Munro Lab

2025

Journal - Research Other

Chan, J. A., & Munro, M. L. (2025). Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy. Journal of General Physiology, 157(1), e202413673. doi: 10.1085/jgp.202413673

2024

Journal - Research Other

Munro, M. L., & Gonano, L. A. (2024). On the mend: Atrial tubulogenesis after tachypacing-induced heart failure. Circulation Research, 135, 755-757. doi: 10.1161/CIRCRESAHA.124.325211

Conference Contribution - Poster Presentation (not in published proceedings)

Tausi, T. F., Zellhuber-McMillan, U., Mishra-Vakaoti, V., Munro, M. L., & Jones, P. P. (2024, August-September). Investigating CK2 phosphorylation and RyR2 clusters. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kinns, A. M., Grayson, T. S., Waddell, H. M. M., & Munro, M. L. (2024, August-September). Sex-specific response to targeting fibrosis in the diabetic heart. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chan, J. A., Vergara-Silva, R., Zellhuber-McMillan, U., Khaing, E. P., Ohline, S. M., Munro, M. L., & Jones, P. P. (2024, August-September). Ryanodine receptor type II ultrastructural remodelling in an Alzheimer’s disease-like mouse model. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Keaney, E. R., Bingham, K. T., de Jonge, W., Coffey, S., Munro, M. L., & Lamberts, R. R. (2024, August). Sex differences in human myocardial function. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2024, August). Dual site phosphorylation of calsequestrin II decreases store overload induced calcium release. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

Atta Manu, E., Munro, M., Ware, A., & McDonald, F. (2024, August-September). The mechanisms through which αENaC negatively modulates breast cancer proliferation and metastasis. Verbal presentation at the Queenstown Research Week (QRW) Cancer Meeting, Queenstown, New Zealand.

Cruz, H. A. E., Sibbles, E. T., Waddell, H. M. M., & Munro, M. L. (2024, August-September). The role of calsequestrin in the modulation of cardiac arrhythmias. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Keaney, E. R., Bingham, K. T., de Jonge, W., Munro, M. L., & Lamberts, R. R. (2024, August-September). Sex differences in human myocardial function. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Grayson, T. S., Kinns, A., & Munro, M. L. (2024, August-September). The impact of biological sex on cardiac fibrosis and its treatment. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Beresford, O. C., Kinns, A., Grayson, T. S., Loehr, J. A., Munro, M. L., & Cully, T. R. (2024, August-September). Localization of NOXX4 in diabetic skeletal muscle. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Atta Manu, E., Munro, M., Ware, A., & McDonald, F. (2024, August-September). The mechanisms through which αENaC negatively modulates breast cancer proliferation and metastasis. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sibbles, E., Jones, P., & Munro, M. (2024, August-September). Calsequestrin-2 glycosylation does not affect Ca²⁺ leak in a non-cardiac cell line. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2024, August-September). Dual site phophorylation of calsequestrin II decreases store overload induced calcium release. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2023

Journal - Research Article

Okolo, C. A., Khaing, E.-P., Mereacre, V., Wallace, R. S., Munro, M. L., Erickson, J. R., & Jones, P. P. (2023). Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation. Cardiovascular Diabetology, 22, 276. doi: 10.1186/s12933-023-02010-3

Parveen, S., Cheah, P. H. S., Worthington, L. P. I., Smither, R. A., Munro, M. L., Bussey, C. T., Lamberts, R. R., & Jones, P. P. (2023). Depressed HCN4 function in the type 2 diabetic sinoatrial node. Molecular & Cellular Biochemistry, 478, 1825-1833. doi: 10.1007/s11010-022-04635-6

Journal - Research Other

Waddell, H. M. M., Mereacre, V., Alvarado, F. J., & Munro, M. L. (2023). Clustering properties of the cardiac ryanodine receptor in health and heart failure. Journal of Molecular & Cellular Cardiology, 185, 38-49. doi: 10.1016/j.yjmcc.2023.10.012

Conference Contribution - Published proceedings: Abstract

Waddell, H., de Jonge, W., & Munro, M. (2023). Preparation of functional human atrial slices and multi-day tissue culture. Heart, Lung & Circulation, 32(Suppl. 3), 680. doi: 10.1016/j.hlc.2023.06.584

Keelty, G. B., de Jonge, W. M., Waddell, H. M. M., & Munro, M. L. (2023). Characterizing transverse tubules in the right atrium of arrhythmic patients. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Poster Presentation (not in published proceedings)

