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Lab personnel

Research interests

  • Sympathetic excitation following acture myocardial infarction
    • Therapeutic effects of ghrelin in acute heart failure
    • Role of the peripheral chemoreflex in sympathetic excitation.
  • Regulation of the pulmonary vasculature
    • Endothelial control of the pulmonary vasculature
    • Sympathetic modulation
    • Pathological changes in the pathogenesis of pulmonary hypertension
    • Pulmonary vascular dysfunction in obesity

Teaching

Selected publications

Schwenke, D. O., Pearson, J. T., Umetani, K., Kangawa, K., & Shirai, M. (2007). Imaging of the pulmonary circulation in the closed-chest rat using synchrotron radiation microangiography. Journal of Applied Physiology, 102, 787-793.

Schwenke, D. O., Gray, E. A., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Campillo, I., … Shirai, M. (2011). Exogenous ghrelin improves blood flow distribution in pulmonary hypertension: Assessed using synchrotron radiation microangiography. Pflügers Archiv: European Journal of Physiology, 462(3), 397-406.  doi: 10.1007/s00424-011-0992-8

Schwenke, D. O., Pearson, J. T., Sonobe, T., Ishibashi-Ueda, H., Shimouchi, A., Kangawa, K., … Shirai, M. (2011). Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology, 110(4), 901-908.  doi: 10.1152/japplphysiol.01318.2010

Schwenke, D. O., Pearson, J. T., Shimochi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., … Cragg, P. A. (2009). Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension: Assessed using synchrotron radiation. Journal of Hypertension, 27(7), 1410-1419.  doi: 10.1097/HJH.0b013e32832af6a1

Sonobe, T., Schwenke, D. O., Pearson, J. T., Yoshimoto, M., Fujii, Y., Umetani, K., & Shirai, M. (2011). Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology, 111(1), 75-80.  doi: 10.1152/japplphysiol.00205.2011

Pearson, J. T., Schwenke, D. O., Jenkins, M. J., Edgley, A. J., Sonobe, T., Ishibashi-Ueda, H., … Shirai, M. (2010). Benefits of synchrotron microangiography for dynamic studies of smooth muscle and endothelial roles in the pathophysiology of vascular disease. AIP Conference Proceedings, 1266(1), 84-88.  doi: 10.1063/1.3478204

Schwenke, D. O., Pearson, J. T., Kangawa, K., Cragg, P. A., & Shirai, M. (2010). Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats. Acta Physiologica, 200(3), 279-287. doi: 10.1111/j.1748-1716.2010.02142.x

Shirai, M., Schwenke, D. O., Eppel, G. A., Evans, R. G., Edgley, A. J., Tsuchimochi, H., … Pearson, J. T. (2009). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical & Experimental Pharmacology & Physiology, 36(1), 107-116.  doi: 10.1111/j.1440-1681.2008.05073.x

Kishimoto, I., Tokudome, T., Schwenke, D. O., Takeshi, S., Hosoda, H., Nagaya, N., & Kangawa, K. (2009). Therapeutic potential of ghrelin in cardiac diseases. Expert Review of Endocrinology & Metabolism, 4(3), 283-289.

Schwenke, D. O., Pearson, J. T., Kangawa, K., Umetani, K., & Shirai, M. (2008). Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: Assessed using synchrotron radiation microangiography. Journal of Applied Physiology, 104(1), 88-96.

Schwenke, D. O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P. A., & Kangawa, K. (2008). Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10), 5172-5176.

Schwenke, D. O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., & Kangawa, K. (2008). Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats. Endocrinology, 149(1), 237-244.

Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry & Physiology Part A, 146(2), 180-188.

Pearson, J. T., Shirai, M., Tsuchimochi, H., Schwenke, D. O., Ishida, T., Kangawa, K., … Yagi, N. (2007). Effects of sustained length-dependent activiation on in situ cross-bridge dynamics in rat hearts. Biophysical Journal, 93, 4319-4329.

Schwenke, D. O., Pearson, J. T., Tsuchimochi, H., Kangawa, K., & Shirai, M. (2007). Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitrix oxide. Clinical & Experimental Pharmacology & Physiology, 34, 88-94.

Pearson, J. T., Shirai, M., Yokoyama, C., Tsuchimochi, H., Schwenke, D. O., Shimouchi, A., … Tanabe, T. (2007). α2-Adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice. Pflügers Archiv: European Journal of Physiology, 454, 29-39.  doi: 10.1007/s00424-006-0175-1

Schwenke, D. O., Pearson, J. T., Kangawa, K., & Shirai, M. (2006). Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats? Acta Physiologica, 186, 309-318.

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Does central nitric oxide elicit pulmonary hypertension in conscious rats? Respiratory Physiology & Neurobiology, 153, 250-260.

Schwenke, D. O., Pearson, J. T., Mori, H., & Shirai, M. (2006). Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. Journal of Pharmacological & Toxicological Methods, 53, 277-283.

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