Integrative analysis to elucidate diffuse gastric cancer progression

Patients with a genetic predisposition for hereditary diffuse-type gastric cancer (HDGC) are often advised to undergo a prophylactic gastrectomy in early adulthood, despite the lifelong consequences of this surgery. Examination of these resected stomachs frequently reveals multiple early-stage DGCs, providing a valuable model for studying the disease's progression. Emerging data suggest that 60-70% of these patients may not progress to life-threatening, metastatic DGC. This presentation will discuss the endoscopic, histologic and molecular features observed in early DGC and highlight AI-based algorithms we have developed to analyze histologic slides, identifying distinct cellular clusters within HDGC lesions. Our research aims to improve patient outcomes by determining which HDGC patients could safely opt for endoscopic surveillance rather than surgery.

Zoom link: https://otago.zoom.us/j/97756704741?pwd=dHJNSW00dkFSdTk2VW1oSVlqOEJsUT09
Meeting ID: 977 5670 4741
Password: bioc