Professor Julia Horsfield

Julia Horsfiled and the Zebrafish tanks Director
BSc (Hons), PhD, DipAppSci

Professor Julia Horsfield is a developmental geneticist based in the Department of Pathology at the University of Otago.

Julia leads a research group investigating the role of chromosome structure in animal development and cancer. Her specific research interest lies in cohesin proteins, which are present in all animals and important for cell division and DNA repair. As the name implies, cohesin proteins' main function is to hold replicated chromosomes together until cells divide. However, they are also involved in gene expression and this is where Julia's research focus lies, particularly in relation to Cornelia de Lange and Roberts syndromes.

Julia has worked with zebrafish as her model animal for the past 12 years. She moved from the University of Auckland to the University of Otago in 2007, introducing Otago researchers to zebrafish in the process. Her enthusiasm for the zebrafish animal model has attracted several senior researchers and their teams to zebrafish and this has ultimately led to the development of the new state-of-the-art facility.

Related Information

Publications

Leask, M., Darroch, H., Morice, E., Calhoun, C., Wilcox, P., Horsfield, J., & Merriman, T. (2024). Beyond GWAS and towards precision medicine equity for Indigenous populations. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract

Labudina, A. A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., … Antony, J., & Horsfield, J. A. (2024). Cohesin composition and dosage independently affect early development in zebrafish. Development, 202593. Advance online publication. doi: 10.1242/dev.202593 Journal - Research Article

Schenk, S., Horsfield, J. A., Dwoskin, L., & Johnson, S. L. (2024). Methamphetamine effects in zebrafish (Danio rerio) depend on behavioral endpoint, dose and test session duration. Pharmacology Biochemistry & Behavior, 240, 173777. doi: 10.1016/j.pbb.2024.173777 Journal - Research Article

Sethi, A., Darroch, H., Horsfield, J., Morris, V., & Göbl, C. (2023). Unravelling the functional impact of the p16INK4a transition into amyloid fibrils using zebrafish recombinant protein. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Sarker, A., Horsfield, J., & Rizwan, S. (2023). Cellular and transcriptional response to endogenous lipid nanoparticles in the resolution of neuroinflammation in a zebrafish model. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

2024

Journal - Research Article

Conference Contribution - Published proceedings: Abstract

2023

Journal - Research Other

Horsfield, J. A. (2023). Full circle: A brief history of cohesin and the regulation of gene expression. FEBS Journal, 290, 1670-1687. doi: 10.1111/febs.16362

Conference Contribution - Published proceedings: Abstract

Lynch, D. M., Meier, M., Labudina, A., Antony, J., & Horsfield, J. A. (2023). How STAG proteins influence cohesins role in cell fate determination. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go

Labudina, A. A., Gimenez, G., Meier, M., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2023). Using a zebrafish stem cell model to understand the molecular basis of cohesinopathies. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Morice, M., Darroch, H., Horsfield, J., Merriman, T., & Leask, M. (2023). The regulatory landscape of metabolism in Polynesian populations. Proceedings of the Society for Developmental Biology 82nd Annual Meeting. (pp. 7). Retrieved from https://www.sdbonline.org

Conference Contribution - Verbal presentation and other Conference outputs

Leask, M., Morice, M., Darroch, H., Horsfield, J., & Merriman, T. R. (2023, August). GWAS and beyond: Towards 'omics based precision medicine discovery for Māori and Pacific people. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Other Research Output

Horsfield, J. (2023, March). The circle of life: Connecting cell division with cell fate. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

2022

Edited Book - Research

Horsfield, J., & Marsman, J. (Eds.). (2022). Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). New York, NY: Springer, 379p. doi: 10.1007/978-1-0716-2140-0

Journal - Research Article

Schierding, W., Horsfield, J. A., & O'Sullivan, J. (2022). Genetic variation as a long-distance modulator of RAD21 expression in humans. Scientific Reports, 12(1), 13035. doi: 10.1038/s41598-022-15081-1

Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207. doi: 10.1096/fj.202101764R

Conference Contribution - Published proceedings: Abstract

Labudina, A. A., Gimenez, G., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2022). Using a zebrafish stem cell model to understand the molecular basis of Cornelia de Lange Syndrome. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Siemonek, A., Van Huffel, S., Gimenez, G., Weeks, R., Horsfield, J. A., Antony, J., & Dunbier, A. (2022). Unraveling the mechanisms involved in the co-regulation of breast cancer associated genes at the 6q25.1 locus. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Schenk, S., Horsfield, J., & Johnson, S. (2022). Zebrafish on "P": Behavioural effects of methamphetamine. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 95). Retrieved from https://www.queenstownresearchweek.org

Conference Contribution - Verbal presentation and other Conference outputs

Sarker, A., Horsfield, J., & Rizwan, S. (2022, November). Lipid nanoparticles reduce immune cell infiltration in a zebrafish model of brain inflammation. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Sarker, A., Horsfield, J., & Rizwan, S. (2022, November). Ednogenous lipid nanoparticles reduce immune cell infiltration in a zebrafish model of neuroinflammation. Verbal presentation at the New Zealand Controlled Release Society (NZCRS) Symposium, Auckland, New Zealand.

