Details
- Close date
- Thursday, 23 February 2023
- Academic background
- Sciences, Health Sciences
- Host campus
- Dunedin
- Qualifications
- Postgraduate Diploma, Honours, Master's
- Department
- Pathology (Dunedin)
- Supervisors
- Dr Cath Drummond, Dr Glen Reid
Overview
In recent years, our understanding of the processes leading to cancer drug resistance have been revolutionised by the discovery of drug tolerant persisters (DTPs).
These cells survive initial treatment, persist in the patient and eventually become permanently resistant. Our preliminary data has identified a novel, noncoding RNA function of the p53 isoform ∆133p53 in regulating DTPs.
Here we will use a range of molecular techniques to investigate how ∆133p53 mRNA allows DTPs to develop stable resistance. This research will provide insight into how drug resistance develops from DTPs, and help to prevent relapse in cancer patients.
Useful information
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