Rosie Brown Laboratory, Research, Centre for Neuroendocrinology

Principal Investigator

Dr Rosie Brown

Email rosemary.brown@otago.ac.nz
Tel +64 3 479 8207
Fax 64 3 479 7323
Department of Physiology website

Research interests

I am interested in how the changing hormones of pregnancy and lactation act on neural circuitry in the maternal brain to influence behaviour. In particular, I focus on maternal behaviour, a complex set of behaviours displayed by a mother that promote the survival and wellbeing of her offspring. Our work aims to understand how hormones normally act to direct a mother's behaviour and how these processes may become disrupted.
At the Centre for Neuroendocrinology, I use transgenic mouse models to address the impact of specific neuroendocrine disruptions on maternal behaviour using behavioural assays. We investigate hormonal actions on neural circuitry underlying parental behaviour using a range of molecular, immunohistochemical and imaging approaches.
I am also interested in how changes in the ability of hormones to access the brain in different physiological or pathological states might underlie changes in hormone function.

Clinical conditions

Postpartum depression
Postpartum anxiety
Maternal obesity

Rosie Brown Laboratory staff & students

Isaiah Cheong, Assistant Research Fellow
Neuroendocrine regulation of maternal behaviour
Email isaiah.cheong@otago.ac.nz

Jenny Clarkson, Research Fellow
Neural circuits required for maternal adaptation to pregnancy
Email jenny.clarkson@otago.ac.nz

Jamie McQuillan, Postdoctoral Fellow
Email jamie.mcquillan@otago.ac.nz

Michael Perkinson, Postdoctoral Fellow
Email michael.perkinson@otago.ac.nz

Logan Wragg, MSc student
Email wralo858@student.otago.ac.nz

Nikkita Murray, Honours student
Email murni023@student.otago.ac.nz

Visit Our people for an alphabetical list of all Centre for Neuroendocrinology staff.

Research Funders

Publications

Pal, T., McQuillan, H. J., Wragg, L., & Brown, R. S. E. (2024). Hormonal actions in the medial preoptic area governing parental behaviour: Novel insights from new tools. Endocrinology. Advance online publication. doi: 10.1210/endocr/bqae152 Journal - Research Article

Menezes, F., Wasinski, F., de Souza, G. O., Nunes, A. P., Bernandes, E. S., dos Santos, S. N., … Brown, R. S. E., … Donato, J., Jr (2024). The pattern of growth hormone action in the mouse brain. Endocrinology, bqae057. Advance online publication. doi: 10.1210/endocr/bqae057 Journal - Research Article

Khant Aung, Z., Ladyman, S. R., & Brown, R. S. E. (2024). Transient loss of satiety effects of leptin in middle-aged male mice. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13386 Journal - Research Article

Perkinson, M. R., Deng, F., Li, Y., Brown, R. S. E., & Lonstein, J. S. (2023). Fiber photometric analysis of nucleus accumbens serotonin release during the display of maternal behavior in female mice. Proceedings of the Society for Neuroscience Annual Meeting. PSTR352.13/HH28. Retrieved from https://www.sfn.org/ Conference Contribution - Published proceedings: Abstract

Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.13350 Journal - Research Article

2024

Journal - Research Article

2023

Journal - Research Article

Smiley, K. O., Phillipps, H. R., Fang, C., Brown, R. S. E., & Grattan, D. R. (2023). Mating-induced prolactin surge is not required for subsequent neurogenesis in male mice. Frontiers in Behavioral Neuroscience, 17, 1227726. doi: 10.3389/fnbeh.2023.1227726

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2023). Mechanisms of lactation-induced infertility in female mice. Endocrinology, 164(5), bqad049. doi: 10.1210/endocr/bqad049

Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2023). Pups and prolactin are rewarding to virgin female and pregnant mice. Journal of Neuroendocrinology, 35, e13232. doi: 10.1111/jne.13232

Conference Contribution - Published proceedings: Abstract

Conference Contribution - Poster Presentation (not in published proceedings)