Sarker, A., Horsfield, J., & Rizwan, S. (2022, September). Lipid nanoparticles reduce immune cell infiltration and NF-κB activity in a zebrafish model of brain inflammation. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Labudina, A. A., Gimenez, G., Ketharnathan, S., Antony, J., & Horsfield, J. A. (2022, September). Using a zebrafish stem cell model to understand the molecular basis of Cornelia de Lange Syndrome. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Antony, J., Gimenez, G., Weth, F., & Horsfield, J. A. (2022, August). Exploring the role of cohesin mutation and Wnt signalling in acute myeloid leukaemia. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Schierding, W., Horsfield, J. A., & O'Sullivan, J. M. (2022, August). Genetic variation as a long-distance modulator of RAD21 expression in humans. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Horsfield, J., & Meier, M. (2022, June). Single cell RNA-seq analysis of cell fate choice in cohesin-deficient Zebrafish embryos. Verbal presentation at the Genetics Otago Single Cell Sequencing Mini Symposium, Dunedin, New Zealand.

Other Research Output

Horsfield, J. (2022, June). Why signalling pathways are altered by cohesin deficiency UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2021

Journal - Research Article

Leask, M., Carleton, C., Leeke, B., Newman, T., Antoun, J., Farella, M., & Horsfield, J. (2021). Riboceine rescues auranofin-induced craniofacial defects in zebrafish. Antioxidants, 10, 1964. doi: 10.3390/antiox10121964

Thomas, A. L., Marsman, J., Antony, J., Schierding, W., O'Sullivan, J. M., & Horsfield, J. A. (2021). Transcriptional regulation of RUNX1: An informatics analysis. Gene, 12(8), 1175. doi: 10.3390/genes12081175

Antony, J., Chin, C. V., & Horsfield, J. A. (2021). Cohesin mutations in cancer: Emerging therapeutic targets. International Journal of Molecular Sciences, 22(13), 6788. doi: 10.3390/ijms22136788

Schierding, W., Horsfield, J. A., & O'Sullivan, J. M. (2021). Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways. Journal of Medical Genetics, 58, 534-542. doi: 10.1136/jmedgenet-2020-107095

Journal - Research Other

Labudina, A., & Horsfield, J. A. (2021). The three-dimensional genome in zebrafish development. Briefings in Functional Genomics, 20(6), 370-377. doi: 10.1093/bfgp/elab008

Conference Contribution - Published proceedings: Abstract

Labudina, A., Antony, J., Meier, M., & Horsfield, J. (2021). Cohesin and pioneer factors act independently in zygotic genome activation in zebrafish. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 58). Retrieved from https://www.faobmb2021.org

Horsfield, J. (2021). Why signalling pathways are altered by cohesin deficiency [Jisnuson Svasit Lecture]. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 43). Retrieved from https://www.faobmb2021.org

Morice, M., Bixley, M., Cadzow, M., Major, T., Phipps-Green, A., Topless, R., Merriman, M., Merriman, T. R., Leask, M., & Horsfield, J. (2021). Replication of a Māori and Pacific-specific T2D-risk variant within JAZF1. New Zealand Medical Journal, 134(1547), (pp. 142). Retrieved from https://www.nzma.org.nz/journal

Siemonek, A., Van Huffel, S., Gimenez, G., Horsfield, J. A., Antony, J., & Dunbier, A. (2021). Unraveling the mechanisms involved in the co-regulation of breast cancer associated genes at the 6q25.1 locus. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Horsfield, J. (2021). The circle of life: Connecting cell division with cell fate [Keynote]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2020

Journal - Research Article

Ketharnathan, S., Labudina, A., & Horsfield, J. A. (2020). Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos. Frontiers in Cell & Developmental Biology, 8, 617545. doi: 10.3389/fcell.2020.617545

Chiu, J. Z. S., Hold, I., Newman, T. A. C., Horsfield, J. A., & McDowell, A. (2020). Chlorogenic acid supplementation benefits zebrafish embryos exposed to auranofin. Pharmaceutics, 12, 1199. doi: 10.3390/pharmaceutics12121199

Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405

Boocock, J., Leask, M., Okada, Y., Asian Genetic Epidemiology Network (AGEN) Consortium, Matsuo, H., Shi, Y., … Cadzow, M., Gosling, A. L., Major, T. J., Horsfield, J. A., … Merriman, T. R. (2020). Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control. Human Molecular Genetics, 29(6), 923-943. doi: 10.1093/hmg/ddaa013

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. Human Molecular Genetics, 29(4), 554-565. doi: 10.1093/hmg/ddz256

Journal - Research Other

Antony, J., Gimenez, G., Taylor, T., Khatoon, U., Day, R., Morison, I. M., & Horsfield, J. A. (2020). BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells. Journal of Molecular Cell Biology, 12(5), 397-399. doi: 10.1093/jmcb/mjz114

Conference Contribution - Published proceedings: Abstract

Kamstra, K., Horsfield, J. A., & Tups, A. (2020). The effects of leptin mutations and diet-induced obesity on glucose homeostasis in the zebrafish. New Zealand Medical Journal, 133(1527), (pp. 129). Retrieved from https://www.nzma.org.nz/journal

Marsman, J., Gimenez, G., Day, R. C., Horsfield, J. A., & Jones, G. T. (2020). A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation. New Zealand Medical Journal, 133(1518), (pp. 98). Retrieved from https://www.nzma.org.nz/journal

2019

Journal - Research Article

Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2

Leask, M., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Marsman, J., Antony, J., … Merriman, T. R., & Horsfield, J. A. (2019). Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRR. Frontiers in Genetics, 9, 733. doi: 10.3389/fgene.2018.00733

Journal - Research Other

Horsfield, J. A. (2019). Packaging development: How chromatin controls transcription in zebrafish embryogenesis. Biochemical Society Transactions, 47(2), 713-724. doi: 10.1042/bst20180617

