
Shannon Frewen BSc Honours 2018
Claudia Lewis BBiomedSc Honours 2017
Lucy Huang BSc Honours 2017
Sarah Sandford BBioMedSc Honours 2016 – David T Jones Prize (topBBioMedSci(Hons) student)
Brin Ryder BSc Honours 2015 – John Miles Prize (top BSc(Hons) student), Best 4th year student presentation
Kate Manners BBioMedSc Honours 2014
Stephen Hall BBioMedSc Honours 2013

Summer Students (Otago)

Ben Topham 2020
Mariana Trasloheros-Reyes 2019
Mitchell Foster 2018
Charlotte Cairns 2016
Claudia Lewis 2016
Sarah Sandford 2015
Brin Ryder 2014
Joanne Lee 2013
Dayle Keown 2012 - best summer studentship report award

Past Lab Members (Otago)

Clare Burn 2012–2014 (Fulbright Science and Innovation Graduate Award recipient 2014)

Past PhD students and where they are now

Dr Kylie Quinn (current RMIT, Melbourne, Australia)

Dr Lisa Connor (currently Senior Lecturer at Victoria University of Wellington, NZ)

Dr Lindsay Ancelet (currently Therapeutic Group Manager, PHARMAC, NZ)

Dr Kelly Prendergast (currently Project Officer, Garvan Institute of Medical Research, Sydney, Australia)

Dr Pia Steigler (currently Postdoctoral Fellow at the University of Capetown, South Africa)

Publications

Kirman, J. R., Weinkove, R., & Borger, J. G. (2024). Immunology across two islands: Understanding the research landscape of Aotearoa (New Zealand) [Interview]. Immunology & Cell Biology, 102(4), 235-239. doi: 10.1111/imcb.12709 Journal - Professional & Other Non-Research Articles

Sircombe, K. J., Kirman, J. R., & Pletzer, D. (2022, August). Can BCG vaccination train innate immune cells to protect against skin and soft tissue infections? Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Ryder, B., Foster, M., Krotky, N., Daniels, N., & Kirman, J. (2022, August). Teaching the unteachable: Training innate immune cells in the lung using the BCG vaccine. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Chen, S., Quan, D. H., Wang, X. T., Sandford, S., Kirman, J. R., Britton, W. J., & Rehm, B. H. A. (2021). Particulate mycobacterial vaccines induce protective immunity against tuberculosis in mice. Nanomaterials, 11, 2060. doi: 10.3390/nano11082060 Journal - Research Article

Blanchett, S., Tsai, C. J. Y., Sandford, S., Loh, J. M. S., Huang, L., Kirman, J. R., & Proft, T. (2021). Intranasal immunisation with Ag85B peptide 25 displayed on Lactococcus lactis using the PilVax platform induces antigen-specific B- and T-cell responses. Immunology & Cell Biology, 99, 767-781. doi: 10.1111/imcb.12462 Journal - Research Article

2024

Journal - Professional & Other Non-Research Articles

2022

Conference Contribution - Poster Presentation (not in published proceedings)

Conference Contribution - Verbal presentation and other Conference outputs

2021

Journal - Research Article

2020

Journal - Research Other

Borger, J. G., Le Gros, G., & Kirman, J. R. (2020). The role of innate lymphoid cells in mucosal immunity. Frontiers in Immunology, 11, 1233. doi: 10.3389/fimmu.2020.01233

2019

Journal - Research Article

Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8⁺ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054

Chen, S., Sandford, S., Kirman, J. R., & Rehm, B. H. A. (2019). Innovative antigen carrier system for the development of tuberculosis vaccines. FASEB Journal, 33, 7505-7518. doi: 10.1096/fj.201802501RR

Ryder, B. M., Sandford, S. K., Manners, K. M., Dalton, J. P., Wiles, S., & Kirman, J. R. (2019). Gr1^int/high cells dominate the early phagocyte response to mycobacterial lung infection in mice. Frontiers in Microbiology, 10, 402. doi: 10.3389/fmicb.2019.00402

Journal - Research Other

Kirman, J. R., Quinn, K. M., & Seder, R. A. (2019). Immunological memory. Immunology & Cell Biology, 97, 615-616. doi: 10.1111/imcb.12280

Steigler, P., Verrall, A. J., & Kirman, J. R. (2019). Beyond memory T cells: Mechanisms of protective immunity to tuberculosis infection. Immunology & Cell Biology, 97, 647-655. doi: 10.1111/imcb.12278

2018

Journal - Research Article

Chen, S., Sandford, S., Kirman, J., & Rehm, B. H. A. (2018). Design of bacterial inclusion bodies as antigen carrier systems. Advanced Biosystems, 2(11), 1800118. doi: 10.1002/adbi.201800118

