Grattan Laboratory

2024

Edited Book - Research

Brunton, P. J., & Grattan, D. R. (Eds.). (2024). Neuroendocrine regulation of mammalian pregnancy and lactation. Cham, Switzerland: Springer, 321p. doi: 10.1007/978-3-031-51138-7

Chapter in Book - Research

Szawka, R. E., Bunn, S. J., Le Tissier, P., Yip, S. H., & Grattan, D. R. (2024). Lactation and the control of the prolactin secretion. In P. J. Brunton & D. R. Grattan (Eds.), Neuroendocrine regulation of mammalian pregnancy and lactation. (pp. 181-221). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-51138-7_7

Grattan, D. R., & Ladyman, S. R. (2024). Maternal recognition of pregnancy. In P. J. Brunton & D. R. Grattan (Eds.), Neuroendocrine regulation of mammalian pregnancy and lactation. (pp. 1-20). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-51138-7_1

Journal - Research Article

Rizwan, M. Z., Kamstra, K., Pretz, D., Shepherd, P. R., Tups, A., & Grattan, D. R. (2024). Conditional deletion of β-catenin in the mediobasal hypothalamus impairs adaptive energy expenditure in response to high fat diet and exacerbates diet-induced obesity. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.1666-23.2024

Journal - Research Other

Grattan, D. R. (2024). Does the brain make prolactin? Journal of Neuroendocrinology, e13432. Advance online publication. doi: 10.1111/jne.13432

Le Tissier, P. R., & Grattan, D. R. (2024). Physiology is all about interactions: The prolactin and growth hormone systems as exemplars. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13416

2023

Journal - Research Article

Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13350

Smiley, K. O., Phillipps, H. R., Fang, C., Brown, R. S. E., & Grattan, D. R. (2023). Mating-induced prolactin surge is not required for subsequent neurogenesis in male mice. Frontiers in Behavioral Neuroscience, 17, 1227726. doi: 10.3389/fnbeh.2023.1227726

Wall, E. G., Desai, R., Khant Aung, Z., Yeo, S. H., Grattan, D. R., Handelsman, D. J., & Herbison, A. E. (2023). Unexpected plasma gonadal steroid and prolactin levels across the mouse estrous cycle. Endocrinology, 164(6), bqad070. doi: 10.1210/endocr/bqad070

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2023). Mechanisms of lactation-induced infertility in female mice. Endocrinology, 164(5), bqad049. doi: 10.1210/endocr/bqad049

Hassan, M., Grattan, D. R., & Leitch, B. (2023). Developmental inhibitory changes in the primary somatosensory cortex of the stargazer mouse model of absence epilepsy. Biomolecules, 13, 186. doi: 10.3390/biom13010186

Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2023). Pups and prolactin are rewarding to virgin female and pregnant mice. Journal of Neuroendocrinology, 35, e13232. doi: 10.1111/jne.13232

Journal - Research Other

Goffin, V., Becu-Villalobos, D., Popovic, V., & Grattan, D. R. (2023). Editorial: Towards targeting prolactin signaling in human diseases: Stimulate or inhibit? Frontiers in Endocrinology, 14, 1213895. doi: 10.3389/fendo.2023.1213895

Conference Contribution - Published proceedings: Abstract

Murrell, C. L., Andrews, Z. B., Grattan, D. R., & Ladyman, S. R. (2023). Insensitivity to the feeding response of exogenous ghrelin develops during pregnancy. Proceedings of the Society for Neuroscience Annual Meeting. PSTR286.14/KK2. Retrieved from https://www.sfn.org/

Stewart, A. M., Grattan, D. R., & Georgescu, T. (2023). The role of lactogenic hormones in suppression of fever responses during late pregnancy. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Poster Presentation (not in published proceedings)

Pal, T., Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2023, August). Dynamics of MPOA prolactin receptor-expressing neurons in freely behaving mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Georgescu, T., Sawyer, I., Gillett, M., Stewart, A., Ladyman, S. R., & Grattan, D. R. (2023, August). Suppression of fever, but not sickness behaviours in late pregnancy in mice [Award lecture]. Verbal presentation at the Brain Health Research Centre (BHRC) Annual Conference, Dunedin, New Zealand.

Grattan, D. (2023, November). How our biology contributes to obesity. Verbal presentation at the Edgar Diabetes and Obesity Research Centre (EDOR) 20th Anniversary Symposium, Dunedin, New Zealand.

Clarkson, J., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2023, August). Stimulating mothers: Dissecting the maternal behaviour neural circuitry using optogenetics. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2022). Prolactin action is necessary for parental behavior in male mice. Journal of Neuroscience, 42(44), 8308-8327. doi: 10.1523/jneurosci.0558-22.2022

Radecki, K. C., Ford, M. J., Phillipps, H. R., Lorenson, M. Y., Grattan, D. R., Yamanaka, Y., & Walker, A. M. (2022). Multiple cell types in the oviduct express the prolactin receptor. FASEB BioAdvances, 4, 485-504. doi: 10.1096/fba.2022-00004

Phillipps, H. R., Khant Aung, Z., & Grattan, D. R. (2022). Elevated prolactin secretion during proestrus in mice: Absence of a defined surge. Journal of Neuroendocrinology, 34, e13129. doi: 10.1111/jne.13129

Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207. doi: 10.1096/fj.202101764R

Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. PNAS, 119(6), e2116972119. doi: 10.1073/pnas.2116972119

Conference Contribution - Published proceedings: Abstract

Young, C. D., Grattan, D. R., & Ladyman, S. (2022). The effect of a Polynesian-specific CREBRF gene variant on pregnancy hormones in a mouse model. In A. Finigan, R. Richards & P. Vakaoti (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices XIX. (pp. 39). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. Retrieved from http://hdl.handle.net/10523/16237

Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Young, C., Grattan, D., & Ladyman, S. (2022). Effect of the Polynesian-specific CREBRF gene variant on lactogenic activity during mouse pregnancy. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 139. Retrieved from https://www.esa-srb-apeg-nzse.org

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2022). Prolactin-induced suppression of gonadotrophin secretion during lactation. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 240. Retrieved from https://www.esa-srb-apeg-nzse.org

Gillett, M. L., Grattan, D. R., & Ladyman, S. R. (2022). The role of prolactin in the small intestine during pregnancy and lactation. New Zealand Medical Journal, 135(1557), (pp. 102). Retrieved from https://journal.nzma.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2022, August-September). Dissecting the neural circuitry controlling maternal behaviour. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kim, J. S., Ganeshan, D., Grattan, D. R., & Iremonger, K. J. (2022, August-September). Hyothalamic CRH neuron activity in motherhood is not altered during stress but can be suppressed by pup exposure. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Khant Aung, Z., Kado, E., Young, C., Grattan, D. R., & Ladyman, S. R. (2022, August). Protective role of a Polynesian-specific variant of CREBRF gene against gestational diabetes mellitus (GDM): Mouse model. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Grattan, D. R. (2022, August). Hypothalamic Wnt/b-catenin signalling is required for normal metabolic homeostasis. Verbal presentation at the Metabolic & Cardiovascular Disease Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Murrell, C. L., Grattan, D. R., & Ladyman, S. R. (2022, August-September). Ghrelin-induced food intake is supressed during pregnancy and restored lactation. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gillett, M. L., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2022, August-September). Prolactin receptors in the epithelial cells of the intestine influence feeding patterns in pregnancy. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Fang, C., Grattan, D. R., & Phillipps, H. R. (2022, August-September). Prolactin receptor-containing POMC neurons in the arcuate nucleus reveal a potential mechanism for prolactin-induced neurogenesis. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Phillipps, H. R., Hackwell, E. C. R., & Grattan, D. R. (2022, August-September). Insulin-like growth factor 2, a prolactin target in the subventricular zone neurogenic niche. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2021

Journal - Research Article

Khant Aung, Z., Kokay, I. C., Grattan, D. R., & Ladyman, S. R. (2021). Prolactin-induced adaptation in glucose homeostasis in mouse pregnancy is mediated by the pancreas and not in the forebrain. Frontiers in Endocrinology, 12, 765976. doi: 10.3389/fendo.2021.765976

Ladyman, S. R., Larsen, C. M., Taylor, R. S., Grattan, D. R., & McCowan, L. M. E. (2021). Case–control study of prolactin and placental lactogen in SGA pregnancies. Reproduction & Fertility, 2(4), 244-250. doi: 10.1530/RAF-21-0020

Aoki, M., Gamayun, I., Wyatt, A., Grünewald, R., Simon-Thomas, M., Philipp, S. E., … Grattan, D. R., & Boehm, U. (2021). Prolactin-sensitive olfactory sensory neurons regulate male preference in female mice by modulating responses to chemosensory cues. Science Advances, 7(41), eabg4074. doi: 10.1126/sciadv.abg4074

Ladyman, S. R., Carter, K. M., Gillett, M. L., Khant Aung, Z., & Grattan, D. R. (2021). A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin. eLIFE, 10, e62260. doi: 10.7554/eLife.62260

Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041

Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., Silva, M. S. B., Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology, 33, e12972. doi: 10.1111/jne.12972

Journal - Research Other

Georgescu, T., Swart, J. M., Grattan, D. R., & Brown, R. S. E. (2021). The prolactin family of hormones as regulators of maternal mood and behavior. Frontiers in Global Women's Health, 2, 767467. doi: 10.3389/fgwh.2021.767467

Clarke, G. S., Gatford, K. L., Young, R. L., Grattan, D. R., Ladyman, S. R., & Page, A. J. (2021). Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms. Obesity, 29(11), 1813-1824. doi: 10.1002/oby.23224

Porteous, R., Haden, P., Hackwell, E. C. R., Singline, A. J., Herde, M. K., Desai, R., … Grattan, D. R., & Herbison, A. E. (2021). Reformulation of PULSAR for analysis of pulsatile LH secretion and a revised model of estrogen negative feedback in mice. Endocrinology, 162(11). doi: 10.1210/endocr/bqab165

Grattan, D. R., & Andrews, Z. B. (2021). Insulin as a neuroendocrine hormone. Journal of Neuroendocrinology, 33, e12966. doi: 10.1111/jne.12966

Conference Contribution - Published proceedings: Abstract

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2021). A novel role for prolactin in paternal behaviour. New Zealand Medical Journal, 134(1544), (pp. 190). Retrieved from https://www.nzma.org.nz/journal

2020

Chapter in Book - Research

Grattan, D. R., & Ladyman, S. R. (2020). Neurophysiological and cognitive changes in pregnancy. In E. A. P. Steegers, M. J. Cipolla & E. C. Miller (Eds.), Handbook of clinical neurology (Vol. 171): Neurology and pregnancy: Pathophysiology and patient care. (pp. 25-55). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-444-64239-4.00002-3

Journal - Research Article

Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2020). Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology, 32, e12908. doi: 10.1111/jne.12908

Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R. (2020). Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology, 32, e12901. doi: 10.1111/jne.12901

Paige, C., Barba-Escobedo, P. A., Mecklenburg, J., Patil, M., Goffin, V., Grattan, D. R., … Price, T. J. (2020). Neuroendocrine mechanisms governing sex differences in hyperalgesic priming involve prolactin receptor sensory neuron signaling. Journal of Neuroscience, 40(37), 7080-7090. doi: 10.1523/jneurosci.1499-20.2020

Stagkourakis, S., Smiley, K. O., Williams, P., Kakadellis, S., Ziegler, K., Bakker, J., Brown, R. S. E., … Grattan, D. R., & Broberger, C. (2020). A neuro-hormonal circuit for paternal behavior controlled by a hypothalamic network oscillation. Cell, 182, 960-975. doi: 10.1016/j.cell.2020.07.007

Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2020). Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology, 32, e12889. doi: 10.1111/jne.12889

Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2020). Pregnancy-induced adaptation of central sensitivity to leptin and insulin. Molecular & Cellular Endocrinology, 516, 110933. doi: 10.1016/j.mce.2020.110933

Yip, S. H., Araujo-Lopes, R., Szawka, R. E., York, J., Hyland, B., Grattan, D. R., & Bunn, S. J. (2020). Morphological plasticity of the tuberoinfundibular dopaminergic neurons in the rat during the estrous cycle and lactation. Journal of Neuroendocrinology, 32(11), e12884. doi: 10.1111/jne.12884

Garratt, M., Try, H., Smiley, K. O., Grattan, D. R., & Brooks, R. C. (2020). Mating in the absence of fertilization promotes a growth-reproduction versus lifespan trade-off in female mice. PNAS, 117(27), 15748-15754. doi: 10.1073/pnas.2003159117

Silva, J. F., Henriques, P. C., Campideli-Santana, A. C., Araujo-Lopes, R., Aquino, N. S. S., Hipolito, L. T. M., … Grattan, D. R., & Szawka, R. E. (2020). Estradiol potentiates but is not essential for prolactin-induced suppression of luteinizing hormone pulses in female rats. Endocrinology, 161, 1-14. doi: 10.1210/endocr/bqaa022

Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Gustafson, P., Knowles, P., Luque, G. M., Grattan, D. R., & Becu-Villalobos, D. (2020). Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake. FASEB Journal, 34, 3902-3914. doi: 10.1096/fj.201902357R

Kokay, I. C., Grattan, D. R., & Murray, J. F. (2020). Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation. Journal of Neuroendocrinology, 32, e12827. doi: 10.1111/jne.12827

Journal - Research Other

Le Tissier, P. R., & Grattan, D. R. (2020). Growth hormone and prolactin: So much still to learn. Journal of Neuroendocrinology, 32(11), e12909. doi: 10.1111/jne.12909

Phillipps, H. R., Yip, S. H., & Grattan, D. R. (2020). Patterns of prolactin secretion. Molecular & Cellular Endocrinology, 502, 110679. doi: 10.1016/j.mce.2019.110679

Conference Contribution - Published proceedings: Abstract

Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2020). Identifying a role for lactogenic hormones in maternal motivation. Journal of the Endocrine Society, 4(Suppl. 1), (pp. A1075). doi: 10.1210/jendso/bvaa046.2131