Journal - Professional & Other Non-Research Articles

Kline, A. D., Krantz, I. D., Bando, M., Shirahige, K., Chea, S., Sakata, T., … Horsfield, J. A., … Haaland, R. E. (2019). Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th Biennial Scientific and Educational Symposium 2018 [Conference report]. American Journal of Medical Genetics Part A, 179(6), 1080-1090. doi: 10.1002/ajmg.a.61108

Conference Contribution - Published proceedings: Abstract

Lee, S., Gemmell, N., & Horsfield, J. (2019). Characterisation of zebrafish meiotic cohesin subunits and their roles in gametogenesis and fertility. Proceedings of the 16th Asian Conference on Transcription. (pp. 75). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Ketharnathan, S., Labudina, A., Lee, S., Antony, J., Morison, I., & Horsfield, J. (2019). Subfunctionalization of cohesin STAG1/2 in zebrafish development and disease. Proceedings of the 16th Asian Conference on Transcription. (pp. 73). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Chin, C. V., Antony, J., He, J., Parsons, K. M., George, A. J., Hannan, R. D., & Horsfield, J. (2019). A synthetic lethal drug screen identifies exploitable vulnerabilities in cohesin-deficient cells. Proceedings of the 16th Asian Conference on Transcription. (pp. 66-67). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Antony, J., Gimenez, G., Taylor, T., Khatoon, U., Day, R., Morison, I. M., & Horsfield, J. A. (2019). Dysregulated transcriptional response to differentiation signals in cohesin-mutant leukemia cells. Proceedings of the 16th Asian Conference on Transcription. (pp. 65). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Schierding, W., Horsfield, J., & O'Sullivan, J. (2019). Common SNPs and cohesin genes: Long distance compensatory regulation reveals gene hubs in cohesinopath. Proceedings of the 16th Asian Conference on Transcription. (pp. 56-57). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-03

Meier, M., Grant, J., Dowdle, A. E., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2019). A zebrafish model for cohesin function in early embryo development. American Journal of Medical Genetics Part A, 179(6), (pp. 1083-1084). doi: 10.1002/ajmg.a.61108

Conference Contribution - Poster Presentation (not in published proceedings)

Kamstra, K., Horsfield, J. A., & Tups, A. (2019, August-September). The effects of leptin mutations and diet-induced weight gain on glucose homeostasis in the zebrafish. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kamstra, K., Horsfield, J. A., & Tups, A. (2019, July). The effects of leptin mutations and diet-induced obesity on glucose homeostasis in the zebrafish. Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.

2018

Journal - Research Article

Ketharnathan, S., Leask, M., Boocock, J., Phipps-Green, A. J., Antony, J., O'Sullivan, J. M., Merriman, T. R., & Horsfield, J. A. (2018). A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Human Molecular Genetics, 27(22), 3964-3973. doi: 10.1093/hmg/ddy295

Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635

Kaur, G., Li, C. G., Chantry, A., Stayner, C., Horsfield, J., & Eccles, M. R. (2018). SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma. Oncotarget, 9(42), 26852-26867. doi: 10.18632/oncotarget.25516

Cukrov, D., Newman, T., Leask, M., Leeke, B., Sarogni, P., Patimo, A., … Horsfield, J., & Musio, A. (2018). Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human Molecular Genetics, 27(17), 3002-3011. doi: 10.1093/hmg/ddy203

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., & Gemmell, N. J. (2018). Identification of sex differences in zebrafish (Danio rerio) brains during early sexual differentiation and masculinisation using 17α-methyltestoterone. Biology of Reproduction, 99(2), 446-460. doi: 10.1093/biolre/iox175

Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2018). Cohesin facilitates zygotic genome activation in zebrafish. Development, 145, dev156521. doi: 10.1242/dev.156521

Schierding, W., Antony, J., Karhunen, V., Vääräsmäki, M., Franks, S., Elliott, P., … Horsfield, J. A., … Cutfield, W. S. (2018). GWAS on prolonged gestation (post-term birth): Analysis of successive Finnish birth cohorts. Journal of Medical Genetics, 55(1), 55-63. doi: 10.1136/jmedgenet-2017-104880

Conference Contribution - Published proceedings: Abstract

Carleton, C., Antoun, J., Low, A., Horsfield, J., & Farella, M. (2018). A novel model for exploring causes and treatment of craniofacial birth defects. European Journal of Orthodontics, 40(5), (pp. e51). doi: 10.1093/ejo/cjy060

Antony, J., Giminez, G., Khatoon, U., Day, R., Morison, I., & Horsfield, J. (2018). Targeted disruption of the cohesin subunit STAG2 leads to loss of insulation and inappropriate gene activation in response to differentiation signals. Blood, 132(Suppl. 1), (pp. 878). doi: 10.1182/blood-2018-99-117965

Leask, M., Merriman, T. R., Dowdle, A., Salvesen, H., Topless, R., Fadason, T., Wei, W., … Horsfield, J. (2018). Non-coding urate-associated variants function in a conserved lincrna regulatory domain that alters MAF transcription. Arthritis & Rheumatology, 70(9, Suppl.), 2238. doi: 10.1002/art.40700

Conference Contribution - Poster Presentation (not in published proceedings)

Vu, H. T. H., Hook, S. M., Horsfield, J. A., & McDowell, A. (2018, August). Comparison of the uptake of rutin-loaded nanoparticles in a zebrafish model. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Chin, C. V., Antony, J., He, J., Parsons, K. M., George, A. J., Hannan, R. D., & Horsfield, J. (2018, August). Identifying synthetic lethal vulnerabilities in cohesin-haploinsufficient MCF10A. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Antony, J., Gimenez, G., & Horsfield, J. A. (2018, August). Chromatin disruption and abnormal cell signalling in cohesin-mutant leukaemia. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

McKinlay, P., Pickery, J.-J., & Horsfield, J. (2017). The GENE-ration game. Junctures, 2017(18), 71-80.