Prendergast, K. A., Daniels, N. J., Petersen, T. R., Hermans, I. F., & Kirman, J. R. (2018). Langerin⁺ CD8α⁺ dendritic cells drive early CD8⁺ T cell activation and IL-12 production during systemic bacterial infection. Frontiers in Immunology, 9, 953. doi: 10.3389/fimmu.2018.00953

Steigler, P., Daniels, N. J., McCulloch, T. R., Ryder, B. M., Sandford, S. K., & Kirman, J. R. (2018). BCG vaccination drives accumulation and effector function of innate lymphoid cells in murine lungs. Immunology & Cell Biology, 96(4), 379-389. doi: 10.1111/imcb.12007

Conference Contribution - Poster Presentation (not in published proceedings)

Ryder, B., Wiles, S., & Kirman, J. (2018, September). BCG immunisation alters lung phagocyte dynamics during early mycobacterial infection of mice. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. E. (2018, August). Differential regulation of MR1- and cytokine stimulated MAIT cells. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Blanchett, S., Loh, J., Kirman, J., & Proft, T. (2018, August). PilVax: A novel peptide carrier for the development of vaccines against tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Ryder, B. M., Steigler, P., Wiles, S., & Kirman, J. R. (2018, August). BCG vaccination induces ILC expansion and alters phagocyte dynamics early after mycobacterial challenge. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Kirman, J. (2018, August). Progress towards development of an improved TB vaccine. Verbal presentation at the Australasian Tuberculosis Conference, Wellington, New Zealand.

Kirman, J. (2018, September). Deciphering the protective immune response to tuberculosis. Verbal presentation at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

2017

Conference Contribution - Published proceedings: Abstract

Ryder, B., Steigler, P., Lewis, C., & Kirman, J. (2017). Innate lymphoid cell response to vaccination against tuberculosis in mice. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 80). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Lamichhane, R., Kirman, J., & Ussher, J. (2017). Differences in the effector functions of MR1- and cytokine stimulated MAIT cells. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 47-48). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Conference Contribution - Poster Presentation (not in published proceedings)

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. (2017, November). Differences in the effector function of MR1- and cytokine stimulated MAIT cells. Poster session presented at the 10th International CD1-MR1 Workshop, Napa, USA.

Conference Contribution - Verbal presentation and other Conference outputs

Ryder, B., Steigler, P., Lewis, C., & Kirman, J. R. (2017, November-December). Innate lymphoid cell response to BCG vaccination in mice. Verbal presentation at the Proceedings of the 46th Australasian Society for Immunology (ASI) Annual Scientific Meeting, Brisbane, Australia.

Ryder, B., Steigler, P., Lewis, C., & Kirman, J. (2017, July). Innate lymphoid cell response to BCG vaccination in mice. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Lamichhane, R., Kirman, J., & Ussher, J. E. (2017, July). Differences in the effector functions of MR1- and Cytokine stimulated MAIT cells. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Kirman, J. R., Henao-Tamayo, M. I., & Agger, E. M. (2016). The memory immune response to tuberculosis. Microbiology Spectrum, 4(6), TBTB2-0009-2016. doi: 10.1128/microbiolspec.TBTB2-0009-2016

Conference Contribution - Published proceedings: Abstract

Steigler, P., & Kirman, J. (2016). Memory CD4 and CD8 T cells are dispensable for BCG-vaccine mediated protection. European Journal of Immunology, 46(Suppl. 1), (pp. 640). doi: 10.1002/eji.201670200

Ryder, B. M., Manners, K., & Kirman, J. R. (2016). Dynamics of phagocytic cells early after mycobacterial lung infection. European Journal of Immunology, 46(Suppl. 1), (pp. 513-514). doi: 10.1002/eji.201670200

Steigler, P., McCulloch, T., & Kirman, J. R. (2016). Mucosal BCG vaccination promotes function and accumulation of innate lymphoid cells in murine lungs. European Journal of Immunology, 46(Suppl. 1), (pp. 146). doi: 10.1002/eji.201670200

Prendergast, K., Petersen, T., Hermans, I., & Kirman, J. (2016). Langerin⁺ CD8a⁺ dendritic cells play a protective role early after systemic bacterial infection in mice. European Journal of Immunology, 46(Suppl. 1), (pp. 104-105). doi: 10.1002/eji.201670200

2015

Journal - Research Article

Kuhn, S., Yang, J., Hyde, E. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2015). IL-1βR-dependent priming of antitumor CD4⁺ T cells and sustained antitumor immunity after peri-tumoral treatment with MSU and mycobacteria. OncoImmunology, 4(10), e1042199. doi: 10.1080/2162402X.2015.1042199

Conference Contribution - Verbal presentation and other Conference outputs

Kirman, J. (2015, July). Innate lymphoid cell (ILC) distribution and function after BCG vaccination of mice. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Auckland, New Zealand.