2019

Edited Book - Research

Coolen, L. M., & Grattan, D. R. (Eds.). (2019). Neuroendocrine regulation of behavior: Current topics in behavioral neurosciences (Vol. 43). Cham, Switzerland: Springer, 447p. doi: 10.1007/978-3-030-38720-4

Chapter in Book - Research

Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In L. M. Coolen & D. R. Grattan (Eds.), Neuroendocrine regulation of behavior: Current topics in behavioral neurosciences (Vol. 43). (pp. 161-210). Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122

Journal - Research Article

Patil, M., Belugin, S., Mecklenburg, J., Wangzhou, A., Paige, C., Barba-Escobedo, P. A., … Grattan, D., … Akopian, A. N. (2019). Prolactin regulates pain responses via a female-selective nociceptor-specific mechanism. iScience, 20, 449-465. doi: 10.1016/j.isci.2019.09.039

Aoki, M., Wartenberg, P., Grūnewald, R., Phillipps, H. R., Wyatt, A., Grattan, D. R., & Boehm, U. (2019). Widespread cell-specific prolactin receptor expression in multiple murine organs. Endocrinology, 60(11), 2587-2599. doi: 10.1210/en.2019-00234

Skinner, N. J., Rizwan, M. Z., Grattan, D. R., & Tups, A. (2019). Chronic light cycle disruption alters central insulin and leptin signaling as well as metabolic markers in male mice. Endocrinology, 160(10), 2257-2270. doi: 10.1210/en.2018-00935

Patil, M., Hovhannisyan, A. H., Wangzhou, A., Mecklenburg, J., Koek, W., Goffin, V., Grattan, D., … Akopian, A. N. (2019). Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent. Journal of Neuroendocrinology, 31, e12759. doi: 10.1111/jne.12759

Kirk, S. E., Grattan, D. R., & Bunn, S. J. (2019). The median eminence detects and responds to circulating prolactin in the male mouse. Journal of Neuroendocrinology, 31, e12733. doi: 10.1111/jne.12733

Brown, R. S. E., Khant Aung, Z., Phillipps, H. R., Barad, Z., Lein, H.-J., Boehm, U., Szawka, R. E., & Grattan, D. R. (2019). Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus. Endocrinology, 160(5), 1323-1332. doi: 10.1210/en.2019-00038

Augustine, R. A., Knowles, P. J., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2019). Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. Journal of Neuroendocrinology, 31, e12702. doi: 10.1111/jne.12702

Yip, S. H., Romanò, N., Gustafson, P., Hodson, D. J., Williams, E. J., Kokay, I. C., … Grattan, D. R., & Bunn, S. J. (2019). Elevated prolactin during pregnancy drives a phenotypic switch in mouse hypothalamic dopaminergic neurons. Cell Reports, 26(7), 1787-1799.e5. doi: 10.1016/j.celrep.2019.01.067

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Kokay, I. C., Stanton, J.-A., & Grattan, D. R. (2019). Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal, 33, 6115-6128. doi: 10.1096/fj.201802262R

Aquino, N. S. S., Kokay, I. C., Perez, C. T., Ladyman, S. R., Henriques, P. C., Silva, J. F., … Grattan, D. R., & Szawka, R. E. (2019). Kisspeptin stimulation of prolactin secretion requires Kiss1 receptor but not in tuberoinfundibular dopaminergic neurons. Endocrinology, 160(3), 522-533. doi: 10.1210/en.2018-00932

Journal - Research Other

Grattan, D. R., & Szawka, R. E. (2019). Kisspeptin and prolactin. Seminars in Reproductive Medicine, 37(2), 93-104. doi: 10.1055/s-0039-3400956

Conference Contribution - Published proceedings: Abstract

Georgescu, T., & Grattan, D. R. (2019). Characterisation of the acute effects of prolactin upon prolactin receptor-expressing neurones in the mouse hypothalamus. Brain & Neuroscience Advances, 3, PT096. doi: 10.1177/2398212819855490

Rizwan, M., Shepherd, P., Tups, A., & Grattan, D. (2019). Region specific deletion of beta-catenin leads to impaired glucose tolerance and increased body weight. Brain & Neuroscience Advances, 3, PS108. doi: 10.1177/2398212819855490

Grattan, D. R. (2019). Prolactin in pregnancy and how it affects maternal metabolism and behaviour. Proceedings of the 101st Annual Meeting of the Endocrine Society. Retrieved from https://www.abstractsonline.com/pp8/#!/5752

Parsons, P. P., Peffer, R. C., Richards-Doran, R., Cowie, D. E., Currie, R. A., Lichti-Kaiser, K., … Grattan, D. R., & Yi, K. D. (2019). Uterine adenocarcinomas in isopyrazam-treated rats occur via a mode of action that has no relevance to humans. Toxicology Letters, 314(Suppl. 1), (pp. S131). [Abstract]

Barad, Z., Grattan, D., & Brown, R. (2019). Prolactin acts on glutamatergic neurons in the ventromedial nucleus of the hypothalamus to modulate maternal aggression. Journal of the Endocrine Society, 3(Suppl. 1), OR06-3. doi: 10.1210/js.2019-OR06-3

Conference Contribution - Poster Presentation (not in published proceedings)

Saraiva, A. M., Dias, G. J., & Grattan, D. R. (2019, September). Bone remodelling regulation during lactation: The role of prolactin and its receptors. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Yip, S. H., Romano, N., Hodson, D. J., Williams, E., Gustafson, P., Kokay, I., … Grattan, D. R., & Bunn, S. J. (2019, September). Elevated prolactin during pregnancy drives a phenotypic switch in mouse hypothalamic dopaminergic neurons. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Khant Aung, Z., Jacobs, I., Grattan, D. R., Brown, R. S. E., & Ladyman, S. R. (2019, August-September). Peripartum prolactin and growth hormone concentrations in diet-induced obese mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Rizwan, M. Z., Shepherd, P. R., Tups, A., & Grattan, D. R. (2019, August-September). Region-specific deletion of β-catenin leads to impaired glucose tolerance and increased bodyweight. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Identifying a novel role for prolactin in the transition to paternal care. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Phillipps, H. R., Khant Aung, Z., & Grattan, D. R. (2019, August-September). Characterisation of plasma prolactin levels during proestrus in mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Hackwell, E. C. R., Brown, R. S. E., Ladyman, S. R., & Grattan, D. R. (2019, August-September). Prolactin action on kisspeptin neurons is required for maintaining lactational infertility. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Ladyman, S. R., & Grattan, D. R. (2019, September). Contribution of central prolactin receptors to changes in energy homeostasis during pregnancy and lactation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2019, September). The effect of reproductive experience on maternal motivation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Yip, S. H., Romano, N., Hodson, D. J., Williams, E., Gustafson, P., Kokay, I., … Grattan, D. R., & Bunn, S. J. (2019, August-September). Switch to motherhood: A glimpse into prolactin secretion. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Investigating the acute effects of prolactin upon hypothalamic prolactin-receptor expressing neurons. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Manning, P. J., Grattan, D., Merriman, T., Manning, T., Williams, S., & Sutherland, W. (2018). Pharmaceutical interventions for weight-loss maintenance: No effect from cabergoline. International Journal of Obesity, 42, 1871-1879. doi: 10.1038/s41366-018-0165-3

Kokay, I. C., Wyatt, A., Phillipps, H. R., Aoki, M., Hermans-Borgmeyer, I., Boehm, U., & Grattan, D. R. (2018). Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse. Journal of Neuroendocrinology, 30, e12634. doi: 10.1111/jne.12634

McEwen, H. J. L., Cognard, E., Ladyman, S. R., Khant-Aung, Z., Tups, A., Shepherd, P. R., & Grattan, D. R. (2018). Feeding and GLP-1 receptor activation stabilize beta-catenin in specific hypothalamic nuclei in male rats. Journal of Neuroendocrinology, 30(6), e12607, 1-10. doi: 10.1111/jne.12607

Ladyman, S. R., Carter, K. M., & Grattan, D. R. (2018). Energy homeostasis and running wheel activity during pregnancy in the mouse. Physiology & Behavior, 194, 83-94. doi: 10.1016/j.physbeh.2018.05.002

Krishnan, M., Major, T. J., Topless, R. K., Dewes, O., Yu, L., Thompson, J. M. D., … Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Diabetologia, 61(7), 1603-1613. doi: 10.1007/s00125-018-4623-1

Ladyman, S. R., Khant Aung, Z., & Grattan, D. R. (2018). Impact of pregnancy and lactation on the long-term regulation of energy balance in female mice. Endocrinology, 159(6), 2324-2336. doi: 10.1210/en.2018-00057

Bernard, V., Lamothe, S., Beau, I., Guillou, A., Martin, A., Le Tissier, P., Grattan, D., … Binart, N. (2018). Autocrine actions of prolactin contribute to the regulation of lactotroph function in vivo. FASEB Journal, 32(9), 4791-4797. doi: 10.1096/fj.201701111RR

Macari, S., Sharma, L. A., Wyatt, A., Maíra da Silva, J., Dias, G. J., Silva, T. A., … Grattan, D. R. (2018). Lactation induces increases in the RANK/RANKL/OPG system in maxillary bone. Bone, 110, 160-169. doi: 10.1016/j.bone.2018.01.032

Grattan, D. R. (2018). Coordination or coincidence? The relationship between prolactin and gonadotropin secretion. Trends in Endocrinology & Metabolism, 29(1), 3-5. doi: 10.1016/j.tem.2017.11.004

Yip, S. H., York, J., Hyland, B., Bunn, S. J., & Grattan, D. R. (2018). Incomplete concordance of dopamine transporter Cre (DAT^IREScre)-mediated recombination and tyrosine hydroxylase immunoreactivity in the mouse forebrain. Journal of Chemical Neuroanatomy, 90, 40-48. doi: 10.1016/j.jchemneu.2017.12.002

Journal - Research Other

Bridges, R. S., & Grattan, D. R. (2018). 30 years after: CNS actions of prolactin: Source, mechanism and physiological significance. Journal of Neuroendocrinology, 31(3), e12669. doi: 10.1111/jne.12669

Major, T. J., Krishnan, M., Topless, R. K., Dewes, O., Thompson, J., de Zoysa, J., Stamp, L. K., … Wilcox, P., Grattan, D., … Merriman, T. R. (2018). Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood". International Journal of Obesity, 42, 1389-1391. doi: 10.1038/s41366-018-0025-1

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569

Journal - Professional & Other Non-Research Articles

Zhang, M., Jones, D. G., & Grattan, D. R. (2018). In memory of Professor Lance Graham Nash, BSci., MSci., PhD. (1961-2016). Journal of Plastination, 30(2), 5-7.

Conference Contribution - Published proceedings: Abstract

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Social Neuroscience 9th Annual Meeting. (pp. 33). Retrieved from https://www.s4sn.org

Ladyman, S. R., Khant Aung, Z., & Grattan, D. R. (2018). Pregnancy-induced adaptations in glucose homeostasis in the mouse requires prolactin receptor expression in the pancreas but not the brain. Endocrine Reviews, 39(2), MON-150. [Abstract]

Lopez-Vicchi, F., Ladyman, S. R., Ornstein, A. M., Luque, G. M., Grattan, D. R., & Becu-Villalobus, D. (2018). Leptin insensitivity and nuclei-specific altered gene expression in hypothalamus of trransgenic mice with chronic hyperprolactinemia. Endocrine Reviews, 39(2), SAT-623-LB. [Abstract]

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Neuroscience 48th Annual Meeting. 108.08. SfN. Retrieved from https://www.sfn.org

Rizwan, M. Z., Shepherd, P., Tups, A., & Grattan, D. (2018). Stabilization of beta-catenin in mouse hypothalamic cell lines. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 348-349). Retrieved from http://www.icn2018.org/

Khant Aung, Z., Grattan, D., & Ladyman, S. R. (2018). Long-term consequences of reproductive experience on metabolic homeostasis in mothers. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 214). Retrieved from http://www.icn2018.org/

Ladyman, S., Carter, K. M., & Grattan, D. (2018). Prolactin drives the decreases in voluntary physical activity in early pregnancy. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 173). Retrieved from http://www.icn2018.org/

Phillipps, H. R., Rand, C., Brown, R. S. E., Stanton, J.-A., & Grattan, D. (2018). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 125). Retrieved from http://www.icn2018.org/

Gustafson, P., Ladyman, S. R., Grattan, D., & Brown, R. S. E. (2018). Changing dynamics of prolactin and leptin transport into the brain during pregnancy and with aging. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 124). Retrieved from http://www.icn2018.org/

Bunn, S., Yip, S. H., Grattan, D., Hyland, B., Szawka, R., Araujo-Lopes, R., & York, J. (2018). Morphological plasticity of hypothalamic dopaminergic neurons during estrous cycle and lactation. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 123-124). Retrieved from http://www.icn2018.org/

Silva, J. F., Henriques, P. C., Campideli-Santana, A. C., Araujo-Lopes, R., Aquino, N. S. S., Lopes-Aguiar, C., Grattan, D., & Szawka, R. E. (2018). Role of estradiol in prolactin-induced suppression of luteinizing hormone pulsatile secretion. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 113-114). Retrieved from http://www.icn2018.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, November). Central prolactin action is required for maintaining lactational diestrus in mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2018, November). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Stanton, J.-A., & Grattan, D. R. (2018, November). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, November). Are impairments in prolactin signalling in the brain of obese mice associated with deficits in maternal care? Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Ladyman, S. R., & Grattan, D. R. (2018, November). Pregnancy and lactation lead to long term changes in body weight and small intestine length in female mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2018, August). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Georgescu, T., & Grattan, D. R. (2018, August). Characterisation of the acute effects of prolactin upon prolactin receptor-expressing neurones in the mouse hypothalamus. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Yip, S. H., Georgescu, T., York, J., Kokay, I., Araujo-Lopes, R., Szawka, R. E., Hyland, B. I., Grattan, D. R., & Bunn, S. J. (2018, August). Adaptation of tuberoinfundibular dopaminergic neurons to estrous cycle and lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2018, August). Central prolactin receptor activation contributes to the hyperphagia of lactation. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gustafson, P. E., Yip, S. H., Bunn, S. J., & Grattan, D. R. (2018, August). Suppression of the response to restraint stress in the lactating mouse. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2018, November). Central prolactin receptor activition contributes to the hyperphagia of lactation. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Barad, Z., Grattan, D. R., & Brown, R. S. E. (2018, November). Fine-tuning the maternal brain: How hormones modulate a mother's behaviour. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Tawngdee, Y., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2018, August). The role of prolactin in reward aspects of maternal behaviour. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, August). Are impairments in prolactin signaling in the brain of obese mice associated with deficits in maternal care? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, August). Central prolactin action is required for maintaining lactational diestrus in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Journal - Research Article