McKinlay, P., Keller, C., & Horsfield, J. (2017). It’s written in your DNA: Or is it? Junctures, 2017(18), 81-87.

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2017). A DNA contact map for the mouse Runx1 gene identifies novel haematopoietic enhancers. Scientific Reports, 7, 13347. doi: 10.1038/s41598-017-13748-8

Lee, S. L. J., Horsfield, J. A., Black, M. A., Rutherford, K., Fisher, A., & Gemmell, N. J. (2017). Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics, 18, 557. doi: 10.1186/s12864-017-3915-z

Stayner, C., Poole, C. A., McGlashan, S. R., Pilanthananond, M., Brauning, R., Markie, D., … Slobbe, L., … Parker, K., Wiles, A., … Leichter, A., Leask, M., … Jennings, M., Horsfield, J. A., Walker, R. J., & Eccles, M. R. (2017). An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports, 7, 1601. doi: 10.1038/s41598-017-01519-4

Conference Contribution - Published proceedings: Abstract

Marsman, J., Thomas, A., Osato, M., O'Sullivan, J., & Horsfield, J. A. (2017). Identifying functional roles for novel cis-regulatory elements predicted to regulate the Runx1 gene. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 789. Retrieved from http://gen2017.w.events4you.currinda.com

Chin, A., Antony, J., & Horsfield, J. (2017). Identifying synthetic lethal drugs for cohesin mutant AML. Proceedings of the 38th Annual Lorne Genome Conference. Retrieved from http://genome-2017.m.asnevents.com.au/

Ketharnathan, S., Leask, M., Merriman, T., & Horsfield, J. (2017). Functional analysis of a gout-associated noncoding snp variant. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 706. Retrieved from http://gen2017.w.events4you.currinda.com

Dowdle, A., Gerton, J., O'Sullivan, J., & Horsfield, J. (2017). Coming of age: The role of nuclear structure in zygotic genome activation. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 540. Retrieved from http://gen2017.w.events4you.currinda.com

Merriman, T. R., Ketharnathan, S., Boocock, J., Phipps-Green, A., Antony, J., Leask, M., … Horsfield, J. (2017). A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression. Arthritis & Rheumatology, 69(Suppl. 10), 2897. doi: 10.1002/art.40321

Cucco, F., Kline, A. D., Krantz, I. D., Horsfield, J., & Musio, A. (2017). Effects of anti-oxidant treatment on genome stability and in vitro growth of Cornelia de Lange syndrome cell lines. American Journal of Medical Genetics Part A, 173A(5), (pp. 1183-1184). doi: 10.1002/ajmg.a.38161

Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., & Horsfield, J. A. (2017). Neural crest origin for cohesinopathy heart defects. American Journal of Medical Genetics Part A, 173(5), (pp. 1178). doi: 10.1002/ajmg.a.38161

Conference Contribution - Verbal presentation and other Conference outputs

Marsman, J., Phillips, V. L., Horsfield, J. A., & Jones, G. T. (2017, September). Finding a function for genetic variants associated with abdominal aortic aneurysm. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Dunbier, A. K., van Huffel, S., Day, R., & Horsfield, J. (2017, September). Epigenetic regulation of genes associated with breast cancer risk and progression. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Antony, J., Morison, I. M., & Horsfield, J. A. (2017, September). Dysregulated transcriptional response to differentiation signals in cohesin-mutant myeloid cells. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Meier, M., Grant, J., Dowdle, A. E., Thomas, A., Gerton, J., Collas, P., … Horsfield, J. A. (2017, September). Cohesin facilitates zygotic genome activation in zebrafish. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Ketharnathan, S., Leask, M., Merriman, T., & Horsfield, J. (2017, January-February). Functional analysis of gout-associated SNP variant rs1967017 upstream of PDZK1. Verbal presentation at the 18th Australia and New Zealand Zebrafish Meeting, Auckland, New Zealand.

Leask, M., Horsfield, J., & Merriman, T. (2017, January-February). A zebrafish system for the functional characterisation of genomic variants. Verbal presentation at the 18th Australia and New Zealand Zebrafish Meeting, Auckland, New Zealand.

Dowdle, A., Meier, M., O'Sullivan, J., Gerton, J., & Horsfield, J. (2017, January-February). Coming of age: The role of nuclear structure during zygotic genome activation. Verbal presentation at the 18th Australia and New Zealand Zebrafish Meeting, Auckland, New Zealand.

