After a difficult 2020, researchers from the HeartOtago group have started the year on a high with several high-quality publications being accepted.
Associate Professor Rajesh Katare has had 3 publications accepted, two of which were authored by PhD students from the Department of Physiology, with both being published in a leading diabetes journal, Diabetilogia (IF: 7.3). The first of these was investigating the role of microRNAs in the survival and renewal of cardiac progenitor cells, and how this may differ in patients with diabetes. The other investigated the role of the non-neuronal cholinergic system and how its activation can help to prevent some of the complications associated with diabetic disease. Both projects involved researches from the HeartOtago group and used tissue collected via HeartOtago to strengthen their findings.
Dr Michelle Munro also published her research into understanding the link between RyR2 clustering and the development of atrial fibrillation into Frontiers in Cell and Developmental Biology, section Molecular Medicine (IF: 5.180). This project heavily relied on the tissue collected through the HeartOtago biobank.
Dr Jeff Erickson has also published two papers. The first is in Cardiovascular Research (IF: 8.168), looking into the relationship between O-GlcNAcylation regulatory enzymes and the function and structure of diabetic hearts. The second is understanding how CaMKII and PKA regulate the localization of HDAC4 in cardiomyocytes, published in Basic Research in Cardiology (IF: 11.981). Again both projects relied on HeartOtago tissue.
Finally, in collaboration with Auckland University, HeartOtago provided tissue and researchers to work on a project understanding how elevated fructose and sorbitol levels have a negative effect on heart function in diabetic patients. This work has been published in Nutrition & Diabetes (4.357).
A huge congratulations to all those involved in these publications and for all the hard work they do.
Papers
Purvis N, Kumari S, Chandrasekera D, Bellae Papannarao J, Gandhi S, van Hout I, Coffey S, Bunton R, Sugunesegran R, Parry D, Davis P, Williams MJA, Bahn A*, Katare R*. Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells. Diabetologia (IF - 7.52), 2021, in press
Saw EL, Pearson JT, Schwenke DO, Munasinghe PE, Tsuchimochi H, Rawal S, Coffey S, Davis P, Bunton R, van Hout I, Kai Y, Williams MJA, Kakinuma Y*, Fronius M* and Katare R*. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Diabetologia (IF - 7.3), 2021, in press.
Munro ML, van Hout I, Aitken-Buck HM, Sugunesegran R, Bhagwat K, Davis PJ, Lamberts RR, Coffey S, Soeller C, Jones PP. Human atrial fibrillation is not associated with remodelling of RyR2 clusters. Frontiers in Cell and Developmental Biology, section Molecular Medicine. 2021 doi: 10.3389/fcell.2021.633704, in press (IF: 5.180)
Prakoso D, Lim SY, Erickson JR, Wallace RS, Lees JG, Tate M, Kiriazis H, Donner DG, Henstridge DC, Davey JR, Qian H, Deo M, Parry LJ, Davidoff AJ, Gregorevic P, Chatham JC, De Blasio MJ, Ritchie RH. Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart. Cardiovascular Research. 2021. Accepted and In Press.
Helmstadter KG; Ljubojevic-Holzer, S; Wood BM; Taheri KD; Erickson JR; Bossuyt J; Bers DM. CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes. Basic Res in Card. 2021. Accepted and In Press.
Daniels LJ, Annandale M, Koutsifeli P, X Li1, Bussey CT, van Hout I, Bunton RW, Davis P, Coffey S, Katare R, Lamberts RR, Delbridge LMD, Mellor KM. Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid accumulation in vitro. In press Nutrition & Diabetes 2021; 11(1):8 (IF: 4.357)