Ladyman, S. R., & Grattan, D. R. (2017). Region-specific suppression of hypothalamic responses to insulin to adapt to elevated maternal insulin secretion during pregnancy. Endocrinology, 158(12), 4257-4269. doi: 10.1210/en.2017-00600

Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114

Gustafson, P., Bunn, S. J., & Grattan, D. R. (2017). The role of prolactin in the suppression of Crh mRNA expression during pregnancy and lactation in the mouse. Journal of Neuroendocrinology, 29(9), e12511. doi: 10.1111/jne.12511

Rizwan, M. Z., Mehlitz, S., Grattan, D. R., & Tups, A. (2017). Temporal and regional onset of leptin resistance in diet-induced obese mice. Journal of Neuroendocrinology, 29(10), e12481. doi: 10.1111/jne.12481

Kirk, S. E., Xie, T. Y., Steyn, F. J., Grattan, D. R., & Bunn, S. J. (2017). Restraint stress increases prolactin-mediated phosphorylation of signal transducer and activator of transcription 5 in the hypothalamus and adrenal cortex in the male mouse. Journal of Neuroendocrinology, 29(6), 1-9. doi: 10.1111/jne.12477

Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474

Gustafson, P., Kokay, I., Sapsford, T., Bunn, S., & Grattan, D. (2017). Prolactin regulation of the HPA axis is not mediated by a direct action upon CRH neurons: Evidence from the rat and mouse. Brain Structure & Function, 222(7), 3191-3204. doi: 10.1007/s00429-017-1395-1

Barad, Z., Grattan, D. R., & Leitch, B. (2017). NMDA receptor expression in the thalamus of the stargazer model of absence epilepsy. Scientific Reports, 7, 42926. doi: 10.1038/srep42926

Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712

Booker, C. S., & Grattan, D. R. (2017). IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Journal of Immunology, 198(1), 270-278. doi: 10.4049/jimmunol.1500648

Conference Contribution - Published proceedings: Abstract

Carter, K. M., Grattan, D. R., & Ladyman, S. R. (2017). Prolactin acutely influences running wheel activity but not ambulatory activity in female mice. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au

Araujo-Lopes, R., Yip, S. H., Silva, J. F., Bernardes, R. G. L., Bello, F. L. M., Henriques, P. C., … Grattan, D. R., & Szawka, R. E. (2017). Estradiol induces a functional switch in arcuate KNDy neurons from kisspeptin to dynorphin to facilitate prolactin secretion. Endocrine Reviews, 38(3, Suppl.), OR23-2. Retrieved from http://www.endocrine.org

Seo, S., Kohe, S. E., Gowing, E., Zheng, Y., Kokay, I., Grattan, D. R., Liu, P., & Oorschot, D. E. (2017). Effect of extreme prematurity on brain monoamine metabolism. Proceedings of the Society for Neuroscience 47th Annual Meeting. 035.06/C44. SfN. Retrieved from https://www.sfn.org/

Nair, B., Khant Aung, Z., Porteous, R., Prescott, M., Ng, J., Yip, S., Augustine, R., Glendining, K., Bouwer, G., Kim, J., Jenkins, D., Silva, M., Brown, C., Campbell, R., Jasoni, C., Bunn, S., Anderson, G., Grattan, D., Herbison, A., & Iremonger, K. (2017). Impact of chronic stress on the neuroendocrine axis in the mouse. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 49). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Conference Contribution - Poster Presentation (not in published proceedings)

Yip, S. H., York, J., Araujo-Lopes, R., Szawka, R. E., Hyland, B., Grattan, D. R., & Bunn, S. J. (2017, July). Morphological plasticity of tuberoinfundibular dopaminergic neurons during estrous cycle and lactation. Poster session presented at the Federation of American Societies for Experimental Biology (FASEB) Science Research Conference: The Growth Hormone (GH)/Prolactin (PRL) Family in Biology and Disease, Steamboat Springs, USA.

Rizwan, M. Z., Shepherd, P., Tups, A., & Grattan, D. R. (2017, September). Stabilization of beta-catenin in mouse hypothalamic cell lines. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2017, September). Pregnancy-induced adaptations in glucose homeostasis in the mouse requires prolactin receptor expression in the pancreas but not the brain. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kaplish, M., Rizwan, M. Z., & Grattan, D. R. (2017, September). The effect of pregnancy-induced adaptations on glucagon like-peptide-1 receptor activation-induced stabilisation of beta-catenin in hypothalamic neurons in female rats. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gustafson, P. E., Bunn, S. J., & Grattan, D. R. (2017, September). Regulation of the maternal hypothalamic-pituitary-adrenal axis by prolactin. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Brown, R. S., Barad, Z., & Grattan, D. R. (2017, September). Changes in prolactin responsiveness of glutamate and nNos neurons in the female mouse brain during lactation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Piet, R., Rønnekleiv, O., Grattan, D., & Micevych, P. (2017, March). Positive feedback and hormone control of preoptic kisspeptin neurons. Verbal presentation at the 3rd World Conference on Kisspeptin, Orlando, USA.

Carter, K., Grattan, D. R., & Ladyman, S. R. (2017, September). Prolactin-induced suppression of acute running wheel activity in female mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Grattan, D. R. (2017, September). Central adaptations to pregnancy. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus. International Journal of Developmental Neuroscience, 53, 18-25. doi: 10.1016/j.ijdevneu.2016.06.005

Ladyman, S. R., & Grattan, D. R. (2016). Central effects of leptin on glucose homeostasis are modified during pregnancy in the rat. Journal of Neuroendocrinology, 28(10). doi: 10.1111/jne.12431

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016

McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2016). Deletion of suppressor of cytokine signaling 3 from forebrain neurons delays infertility and onset of hypothalamic leptin resistance in response to a high caloric diet. Journal of Neuroscience, 36(27), 7142-7153. doi: 10.1523/jneurosci.2714-14.2016

Alqaisi, K. M., Lamare, M. D., Grattan, D. R., Damsteegt, E. L., Schneider, W. J., & Lokman, P. M. (2016). A comparative study of vitellogenesis in Echinodermata: Lessons from the sea star. Comparative Biochemistry & Physiology Part A, 198, 72-86. doi: 10.1016/j.cbpa.2016.04.013

Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016). Maternal obesity in the mouse compromises the blood-brain barrier in the arcuate nucleus of offspring. Endocrinology, 157(6), 2229-2242. doi: 10.1210/en.2016-1014

Macari, S., Ajay Sharma, L., Wyatt, A., Knowles, P., Szawka, R. E., Garlet, G. P., Grattan, D. R., Dias, G. J., & Silva, T. A. (2016). Osteoprotective effects of estrogen in the maxillary bone depend on ERα. Journal of Dental Research, 95(6), 689-696. doi: 10.1177/0022034516633154

Vergara-Castañeda, E., Grattan, D. R., Pasantes-Morales, H., Pérez-Domínguez, M., Cabrera-Reyes, E. A., Morales, T., & Cerbón, M. (2016). Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor. Brain Research, 1636, 193-199. doi: 10.1016/j.brainres.2016.02.011

Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350

Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605

Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519

Journal - Research Other

Grattan, D. R. (2016). The eyes have it! Protective role of prolactin in the retina. EBioMedicine, 8, 26-27. doi: 10.1016/j.ebiom.2016.05.030

Grattan, D. R., & Akopian, A. N. (2016). Oscillating from neurosecretion to multitasking dopamine neurons [Preview]. Cell Reports, 15(4), 681-682. doi: 10.1016/j.celrep.2016.04.013

Conference Contribution - Published proceedings: Abstract

Grattan, D. R., McEwen, H., Ladyman, S., & Shepherd, P. (2016). Feeding and GLP-1 receptor activation stabilize β-catenin in specific hypothalamic nuclei in male rats. Proceedings of the Society for Neuroscience 46th Annual Meeting. 731.21/CCC15. SfN. Retrieved from https://www.sfn.org/

Macari, S., Sharma, L., Wyatt, A., Knowles, P., Szawka, R., Grattan, D., Dias, G., & Silva, T. (2016). The osteoprotective effect of estrogen receptor alpha in maxillary bone. Journal of Dental Research, 95(Spec Iss B), 1277. Retrieved from http://www.iadr.org/

Gustafson, P. E., Bunn, S. J., & Grattan, D. R. (2016). Does prolactin mediate the suppression of the maternal stress response? Endocrine Reviews, 37(2, Suppl.), FRI-506. Retrieved from http://press.endocrine.org/series/endo-meetings

Kokay, I. C., Szawka, R. E., & Grattan, D. R. (2016). Kisspeptin stimulation of prolactin secretion is not mediated by a direct action on tuberoinfundibular neurons. Endocrine Reviews, 37(2, Suppl.), FRI-503. Retrieved from http://press.endocrine.org/series/endo-meetings

Kirk, S., Grattan, D. R., & Bunn, S. J. (2016). Stress-induced prolactin signalling in the male mouse. Endocrine Reviews, 37(2, Suppl.), FRI-507. Retrieved from http://press.endocrine.org/series/endo-meetings

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Gustafson, P. E., Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2016). Conditional deletion of prolactin receptor gene reveals remarkable redundancy in feedback regulation of tuberoinfundibular dopamine neurons by prolactin. Endocrine Reviews, 37(2, Suppl.), FRI-504. Retrieved from http://press.endocrine.org/series/endo-meetings

Conference Contribution - Poster Presentation (not in published proceedings)

Yip, S. H., York, J., Hyland, B., Grattan, D. R., & Bunn, S. J. (2016, August-September). Revealing the morphological plasticity of tuberoinfundibular dopaminergic neurons using an in vivo viral-mediated cell filling technique. Poster session presented at the 17th international Congress of Endocrinology in conjunction with the 15th Annual Meeting of the Chinese Society of Endocrinology, Beijing, China.

York, J., Yip, S. H., Hyland, B., Grattan, D. R., & Bunn, S. J. (2016, August). Morphological characterization of tyrosine hydroxylase immunoreactive neurons in the rat hypothalamus. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2016, August). Impaired pregnancy-induced changes to glucose homeostasis in mice lacking prolactin receptors in the pancreas. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Lien, R., Brown, R. S. E., Kokay, I. C., & Grattan, D. R. (2016, August). Role of kisspeptin in the prolactin-induced suppression of the pulsatile secretion of luteinizing hormone. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Grattan, D. (2016, August-September). Feeding-induced stabilisation of beta-catenin in the hypothalamus: A novel pathway in the homeostatic regulation of metabolism? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Kaplish, M., Ladyman, S. R., & Grattan, D. R. (2016, August). The effect of pregnancy-induced adaptations on glucagon like-peptide-1 receptor activation-induced stabilisation of beta-catenin in hypothalamic neurons in female rats. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

MacLeod, M. A., Ladyman, S. R., & Grattan, D. R. (2016, August). The effect of prolactin on AgRP neurons in the arcuate nucleus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Boyes, K., Kokay, I. C., Wyatt, A., Boehm, U., & Grattan, D. R. (2016, August). The role of the prolactin receptor in the developing brain. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Carter, K., Rizwan, M., Ladyman, S. R., & Grattan, D. R. (2016, August). Feeding-induced regulation of Wnt/beta catenin signaling in the mouse hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., … Grattan, D. R. (2016, August). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Yip, S. H., York, J., Hyland, B., Grattan, D., & Bunn, S. J. (2016, August). Changes in dendritic spine density of tuberoinfundibular dopaminergic neurons associated with estrous cyclicity in the rat. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

2015

Chapter in Book - Research

Grattan, D. R., & Le Tissier, P. (2015). Hypothalamic control of prolactin secretion, and the multiple reproductive functions of prolactin. In T. M. Plant & A. J. Zeleznik (Eds.), Knobil and Neill's Physiology of reproduction (Vol. 1). (4th ed.) (pp. 469-526). Elsevier. doi: 10.1016/B978-0-12-397175-3.00012-0

Journal - Research Article

Grattan, D. R. (2015). 60 years of neuroendocrinology: The hypothalamo-prolactin axis. Journal of Endocrinology, 226(2), T101-T122. doi: 10.1530/joe-15-0213

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2015). Effects of prolactin and lactation on A15 dopamine neurons in the rostral preoptic area of female mice. Journal of Neuroendocrinology, 27(9), 708-717. doi: 10.1111/jne.12297

Conference Contribution - Published proceedings: Abstract

Steyn, F., Gounden, S., Veldhuis, J. D., Grattan, D. R., & Chen, C. (2015). Prolactin as a key regulator of growth hormone pulsatility in lactation, acting via somatostatin. Endocrine Reviews, 36(2, Suppl.), PP04-3. Retrieved from http://press.endocrine.org/series/endo-meetings

Steyn, F., Gounden, S., Veldhuis, J. D., Grattan, D. R., & Chen, C. (2015). Prolactin as a key regulator of growth hormone pulsatility in lactation, acting via somatostatin. Endocrine Reviews, 36(2, Suppl.), THR-443. Retrieved from http://press.endocrine.org/series/endo-meetings

Bunn, S., Williams, E., Yip, J., & Grattan, D. (2015). Prolactin-dependent regulation of enkephalin expression in the tuberoinfundibular dopaminergic neurons of the lactating mouse. Journal of Neurochemistry, 134(Suppl. 1), (pp. 228). doi: 10.1111/jnc.13188

Conference Contribution - Poster Presentation (not in published proceedings)

Yip, S. H., Williams, E., Grattan, D., & Bunn, S. (2015, September). Prolactin receptor-mediated enkephalin expression in TIDA neurons of late pregnant and lactating mice. Poster session presented at the 3rd Joint Meeting of the British and French Societies for Neuroendocrinology (BSN-SNE), Lille, France.