2014

Journal - Research Article

Prendergast, K. A., Osmond, T. L., Ochiai, S., Hermans, I. F., & Kirman, J. R. (2014). Sustained in vivo depletion of splenic langerin⁺ CD8α⁺ dendritic cells is well-tolerated by lang-DTREGFP mice. Journal of Immunological Methods, 406, 104-109. doi: 10.1016/j.jim.2014.02.005

2013

Journal - Research Article

Bassett, I. M., Lun, S., Bishai, W. R., Guo, H., Kirman, J. R., Altaf, M., & O'Toole, R. F. (2013). Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen. Journal of Microbiology, 51(5), 651-658. doi: 10.1007/s12275-013-3099-4

Kuhn, S., Hyde, E. J., Yang, J., Rich, F. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2013). Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immune-activating agents. Journal of Immunology, 191(4), 1984-1992. doi: 10.4049/jimmunol.1301135

Conference Contribution - Published proceedings: Abstract

Steigler, P., Ancelet, L. R., Petersen, T. R., & Kirman, J. R. (2013). Novel adoptive transfer model to identify protective memory CD4⁺T cell subsets in mycobacterial infection. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 178-179). Retrieved from http://www.asi2013.org/

Kuhn, S., Hyde, E. J., Yang, J., Rich, F. J., Harper, J. L., Kirman, J. R., & Ronchese, F. (2013). Successful reprogramming of the tumour microenvironment with immune-activating agents elicits inflammatory DC and activates innate and adaptive effectors. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 91). Retrieved from http://www.asi2013.org/

Al Barwani, F., Young, S., Baird, M., Kirman, J., Larsen, D., & Ward, V. (2013). The sweetening of VLP. Proceedings of 15th Conference on Formulation and Delivery of Bioactives: Found in Translation. Retrieved from http://bioactives.otago.ac.nz/

2012

Journal - Research Article

Ancelet, L., & Kirman, J. (2012). Shaping the CD4⁺ memory immune response against tuberculosis: The role of antigen persistence, location and multi-functionality. Biomolecular Concepts, 3(1), 13-20. doi: 10.1515/BMC.2011.051

Rich, F. J., Kuhn, S., Hyde, E. J., Harper, J. L., Ronchese, F., & Kirman, J. R. (2012). Induction of T cell responses and recruitment of an inflammatory dendritic cell subset following tumor immunotherapy with Mycobacterium smegmatis. Cancer Immunology, Immunotherapy, 61(12), 2333-2342. doi: 10.1007/s00262-012-1291-8

Prendergast, K. A., & Kirman, J. R. (2012). Dendritic cell subsets in mycobacterial infection: Control of bacterial growth and T cell responses. Tuberculosis, 93(2), 115-122. doi: 10.1016/j.tube.2012.10.008

Ancelet, L. R., Aldwell, F. E., Rich, F. J., & Kirman, J. R. (2012). Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4⁺ T cell memory immune response. PLoS ONE, 7(9), e45888. doi: 10.1371/journal.pone.0045888

Ancelet, L., Rich, F. J., Delahunt, B., & Kirman, J. R. (2012). Dissecting memory T cell responses to TB: Concerns using adoptive transfer into immunodeficient mice. Tuberculosis, 92(5), 422-433. doi: 10.1016/j.tube.2012.05.008

2010

Journal - Research Article

Connor, L. M., Harvie, M. C., Rich, F. J., Quinn, K. M., Brinkmann, V., Le Gros, G., & Kirman, J. R. (2010). A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination. European Journal of Immunology, 40, 2482-2492. doi: 10.1002/eji.200940279

Chandrahasen, C., Grimwood, K., Redshaw, N., Rich, F. J., Wood, C., Stanley, J., Kirman, J. R., on behalf of the New Zealand Rotavirus Study Group. (2010). Geographical differences in the proportion of human group A rotavirus strains within New Zealand during one epidemic season. Journal of Medical Virology, 82(5), 897-902. doi: 10.1002/jmv.21739

2008

Journal - Research Article

Grimwood, K., Cohet, C., Rich, F. J., Cheng, S., Wood, C., Redshaw, N., … Kirman, J. R. (2008). Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand. Epidemiology & Infection, 136(10), 1333-1341. doi: 10.1017/S0950268807000180

Quinn, K. M., Rich, F., Goldsack, L. M., de Lisle, G. W., Buddle, B. M., Delahunt, B., & Kirman, J. R. (2008). Accelerating the secondary immune response by inactivating CD4⁺CD25⁺ T regulatory cells prior to BCG vaccination does not enhance protection against tuberculosis. European Journal of Immunology, 38(3), 695-705.

