Two Hands-On students practise carrying out experiments on petunia plants.
In an exciting week of discovery and hands-on science, over 20 Year 12 and 13 students from across the country participated in the 2025 Hands-On at Otago program in the University of Otago’s Department of Biochemistry in January.
Designed to give high school students a taste of university life, Hands-On at Otago provides participants with the opportunity to engage with world-class researchers and explore the cutting-edge science shaping our understanding of life itself.
The week in Biochemistry was led by Dr Ben Peters, Dr Nicole Power, and Alex Bohles, who guided students through a series of experiments and interactive learning experiences centred around the molecular foundations of life.
Throughout the week, participants were immersed in the intricate world of DNA, proteins, and small molecules—key elements that make life possible. From investigating plant genetic modifications to exploring human health at the molecular level, students learned how biochemists use advanced techniques to unravel the mysteries of life.
Day 1: Exploring Molecular Tools and Plant Genetic Engineering
The first day of the program introduced students to the precision tools used by biochemists in their research, including pipettes that measure as accurately as five thousandths of a teaspoon. The group then got hands-on with Agrobacterium infiltrations—a technique used to introduce genetic material into plant cells. This process is used to study the molecular basis of plant development and identify key genes that drive specific plant functions.
Day 2: DNA, Proteins, and the Blueprint of Life
On day two, the students delved into the heart of biochemistry: DNA and proteins. DNA, often referred to as the blueprint of life, was explored through practical experiments where participants cut up DNA sequences. They also learned how changes in DNA can lead to different traits. The group analysed proteins found in blood samples to identify disorders such as analbuminemia and multiple myeloma. Later, they toured the department’s protein research facilities and observed protein crystals up close.
Day 3: Small Molecules and Their Big Impact
The third day focused on some of the small molecules that can have a major impact on human health. Students measured lactic acid levels in everyday foods like soy sauce and yogurt. They also joined the Genetics programme for a department-wide tour, where they met some of the many research groups in the Department. These groups study a wide range of topics—from human health, to agriculture, to climate adaptation in green-lipped mussels, and much more.
Day 4: The Ups and Downs of Scientific Discovery
The final day brought mixed results from the Agrobacterium infiltrations conducted earlier in the week. While the experiments weren’t as successful as hoped, participants embraced the learning opportunity, understanding that setbacks are an essential part of the scientific process. The group also measured their own biomarkers, tracking blood glucose, triacylglycerol, and lactic acid levels during intense exercise and after meals, gaining first-hand insight into how biochemistry is key to understanding human health.
For many participants, the week sparked a newfound interest in biochemistry and the possibility of pursuing a science career. “Biochemistry was really eye-opening for me. I learned a lot of new things!” said one enthusiastic student. Another added, “Maybe this is the course for me?!”
Two Hands-On students learn how to use pipettes.
Hands-On at Otago Biochemistry participants 2025.