Williams, E. J., Yip, S. H., Grattan, D. R., & Bunn, S. (2015, August-September). Prolactin signalling in the arcuate nucleus of pregnant and lactating mice. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kirk, S., Grattan, D., & Bunn, S. (2015, August-September). Decreased permeability of the median eminence in response to acute prolactin elevation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kim, T., Grattan, D., & Jasoni, C. (2015, August-September). Maternal obesity compromises the blood-brain barrier in the developing fetus. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Phillipps, H. R., Brown, R. S. E., Rand, C., Stanton, J.-A., & Grattan, D. R. (2015, August). Prolactin influence on the mouse choroid plexus transcriptome. Verbal presentation at the 7th Annual New Zealand Next Generation Sequencing (NGS) Conference, Palmerston North, New Zealand.

2014

Journal - Research Article

Booker, C. S., & Grattan, D. R. (2014). Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation. PeerJ, 2, e560. doi: 10.7717/peerj.560

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. Journal of Neuroendocrinology, 26(12), 898-908. doi: 10.1111/jne.12223

Kim, D. W., Young, S. L., Grattan, D. R., & Jasoni, C. L. (2014). Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse. Biology of Reproduction, 90(6), 130. doi: 10.1095/biolreprod.113.117259

Koch, C. E., Lowe, C., Legler, K., Benzler, J., Boucsein, A., Böttiger, G., Grattan, D. R., … Tups, A. (2014). Central adiponectin acutely improves glucose tolerance in male mice. Endocrinology, 155(5), 1806-1816. doi: 10.1210/en.2013-1734

Brown, R. C., McLay-Cooke, R. T., Richardson, S. L., Williams, S. M., Grattan, D. R., & Chisholm, A. W.-A. H. (2014). Appetite response among those susceptible or resistant to obesity. International Journal of Endocrinology, 2014, 512013. doi: 10.1155/2014/512013

Araujo-Lopes, R., Crampton, J. R., Aquino, N. S. S., Miranda, R. M., Kokay, I. C., Reis, A. M., … Grattan, D. R., & Szawka, R. E. (2014). Prolactin regulates kisspeptin neurons in the arcuate nucleus to suppress LH secretion in female rats. Endocrinology, 155(3), 1010-1020. doi: 10.1210/en.2013-1889

Liu, X., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. Endocrinology, 155(1), 193-203. doi: 10.1210/en.2013-1621

Journal - Research Other

Dobolyi, A., Grattan, D. R., & Stolzenberg, D. S. (2014). Preoptic inputs and mechanisms that regulate maternal responsiveness. Journal of Neuroendocrinology, 26(10), 627-640. doi: 10.1111/jne.12185

Gore, A. C., Balthazart, J., Bikle, D., Carpenter, D. O., Crews, D., Czernichow, P., … Grattan, D., … Watson, C. S. (2014). Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al. Frontiers in Neuroendocrinology, 35(1), 2-5. doi: 10.1016/j.yfrne.2013.09.003

Conference Contribution - Published proceedings: Abstract

Grattan, D. R., Kokay, I. C., Brown, R. S. E., Larsen, C. M., Wyatt, A., & Le Tissier, P. R. (2014). Conditional deletion of the prolactin receptor to identify brain-specific actions of prolactin. Endocrine Reviews, 35(3, Suppl.), OR35-4. Retrieved from http://press.endocrine.org/series/endo-meetings

Brown, R. S. E., Larsen, C. M., Cashen, S., Wyatt, A., Kokay, I. C., Knowles, P., … Grattan, D. R. (2014). Prolactin-sensitive GABAergic neurons contribute to the normal postpartum expression of maternal behaviour. Proceedings of the 8th International Congress of Neuroendocrinology (ICN) including the 18th Annual Meeting of the Society for Behavioural Neuroendocrinology. 277. Retrieved from http://icn-2014.p.asnevents.com.au

Gustafson, P., Bunn, S., & Grattan, D. (2014). Suppression of basal HPA axis activity in the late pregnant and lactating mouse. Proceedings of the Medical Sciences Congress (MedSci). (pp. 18). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Kirk, S. E., Grattan, D. R., & Bunn, S. J. (2014). Prolactin signalling in the median eminence and mediobasal hypothalamus of the male mouse. Proceedings of the Medical Sciences Congress (MedSci). (pp. 17). Retrieved from http://www.physoc.org.nz/meetings/archive/medsci-2014-abstracts

Black, E., Grattan, D., & Ferguson, A. (2014). Prolactin influences the excitability of subfornical organ neurons. FASEB Journal, 28(1, Suppl.), 1129.3. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Grattan, D. (2014, August). Hormone-induced plasticity in appetite regulation during pregnancy. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2013

Journal - Research Article

Benzler, J., Andrews, Z. B., Pracht, C., Stöhr, S., Shepherd, P. R., Grattan, D. R., & Tups, A. (2013). Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology, 154(12), 4737-4745. doi: 10.1210/en.2013-1746

Ladyman, S. R., & Grattan, D. R. (2013). JAK-STAT and feeding. JAK-STAT, 2(2), e23675. doi: 10.4161/jkst.23675

Phillipps, H. R., Ladyman, S. R., & Grattan, D. R. (2013). Maintained expression of genes associated with metabolism in the ventromedial hypothalamic nucleus despite development of leptin resistance during pregnancy in the rat. Physiological Reports, 1(6), e00162. doi: 10.1002/phy2.162

Romanò, N., Yip, S. H., Hodson, D. J., Guillou, A., Parnaudeau, S., Kirk, S., … Bunn, S. J., Grattan, D. R., … Martin, A. O. (2013). Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release. Journal of Neuroscience, 33(10), 4424-4433. doi: 10.1523/jneurosci.4415-12.2013

Journal - Research Other

Gore, A. C., Balthazart, J., Bikle, D., Carpenter, D. O., Crews, D., Czernichow, P., … Grattan, D., … Watson, C. S. (2013). Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich et al. Endocrinology, 154(11), 3957-3960. doi: 10.1210/en.2013-1854

Journal - Professional & Other Non-Research Articles

Grattan, D. (2013). Why should we choose to publish in the Journal of Neuroendocrinology? Journal of Neuroendocrinology, 25(12), 1239-1240. doi: 10.1111/jne.12119

Conference Contribution - Published proceedings: Abstract

Kokay, I. C., Guy, N. H., Le Tissier, P. R., & Grattan, D. R. (2013). Distribution of growth hormone responsive neurons in the mouse hypothalamus. Endocrine Reviews, 34(3, Suppl.), SAT-106. Retrieved from http://press.endocrine.org/series/endo-meetings

Brown, R. S. E., Banks, W. A., Binart, N., & Grattan, D. R. (2013). Saturable transport of prolactin across the blood-brain barrier is independent of the prolactin receptor. Endocrine Reviews, 34(3, Suppl.), MON-135. Retrieved from http://press.endocrine.org/series/endo-meetings

McEwen, H. J. L., Cognard, E., Ladyman, S. R., Shepherd, P. R., & Grattan, D. R. (2013). Regulation of beta-catenin by GLP-1 in the hypothalamus. Endocrine Reviews, 34(3, Suppl.), SAT-825. Retrieved from http://press.endocrine.org/series/endo-meetings

Kirk, S., Grattan, D. R., & Bunn, S. J. (2013). Lactation-induced changes in phospho-STAT5 and phospho-ERK signalling in tuberoinfundibular dopaminergic neurons. Proceedings of the Australasian Neuroscience Society (ANS) Annual Meeting. (pp. 35). Retrieved from http://www.ans.org.au/

Bunn, S. J., Yip, S. H., Kirk, S. E., Gustafson, P. E., & Grattan, D. R. (2013). Modification of prolactin signaling in the arcuate nucleus of the mouse during lactation. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions

Szawka, R. E., Lopes, R. A., Crampton, J., Aquino, N. S. S., Miranda, R. M., Kokay, I., … Grattan, D. R. (2013). Prolactin regulation of kisspeptin neurons in the arcuate nucleus: A pathway for suppression of luteinizing hormone secretion. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions

Grattan, D. (2013). Prolactin/placental lactogen play critical roles in the maternal adaptation to pregnancy. Proceedings of the Gravida Annual Science Symposium: How Can We Create a Better Future For All New Zealanders? Retrieved from http://www.gravida.org.nz/video/gravida-science-symposium-2013/

Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013). Prolactin transport into the brain does not require the prolactin receptor. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 79). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Conference Contribution - Poster Presentation (not in published proceedings)

Larsen, C. M., Douglas, S., McCowan, L., & Grattan, D. R. (2013, August). Prolactin, a possible marker for small gestation age babies. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kim, T., Young, S., Glendining, K., Grattan, D., & Jasoni, C. (2013, August). Obesity during pregnancy alters immune responses in the placenta. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Douglas, S., Grattan, D. R., McCowan, L., & Larsen, C. M. (2013, August). Association between serum prolactin levels and depression at twenty weeks' gestation in nulliparous women. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kirk, S., Grattan, D., & Bunn, S. (2013, August). Prolactin signalling in the mouse median eminence. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Gustafson, P., Bunn, S., & Grattan, D. (2013, August). Regulation of the stress response during pregnancy and lactation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cashen, S., Larsen, C. M., & Grattan, D. R. (2013, August). Prolactin action on GABAergic neurons is required for normal expression of maternal behaviour in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013, August). Prolactin transport into the brain does not require the prolactin receptor. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Journal - Research Article

Adler, E. S., Hollis, J. H., Clarke, I. J., Grattan, D. R., & Oldfield, B. J. (2012). Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat. Journal of Neuroscience, 32(45), 15913-15921. doi: 10.1523/jneurosci.2591-12.2012

Benzler, J., Ganjam, G. K., Krüger, M., Pinkenburg, O., Kutschke, M., Stöhr, S., … Grattan, D. R., & Tups, A. (2012). Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism. Biochemical Journal, 447(1), 175-184. doi: 10.1042/bj20120834

Ladyman, S. R., Fieldwick, D. M., & Grattan, D. R. (2012). Suppression of leptin-induced hypothalamic JAK/STAT signaling and feeding response during pregnancy in the mouse. Reproduction, 144(1), 83-90. doi: 10.1530/rep-12-0112

Yip, S. H., Eguchi, R., Grattan, D. R., & Bunn, S. J. (2012). Prolactin signalling in the mouse hypothalamus is primarily mediated by signal transducer and activator of transcription factor 5b but not 5a. Journal of Neuroendocrinology, 24(12), 1484-1491. doi: 10.1111/j.1365-2826.2012.02357.x

Li, Q., Li, N., Le Tissier, P., Grattan, D. R., & Kerman, K. (2012). Miniaturized electrochemical immunosensor for label-free detection of growth hormone. Electroanalysis, 24(6), 1272-1276. doi: 10.1002/elan.201200074

Brown, R. S. E., Piet, R., Herbison, A. E., & Grattan, D. R. (2012). Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons. Endocrinology, 153(5), 2375-2384. doi: 10.1210/en.2011-2005

Sapsford, T. J., Kokay, I. C., Östberg, L., Bridges, R. S., & Grattan, D. R. (2012). Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action. Journal of Comparative Neurology, 520(5), 1062-1077. doi: 10.1002/cne.22775

Larsen, C. M., & Grattan, D. R. (2012). Prolactin, neurogenesis, and maternal behaviors. Brain, Behavior & Immunity, 26(2), 201-209. doi: 10.1016/j.bbi.2011.07.233

Conference Contribution - Published proceedings: Abstract

Brown, R. S., Herbison, A. E., & Grattan, D. R. (2012). The suppression of kisspeptin in the RP3V during lactation in mice. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://am2012.sfn.org/am2012/

Yip, S. H., Eguchi, R., Grattan, D. R., & Bunn, S. J. (2012). Prolactin signals via the Stat5B but not the Stat5A pathway in the mouse hypothalamus. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 145). Retrieved from http://www.ans.org.au/ans-annual-conference/

Gustafson, P., Bunn, S., & Grattan, D. (2012). Characterisation of a tamoxifen-inducible STAT5 knockout mouse. New Zealand Medical Journal, 125(1367). Retrieved from http://www.nzma.org.nz/journal

Bunn, S. J., Yip, S. H., Eguchi, R., & Grattan, D. (2012). Prolactin signaling in the mouse hypothalamus. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

Sapsford, T. J., Kokay, I. C., & Grattan, D. R. (2012). Prolactin acts directly on somatostatin neurons in the hypothalamic paraventricular nucleus. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012

McEwen, H. J. L., Smith, G. C., Ladyman, S. R., Grattan, D. R., & Shepherd, P. R. (2012). Phosphorylation of Akt by antipsychotic drugs is induced indirectly through dysregulation of glucose homeostasis. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 64). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Augustine, R., Bouwer, G., Scott, V., Seymour, A., Grattan, D. R., & Brown, C. H. (2012). Increased expression of suppressors of cytokine signalling in the supraoptic and paraventricular nuclei of pregnant and lactating rats. Proceedings of the Medical Sciences Congress (MedSci). (pp. 62). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Kirk, S., Gustafson, P., Grattan, D., & Bunn, S. (2012). Changes in hypothalamic signalling in tuberoinfundibular dopaminergic neurons during lactation. Proceedings of the Medical Sciences Congress (MedSci). (pp. 55). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

2011

Journal - Research Article

Phillipps, H. R., Kokay, I. C., Grattan, D. R., & Hurst, P. R. (2011). X-linked inhibitor of apoptosis protein and active caspase-3 expression patterns in antral follicles in the sheep ovary. Reproduction, 142, 855-867. doi: 10.1530/rep-11-0177