2016

Journal - Research Article

Newman, T., Jhinku, N., Meier, M., & Horsfield, J. (2016). Dietary intake influences adult fertility and offspring fitness in zebrafish. PLoS ONE, 11(11), e01663394. doi: 10.1371/journal.pone.0166394

Schierding, W., Antony, J., Cutfield, W. S., Horsfield, J. A., & O'Sullivan, J. M. (2016). Intergenic GWAS SNPs are key components of the spatial and regulatory network for human growth. Human Molecular Genetics, 25(15), 3372-3382. doi: 10.1093/hmg/ddw165

Chatterjee, A., Lagisz, M., Rodger, E. J., Zhen, L., Stockwell, P. A., Duncan, E. J., Horsfield, J. A., … Nakagawa, S. (2016). Sex differences in DNA methylation and expression in zebrafish brain: A test of an extended ‘male sex drive’ hypothesis. Gene, 590, 307-316. doi: 10.1016/j.gene.2016.05.042

Dasgupta, T., Antony, J., Braithwaite, A. W., & Horsfield, J. A. (2016). HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting cohesin-dependent transcription in MCF7 cancer cells. Journal of Biological Chemistry, 291(24), 12761-12770. doi: 10.1074/jbc.M115.704627

Conference Contribution - Published proceedings: Abstract

Marsman, J., Thomas, A. L., Osato, M., O'Sullivan, J. M., & Horsfield, J. A. (2016). A Runx1 interactome identifies novel hematopoietic enhancers. Blood, 128(22), 726. Retrieved from http://www.bloodjournal.org

van Huffel, S., Day, R. C., Antony, J., Marsman, J., Horsfield, J. A., & Dunbier, A. K. (2016). 4CSeq analysis of a breast cancer susceptibility locus on 6q25.1. Cancer Research, 76(14, Suppl.), 4518. doi: 10.1158/1538-7445.AM2016-4518

Hold, I., Chiu, J. Z. S., Newman, T. A. C., Horsfield, J. A., & McDowell, A. (2016). A zebrafish model demonstrates that chlorogenic acid rescues developmental abnormalities induced by oxidative stress. Proceedings of the Drug Delivery Australia Conference. (pp. 50). Retrieved from http://www.crsaustralia.org/

Carleton, C., Leeke, B., Leask, M., Farella, M., Antoun, J., & Horsfield, J. (2016). A novel model for exploring the causes and treatments of craniofacial birth defects. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026

Newman, T., Leeke, B., Carleton, C., Leask, M., Hampton, M., & Horsfield, J. (2016). How zebrafish can help understand craniofacial biology. Proceedings of the Sir John Walsh Research Institute Research Symposium. (pp. 16-17). Retrieved from http://www.otago.ac.nz/sjwri/news/otago621026

Conference Contribution - Poster Presentation (not in published proceedings)

Hold, I., Chiu, J. Z. S., Newman, T. A. C., Horsfield, J. A., & McDowell, A. (2016, July). The phytochemical chlorogenic acid rescues oxidative damage in a zebrafish model. Poster session presented at the Controlled Release Society (CRS) 43rd Annual Meeting & Exposition, Seattle, WA.

Conference Contribution - Verbal presentation and other Conference outputs

Antony, J., & Horsfield, J. A. (2016, August-September). Targeting cohesin mutant myeloid leukaemias. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Gemmell, N. J., Todd, E. V., Liu, H., Lee, S., Lamm, M. S., Rutherford, K., Horsfield, J. A., Black, M. A., & Godwin, J. R. (2016, August-September). Fishing for answers with RNA-seq. Keynote presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Newman, T. A. C., Carleton, C. R., Leeke, B., Hampton, M. B., & Horsfield, J. A. (2015). Embryonic oxidative stress results in reproductive impairment for adult zebrafish. Redox Biology, 6, 648-655. doi: 10.1016/j.redox.2015.10.010

Schuster, K., Leeke, B., Meier, M., Wang, Y., Newman, T., Burgess, S., & Horsfield, J. A. (2015). A neural crest origin for cohesinopathy heart defects. Human Molecular Genetics, 24(24), 7005-7016. doi: 10.1093/hmg/ddv402

Antony, J., Dasgupta, T., Rhodes, J. M., McEwan, M. V., Print, C. G., O'Sullivan, J. M., & Horsfield, J. A. (2015). Cohesin modulates transcription of estrogen-responsive genes. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1849(3), 257-269. doi: 10.1016/j.bbagrm.2014.12.011

Conference Contribution - Published proceedings: Abstract

Hold, I., Chiu, J. Z. S., Newman, T., Horsfield, J. A., & McDowell, A. (2015). The antioxidant activity of chlorogenic acid isolated from puha, a New Zealand native plant, in a zebrafish model. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Carleton, C., Antoun, J., Farella, M., Leeke, B., & Horsfield, J. (2015). A novel model for exploring craniofacial birth defects. Journal of Dental Research, 94(Spec Iss B), 2343906. Retrieved from http://www.iadr.org/

2014

Journal - Research Article

O'Sullivan, J. M., Doynova, M. D., Antony, J., Pichlmuller, F., & Horsfield, J. A. (2014). Insights from space: Potential role of diet in the spatial organization of chromosomes. Nutrients, 6(12), 5724-5739. doi: 10.3390/nu6125724

Leeke, B., Marsman, J., O'Sullivan, J. M., & Horsfield, J. A. (2014). Cohesin mutations in myeloid malignancies: Underlying mechanisms. Experimental Hematology & Oncology, 3, 13. doi: 10.1186/2162-3619-3-13

Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Meier, M., Antony, J., Mönnich, M., & Horsfield, J. A. (2014). Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1839(1), 50-61. doi: 10.1016/j.bbagrm.2013.11.007

Journal - Research Other

Chatterjee, A., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2014). Base-resolution DNA methylation landscape of zebrafish brain and liver [Data in brief]. Genomics Data, 2, 342-344. doi: 10.1016/j.gdata.2014.10.008