Cheong, I., Clarkson, J., & Brown, R. S. E. (2023, August). Dynamic changes in hormone receptor expressionin galanin neurons in the MPOA of pregnant and lactating female mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Pal, T., Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2023, August). Dynamics of MPOA prolactin receptor-expressing neurons in freely behaving mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Campbell, G., Brown, R., & Iremonger, K. J. (2023, August). Investigating the influence of postpartum stress on anxiety and maternal motivation in dams and on offspring anxiety outcomes. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Clarkson, J., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2023, August). Stimulating mothers: Dissecting the maternal behaviour neural circuitry using optogenetics. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Khant Aung, Z., Masih, R. R., Desroziers, E., Campbell, R. E., & Brown, R. S. E. (2022). Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome. Journal of Neuroendocrinology, 34, e13206. doi: 10.1111/jne.13206

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2022). Prolactin action is necessary for parental behavior in male mice. Journal of Neuroscience, 42(44), 8308-8327. doi: 10.1523/jneurosci.0558-22.2022

Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. PNAS, 119(6), e2116972119. doi: 10.1073/pnas.2116972119

Conference Contribution - Published proceedings: Abstract

Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2022). Prolactin-induced suppression of gonadotrophin secretion during lactation. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 240. Retrieved from https://www.esa-srb-apeg-nzse.org

Brown, R. (2022). Prolactin as a key regulator of maternal care-giving behaviour in mothers. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 224. Retrieved from https://www.esa-srb-apeg-nzse.org

Conference Contribution - Poster Presentation (not in published proceedings)

Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2022, August-September). Dissecting the neural circuitry controlling maternal behaviour. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Wragg, L. J., Cheong, I., & Brown, R. S. E. (2022, August-September). Estrogen regulation of maternal aggression: A role for VMHvl in regulating fertility? Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Brown, R. S. E. (2022, August-September). Novel roles for prolactin in fine-tuning maternal responses. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2021

Journal - Research Article

Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041

Journal - Research Other

Georgescu, T., Swart, J. M., Grattan, D. R., & Brown, R. S. E. (2021). The prolactin family of hormones as regulators of maternal mood and behavior. Frontiers in Global Women's Health, 2, 767467. doi: 10.3389/fgwh.2021.767467

Conference Contribution - Published proceedings: Abstract

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2021). A novel role for prolactin in paternal behaviour. New Zealand Medical Journal, 134(1544), (pp. 190). Retrieved from https://www.nzma.org.nz/journal

2020

Journal - Research Article

Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2020). Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology, 32, e12908. doi: 10.1111/jne.12908

Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R. (2020). Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology, 32, e12901. doi: 10.1111/jne.12901

Stagkourakis, S., Smiley, K. O., Williams, P., Kakadellis, S., Ziegler, K., Bakker, J., Brown, R. S. E., … Grattan, D. R., & Broberger, C. (2020). A neuro-hormonal circuit for paternal behavior controlled by a hypothalamic network oscillation. Cell, 182, 960-975. doi: 10.1016/j.cell.2020.07.007

Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2020). Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology, 32, e12889. doi: 10.1111/jne.12889

Journal - Research Other

Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2020). The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology, 167, 107911. doi: 10.1016/j.neuropharm.2019.107911

Conference Contribution - Published proceedings: Abstract

Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2020). Identifying a role for lactogenic hormones in maternal motivation. Journal of the Endocrine Society, 4(Suppl. 1), (pp. A1075). doi: 10.1210/jendso/bvaa046.2131

2019

Chapter in Book - Research

Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In L. M. Coolen & D. R. Grattan (Eds.), Neuroendocrine regulation of behavior: Current topics in behavioral neurosciences (Vol. 43). (pp. 161-210). Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122

Journal - Research Article

Brown, R. S. E., Khant Aung, Z., Phillipps, H. R., Barad, Z., Lein, H.-J., Boehm, U., Szawka, R. E., & Grattan, D. R. (2019). Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus. Endocrinology, 160(5), 1323-1332. doi: 10.1210/en.2019-00038

Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology, 160(4), 880-890. doi: 10.1210/en.2018-01065

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Kokay, I. C., Stanton, J.-A., & Grattan, D. R. (2019). Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal, 33, 6115-6128. doi: 10.1096/fj.201802262R