Conference Contribution - Published proceedings: Abstract

Chandrahasen, C., Redshaw, N., Grimwood, K., Wood, C., Rich, F., & Kirman, J. (2008). Shifting strains: the changing face of rotavirus in New Zealand. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 22-23). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Oral-Abstracts-NZMS-2008.pdf

2007

Journal - Research Article

Goldsack, L., & Kirman, J. R. (2007). Half-truths and selective memory: Interferon gamma, CD4⁺ T cells and protective memory against tuberculosis. Tuberculosis, 87, 465-473. doi: 10.1016/j.tube.2007.07.001

Journal - Research Other

Redshaw, N., Wood, C., Rich, F., Grimwood, K., & Kirman, J. R. (2007). Human bocavirus in infants, New Zealand [Letter to the editor]. Emerging Infectious Diseases, 13(11), 1797-1799.

2006

Journal - Research Article

Matheson, J. W., Rich, F. J., Cohet, C., Grimwood, K., Huang, Q. S., Penny, D., Hendy, M. D., & Kirman, J. R. (2006). Distinct patterns of evolution between respiratory syncytial virus subgroups A and B from New Zealand isolates collected over thirty-seven years. Journal of Medical Virology, 78(10), 1354-1364. doi: 10.1002/jmv.20702

Quinn, K. M., McHugh, R. S., Rich, F. J., Goldsack, L. M., de Lisle, G. W., Buddle, B. M., Delahunt, B., & Kirman, J. R. (2006). Inactivation of CD4⁺CD25⁺ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load. Immunology & Cell Biology, 84, 467-474.

2005

Conference Contribution - Published proceedings: Abstract

Grimwood, K., Cohet, C., Rich, F., Huang, Q. S., Matheson, J., Penny, D., & Kirman, J. (2005). Molecular evolution of respiratory syncytial viruses in New Zealand. Respirology, 10(Suppl. 1), (pp. A20). doi: 10.1111/j.1440-1843.2005.00663.x-i1

2004

Conference Contribution - Published proceedings: Abstract

Grimwood, K., Cohet, C., Matheson, J., Rich, F., Huang, Q., Penny, D., & Kirman, J. (2004). Molecular evolution of respiratory syncytial viruses in New Zealand. Canadian Journal of Infectious Diseases. 15(2), (pp. 119). [Abstract]

2000

Journal - Research Article

Kirman, J., Zakaria, Z., McCoy, K., Delahunt, B., & Le Gros, G. (2000). Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice. Infection & Immunity, 68(5), 2976-2978. doi: 10.1128/IAI.68.5.2976-2978.2000

1999

Journal - Research Article

Erb, K. J., Hou, S., Hyland, L., Kirman, J., Moll, H., & Le Gros, G. (1999). Constitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8⁺ T cells secreting interleukin 4 or interleukin 5. Immunology Letters, 68(2-3), 383-390. doi: 10.1016/S0165-2478(99)00088-7

Erb, K. J., Kirman, J., Delahunt, B., Moll, H., & Le Gros, G. (1999). Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling. European Cytokine Network, 10(2), 147-154.

Kirman, J., McCoy, K. D., Hook, S., Prout, M., Delahunt, B., Orme, I., … Le Gros, G. (1999). CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infection & Immunity, 67(8), 3786-3792.

1998

Journal - Research Article

Erb, K. J., Kirman, J., Delahunt, B., Chen, W. X., & Le Gros, G. (1998). IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in mice. Immunology & Cell Biology, 76(1), 41-46. doi: 10.1046/j.1440-1711.1998.00719.x

Erb, K. J., Kirman, J., Woodfield, L., Wilson, T., Watson, J. D., & Le Gros, G. (1998). Identification of potential CD8⁺ T-cell epitopes of the 19kDa and AhpC proteins from Mycobacterium tuberculosis: No evidence for CD8⁺ T-cell priming against the identified peptides after DNA-vaccination of mice. Vaccine, 16(7), 692-697.

Journal - Research Other

Kirman, J., & Le Gros, G. (1998). Which is the true regulator of Th₂ cell development in allergic immune responses? [Editorial]. Clinical & Experimental Allergy, 28(8), 908-910. doi: 10.1046/j.1365-2222.1998.00355.x