Tristão Cruz, A., de Jonge, W. M., Waddell, H. M. M., & Munro, M. L. (2023, August). Sex differences in the fibrotic remodelling of diabetic patients. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Baxter, K. E., de Jonge, W. M., & Munro, M. L. (2023, August). Organisation of calsequestrin-2 in a failing and diabetic heart. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kilworth, J. N. K., Munro, M. L., & McDonald, F. J. (2023, August). Investigating the functional interaction between the epithelial sodium channel and Ca²⁺ signalling in breast cancer. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Atta Manu, E., Munro, M., Ware, A., & McDonald, F. (2023, August). The mechanisms through which ENaC negatively modulates breast cancer proliferation and metastasis. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Chan, J. A., Ohline, S. M., Munro, M. L., & Jones, P. P. (2023, August). Ryanodine type II receptor clustering in Alzheimer's disease. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Sibbles, E., Jones, P., & Munro, M. (2023, August). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cruz, H. A. E., Jones, P. P., & Munro, M. L. (2023, August). Determining the functional effect of phosphorylated calsequestrin II in heart failure. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Waddell, H. M. M., de Jonge, W. M., & Munro, M. L. (2023, August). Adenoviral transduction of human CSQ2 into atrial biopsies. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Other

Sibbles, E. T., Waddell, H. M. M., Mereacre, V., Jones, P. P., & Munro, M. L. (2022). The function and regulation of calsequestrin-2: Implications in calcium-mediated arrhythmias. Biophysical Reviews, 14, 329-352. doi: 10.1007/s12551-021-00914-6

Conference Contribution - Published proceedings: Abstract

Silva, R., Ohline, S., Munro, M., & Jones, P. (2022). Role of ryanodine receptor clustering in Alzheimer's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.queenstownresearchweek.org

Conference Contribution - Poster Presentation (not in published proceedings)

Waddell, H. M. M., de Jonge, W. M., & Munro, M. L. (2022, August-September). Preparation of functional human atrial slices and multi-day tissue culture. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Iposu, K. O., Waddell, H. M. M., & Munro, M. L. (2022, August-September). Characterisation of t-tubules and dyads in human atrial myocytes. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. (2022, June). Biphasic regulation of RyR2 activity by calsequestrin-2: Implications in Ca-mediated arrhythmias. Invited presentation at the XXIV World Congress of the International Society for Heart Research (ISHR), Berlin, Germany.

Sibbles, E., Jones, P., & Munro, M. (2022, August-September). Determining the functional effect of CSQ2 glycosylation on calcium-handling and heart failure. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Cruz, E., Sibbles, E., & Munro, M. (2022, August-September). How the ratio of RyR2 and CSQ2 play a role in pro-arrhythmogenic Ca²⁺ release. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2021

Journal - Research Article

Munro, M. L., van Hout, I., Aitken-Buck, H., Sugunesegran, R., Bhagwat, K., Davis, P. J., Lamberts, R. R., Coffey, S., … Jones, P. P. (2021). Human atrial fibrillation is not associated with remodeling of ryanodine receptor clusters. Frontiers in Cell & Developmental Biology, 9, 633704. doi: 10.3389/fcell.2021.633704

2020

Journal - Research Other

Munro, M. L., & Jones, P. P. (2020). Too much of a good thing? Establishing a role of excessive RyR2 dephosphorylation in heart disease. Journal of Physiology, 598(6), 1115-1116. doi: 10.1113/jp279569

2019

Journal - Research Article

Chakraborty, A. D., Gonano, L. A., Munro, M. L., Smith, L. J., Thekkedam, C., Staudacher, V., Gamble, A. B., … Jones, P. P. (2019). Activation of RyR2 by class I kinase inhibitors. British Journal of Pharmacology, 176, 773-786. doi: 10.1111/bph.14562

Conference Contribution - Poster Presentation (not in published proceedings)

Hinton, L., Jones, P., & Munro, M. (2019, September). Role protein kinase CK2 in regulation of the cardiac Ryanodine Receptor. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., van Hout, I., Sugunesegran, R., Bhagwat, K., Davis, P. J., Bunton, R. W., Coffey, S., … Jones, P. P. (2019, September). Resolving the role of dyadic organisation in cardiac dysfunction. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2018

Journal - Research Article

Munro, M. L., Shen, X., Ward, M., Ruygrok, P. N., Crossman, D. J., & Soeller, C. (2018). Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts. Scientific Reports, 8(1), 2957. doi: 10.1038/s41598-018-21199-y

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., Jayasinghe, I. D., Crossman, D. J., Baddeley, D., Soeller, C., & Jones, P. P. (2018, August). Super resolved calcium channel organisation in the heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Okolo, C. A., McLay, J. C., McLachlan, J. J., Munro, M., Tanner, C., Chakraborty, A. D., Erickson, J. R., & Jones, P. P. (2018, August). Regulation of RyR2 by O-linked glycosylation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2017

Journal - Research Article

Crossman, D. J., Shen, X., Jüllig, M., Munro, M., Hou, Y., Middleditch, M., … Soeller, C. (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. doi: 10.1093/cvr/cvx055

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., & Soeller, C. S. (2017, September). Prenatal formation of early t-tubules in the sheep heart. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2016

Journal - Research Article

Munro, M. L., Jayasinghe, I. D., Wang, Q., Quick, A., Wang, W., Baddeley, D., … Soeller, C. (2016). Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. Journal of Cell Science, 129, 4388-4398. doi: 10.1242/jcs.196873

Munro, M. L., & Soeller, C. (2016). Early transverse tubule development begins in utero in the sheep heart. Journal of Muscle Research & Cell Motility, 37(6), 195-202. doi: 10.1007/s10974-016-9462-4

Conference Contribution - Published proceedings: Abstract

Munro, M. L., Shen, X., Ward, M., Crossman, D. J., & Soeller, C. (2016). Relationship between multi-scale cardiomyocyte organization and function in trabeculae of the failing human heart. Biophysical Journal, 110(3, Suppl. 1), (pp. 598a). doi: 10.1016/j.bpj.2015.11.3195

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., Jayasinghe, I. D., Shen, X., Wang, W., Ward, M., Baddeley, D., … Soeller, C. (2016, August). Multi-scale cardiomyocyte organisation as a determinant of cardiac function. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Awarded Doctoral Degree

Munro, M. L. (2016). Multi-scale cardiomyocyte organisation as a determinant of cardiac function (PhD). University of Auckland, Auckland, New Zealand. Retrieved from http://hdl.handle.net/2292/29358

2015

Journal - Research Article

Jayasinghe, I. D., Clowsley, A. H., Munro, M., Hou, Y., Crossman, D. J., & Soeller, C. (2015). Revealing T-tubules in striated muscle with new optical super-resolution microscopy techniques. European Journal of Translational Myology, 25(1), 15-26. doi: 10.4081/ejtm.2015.4747

Conference Contribution - Published proceedings: Abstract

Munro, M. L., Jayasinghe, I. D., Wang, W., Baddeley, D., Wehrens, X. H. T., & Soeller, C. (2015). Nanoscale changes in ryanodine receptor organization in JPH2 transgenic mice. Journal of Molecular & Cellular Cardiology, 86(Suppl.), (pp. S65). doi: 10.1016/j.yjmcc.2015.07.025

Munro, M. L., Shen, X., Ward, M., Crossman, D. J., & Soeller, C. (2015). The relationship between function and cellular organization in the failing human heart. Journal of Molecular & Cellular Cardiology, 86(Suppl.), (pp. S63). doi: 10.1016/j.yjmcc.2015.07.025

Conference Contribution - Verbal presentation and other Conference outputs

Munro, M. L., Jayasinghe, I. D., Shen, X., Wang, W., Ward, M., Baddeley, D., … Soeller, C. (2015, August-September). The role of cardiomyocyte organisation in the cardiac structure-function relationship. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2014

Journal - Research Article

Jayasinghe, I. D., Munro, M., Baddeley, D., Launikonis, B. S., & Soeller, C. (2014). Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging. Journal of the Royal Society Interface, 11(99), 20140570. doi: 10.1098/rsif.2014.0570

Wang, W., Landstrom, A. P., Wang, Q., Munro, M. L., Beavers, D., Ackerman, M. J., … Wehrens, X. H. T. (2014). Reduced junctional Na⁺/Ca²⁺-exchanger activity contributes to sarcoplasmic reticulum Ca²⁺ leak in junctophilin-2-deficient mice. American Journal of Physiology: Heart & Circulatory Physiology, 307(9), H1317-H1326. doi: 10.1152/ajpheart.00413.2014

Conference Contribution - Published proceedings: Abstract

Jayasinghe, I. D., Munro, M., Baddeley, D., Launikonis, B. S., & Soeller, C. (2014). Resolving the calcium release machinery of mammalian fast- and slow-twitch skeletal muscle. Biophysical Journal, 106(2, Suppl. 1), (pp. 123a-124a). doi: 10.1016/j.bpj.2013.11.736

Munro, M., Wang, W., Baddeley, D., Wehrens, X., & Soeller, C. (2014). Nanoscale changes in the organisation of junctional proteins in JPH2 transgenic mice. Biophysical Journal, 106(2, Suppl. 1), (pp. 448a). doi: 10.1016/j.bpj.2013.11.2537

2013

Conference Contribution - Published proceedings: Abstract

Munro, M. L., Wang, W., Baddeley, D., Beavers, D., Wehrens, X. H. T., & Soeller, C. (2013). The organisation of calcium handling and junctional proteins in JPH2 transgenic mice. Journal of Molecular & Cellular Cardiology, 65(Suppl.), (pp. S133). doi: 10.1016/j.yjmcc.2013.10.011

Munro, M., Wang, W., Baddeley, D., Wehrens, X., & Soeller, C. (2013). The organisation of T-tubules and junctional proteins in JPH2 transgenic mice. Heart, Lung & Circulation, 22(Suppl. 1), (pp. S9). doi: 10.1016/j.hlc.2013.05.019

2012

Conference Contribution - Published proceedings: Abstract

Munro, M. L., Baddeley, D., & Soeller, C. (2012). Distribution of Gα_s and co-localisation with calcium handling proteins in rat cardiomyocytes. Heart, Lung & Circulation, 21(12), (pp. 862). doi: 10.1016/j.hlc.2012.08.029