Conference Contribution - Published proceedings: Abstract

Barad, Z., Grattan, D., & Brown, R. (2019). Prolactin acts on glutamatergic neurons in the ventromedial nucleus of the hypothalamus to modulate maternal aggression. Journal of the Endocrine Society, 3(Suppl. 1), OR06-3. doi: 10.1210/js.2019-OR06-3

Conference Contribution - Poster Presentation (not in published proceedings)

Khant Aung, Z., Jacobs, I., Grattan, D. R., Brown, R. S. E., & Ladyman, S. R. (2019, August-September). Peripartum prolactin and growth hormone concentrations in diet-induced obese mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Identifying a novel role for prolactin in the transition to paternal care. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Hackwell, E. C. R., Brown, R. S. E., Ladyman, S. R., & Grattan, D. R. (2019, August-September). Prolactin action on kisspeptin neurons is required for maintaining lactational infertility. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2019, September). The effect of reproductive experience on maternal motivation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Investigating the acute effects of prolactin upon hypothalamic prolactin-receptor expressing neurons. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Conference Contribution - Published proceedings: Abstract

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Social Neuroscience 9th Annual Meeting. (pp. 33). Retrieved from https://www.s4sn.org

Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Neuroscience 48th Annual Meeting. 108.08. SfN. Retrieved from https://www.sfn.org

Phillipps, H. R., Rand, C., Brown, R. S. E., Stanton, J.-A., & Grattan, D. (2018). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 125). Retrieved from http://www.icn2018.org/

Gustafson, P., Ladyman, S. R., Grattan, D., & Brown, R. S. E. (2018). Changing dynamics of prolactin and leptin transport into the brain during pregnancy and with aging. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 124). Retrieved from http://www.icn2018.org/

Brown, R. S. E. (2018). Prolactin signaling in the medial preoptic area is critical for maternal behavior. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 64). Retrieved from http://www.icn2018.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, November). Central prolactin action is required for maintaining lactational diestrus in mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Stanton, J.-A., & Grattan, D. R. (2018, November). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, November). Are impairments in prolactin signalling in the brain of obese mice associated with deficits in maternal care? Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Barad, Z., Grattan, D. R., & Brown, R. S. E. (2018, November). Fine-tuning the maternal brain: How hormones modulate a mother's behaviour. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.

Brown, R. S. E. (2018, August). The modulation of maternal behaviour by prolactin. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Tawngdee, Y., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2018, August). The role of prolactin in reward aspects of maternal behaviour. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, August). Are impairments in prolactin signaling in the brain of obese mice associated with deficits in maternal care? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, August). Central prolactin action is required for maintaining lactational diestrus in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Journal - Research Article

Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114

Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474

Conference Contribution - Poster Presentation (not in published proceedings)

Brown, R. S., Barad, Z., & Grattan, D. R. (2017, September). Changes in prolactin responsiveness of glutamate and nNos neurons in the female mouse brain during lactation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016

Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519

Conference Contribution - Published proceedings: Abstract

Brown, R. (2016). Population-specific deletion of hypothalamic prolactin receptors identifies a critical role for maternal behaviour. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Gustafson, P. E., Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2016). Conditional deletion of prolactin receptor gene reveals remarkable redundancy in feedback regulation of tuberoinfundibular dopamine neurons by prolactin. Endocrine Reviews, 37(2, Suppl.), FRI-504. Retrieved from http://press.endocrine.org/series/endo-meetings

Conference Contribution - Poster Presentation (not in published proceedings)

Lien, R., Brown, R. S. E., Kokay, I. C., & Grattan, D. R. (2016, August). Role of kisspeptin in the prolactin-induced suppression of the pulsatile secretion of luteinizing hormone. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., … Grattan, D. R. (2016, August). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

2015

Journal - Research Article

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2015). Effects of prolactin and lactation on A15 dopamine neurons in the rostral preoptic area of female mice. Journal of Neuroendocrinology, 27(9), 708-717. doi: 10.1111/jne.12297

Conference Contribution - Verbal presentation and other Conference outputs

Phillipps, H. R., Brown, R. S. E., Rand, C., Stanton, J.-A., & Grattan, D. R. (2015, August). Prolactin influence on the mouse choroid plexus transcriptome. Verbal presentation at the 7th Annual New Zealand Next Generation Sequencing (NGS) Conference, Palmerston North, New Zealand.