Journal - Professional & Other Non-Research Articles

Kline, A. D., Calof, A. L., Schaaf, C. A., Krantz, I. D., Jyonouchi, S., Yokomori, K., … Horsfield, J., … Dorsett, D. (2014). Cornelia de Lange syndrome: Further delineation of phenotype, cohesin biology and educational focus, 5th Biennial Scientific and Educational Symposium abstracts [Conference report]. American Journal of Medical Genetics Part A, 164(6), 1384-1393. doi: 10.1002/ajmg.a.36417

Conference Contribution - Published proceedings: Abstract

White, J., van Huffel, S., Antony, J., Horsfield, J. A., & Dunbier, A. K. (2014). Expression of genes spanning a breast cancer susceptibility locus on 6q25.1 is modulated by epigenetic modification. Cancer Research, 74(19, Suppl.), 403. doi: 10.1158/1538-7445.AM2014-403

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J. (2014, November). Transcriptional control mediated by cohesion and Ctcf in earl zebrafish development. Verbal presentation at the Genetics Otago Annual Symposium & Workshop, Dunedin, New Zealand.

Horsfield, J. (2014, September). Zebrafish: An interdisciplinary tool to model human genetic disorders. Verbal presentation at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Horsfield, J., McEwan, M., Antony, J., Meier, M., & Rhodes, J. (2014, January). A role for cohesin in pluripotency and zygotic genome activation during zebrafish embryogenesis. Verbal presentation at the 6th Asia Oceania Zebrafish Meeting, Hongkong.

2013

Journal - Research Article

Chatterjee, A., Ozaki, Y., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2013). Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-989. doi: 10.4161/epi.25797

Conference Contribution - Poster Presentation (not in published proceedings)

Newman, T. A. C., Hampton, M. B., & Horsfield, J. A. (2013, August). The developmental consequences of oxidative stress. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Meier, M., & Horsfield, J. (2013, August). Transcriptional control mediated by cohesion and CTCF in early zebrafish development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Antony, J., O'Sullivan, J. M., & Horsfield, J. A. (2013, August). Cohesin influences ERα regulation of the TFF locus in breast cancer cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J. (2013, September). Fishing for a cure: How zebrafish can help understand human disease. Verbal presentation at the Inaugural Genetics Week, Dunedin, New Zealand.

Marsman, J., O'Neill, A. C., Kao, B. R.-Y., Rhodes, J. M., Mönnich, M., & Horsfield, J. A. (2013, August). Cohesin and CTCF contact cis regulatory elements to control spatiotemporal runx1 expression during zebrafish development. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Horsfield, J., McEwan, M., Antony, J., Meier, M., & Rhodes, J. (2013, August). A role for cohesin in pluripotency and zygotic genome activation during zebrafish embryogenesis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

McEwan, M. V., Eccles, M. R., & Horsfield, J. A. (2012). Cohesin is required for activation of MYC by estradiol. PLoS ONE, 7(11), e49160. doi: 10.1371/journal.pone.0049160

Marsman, J., & Horsfield, J. A. (2012). Long distance relationships: Enhancer-promoter communication and dynamic gene transcription. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1819(11-12), 1217-1227. doi: 10.1016/j.bbagrm.2012.10.008

Horsfield, J. A., Print, C. G., & Mönnich, M. (2012). Diverse developmental disorders from The One Ring: Distinct molecular pathways underlie the cohesinopathies. Frontiers in Genetics, 3, 171. doi: 10.3389/fgene.2012.00171

Deardorff, M. A., Wilde, J. J., Albrecht, M., Dickinson, E., Tennstedt, S., Braunholz, D., Mönnich, M., … Horsfield, J. A., & Kaiser, F. J. (2012). RAD21 mutations cause a human cohesinopathy. American Journal of Human Genetics, 90(6), 1014-1027. doi: 10.1016/j.ajhg.2012.04.019

Conference Contribution - Published proceedings: Abstract

Newman, T., Hampton, M., & Horsfield, J. (2012). A developmental role for Peroxiredoxin 3. Proceedings of the Oxygen Theme Meeting. (pp. 15). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

Newman, T., Hampton, M., & Horsfield, J. (2012, September). Peroxiredoxin 3 protects zebrafish development against mitochondrial oxidative stress. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Marsman, J., O'Neill, A., Kao, B., More, H., Rhodes, J., Mönnich, M., Young, S., & Horsfield, J. (2012, September). Cohesin and CTCF cooperate to initiate haematopoietic expression of RUNXI in zebrafish. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Dasgupta, T., & Horsfield, J. (2012, September). Cohesin: A potential regulator of estrogen-mediated gene expression in breast cancer. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Marsman, J., O'Neill, A., Kao, B., More, H., Rhodes, J., Mönnich, M., Young, S., & Horsfield, J. (2012, September). Cohesin and CTCF cooperate to initiate haematopoietic expression of runx1 in zebrafish. Poster session presented at the Division of Health Sciences Research Forum: Health Matters: Research Excellence at Otago, Dunedin, New Zealand.

