Researchers from the HeartOtago group have fostered a collaboration with a group in Norway, looking into the differences in patients with distinct forms of heart failure. This collaboration has extensively utilised the tissue collected by HeartOtago for experiments performed both here in Dunedin, New Zealand and in Oslo, Norway, to better understand structural and functional features of patients who have heart failure with a preserved ejection fraction (amount of blood pumped per beat) and patients with heart failure and a reduced ejection fraction. This work has recently been published in one of the leading cardiovascular journals, the Journal of the American College of Cardiology (IF: 20.589) highlighting how HeartOtago contributes to strengthening international collaborations and world leading cardiovascular research.
Paper
Frisk M, Le C, Hou Y, Røe AT, Manfra O, da Silva GJJ, van. Hout I, Norden ES, Lamberts RR, Dahl CP, Shen X, Sjaastad I, Lunde IG, Coffey S, Ole AC, Sejersted M, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE. Disrupted t-tubule structure and Ca2+ homeostasis are prominent features of HFrEF but not HFpEF. Journal of the American College of Cardiology, 2021;77:405–19 (IF: 20.589)