Ladyman, S. R., Sapsford, T. J., & Grattan, D. R. (2011). Loss of acute satiety response to cholecystokinin in pregnant rats. Journal of Neuroendocrinology, 23(11), 1091-1098. doi: 10.1111/j.1365-2826.2011.02191.x

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2011). Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse. Biology of Reproduction, 84(4), 826-836. doi: 10.1095/biolreprod.110.089185

Sjoeholm, A., Bridges, R. S., Grattan, D. R., & Anderson, G. M. (2011). Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats. Endocrinology, 152(5), 1979-1988. doi: 10.1210/en.2010-1220

Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2011). Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology, 152(4), 1541-1550. doi: 10.1210/en.2010-1100

Kokay, I. C., Petersen, S. L., & Grattan, D. R. (2011). Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility. Endocrinology, 152(2), 526-535. doi: 10.1210/en.2010-0668

Journal - Research Other

Grattan, D. (2011). A mother's brain knows [Neuroendocinology Briefing 38]. Journal of Neuroendocrinology, 23(11), 1188-1189. doi: 10.1111/j.1365-2826.2011.02175.x

Conference Contribution - Published proceedings: Abstract

Alqaisi, K., Grattan, D., Lamare, M., Wynne-Edwards, K., & Lokman, M. (2011). Steroidogenic activity in ovary and pyloric caeca during the annual reproductive cycle of common New Zealand starfish Patiriella regularis. Proceedings of the New Zealand Marine Sciences Society (NZMSS) Conference: Understanding, Managing, and Conserving our Marine Environment. (pp. 33). Retrieved from http://nzmss.org/assets/Conference/NZMSS2011AbstractsPosterPresentations.pdf

Larsen, C. M., & Grattan, D. R. (2011). Altered hypothalamic development associated with delayed puberty as a result of postpartum anxiety in mothers. Endocrine Reviews, 32(3, Suppl.), P1-771. Retrieved from http://press.endocrine.org/series/endo-meetings

Rizwan, M. Z., Crampton, J. R., Grattan, D. R., & Anderson, G. M. (2011). Changes in RFamide-related peptide-3 (RFRP-3) gene expression during lactation. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 150). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Yip, S. H., Grattan, D. R., & Bunn, S. J. (2011). Enkephalin expression in the tuberoinfundibular dopaminergic neurons of the lactating mouse is prolactin-dependent. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 65). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf

Brown, R., McLay-Cooke, R., Richardson, S., Williams, S., Grattan, D., & Chisholm, A. (2011). Gut hormone profiles among those susceptible or resistant to obesity. Annals of Nutrition & Metabolism, 58(Suppl. 3), (pp. 313-314). doi: 10.1159/000334393

Romano, N., Yip, S. H., Hodson, D. J., Guillou, A., Parnaudeau, S., Tronche, F., … Bunn, S. J., Grattan, D. R., … Martin, A. O. (2011). Phenotypic and functional plasticity in hypothalamic dopamine neurons associated with robust electrophysiological properties. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main

Rizwan, M. Z., Bergin, D. H., Grattan, D. R., & Anderson, G. M. (2011). Evidence that hypothalamic rfamide related peptide-3 (rfrp-3) neurons act as a conduit between prolactin and the stress axis. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main

Larsen, C. M., & Grattan, D. R. (2011). Prolactin-induced activation of pStat5 in the maternal brain during pregnancy, and following postpartum re-exposure, in mice. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main

McEwen, H. J. L., Ladyman, S. R., Cognard, E., Shepherd, P. R., & Grattan, D. R. (2011). Activation of the Wnt signalling pathway in the hypothalamus by metabolic parameters and its potential: Possible involvement in the glucose homeostasis? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.25. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Yip, S. H., Kirk, S., Grattan, D. R., & Bunn, S. J. (2011). Prolactin signaling in the tuberoinfundibular dopaminergic neurons of the lactating mouse. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.22. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Augustine, R. A., Bouwer, G. T., Scott, V., Grattan, D. R., & Brown, C. H. (2011). Effects of prolactin on signal transduction pathways in the supraoptic and paraventricular nuclei of diestrous and lactating rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.15. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Douglas, S., Winter, P., Grattan, D. R., & Larsen, C. M. (2011). GABA receptor subunit expression is altered during pregnancy and postpartum in mice with postpartum anxiety induced by low prolactin during pregnancy. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.11. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Rizwan, M. Z., Bergin, D. H., Grattan, D. R., & Anderson, G. M. (2011). Hypothalamic RFamide related peptide-3 (RFRP-3) neurons respond to the anxiolytic hormone prolactin and modulate the stress axis. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 4.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Sapsford, T. J., Wyatt, A. K., Kokay, I. C., & Grattan, D. R. (2011). Mechanisms of prolactin suppression of stress responsiveness. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 4.6. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Yip, S. H., Eguchi, R., Bunn, S. J., & Grattan, D. R. (2011). Prolaction activates Stat5b but not Stat5a signaling in the mouse hypothalamus. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 4.4. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Rizwan, M., Bergin, D., Grattan, D., & Anderson, G. (2011). RFamide related peptide-3: The missing link between prolactin and the stress axis? New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf

Grattan, D. (2011). Neuroendocrine regulation of energy balance during pregnancy and its implications in obesity. Obesity Research & Clinical Practice, 5(Suppl. 1), (pp. S9). doi: 10.1016/j.orcp.2011.08.070

Scherf, E., Ladyman, S., & Grattan, D. (2011). Patterns of α-MSH-induces neuronal activation in the pregnant rat brain. New Zealand Medical Journal, 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Grattan, D. (2011). Hormone induced adaptations in the maternal brain to facilitate reproduction. Proceedings of the Centre for Reproduction and Genomics Third Annual Research Colloquium. (pp. 9). Retrieved from http://www.crg.org.nz/colloquium/programme-2011.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Phillipps, H. R., Kokay, I. C., Grattan, D. R., & Hurst, P. R. (2011, August). Role of prolactin in follicular development during the sheep estrous cycle. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Larsen, C. M., McFadden, S., & Grattan, D. R. (2011, June). Identification of prolactin-sensitive brain regions in the maternal brain using prolactin-induced phosphorylation of STAT5. Poster session presented at the Society for Behavioral Neuroendocrinology 15^th Annual Meeting, Querétaro, México.

Conference Contribution - Verbal presentation and other Conference outputs

Larsen, C. M., Douglas, S., & Grattan, D. R. (2011, October). Impact of a calcium caseinate-enriched diet during pregnancy on postpartum GABA receptor subunit expression. Verbal presentation at the World Congress on Reproductive Biology, Cairns, Australia.

Crampton, J., Kokay, I., Sapsford, T., & Grattan, D. (2011, August). Prolactin regulation of kisspeptin neurons. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Wojciechowski, I., Larsen, C. M., & Grattan, D. R. (2011, August). Prolactin-induced activation in the maternal brain during late pregnancy. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Scherf, E. M., Ladyman, S. R., & Grattan, D. R. (2011, August). Patterns of α-MSH-induced neuronal activation in the pregnant rat brain. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Ladyman, S. R., & Grattan, D. R. (2011, August). Pregnancy-induced adaptations in the neuroendocrine networks controlling metabolism. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Grattan, D. R. (2011, August). Prolactin, pregnancy and the maternal brain. Keynote presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2010

Chapter in Book - Research

Larsen, C. M., & Grattan, D. R. (2010). Exposure to female pheromones during pregnancy causes postpartum anxiety in mice. In G. Litwack (Ed.), Pheromones: Vitamins & Hormones (Vol. 83). (pp. 137-149). Amsterdam: Academic Press. doi: 10.1016/S0083-6729(10)83005-5

Journal - Research Article

Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., … Anderson, G. M., Grattan, D. R., & Tups, A. (2010). Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience, 30(48), 16180-16187. doi: 10.1523/JNEUROSCI.3202-10.2010

Rouet, V., Bogorad, R. L., Kayser, C., Kessal, K., Genestie, C., Bardier, A., Grattan, D. R., … Goffin, V. (2010). Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors. PNAS, 107(34), 15199-15204. doi: 10.1073/pnas.0911651107

Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010). Hormone interactions regulating energy balance during pregnancy. Journal of Neuroendocrinology, 22, 805-817. doi: 10.1111/j.1365-2826.2010.02017.x

Larsen, C. M., & Grattan, D. R. (2010). Prolactin-induced mitogenesis in the subventricular zone of the maternal brain during early pregnancy is essential for normal postpartum behavioral responses in the mother. Endocrinology, 151, 3805-3814. doi: 10.1210/en.2009-1385

Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010). Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology, 22(6), 534-542. doi: 10.1111/j.1365-2826.2010.01975.x

Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208

Journal - Professional & Other Non-Research Articles

Grattan, D. R. (2010). [Editorial]. Journal of Neuroendocrinology, 22, 629. doi: 10.1111/j.1365-2826.2010.02036.x

Conference Contribution - Published proceedings: Abstract

Larsen, C. M., & Grattan, D. R. (2010). Impact of prolactin-induced neurogenesis in the maternal brain during pregnancy on post partum mood and behaviour. Proceedings of the 4th International Conference of Parental Brain: Neurobiology, Behaviour and the Next Generation. (pp. 26). Retrieved from http://www.edinburghneuroscience.ed.ac.uk/parentalbrain2010/

Larsen, C. M., & Grattan, D. R. (2010). A diet rich in the milk protein calcium casienate throughout pregnancy prevents postpartum anxiety in mice. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx

Ladyman, S. R., & Grattan, D. R. (2010). Leptin resistance during pregnancy is associated with a loss of the satiety response to cholecystokinin. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx

Conference Contribution - Poster Presentation (not in published proceedings)

Winter, P., Larsen, C. M., & Grattan, D. R. (2010, November-December). Changes in expression of GABA_A and GABA_B receptor subunits in specific brain regions during pregnancy and postpartum in mice with postpartum anxiety. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Fieldwick, D. M., Ladyman, S. R., & Grattan, D. R. (2010, November-December). Suppression of leptin induced pSTAT3 in the hypothalamus of pregnant mice. Poster session presented at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Larsen, C. M., Madhill, S., Kokay, I. C., & Grattan, D. R. (2010, July). Prolactin action is required for long-term retention of maternal responsiveness to pups. Poster session presented at the 7th International Congress of Neuroendocrinology (ICN), Rouen, France.

Winter, P., Larsen, C., & Grattan, D. (2010, September). Mice with postpartum anxiety have a differential expression of GABA_A and GABA_B receptor subunits in the bed nucleus of the stria terminalis during pregnancy and the postpartum period. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Yip, S. H., Grattan, D. R., & Bunn, S. J. (2010, November-December). Prolactin-dependent enkephalin expression in TIDA neurons of lactating mice. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2010, November-December). Regulation of kisspeptin neurons by prolactin. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

McFadden, S., Larsen, C. M., & Grattan, D. R. (2010, November-December). Prolactin-induced activation in the maternal brain during early pregnancy. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Ladyman, S. R., & Grattan, D. R. (2010, November-December). Development of hypothalamic insulin resistance during pregnancy. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Larsen, C. M., & Grattan, D. R. (2010, November-December). A calcium casienate-enriched diet throughout pregnancy increases maternal neurogenesis during pregnancy and prevents anxiety postpartum in mice. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Rizwan, M., Crampton, J., Grattan, D., & Anderson, G. (2010, November-December). Changes in RFamide-related peptide-3 (RFRP-3) gene expression during lactation. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Sapsford, T. J., Kokay, I. C., & Grattan, D. R. (2010, November-December). Prolactin does not act directly on corticotrophin-releasing hormone neurons in the rat paraventricular nucleus. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Quennell, J. H., Howell, C. S., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2010, November-December). The regulation of kisspeptin neurons by leptin. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Other Research Output

Grattan, D. (2010, March). Turning a Woman into a Mum: How pregnancy hormones influence the maternal brain. Brain Day Dunedin, University of Otago, New Zealand. [Public Seminar].

2009

Chapter in Book - Research

Grattan, D. R., & Bridges, R. S. (2009). Prolactin actions in the brain. In D. W. Pfaff, A. P. Arnold, A. M. Etgen, S. E. Fahrbach & R. T. Rubin (Eds.), Hormones, brain and behavior (Vol. 4). (2nd ed.) (pp. 2471-2503). San Diego, CA: Academic Press.

Journal - Research Article

Yang, J. J., Larsen, C. M., Grattan, D. R., & Erskine, M. S. (2009). Mating-induced neuroendocrine responses during pseudopregnancy in the female mouse. Journal of Neuroendocrinology, 21(1), 30-39. doi: 10.1111/j.1365-2826.2008.01803.x

Ladyman, S. R., Tups, A., Augustine, R. A., Swahn-Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009). Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. Journal of Neuroendocrinology, 21(5), 449-456. doi: 10.1111/j.1365-2826.2009.01862.x

Quennell, J. H., Mulligan, A. C., Tups, A., Liu, X., Phipps, S. J., Kemp, C. J., Herbison, A. E., Grattan, D. R., & Anderson, G. M. (2009). Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology, 150(6), 2805-2812. doi: 10.1210/en.2008-1693

Journal - Professional & Other Non-Research Articles

Grattan, D. (2009). Editorial. Journal of Neuroendocrinology, 21(1), 1. doi: 10.1111/j.1365-2826.2008.01808.x

Conference Contribution - Published proceedings: Abstract

Alyousif, Y., Scott, V., Kokay, I., Grattan, D., & Brown, C. (2009). Cellular mechanisms of prolactin regulation of oxytocin neurons in reproduction. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf

Alyousif, Y., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2009). Cellular mechanisms of prolactin regulation of oxytocin neurons in reproduction. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2009). Mechanism of hyperprolactinaemia-induced infertility. New Zealand Medical Journal, 122(1299). Retrieved from http://journal.nzma.org.nz/journal/122-1299/3706/content.pdf

Larsen, C. M., & Grattan, D. R. (2009). Low prolactin during early pregnancy causes postpartum anxiety and impaired maternal behavior: Role of neurogenesis? Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Douglas, H. R., Kokay, I. C., Grattan, D. R., & Hurst, P. R. (2009). Localization of X-linked inhibitor of apoptosis protein mRNA in sheep ovary. Biology of Reproduction. 81(Suppl. 1), (pp. 527). [Abstract]

Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2009). Regulation of kisspeptin neurons by leptin. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Kokay, I. C., Ostberg, L., & Grattan, D. R. (2009). Differential responsiveness to prolactin within different hypothalamic nuclei. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Larsen, C. M., & Grattan, D. R. (2009). Low prolactin in early pregnancy, or maternal anxiety postpartum, delay the onset of puberty. Proceedings of the Endocrine Society's 91st Annual Meeting. Retrieved from http://www.abstracts2view.com/endo/

Conference Contribution - Poster Presentation (not in published proceedings)

Booker, C., Kokay, I., & Grattan, D. (2009, July). Examining the central appetite-reducing effects of interleukin-18: Preliminary investigations into expression of components of the interleukin-18 signalling pathway. Poster session presented at the 33rd New Zealand Society for the Study of Diabetes Annual Scientific Meeting, Dunedin, New Zealand.