Pilanthananond, M., Stayner, C., Horsfield, J., & Eccles, M. (2012, August). Pathogenicity studies of a ciliopathy gene, mks3, in zebrafish embryos. Poster session presented at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

McEwan, M. V., Eccles, M., & Horsfield, J. A. (2012, August). Cohesin is required for activation of MYC by estradiol. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Rhodes, J. M., McEwan, M., & Horsfield, J. A. (2011). Gene regulation by cohesin in cancer: Is the ring an unexpected party to proliferation? Molecular Cancer Research, 9(12), 1587-1607. doi: 10.1158/1541-7786.mcr-11-0382

Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. (2011). A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE, 6(5), e20051. doi: 10.1371/journal.pone.0020051

Conference Contribution - Published proceedings: Abstract

Kaiser, F. J., Braunholz, D., Wilde, J., Albrecht, M., Clark, D., Rampuria, A., … Horsfield, J. A., & Deardorff, M. A. (2011). Mutations in RAD21 as a cause of a new cohesinopathy. Proceedings of the German Society of Human Genetics Jahrestagung [Annual Convention]. (pp. 46). GfH. Retrieved from http://www.gfhev.de/de/kongress/2011_Abstractband.pdf

Kaiser, F. J., Braunholz, D., Wilde, J., Gil-Rodriguez, C., Albrecht, M., Clark, D., … Horsfield, J. A., & Deardorff, M. A. (2011). Mutations in RAD21 as a cause of a new cohesinopathy. European Journal of Human Genetics, 19(Suppl. 2), (pp. 28). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Kaur, G., Horsfield, J., & Eccles, M. R. (2011, September). Transcriptional regulation of PAX2 in cancer cells by transforming growth factor beta (TGF-β): Direct binding of R-SMADs to the PAX2 promoter? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. (2011, May). A zebrafish model of Roberts Syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. Verbal presentation at the Cohesin Biology and the Cohesinopathies Third Informal Meeting, Barga (Lucca), Italy.

Mönnich, M., Kuriger, Z., & Horsfield, J. (2011, September). Understanding human "cohesinopathy" syndromes using zebrafish. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Rhodes, J., & Horsfield, J. (2011, September). Regulation of pluripotency genes by cohesin. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kaur, G., Horsfield, J., & Eccles, M. R. (2011, September). Transcriptional regulation of PAX2 in cancer cells by transforming growth factor beta (TGF-β): Direct binding of R-SMADs to the PAX2 promoter? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kao, B. R., Marsman, J., & Horsfield, J. A. (2011, September). A cohesin–dependent mechanism of runx1 regulation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Horsfield, J. (2011, July). Zebrafish as a tool for investigating neuronal disorders. Verbal presentation at the Brain Health Research Centre Conference, Dunedin, New Zealand.

Horsfield, J. (2011, December). Chromatin proteins that modulate oestrogen-dependent gene expression provide a new opportunity for drug targeting in breast cancer. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.

Rhodes, J., Bentley, F., & Horsfield, J. (2011, February). Regulation of gene expression by cohesin. Verbal presentation at the 12th Australia & New Zealand Zebrafish Meeting, Brisbane, Australia.

Rhodes, J., Bentley, F., & Horsfield, J. (2011, February). Direct regulation of c-Myc by cohesin. Verbal presentation at the 32nd Annual Lorne Genome Conference, Lorne, Australia.

Mönnich, M., Kuriger, Z., & Horsfield, J. (2011, February). Understanding human ″cohensinopathy″ syndromes using zebrafish. Verbal presentation at the 32nd Annual Lorne Genome Conference, Lorne, Australia.

Le Mée, G., Weeks, R., Horsfield, J., & Morison, I. (2011, February). Using zebrafish models to study the role of TES in childhood leukaemia (ALL). Verbal presentation at the 12th Australia & New Zealand Zebrafish Meeting, Brisbane, Australia.

Mönnich, M., Kuriger, Z., & Horsfield, J. (2011, February). Zebrafish as a model for human cohesinopathies. Verbal presentation at the 12th Australia & New Zealand Zebrafish Meeting, Brisbane, Australia.

2010

Journal - Research Article

Rhodes, J. M., Bentley, F. K., Print, C. G., Dorsett, D., Misulovin, Z., Dickinson, E. J., … Horsfield, J. A. (2010). Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology, 344, 637-649. doi: 10.1016/j.ydbio.2010.05.493

Conference Contribution - Published proceedings: Abstract

Rhodes, J., Bentley, F., & Horsfield, J. (2010). Direct regulation of c-Myc by cohesin. New Zealand Medical Journal, 123(1321). Retrieved from http://journal.nzma.org.nz/journal/123-1321/4329/content.pdf

Mönnich, M., Dickinson, E., Doidge, Z., Print, C., Eccles, M., Robertson, S., & Horsfield, J. (2010). Modelling human "Cohesinopathies" in zebrafish. American Journal of Medical Genetics Part A, (7), 152A, (pp. 1637). doi: 10.1002/ajmg.a.33439

Horsfield, J. (2010). Using zebrafish to understand cancer: Regulation of c-Myc by cohesin. Proceedings of the Centre for Reproduction and Genomics Second Annual Research Colloquium. (pp. 13). Retrieved from http://www.crg.org.nz/colloquium/colloquium.aspx

Conference Contribution - Poster Presentation (not in published proceedings)

Kaur, G., Horsfield, J., & Eccles, M. (2010, August-September). Regulation of paired box factor 2 (PAX2) by transforming growth factor beta (TGF-β). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kaur, G., Horsfield, J., & Eccles, M. (2010, September). The role of transforming growth factor beta (TGF- ) in regulating paired box factor 2 (PAX2)? Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J., & Rhodda, J. (2010, March-April). Zebrafish as a laboratory animal model: A short history of the Otago Zebrafish Facility. Invited presentation at the Australia and New Zealand Laboratory Animal Association: NZ Branch Conference, Dunedin, New Zealand.

