Translational pharmacogenomics research from molecule to bedside
The Carney Centre for Pharmacogenomics is a collaboration between research groups based at the University of Otago, Christchurch.
Together, we span a wide range of clinical, pharmacological and genetic expertise. As a result we have a strongly collaborative, multidisciplinary approach to pharmacogenomic research.
Our research
Our current research programmes focus on several aspects of pharmacogenetics, pharmacogenomics and related topics. For example, we are studying:
- Potential genetic factors underlying serious adverse reactions, or unusual responses to drugs
- Genome-wide gene expression effects of the mood stabiliser drug sodium valproate, in a human induced pluripotent stem cell (iPSC) line
- Epigenetic effects of drugs
We use a range of methods for these projects, including DNA sequence analysis of specific pharmacogenes, application of genome-wide methods such as whole exome and whole genome sequencing, as well as RNA-sequencing, methylome analysis, and application of novel technologies such as nanopore DNA sequencing.