2008

Chapter in Book - Research

Freeman, M. E., Grattan, D. R., & Houpt, T. A. (2008). The hypothalamus. In P. M. Conn (Ed.), Neuroscience in medicine. (3rd ed.) (pp. 301-358). Totowna, NJ: Humana Press.

Woodside, B., Augustine, R. A., Ladyman, S. R., Naef, L., & Grattan, D. R. (2008). Role of prolactin in the metabolic adaptations to pregnancy and lactation. In R. S. Bridges (Ed.), Neurobiology of the parental brain. (pp. 249-267). London: Academic Press.

Journal - Research Article

Grattan, D. R., Steyn, F. J., Kokay, I. C., Anderson, G. M., & Bunn, S. J. (2008). Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. Journal of Neuroendocrinology, 20(4), 497-507. doi: 10.1111/j.1365-2826.2008.01661.x

Grattan, D. R., & Kokay, I. C. (2008). Prolactin: A pleiotropic neuroendocrine hormone. Journal of Neuroendocrinology, 20(6), 752-763. doi: 10.1111/j.1365-2826.2008.01736.x

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2008). Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Endocrinology, 149(6), 3206-3214. doi: 10.1210/en.2007-1623

Larsen, C. M., Kokay, I. C., & Grattan, D. R. (2008). Male pheromones initiate prolactin-induced neurogenesis and advance maternal behavior in female mice. Hormones & Behavior, 53(4), 509-517. doi: 10.1016/j.yhbeh.2007.11.020

Anderson, G. M., Kieser, D. C., Steyn, F. J., & Grattan, D. R. (2008). Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. Endocrinology, 149(4), 1562-1570. doi: 10.1210/en.2007-0867

Augustine, R. A., & Grattan, D. R. (2008). Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology, 149(3), 1049-1055. doi: 10.1210/en.2007-1018

Augustine, R. A., Ladyman, S. R., & Grattan, D. R. (2008). From feeding one to feeding many: Hormone-induced changes in bodyweight homeostasis during pregnancy (Symposium report). Journal of Physiology, 586(2), 387-397. doi: 10.1113/jphysiol.2007.146316

Journal - Research Other

Grattan, D. R. (2008). Fetal programming from maternal obesity: Eating too much for two? Endocrinology, 149(11), 5345-5347. doi: 10.1210/en.2008-1106

Conference Contribution - Published proceedings: Abstract

Geddes, R. S. E., Herbison, A. E., & Grattan, D. R. (2008). Mechanisms of prolactin induced inhibition of gonadotropin-releasing hormone (GnRH) neurons. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Kokay, I. C., Geddes, R. S. E., & Grattan, D. R. (2008). Characterisation of prolactin-sensitive neurons in regions of the preoptic area and rostral hypothalamus involved in the control of fertility in the rat. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Larsen, C. M., & Grattan, D. R. (2008). Decreased serum prolactin in early pregnancy results in postpartum anxiety. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Conference Contribution - Poster Presentation (not in published proceedings)

Kokay, I., & Grattan, D. (2008, October). Prolactin receptors are expressed on kisspeptin neurons in the rostral and mediobasal hypothalamus of the rat. Poster session presented at the 1st World Conference on Kisspeptin Signaling in the Brain, Cordoba, Spain.

Conference Contribution - Verbal presentation and other Conference outputs

Yip, S. H., Grattan, D. R., & Bunn, S. J. (2008, November). Prolactin enhances enkephalin expression in mediobasal hypothalamic cell cultures. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Sapsford, T. J., Anderson, G. M., & Grattan, D. R. (2008, November). Effect of pregnancy-like changes in estradiol and progesterone levels on the neuroendocrine regulation of prolactin secretion. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Sjoeholm, A., Grattan, D., & Anderson, G. (2008, November). Enhanced brain responsiveness to prolactin in reproductively experienced females is selectively through the STAT5 signaling pathway. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Quennell, J., Grattan, D., & Anderson, G. (2008, November). Kisspeptin as a mediator of leptin signaling in the reproductive system. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Larsen, C. M., & Grattan, D. R. (2008, November). Low serum prolactin in early pregnancy results in postpartum pregnancy anxiety. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Booker, C., Kokay, I. C., & Grattan, D. R. (2008, November). Expression of interleukin-18 signalling components in areas of the rodent brain involved in energy metabolism. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2007

Journal - Research Article

Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351.

Josephs, T., Waugh, H., Kokay, I., Grattan, D., & Thompson, M. (2007). Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. Journal of Endocrinology, 194, 305-312.

Grattan, D. R., Ladyman, S. R., & Augustine, R. A. (2007). Hormonal induction of leptin resistance during pregnancy. Physiology & Behavior, 91, 366-374.

Brown, C. H., & Grattan, D. R. (2007). Does maternal oxytocin protect the fetal brain? Trends in Endocrinology & Metabolism, 18(6), 225-226.

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Differential effects of centrally-administered oestrogen antagonist ICI-182,780 on oestrogen-sensitive functions in the hypothalamus. Journal of Neuroendocrinology, 19(1), 26-33. doi: 10.1111/j.1365-2826.2006.01499.x

Möderscheim, T. A. E., Gorba, T., Pathipati, P., Kokay, I. C., Grattan, D. R., Williams, C. E., & Scheepens, A. (2007). Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience, 145, 963-973.

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation. Journal of Neuroendocrinology, 19(10), 788-793. doi: 10.1111/j.1365-2826.2007.01590.x

Conference Contribution - Published proceedings: Abstract

Capstick, A., Kokay, I., & Grattan, D. (2007). Changes in prolactin receptor expression in the paraventricular nucleus during pregnancy and lactation: Possible modulation of the attenuated stress response. Endocrine Journal. 54(Suppl), (pp. 183). [Abstract]

Walker, K., Kokay, I., & Grattan, D. (2007). The use of laser capture microdissection to isolate homogeneous neurons for reverse transcriptase polymerase chain reaction. Endocrine Journal. 54(Suppl), (pp. 186). [Abstract]

Larsen, C., Kokay, I., & Grattan, D. (2007). Male pheromones induce hyperprolactinemia, which subsequently mediates the pheromonal advancement of maternal behavior. Endocrine Journal. 54(Suppl), (pp. 183). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Larsen, C. M., Kokay, I. C., & Grattan, D. R. (2007, June). Male pheromones alter levels of prolactin and prolactin receptor mRNA in nuclei that regulate maternal behavior in virgin female mice. Poster session presented at the Endocrine Society's 89th Annual Meeting, Toronto, Canada.

Conference Contribution - Verbal presentation and other Conference outputs

Grattan, D. R., Jasoni, C., Liu, X., & Herbison, A. E. (2007, June). Detection of prolactin receptor mRNA in identified GnRH neurons by single cell RT-PCR. Verbal presentation at the Endocrine Society 89th Annual Meeting, Toronto, Canada.

2006

Chapter in Book - Research

Grattan, D. R., & Möderscheim, T. A. E. (2006). Interaction of growth hormone and prolactin in brain circuits. In F. J. Nyberg (Ed.), The somatotrophic axis in brain function. (pp. 111-123). Amsterdam: Elsevier.

Journal - Research Article

Anderson, G. M., Grattan, D. R., van den Ancker, W., & Bridges, R. S. (2006). Reproductive experience increases prolactin responsiveness in the medial preoptic area and arcuate nucleus of female rats. Endocrinology, 147(10), 4688-4694.

Anderson, G. M., Beijer, P., Bang, A. S., Fenwick, M. A., Bunn, S. J., & Grattan, D. R. (2006). Suppression of prolactin-induced signal transducer and activator of transcription 5b signaling and induction of suppressors of cytokine signaling messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat during late pregnancy and lactation. Endocrinology, 147(10), 4996-5005.

Kokay, I. C., Bull, P. M., Davis, R. L., Ludwig, M., & Grattan, D. R. (2006). Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 290, R1216-R1225. doi: 10.1152/ajpregu.00730.2005

Andrews, Z. B., Zhao, H., Frugier, T., Meguro, R., Grattan, D. R., Koishi, K., & McLennan, I. S. (2006). Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits. Neurobiology of Disease, 21, 568-575. doi: 10.1016/j.nbd.2005.09.001

Conference Contribution - Published proceedings: Abstract

Geddes, R. S. E., Phipps, S. J., Grattan, D. R., & Anderson, G. M. (2006). Leptin treatment does not activate STAT3 in GnRH neurons: Evidence for indirect regulation. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Steyn, F., Anderson, G., & Grattan, D. (2006). Induction of SOCS mRNA within the arc during late pregnancy is driven by progesterone withdrawal in the presence of oestrogen. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Augustine, R., Bunn, S., & Grattan, D. (2006). Quantitation of leptin receptor mRNA in the hypothalamus of the extended-pseudopregnant rat. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Geddes, R., Grattan, D., & Anderson, G. (2006). Leptin does not act directly on gonadotrophin releasing hormone neurons to regulate fertility in rats. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf

Anderson, G. M., & Grattan, D. R. (2006). Regulation of central prolactin receptor mRNA: Interactive effects of estrogen and prolactin. Frontiers in Neuroendocrinology. 27, (pp. 64-65). [Abstract]

Kokay, I. C., Petersen, S. L., & Grattan, D. R. (2006). Absence of prolactin receptor mRNA in GnRH neurons. Frontiers in Neuroendocrinology. 27, (pp. 65-66). [Abstract]

Larsen, C. M., Kokay, I. C., & Grattan, D. R. (2006). The presence of a male mouse initiates mitogenesis in the subventricular zone in virgin C57B6 mice. Frontiers in Neuroendocrinology. 27, (pp. 80-81). [Abstract]

Augustine, R. A., Ladyman, S. R., Swahn Azavedo, A. M., Kokay, I. C., & Grattan, D. R. (2006). Pregnancy-induced leptin resistance involves a loss of appetite suppression by alpha-melanocyte stimulating hormone. Endocrine Journal. 53(Suppl.), (pp. 100). [Abstract]

2005

Journal - Research Article

Ladyman, S. R., & Grattan, D. R. (2005). Suppression of leptin receptor messenger ribonucleic acid and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology, 146(9), 3868-3874.

Ma, E., Lau, J., Grattan, D. R., Lovejoy, D. A., & Wynne-Edwards, K. E. (2005). Male and female prolactin receptor mRNA expression in the brain of a biparental and a uniparental hamster, Phodopus, before and after the birth of a litter. Journal of Neuroendocrinology, 17(2), 81-90.

Ma, F. Y., Anderson, G. M., Gunn, T. D., Goffin, V., Grattan, D. R., & Bunn, S. J. (2005). Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons. Endocrinology, 146(12), 5112-5119.

Kokay, I. C., & Grattan, D. R. (2005). Expression of mRNA for prolactin receptor (long form) in dopamine and pro-opiomelanocortin neurones in the arcuate nucleus of non-pregnant and lactating rats. Journal of Neuroendocrinology, 17, 827-835.

Ma, F. Y., Grattan, D. R., Goffin, V., & Bunn, S. J. (2005). Prolacting-regulated tyrosine hydroxylase activity and messenger ribonucleic acid expression in mediobasal hypothalamic cultures: The differential role of specific protein kinases. Endocrinology, 146(1), 93-102.

Conference Contribution - Published proceedings: Abstract

Grattan, D., Kokay, I., Bull, P., Davis, R., & Ludwig, M. (2005). Prolactin regulation of oxytocin but not vasopressin neurons. The Physiologist. 48(3). Retrieved from http://www.the-aps.org/publications/tphys/images/JuneTphysConferenceMaterial.pdf

McLennan, I. S., Andrews, Z. B., Frugier, T., Zhao, H., Grattan, D. R., & Koishi, K. (2005). Is transforming growth factor β2 a susceptibility factor for Parkinson's disease? In A. B. Roberts, M. B. Sporn & J. M. McPherson (Eds.), Roles of TGF-β in Disease Pathogenesis: Novel Therapeutic Strategies. (pp. 54). Keystone, CO, USA: Keystone Resort. [Abstract]

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2005). Use of the oestrogen receptor antagonist ICI-182,780 to alter central steroid actions. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1218/1568/content.pdf

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2005). Changes in sex steroid levels induce socs expression and prolactin secretion during late pregnancy. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. (NZ60). Retrieved from http://nzse.rsnz.org/

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2005). Does estrogen regulate prolactin secretion by inducing SOCS expression during late pregnancy? Proceedings of the 35th Annual Meeting of the Society for Neuroscience. (763.15). Washington DC: SfN. [Abstract]

Kokay, I. C., Pilcher, J. M., & Grattan, D. R. (2005). Prolactin feedback may be important for enkephalin induction in tuberoinfundibular dopaminergic neurons during late pregnancy and lactation. Proceedings of the Medical Sciences Congress of the New Zealand Biomedical and Medical Societies. (pp. 54-55). [Abstract]

Kokay, I. C., Pilcher, J. M., & Grattan, D. R. (2005). Detection of prolactin receptor mRNA in enkephalin-producing tuberoinfundibular dopaminergic neurons during late pregnancy and lactation. Proceedings of the Society for Neuroscience 35th Annual Meeting. Washington, DC: SfN. [Abstract]

Grattan, D. R., Anderson, G. M., & Herbison, A. E. (2005). A mouse model of hyperprolactinaemia-induced infertility. Proceedings of the Medical Sciences Congress. (pp. 54). [Abstract]

2004

Journal - Research Article

Andrews, Z. B., & Grattan, D. R. (2004). The roles of dopamine and the neurointermediate lobe of the pituitary in the regulation of prolactin secretion during late pregnancy in rats. Journal of Neuroendocrinology, 16, 859-865.