2014

Journal - Research Article

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. Journal of Neuroendocrinology, 26(12), 898-908. doi: 10.1111/jne.12223

Liu, X., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. Endocrinology, 155(1), 193-203. doi: 10.1210/en.2013-1621

Conference Contribution - Published proceedings: Abstract

Grattan, D. R., Kokay, I. C., Brown, R. S. E., Larsen, C. M., Wyatt, A., & Le Tissier, P. R. (2014). Conditional deletion of the prolactin receptor to identify brain-specific actions of prolactin. Endocrine Reviews, 35(3, Suppl.), OR35-4. Retrieved from http://press.endocrine.org/series/endo-meetings

Brown, R. S. E., Larsen, C. M., Cashen, S., Wyatt, A., Kokay, I. C., Knowles, P., … Grattan, D. R. (2014). Prolactin-sensitive GABAergic neurons contribute to the normal postpartum expression of maternal behaviour. Proceedings of the 8th International Congress of Neuroendocrinology (ICN) including the 18th Annual Meeting of the Society for Behavioural Neuroendocrinology. 277. Retrieved from http://icn-2014.p.asnevents.com.au

2013

Conference Contribution - Published proceedings: Abstract

Brown, R. S. E., Banks, W. A., Binart, N., & Grattan, D. R. (2013). Saturable transport of prolactin across the blood-brain barrier is independent of the prolactin receptor. Endocrine Reviews, 34(3, Suppl.), MON-135. Retrieved from http://press.endocrine.org/series/endo-meetings

Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013). Prolactin transport into the brain does not require the prolactin receptor. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 79). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Conference Contribution - Verbal presentation and other Conference outputs

Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013, August). Prolactin transport into the brain does not require the prolactin receptor. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2012

Journal - Research Article

Brown, R. S. E., Piet, R., Herbison, A. E., & Grattan, D. R. (2012). Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons. Endocrinology, 153(5), 2375-2384. doi: 10.1210/en.2011-2005

Conference Contribution - Published proceedings: Abstract

Brown, R. S., Herbison, A. E., & Grattan, D. R. (2012). The suppression of kisspeptin in the RP3V during lactation in mice. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://am2012.sfn.org/am2012/

2011

Journal - Research Article

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2011). Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse. Biology of Reproduction, 84(4), 826-836. doi: 10.1095/biolreprod.110.089185

2010

Journal - Research Article

Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208

Conference Contribution - Verbal presentation and other Conference outputs

Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2010, November-December). Regulation of kisspeptin neurons by prolactin. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Brown, R. (2010, November-December). Kisspeptin regulation of prolactin secretion. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Awarded Doctoral Degree

Brown, R. (2010). The mechanism of hyperprolactinaemia-induced infertility (PhD). University of Otago, Dunedin, New Zealand. 207p.

2009

Conference Contribution - Published proceedings: Abstract

Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2009). Mechanism of hyperprolactinaemia-induced infertility. New Zealand Medical Journal, 122(1299). Retrieved from http://journal.nzma.org.nz/journal/122-1299/3706/content.pdf

2008

Conference Contribution - Published proceedings: Abstract

Geddes, R. S. E., Herbison, A. E., & Grattan, D. R. (2008). Mechanisms of prolactin induced inhibition of gonadotropin-releasing hormone (GnRH) neurons. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Kokay, I. C., Geddes, R. S. E., & Grattan, D. R. (2008). Characterisation of prolactin-sensitive neurons in regions of the preoptic area and rostral hypothalamus involved in the control of fertility in the rat. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

2006

Conference Contribution - Published proceedings: Abstract

Geddes, R. S. E., Phipps, S. J., Grattan, D. R., & Anderson, G. M. (2006). Leptin treatment does not activate STAT3 in GnRH neurons: Evidence for indirect regulation. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

Geddes, R., Grattan, D., & Anderson, G. (2006). Leptin does not act directly on gonadotrophin releasing hormone neurons to regulate fertility in rats. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf