Dr Kathryn Hally, Department of Surgery and Anaesthesia, Our people, University of Otago, Wellington

PhD (VUW), BBMedSc (Hons) (VUW)

Contact details

Department of Surgery & Anaesthesia
Te Tari Hāparapara, Te Tari Whāomoomo
University of Otago, Wellington
PO Box 7343
Wellington South

Tel +64 4 918 5610
Email kathryn.hally@otago.ac.nz

Current roles

Postdoctoral Fellow, UOW
Adjunct Research Fellow, VUW
Scientist, Wellington Cardiovascular Research Group
Heart Foundation Research Fellow

Research expertise

Translational cardiovascular medicine
Innate immunology
Platelet biology
Flow cytometry

Background

I completed both my undergraduate and postgraduate studies in Biomedical Science at Victoria University of Wellington. I finished my PhD in 2018 and moved to The University of Otago, Wellington, to take up a Postdoctoral Fellow position within the Department of Surgery. My current research is focused on developing inflammation-based risk scores for predicting good myocardial repair following a myocardial infarction. I have extensive technical expertise in full-spectrum flow cytometry and utilize this skillset to interrogate circulating immune cell phenotype for biomarker discovery. If we are able to identify patients that experience bad cardiac repair post-infarction, we can begin to personalize their therapy and rehabilitation to ensure beneficial long-term cardiac health for these individuals.

I work as a part of the Wellington Cardiovascular Research Group, which is a collaborative effort between The University of Otago, Victoria University and Capital and Coast DHB. Combined, we have expertise in both basic science and in clinical practice and work together to ensure the translation of our work from the bench into the clinic.

Publications

Jones, C., La Flamme, A., Larsen, P., & Hally, K. (2024). CPHEN-017: Comprehensive phenotyping of neutrophil extracellular traps (NETs) on peripheral human neutrophils [Phenotype report]. Cytometry Part A. Advance online publication. doi: 10.1002/cyto.a.24851 Journal - Research Article

van der Woude, H., Phan, K., Kenwright, D. N., Goossens, L., Hally, K. E., Currie, M. J., … Henry, C. E. (2024). Development of a long term, ex vivo, patient-derived explant model of endometrial cancer. PLoS ONE, 19(4), e0301413. doi: 10.1371/journal.pone.0301413 Journal - Research Article

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2023). Neutrophil-enriched biomarkers and long-term prognosis in acute coronary syndrome: A systematic review and meta-analysis. Journal of Cardiovascular Translational Research. Advance online publication. doi: 10.1007/s12265-023-10425-2 Journal - Research Article

Holley, A., Yiu, J., Hally, K., & Larsen, P. (2023). Neutrophil biomarkers and long-term prognosis in acute coronary syndrome: A systematic review and meta-analysis. Heart, Lung & Circulation, 32(Suppl. 3), 678. doi: 10.1016/j.hlc.2023.06.582 Conference Contribution - Published proceedings: Abstract

Hummel, S., Hally, K., & Larsen, P. (2023). Activated platelets do not enhance Neutrophil Extracellular Trap (NET) formation. Heart, Lung & Circulation, 32(Suppl. 3), 662. doi: 10.1016/j.hlc.2023.06.563 Conference Contribution - Published proceedings: Abstract

2024

Journal - Research Article

2023

Journal - Research Article

Symonds, E. K. C., Black, B., Brown, A., Meredith, I., Currie, M. J., Hally, K. E., & Danielson, K. M. (2023). Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti-inflammatory phenotype in vitro. Journal of Extracellular Biology, 2, e104. doi: 10.1002/jex2.104

Symonds, E. K. C., Wilms, H., Finlayson, C., Hally, K. E., Black, B., Sparks, S. V., … Dennett, E. R., Danielson, K. M., & Meredith, I. (2023). Volumetric assessment of fat graft retention over implant by MRI. Australasian Journal of Plastic Surgery, 6(1), 70234. doi: 10.34239/ajops.70234

Ferrer-Font, L., Kraker, G., Hally, K. E., & Price, K. M. (2023). Ensuring full spectrum flow cytometry data quality for high-dimensional data analysis. Current Protocols, 3, e657. doi: 10.1002/cpz1.657

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2023). Increased levels of low density neutrophils (LDNs) in myocardial infarction. Acta Cardiologica, 78(1), 47-54. doi: 10.1080/00015385.2021.2015145

Conference Contribution - Published proceedings: Abstract

Blackshaw, C., Hally, K., Harding, S., Fairley, S., Larsen, P., & Holley, A. (2023). Gender differences in demographics, management, and clinical outcomes in AMI patients. Heart, Lung & Circulation, 32(Suppl. 3), 386. doi: 10.1016/j.hlc.2023.06.382

2022

Journal - Research Other

van der Woude, H., Hally, K. E., Currie, M. J., Gasser, O., & Henry, C. E. (2022). Importance of the endometrial immune environment in endometrial cancer and associated therapies. Frontiers in Oncology, 12, 975201. doi: 10.3389/fonc.2022.975201

Hally, K. E., Ferrer-Font, L., Pilkington, K. R., & Larsen, P. D. (2022). OMIP 083: A 21-marker 18-color flow cytometry panel for in-depth phenotyping of human peripheral monocytes. Cytometry Part A, 101, 374-379. doi: 10.1002/cyto.a.24545

Conference Contribution - Published proceedings: Abstract

van der Woude, H., Hally, K., Currie, M., & Henry, C. (2022). Ex vivo culture of patient-derived endometrial cancer tumour for immunological characterisation and exploration of levonorgestrel resistance. Proceedings of the New Zealand Branch of the Australian and New Zealand Society for Immunology (NZASI) Conference. (pp. 12). Retrieved from https://nzasi2022.com/programme

Conference Contribution - Verbal presentation and other Conference outputs

Symonds, E., Hally, K., Smith, R., Brown, A., Currie, M., Phillips, E., … Dennett, E., Meredith, I., & Danielson, K. (2022, August). Messengers in the microenvironment: The role of extracellular vesicles in fat graft retention for breast reconstruction. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Symonds, E., Hally, K., Brown, A., Currie, M., Dennett, E., Meredith, I., & Danielson, K. (2022, August). ADSC-EVs and macrophage polarisation in fat grafting for breast reconstruction post-mastectomy. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

van der Woude, H., Hally, K., Currie, M., & Henry, C. (2022, August). Ex vivo culture of patient-derived endometrial cancer tumour. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Hally, K. E., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2021). A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction. Scientific Reports, 11, 12705. doi: 10.1038/s41598-021-92108-z

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis, 121, 1637-1649. doi: 10.1055/s-0041-1728763

Journal - Research Other

Cognasse, F., Hally, K., Fauteux-Daniel, S., Eyraud, M.-A., Arthaud, C.-A., Fagan, J., … Larsen, P. (2021). Effects and side effects of platelet transfusion. Hamostaseologie, 41, 128-135. doi: 10.1055/a-1347-6551

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Shi, B., Harding, S., & Larsen, P. (2021). Using principal component analysis to create prognostic cytokine scores for adverse outcome in acute myocardial infarction. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S57-S58). doi: 10.1016/j.hlc.2021.05.003

2020

Journal - Research Article

Kristono, G. A., Holley, A. S., Hally, K. E., Brunton-O'Sullivan, M. M., Shi, B., Harding, S. A., & Larsen, P. D. (2020). An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction. Cytokine: X, 2, 100037. doi: 10.1016/j.cytox.2020.100037

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2020). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica, 75(6), 497-502. doi: 10.1080/00015385.2019.1611189

Journal - Research Other

Hally, K., Fauteux-Daniel, S., Hamzeh-Cognasse, H., Larsen, P., & Cognasse, F. (2020). Revisiting platelets and Toll-like receptors (TLRs): At the interface of vascular immunity and thrombosis. International Journal of Molecular Sciences, 21(17), 6150. doi: 10.3390/ijms21176150

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Harding, S., & Larsen, P. (2020). Trends in inflammatory cytokine levels over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S293). doi: 10.1016/j.hlc.2020.09.574

Brunton-O'Sullivan, M., Holley, A., Hally, K., Kristono, G., Bird, G., Harding, S., & Larsen, P. (2020). Examining the relationship between infarct size and circulating extracellular matrix biomarkers over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S257-S258). doi: 10.1016/j.hlc.2020.09.495

Yiu, J., Hally, K., Holley, A., & Larsen, P. (2020). Circulating low-density neutrophils in acute myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S242). doi: 10.1016/j.hlc.2020.09.464

2019

Journal - Research Article

Hally, K. E., Bird, G. K., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation. PLoS ONE, 14(10), e0223444. doi: 10.1371/journal.pone.0223444

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: Results of a randomized, cross-over trial. Platelets, 30(5), 599-607. doi: 10.1080/09537104.2018.1479520

Conference Contribution - Published proceedings: Abstract

Bird, G., Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2019). The role of B cells in acute myocardial infarction. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2019.05.047

Brunton-O'Sullivan, M., Holley, A., Hally, K., Harding, S., & Larsen, P. (2019). An exploratory factor analysis of circulating extracellular matrix biomarkers in acute myocardial infarction. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S14). doi: 10.1016/j.hlc.2019.05.039

Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2019). Platelet toll-like receptor expression and toll-like receptor-mediated platelet responses in healthy and acute myocardial infarction subjects. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S1-S2). doi: 10.1016/j.hlc.2019.05.007

2018

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). Platelets regulate leucocyte responses to Toll-like receptor stimulation. Clinical & Translational Immunology, 7, e1036. doi: 10.1002/cti2.1036

Journal - Research Other

Hally, K. E., Danielson, K. M., & Larsen, P. D. (2018). Looking to the future: Spotlight on emerging biomarkers for predicting cardiovascular risk. Current Epidemiology Reports, 5, 230-242. doi: 10.1007/s40471-018-0158-8

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2018). Neutrophil activation in response to Toll-like receptor stimulation is regulated by platelets. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S332). doi: 10.1016/j.hlc.2018.06.644

2017

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2017). Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thrombosis Research, 158, 8-15. doi: 10.1016/j.thromres.2017.07.031

Conference Contribution - Published proceedings: Abstract

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2017). Platelets modulate the leukocyte responses to Toll-like receptor stimulation. Proceedings of the 46th Australasian Society for Immunology (ASI) Annual Scientific Meeting. 242. Retrieved from http://www.asi2017.org/

2016

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2016). Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy. Thrombosis Research, 148, 89-95. doi: 10.1016/j.thromres.2016.10.026

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Larsen, P., & Harding, S. (2016). Platelet toll-like receptor (TLR)-9 expression increases in acute coronary syndrome (ACS) patients and following platelet activation. Heart, Lung & Circulation, 25(Suppl. 2), (pp. S56). doi: 10.1016/j.hlc.2016.06.127

2015

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Larsen, P., & Harding, S. (2015). Platelet activation by toll-like receptor (TLR)-9 agonism in acute coronary syndrome (ACS) patients on dual anti-platelet therapy. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S159). doi: 10.1016/j.hlc.2015.06.112

2014

Conference Contribution - Published proceedings: Abstract

Hally, K., Johnston, L., Holley, A., Larsen, P., & Harding, S. (2014). Platelet count and platelet function testing in acute coronary syndromes. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e26). doi: 10.1016/j.hlc.2014.04.192