Ladyman, S. R., & Grattan, D. R. (2004). Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology, 145(8), 3704-3711.

Ma, F. Y., Grattan, D. R., Bobrovskaya, L., Dunkley, P. R., & Bunn, S. J. (2004). Angiotensin II regulates tyrosine hydroxylase activity and mRNA expression in rat mediobasal hypothalamic cultures: The role of specific protein kinases. Journal of Neurochemistry.

Conference Contribution - Published proceedings: Abstract

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2004). Expression of estrogen and progesterone receptors within tuberoinfundibular dopaminergic (TIDA) neurons during diestrus, pregnancy and lactation. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. (NZ04). Retrieved from http://nzse.rsnz.org/

Anderson, G. M., & Grattan, D. R. (2004). Do suppressors of cytokine signalling (SOCS) proteins cause hyperprolactinaemia during late pregnancy and lactation? Proceedings of the New Zealand Society of Endocrinology Annual Meeting. (NZ22). Retrieved from http://nzse.rsnz.org/

Fenwick, M. A., Ma, F. Y., Grattan, D. R., & Anderson, G. M. (2004). Prolactin alters STAT5A but not STAT5B signalling in GNRH neurons. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. (NZ23). Retrieved from http://nzse.rsnz.org/

Augustine, R. A., Bunn, S. J., & Grattan, D. R. (2004). Hyperphagia in the pseudopregnant rat is associated with normal hypothalamic response to leptin. Proceedings of the Australasian Winter Conference on Brain Research. (7.2), (pp. 40). [Abstract]

Augustine, R. A., Bunn, S. J., & Grattan, D. R. (2004). Hypothalamic response to leptin is not suppressed in hyperphagic pseudopregnant rats. Proceedings of the Society for Neuroscience Abstracts. (893.20). Retrieved from http://sfn.scholarone.com/itin2004/index.html

Augustine, R., Bunn, S., & Grattan, D. (2004). Differing hypothalamic responses in pseudopregnant and pregnant rats after central leptin administration. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1086/content.pdf

Ladyman, S. R., & Grattan, D. R. (2004). Leptin-induced phosphorylation of STAT3 in alpha-MSH neurons is maintained during pregnancy in the rat. Proceedings of the Society for Neuroscience Abstracts. (893.21). Retrieved from http://sfn.scholarone.com/itin2004/index.html

Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2004). Central administration of the estrogen antagonist ICI-182,780 alters LH pulse frequency in estrogen-treated ovariectomised rats. Proceedings of the International Australasian Winter Conference on Brain Research. 22(8.4). Retrieved from http://www.awcbr.org

Grattan, D. R., & Anderson, G. M. (2004). Central administation of the estrogen antagonist ICI-182,780 aletrs LH pulse frequency in estrogen-treated ovariectomised rats. Proceedings of the International Australasian Winter Conference on Brain Research. 22. [Abstract]

Anderson, G. M., Kieser, J. A., & Grattan, D. R. (2004). Hyperprolactinaemia-induced inhibition of GnRH neurons is steroid-dependent. Proceedings of the 34th Annual Meeting of the Society for Neuroscience. (Prog No.885.11). Retrieved from http://sfn.scholarone.com

Bang, A. S., Grattan, D. R., & Anderson, G. M. (2004). Effect of lactation on prolactin signalling by STAT5b in gonadotrophin releasing hormone (GnRH) and tuberoinfundibular dopaminergic neurons. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1091/content.pdf

Anderson, G. M., Bang, A. S., & Grattan, D. R. (2004). Lactation alters prolactin-induced STAT5b signalling in hypothalamic neurons. Proceedings of the International Australasian Winter Conference on Brain Research. 22, (pp. A8.9). [Abstract]

Kieser, D. C., Grattan, D. R., & Anderson, G. M. (2004). The effects of anti-psychotic drug-induced hyperprolactinaemia on reproductive neuroendocrine function in female rats. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1091/content.pdf

Kokay, I. C., Davis, R., & Grattan, D. R. (2004). Increased expression of prolactin receptor mRNA in oxytocin neurons in the maternal rat hypothalamus. Proceedings of the Australasian Winter Conference on Brain Research. (pp. 48). Retrieved from http://psy.otago.ac.nz/awcbr/index.html

Moderscheim, T. A. E., Kokay, I., Grattan, D., Williams, C. E., & Scheepens, A. (2004). Activation of an autocrine/paracrine lactogenic system following hypoxic-ischemic brain injury in the juvenile rat. Federation of European Neuroscience Societies Forum Abstracts. 2. [Abstract]

Larsen, C. M., Kokay, I. C., & Grattan, D. R. (2004). The presence of a male mouse advances maternal behavior in virgin C57B6 mice. Proceedings of the Australasian Winter Conference on Brain Research. (pp. 48). Retrieved from http://psy.otago.ac.nz/awcbr/index.html

Bunn, S. J., Ma, F. Y., & Grattan, D. R. (2004). Prolactin stimulates STAT5b phosphorylation and nuclear translocation in cultured fetal rat dopaminergic hypothalamic neurons. Journal of Neurochemistry, 88(Suppl. 1), (pp. 82). doi: 10.1046/j.1474-1644.2003.2314p33_01.x

Davis, R., Kokay, I., & Grattan, D. (2004). Localisation of prolactin receptor mRNA in identified magnocellular neurons in the female rat brain using dual-label in situ hybridisation histochemistry. New Zealand Medical Journal, 117(1202). Retrieved from http://journal.nzma.org.nz/journal/117-1202/1091/content.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Frugier, T., Andrews, Z. B., Zhao, H., Grattan, D. R., Koishi, K., & McLennan, I. S. (2004, October). Transforming growth factor beta 2: A susceptibiity factor in Parkinson's disease. Poster session presented at the Society for Neuroscience 34th Annual Meeting, San Diego, California.

Frugier, T., Andrews, Z. B., Grattan, D. R., & McLennan, I. S. (2004, January). Is transforming growth factor beta 2 a susceptibility factor in Parkinson's disease? Poster session presented at the 24th Annual Meeting of the Australian Neuroscience Society, Melbourne, Australia.

2003

Journal - Research Article

Augustine, R. A., Kokay, I. C., Andrews, Z. B., Ladyman, S. R., & Grattan, D. R. (2003). Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation. Journal of Molecular Endocrinology, 31, 221-232.

Anderson, S. T., Kokay, I. C., Lang, T., Grattan, D. R., & Curlewis, J. D. (2003). Quantification of prolactin-releasing peptide (PrRP) mRNA expression in specific brain regions of the rat during the oestrous cycle and in lactation. Brain Research, 973(1), 64-73. doi: 10.1016/S0006-8993(03)02543-5

Bridges, R. S., & Grattan, D. R. (2003). Prolactin-induced neurogenesis in the maternal brain. Trends in Endocrinology & Metabolism, 14(5), 199-201.

Todd, B. J., Ladyman, S. R., & Grattan, D. R. (2003). Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats. Journal of Neuroendocrinology, 15, 61-68.

Andrews, Z. B., & Grattan, D. R. (2003). Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation. Journal of Neuroendocrinology, 15, 227-236.

Conference Contribution - Published proceedings: Abstract

Kokay, I. C., & Grattan, D. R. (2003). Prolactin receptor expression in tuberoinfundibular dopamine neurons: Effect of lactation. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003

Bunn, S. J., Ma, F. Y., Bobrovskaya, L., Dunkley, P. R., & Grattan, D. R. (2003). Angiotensin II activates tyrosine hydroxylase activity and gene expression in cultured hypothalamic dopaminergic neurons. Proceedings of the 21st International Australasian Winter Conference on Brain Research. 21. Queenstown: AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts2003.htm#Bunn

Ladyman, S. R., & Grattan, D. R. (2003). Exogenous leptin does not suppress appetite in pregnant rats. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003

Anderson, G. M., Augustine, R. A., & Grattan, D. R. (2003). Reduced TIDA neuronal activity during prolactin surges of early pregnancy is associated with increased mRNA for suppressor of cytokine signalling (SOCS) proteins. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003

Ma, F. Y., Grattan, D. R., & Bunn, S. J. (2003). Prolactin regulation of tyrosine hydroxylase activity and expression in cultured hypothalamic dopaminergic neurons. Proceedings of the Endocrine Society of Australia. 46, (pp. 185). [Abstract]

Ladyman, S. R., & Grattan, D. R. (2003). Effect of intracerebroventricular leptin administration on food intake in pregnant and cycling rats. Proceedings of the Endocrine Society of Australia. 46(185), (pp. 203-204). [Abstract]

Grattan, D. R., Liu, L., Augustine, R. A., Davey, H. W., & Bunn, S. J. (2003). Sex differences in hypothalamic dopamine neurons are independent of prolactin signalling through STAT5b. Trabajos del Instituto Cajal. Tomo LXXIX, (pp. 208-209). [Abstract]

Gunn, T. D., Ma, F. Y., Grattan, D. R., & Bunn, S. J. (2003). Prolactin activation of the STAT-signalling pathway in cultured hypothalamic dopaminergic neurons. Proceedings of the 21st International Australasian Winter Conference on Brain Research. Queenstown: AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts2003.htm#Gunn

2002

Journal - Research Article

Andrews, Z. B., & Grattan, D. R. (2002). Opioid control of prolactin secretion in late pregnant rats is mediated by tuberoinfundibular dopamine neurons. Neuroscience Letters, 328, 60-64.

Pi, X.-J., Voogt, J., & Grattan, D. R. (2002). Detection of prolactin receptor mRNA in the corpus striatum and substantia nigra of the rat. Journal of Neuroscience Research, 67, 551-558.

Journal - Research Other

Grattan, D. R. (2002). Behavioural significance of prolactin signalling in the central nervous system during pregnancy and lactation. Reproduction, 123(4), 497-506. doi: 10.1530/rep.0.1230497

Conference Contribution - Published proceedings: Abstract

Andrews, Z. B., & Grattan, D. R. (2002). Opioid receptor regulation of prolactin secretion at the end of pregnancy. New Zealand Medical Journal, 115(114). [Abstract]

Todd, B. J., & Grattan, D. R. (2002). Evidence supporting a role for GABA in mediating the effects of leptin on the reproductive axis. New Zealand Medical Journal, 115(116). [Abstract]

Xie, T., Mclauchlan, M., Waxman, D., Grattan, D. R., Wilkins, R., & Davey, H. W. (2002). Expression of Igf-1 in response to growth hormone is mediated by the JAK-STAT5b intracellular signalling pathway. In G. Nicholls (Ed.) New Zealand Medical Journal, 115, (pp. 225). Dunedin: Southern Colour Print. [Abstract]

Ma, F., Grattan, D. R., & Bunn, S. J. (2002). Angiotensin II increases tyrosine hydroxylase activity in hypothalamic tuberoinfundibular dopaminergic neurons. Proceedings of the 45th Annual Scientific Meeting. 45, (pp. 160). Endocrine Society of Australia. [Abstract]

Liu, L., Davey, H. W., Augustine, R. A., Bunn, S. J., & Grattan, D. R. (2002). Sex differences in the neuroendocrine regulation of prolactin secretion are not mediated by the transcriptions factor STAT5b. Proceedings of the 45th Annual Scientific Meeting. 45, (pp. 164). Endocrine Society of Australia. [Abstract]

2001

Chapter in Book - Research

Grattan, D. R. (2001). The actions of prolactin in the brain during pregnancy and lactation. In J. A. Russell, A. J. Douglas, R. J. Windle & C. D. Ingram (Eds.), Progress in Brain Research. (pp. 153-171). London: Elsevier.

Journal - Research Article

Davey, H. W., Xie, T., McLachlan, M. J., Wilkins, R. J., Waxman, D. J., & Grattan, D. R. (2001). STAT5b is required for growth hormone-induced liver Igf-I gene expression. Endocrinology, 142, 3836-3841.

Grattan, D. R., Pi, X. J., Andrews, Z. B., Augustine, R. A., Kokay, I. C., Summerfield, M. R., Todd, B., & Bunn, S. J. (2001). Prolactin receptors in the brain during pregnancy and lactation: Implications for behaviour. Hormones & Behavior, 40, 115-124.

Davey, H. W., Xie, T., McLachlan, M. J., Wilkins, R. J., Waxman, D., & Grattan, D. R. (2001). STAT5b is required for GH-induced liver Igf-I gene expression. Endocrinology, 142(9), 3836-3841.

Grattan, D. R., Xu, J., McLachlan, M. J., Kokay, I. C., Bunn, S. J., Hovey, R. C., & Davey, H. W. (2001). Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b. Endocrinology, 142(9), 3935-3940.

Andrews, Z. B., Kokay, I. C., & Grattan, D. R. (2001). Dissociation of prolactin secretion from tuberoinfundibular dopamine activity in late pregnant rats. Endocrinology, 142(6), 2719-2724.

Kornblatt, J. J., & Grattan, D. R. (2001). Lactation alters γ-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat. Neuroendocrinology, 73, 175-184.

Conference Contribution - Published proceedings: Abstract

Ma, F., Grattan, D. R., & Bunn, S. J. (2001). The characterisation of tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons in vitro. 19th International Australasian Winter Conference on Brain Research. http://www. awcbr.org. Retrieved from http://www.awcbr.org

Grattan, D. R., Kokay, I. C., Orre, H. C., & Summerfield, M. (2001). Neurochemical identification of hypothalamic neurons expressing prolactin receptors during lactation in the rat. In D. S. Loiselle (Ed.), Proceedings of the Physiological Society of New Zealand. 20, (pp. 52). New Zealand: Physiological Society of New Zealand. [Abstract]

Augustine, R. A., Kokay, I. C., & Grattan, D. R. (2001). Quantitation of prolactin receptor mRNA in the maternal rat brain using real-time PCR. Proceedings of the 44th Annual Scientific Meeting. 44(Section 3), (pp. 27). Australia: Endocrine Society of Australia. [Abstract]

Grattan, D. R., Augustine, R. A., & Kokay, I. C. (2001). Use of real-time PCR for quantitation of mRNA expression in microdissected hypothalamic nuclei. 19th International Australasian Winter Conference on Brain Research. 19, (pp. 30). http://www.awcbr.org. Retrieved from http://www.awcbr.org

Grattan, D. R., Lang, T., Kokay, I. C., Anderson, S. T., & Curlewis, J. (2001). Does the novel prolactin-releasing peptide play a physiological role in the regulation of prolactin secretion? Proceedings of the 44th Annual Scientific Meeting. 44(Section 3), (pp. 8). Australia: Endocrine Society of Australia. [Abstract]

Andrews, Z. B., & Grattan, D. R. (2001). Opioid-medicated inhibition of tuberoinfundibular dopaminergic neuronal activity contributes to the ante-partum prolactin surge in rats. The Proceedings of the 44th Annual Scientific Meeting. 44(Section 3), (pp. 7). Australia: Endocrine Society of Australia. [Abstract]

Andrews, Z. B., & Grattan, D. R. (2001). Kappa and Mu opioid regulation of prolactin secretion in late pregnant rats. 19th International Australasian Winter Conference on Brain Research. Retrieved from http://www.awcbr.org

Todd, B., Davis, G. H., & Grattan, D. R. (2001). Naloxone fails to reverse the suppression of pulsatile luteinising hormone secretion in the ovariectomised, estrogen-treated, obese Zucker rat. 44th Annual Scientific Meeting. 44(Section 3), (pp. 16). Australia: Endocrine Society of Australia. [Abstract]

Andrews, Z. B., & Grattan, D. R. (2001). Temporal changes in tuberoinfundibular dopaminergic neuronal activity during pregnancy in the rat. Proceedings of the 44th Annual Scientific Meeting. 44(Section 3), (pp. 26). Australia: The Endocrine Society of Australia. [Abstract]

Todd, B. J., Andrews, Z. B., & Grattan, D. R. (2001). Development of pituitary hormone radioimmunoassays on microtitre plates. Proceedings of the 44th Annual Scientific Meeting. 44(Section 3), (pp. 31). Australia: The Endocrine Society of Australia. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Davey, H. W., Xie, T., McLachlan, M. J., Wilkins, R. J., Waxman, D. J., & Grattan, D. R. (2001). STAT5b is required for growth hormone-induced liver Igf-I gene expression. Verbal presentation at the 75th Annual Meeting of the Endocrinology Society (USA)

2000

Journal - Research Article

Davis, A. M., Grattan, D. R., & McCarthy, M. M. (2000). Decreasing GAD activity neonatally attenuates steroid-induced sexual differentiation of the rat brain. Behavioral Neuroscience, 114, 923-933.

Yoo, M.-J., Searles, R. V., He, J.-R., Shen, W.-B., Grattan, D. R., & Selmanoff, M. (2000). Castration rapidly decreases hypothalamic γ-aminobutyric acidergic neuronal activity in both male and female rats. Brain Research, 878, 1-10.

Conference Contribution - Published proceedings: Abstract

Todd, B., Davis, G., & Grattan, D. R. (2000). Pulsatile luteinising hormone secretion is impaired in the ovariectomised estrogen-treated obese Zucker rat. Proceedings of the University of Otago Medical School. 78, (pp. 29P). [Abstract]

Grattan, D. R., Xu, J., McLachlan, M. J., Kokay, I. C., Bunn, S. J., & Davey, H. W. (2000). Impaired feedback regulation of prolactin secretion in stat5b-deficient mice. Proceedings of the 11th International Congress of Endocrinology. (pp. 1429). [Abstract]

Todd, B., & Grattan, D. R. (2000). Picrotoxin does not affect the suppression of luteinizing hormone secretion by the suckling stimulus during lactation. Proceedings of the British Neuroendocrine Group. (pp. 43). [Abstract]

Todd, B. J., Ladyman, S. R., Davis, G., & Grattan, D. R. (2000). Characterisation of luteinising hormone secretion in the female obese Zucker rat. Proceedings of the University of Otago Medical School. 78, (pp. 29). [Abstract]

Todd, B., & Grattan, D. R. (2000). Pulsatile luteinising hormone secretation is impaired in the ovariectomised, estrogen-treated obese Zucker rat. Trabajos del Instituto Cajal. (pp. 410-412). [Abstract]

Grattan, D. R. (2000). Prolactin receptors in the brain during pregnancy and lactation: implications for behaviour. Trabajos del Instituto Cajal. (pp. 12-14). [Abstract]

1999

Journal - Research Article

Davey, H. W., Park, S. H., Grattan, D. R., McLachlan, M. J., & Waxman, D. J. (1999). STAT5b deficient mice are growth hormone (GH) pulse-resistant: Role of STAT5b in sex-specific liver P450 expression. Journal of Biological Chemistry, 274, 35331-35336.

Pi, X.-J., & Grattan, D. R. (1999). Expression of prolactin receptor mRNA is increased in the preoptic area of lactating rats. Endocrine, 11(1), 91-98.

Pi, X.-J., & Grattan, D. R. (1999). Increased prolactin receptor immunoreactivity in the hypothalamus of lactating rats. Journal of Neuroendocrinology, 11, 693-705.

Pi, X.-J., & Grattan, D. R. (1999). Increased expression of both short and long forms of prolactin receptor mRNA in hypothalamic nuclei of lactating rats. Journal of Molecular Endocrinology, 23, 13-22.

Davey, H. W., Park, S.-H., Grattan, D. R., McLachlan, M. J., & Waxman, D. (1999). STAT5b-deficient mice are growth hormone pulse-resistant: Role of STAT5b in sex-specific liver P450 expression. Journal of Biological Chemistry, 274(50), 35331-35336.

Conference Contribution - Published proceedings: Abstract

Andrews, Z. B., & Grattan, D. R. (1999). Dissociation of prolactin secretion from tuberoinfundibular dopamine activity at the end of pregnancy in rats. Endocrine Society of Australia. 42, (pp. 241). [Abstract]

Grattan, D. R., & Porteous, R. (1999). Expression of prolactin receptors in tuberoinfundibular dopaminergic neurons in the arcuate nucleus of the estrogen-treated ovaraectomized rat. Endocrine Society of Australia. 42, (pp. 251). [Abstract]

Todd, B., & Grattan, D. R. (1999). GABAergic neuronal activity in microdissected brain regions from the lactating rat. Endocrine Society of Australia Conference Abstracts. 42, (pp. 239). [Abstract]

Anderson, S. T., Grattan, D. R., & Curlewis, J. D. (1999). Distribution of prolactin-releasing peptide (PrRP) mRNA in the rat hypothalamus and medulla oblongata. Society for Neuroscience Abstracts. 25(478.1). [Abstract]

Franks, S. J., Oorschot, D. E., & Grattan, D. R. (1999). Changes in the number of axo-spinous synapses in the ventromedial hypothalmic nucleus during the estrous cycle of the rat. Proceedings of the Physiological Society of New Zealand. 18. Wellington. [Abstract]

Todd, B. J., Grattan, D. R., Kokay, I. C., & Cook, C. J. (1999). Use of microdialysis to monitor extracellular GABA in the preoptic region of the conscious, lactating rat. International Journal of Neuroscience, 97, (pp. 248). Overseas Publishers Association. [Abstract]

Grattan, D. R., Smith, A., & Kokay, I. C. (1999). Effect of neonatal manipulations of gonadal steroids on GABAergic neuronal activity in the adult rat hypothalamus. International Journal of Neuroscience. 97, (pp. 247). Overseas Publishers Association. [Abstract]

Ghose, K., Rambhai, S., Kokay, I. C., & Grattan, D. R. (1999). The menstrual cycle and platelet GABA levels. The 9th International Headache Society Congress. Abstract I. Barcelona: Support Servis, SA. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Davey, H. W., Park, S. H., Grattan, D. R., McLachlan, M. J., & Waxman, D. J. (1999). STAT5b deficient mice are growth hormone (GH) pulse-resistant: Role of STAT5b in sex-specific liver P450 expression. Verbal presentation at the Queenstown Molecular Biology Meeting

Davey, H. W., Park, S. H., Grattan, D. R., McLachlan, M. J., & Waxman, D. J. (1999). STAT5b deficient mice are growth hormone (GH) pulse-resistant: Role of STAT5b in sex-specific liver P450 expression. Verbal presentation at the Cytochrome P450 Meeting

Grattan, D. R., & Andrews, Z. (1999). Dissociation of prolactin secretion from tuberoinfundibular dopamine activity during late pregnancy in rats. Verbal presentation at the British Neuroendocrine Group

Grattan, D. R., & Porteous, R. (1999). Co-localization of prolactin-receptor immunoreactivity with tyrosine hydroxylase but not a-endorphin in the arcuate nucleus of the lactating rat. Verbal presentation at the International Symposium on Neuroendocrine Adaptation During Pregnancy

1998

Journal - Research Article

Pi, X.-J., & Grattan, D. R. (1998). Differential expression of the two forms of prolactin receptor mRNAwithin microdissected hypothalamic nuclei of the rat. Molecular Brain Research, 59, 1-12.

Pi, X.-J., & Grattan, D. R. (1998). Distribution of prolactin receptor immunoreactivity in the brain of estrogen-treated, ovariectomised rats. Journal of Comparative Neurology, 394, 462-474.

Conference Contribution - Published proceedings: Abstract

Grattan, D. R., Kokay, I. C., & Graham, N. H. (1998). Progesterone stimulates GABA neurons in the preoptic region of the estrogen-treated ovariectomized rat. Proceedings of the Society for Neuroscience. 24, (pp. 244.12). [Abstract]

Mi-Jeong, Y., Searles, R. V., He, J.-R., Grattan, D. R., & Selmanoff, M. (1998). Castration rapidly decreases hypothalamic GABA turnover in both male and female rats. Proceedings of the Society for Neuroscience. 24, (pp. 545.5). [Abstract]

Pi, X.-J., & Grattan, D. R. (1998). Increased expression of prolactin receptor mRNA in the rat mediobasal hypothalamus during lactation. Proceedings of the Society for Neuroscience. 24, (pp. 53.5). [Abstract]

Pi, X.-J., & Grattan, D. R. (1998). Differential expression of the two forms of prolactin receptor mRNA within microdissected hypothalamic nuclei of the rat. International Journal of Neuroscience. 97, (pp. 248). [Abstract]

Todd, B. J., Kokay, I. C., Cook, C. J., & Grattan, D. R. (1998). Use of microdialysis to monitor extracellular GABA in the preoptic region of the conscious, lactating rat. International Journal of Neuroscience, 97, (pp. 248). [Abstract]

Grattan, D. R., Kokay, I. C., & Graham, N. H. (1998). Progesterone stimulates GABA neurons in the preoptic region of the estrogen-treated ovariectomized rat. Society for Neuroscience Abstracts. 24, (pp. 620). Washington D.C.: Society for Neuroscience. [Abstract]

Ghose, K., Grattan, D. R., Kokay, I. C., & Berry, D. (1998). Effect of vigabatrin on platelet GABA levels. XII International Migraine Trust Symposium. London: The Clarksworth Group, Huddersfield, UK. [Abstract]

1997

Journal - Research Article

Kornblatt, J. J., & Grattan, D. R. (1997). Effect of lactation on activity on GABAergic neurons in the rat hypothalamus. Proceedings of the Society for Neuroscience, 23, 798.10.

Grattan, D. R., & Selmanoff, M. (1997). Sex differences in the activity of y-aminobutyric acidergic neurons in the rat hypothalamus. Brain Research, 775, 244-249.

Luine, V. N., Grattan, D. R., & Selmanoff, M. (1997). Gonadal hormones alter hypothalamic GABA and glutamate levels. Brain Research, 747(1), 165-168.

Conference Contribution - Published proceedings: Abstract

Pi, X. J., & Grattan, D. R. (1997). Distribution of prolactin receptor immunoreactivity in the brain of the estrogen-treated, ovariectomized rat. Proceedings of the Otago Medical School Research Society. 75(1), (pp. 22). [Abstract]

Grattan, D. R., & Graham, N. A. (1997). Progesterone stimulation of hypothalamic GABAergic neuronal activity in the estrogen-treated ovariectomized rat. International Journal of Neuroscience. 94, (pp. 95). [Abstract]

1996

Journal - Research Article

Davis, A. M., Grattan, D. R., Selmanoff, M., & McCarthy, M. M. (1996). Sex differences in glutamic acid decarboxylase mRNA in neonatal rat brain: implications for sexual differentiation. Hormones & Behavior, 30(4), 538-552.

Sagrillo, C. A., McCarthy, M. M., Selmanoff, M., & Grattan, D. R. (1996). Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors. Behavior Genetics, 26, 241-277.

Grattan, D. R., Rocca, M. S., Strauss, K. I., Sagrillo, C. A., & Selmanoff, M. (1996). GABAergic neuronal activity and mRNA levels for both forms of glutamic acid decarboxylase (GAD65 and GAD67) are reduced in the diagonal band of Broca during the afternoon of proestrus. Brain Research, 733, 46-55.

Grattan, D. R., Rocca, M. S., Sagrillo, C. A., McCarthy, M. M., & Selmanoff, M. (1996). Antiandrogen microimplants into the rostral medial preoptic area decrease g-amniobutyric acidergic neuronal activity and increase luteinizing hormone secretion in the intact male rat. Endocrinology, 137, 4167-4173.