Other Research Output

Horsfield, J. (2010, March). Understanding human developmental disease and cancer using Zebrafish. University of Otago Department of Pathology Seminar, Dunedin, New Zealand. [Department Seminar].

2009

Journal - Research Article

Mönnich, M., Banks, S., Eccles, M., Dickinson, E., & Horsfield, J. (2009). Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expression Patterns, 9(8), 586-594. doi: 10.1016/j.gep.2009.08.004

Conference Contribution - Published proceedings: Abstract

Moennich, M., Banks, S., & Horsfield, J. (2009). Analysis of cohesin and condensin genes during zebrafish development. Proceedings of the 6th European Zebrafish Genetics and Development Meeting. Retrieved from http://www.zebrafish2009.org/home.html

Horsfield, J. A., Anagnostou, S. H., Hu, J. K.-H., Cho, K. H. Y., Geisler, R., Lieschke, G., … Crosier, P. S. (2009). Cohesin-dependent regulation of gene expression in zebrafish. American Journal of Medical Genetics Part A, 149A(8), (pp. 1621-1622). doi: 10.1002/ajmg.a.32911

Conference Contribution - Poster Presentation (not in published proceedings)

Holman, S., Horsfield, J., & Robertson, S. (2009, September). A fishy situation: Exploring the function of WTX during development. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Moennich, M., Dickinson, E., Doidge, Z., Print, C., Eccles, M., Robertson, S., & Horsfield, J. (2009, May). Modelling human ″cohesinopathies″ in zebrafish. Verbal presentation at the Cohesin Biology and the Cohesinopathies Second Informal Meeting, Siena, Italy.

2008

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J. (2008, February). Investigating chromosome cohesin syndromes in zebrafish. Verbal presentation at the Asia Pacific Zebrafish Network Meeting, Waiheke Island, New Zealand.

Horsfield, J. (2008, August-September). Modelling human ″cohesinopathies″ in zebrafish. Invited presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Horsfield, J. A., Anagnostou, S. H., Hu, J. K.-H., Cho, K. H. Y., Geisler, R., Lieschke, G., … Crosier, P. S. (2008, June). Cohesin-dependent regulation of gene expression in zebrafish. Verbal presentation at the 3rd Scientific Cornelia de Lange Syndrome Symposium, Chicago, IL.

2007

Journal - Research Article

Horsfield, J. A., Anagnostou, S. H., Hu, J. K.-H., Cho, K. H. Y., Geisler, R., Lieschke, G., … Crosier, P. S. (2007). Cohesin-dependent regulation of Runx genes. Development, 134, 2639-2649. doi: 10.1242/dev.002485

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J. (2007, February). Cohesin-dependent regulation of gene expression. Verbal presentation at the 8th Australia and New Zealand Zebrafish Workshop, Geelong, Australia.

Horsfield, J., Print, C., Crosier, K., & Crosier, P. (2007, August-September). Divide and conquer: Linking Rad21 with cancer pathways. Verbal presentation at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

2006

Conference Contribution - Verbal presentation and other Conference outputs

Horsfield, J. (2006, August-September). Developmental roles for cohesin: A novel use for glue. Verbal presentation at the 16th Queenstown Moecular Biology Meetings, Queenstown, New Zealand.

Horsfield, J. (2006, November). Developmental roles for cohesin: A novel use for glue. Verbal presentation at the 9th Annual Australian Cell Cycle Workshop, Melbourne, Australia.

Horsfield, J. (2006, November-December). Cohesin-dependent regulation of runx genes. Verbal presentation at the Medical Sciences Congress, Rotorua, New Zealand.

2004

Journal - Research Article

Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., … Richardson, H. (2004). A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in drosophilia. Genetics, 168(1), 227-251. doi: 10.1534/genetics.104.026617

2003

Journal - Research Article

Kalev-Zylinska, M. L., Horsfield, J. A., Flores, M. V., Postlethwait, J. H., Chau, J. Y., Cattin, P. M., … Crosier, K. E. (2003). Runx3 is required for hematopoietic development in zebrafish. Developmental Dynamics, 228(3), 323-336. doi: 10.1002/dvdy.10388

2002

Journal - Research Article

Crosier, P. S., Kalev-Zylinska, M. L., Hall, C. J., Flores, M. V. C., Horsfield, J. A., & Crosier, K. E. (2002). Pathways in blood and vessel development revealed through zebrafish genetics. International Journal of Developmental Biology, 46, 493-502.

Brumby, A. M., Zraly, C. B., Horsfield, J. A., Secombe, J., Saint, R., Dingwall, A. K., & Richardson, H. (2002). Drosophila cyclin E interacts with components of the Brahma complex. EMBO Journal, 21(13), 3377-3389. doi: 10.1093/emboj/cdf334

Horsfield, J., Ramachandran, A., Reuter, K., Lavallie, E., Collins-Racie, L., Crosier, K., & Crosier, P. (2002). Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mechanisms of Development, 115, 15-26. doi: 10.1016/S0925-4773(02)00094-1

1998

Journal - Research Article

Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.

1996

Conference Contribution - Published proceedings: Abstract

Irvine, J., Horsfield, J. A., & Tate, W. P. (1996). Factors influencing +1 and -1 frameshifting on mammalian ribosomes. Proceedings of the University of Otago Medical School. 74(1), (pp. 8). Dunedin: University of Otago. [Abstract]

1995

Journal - Research Article

Tate, W. P., Poole, E. S., Horsfield, J. A., Mannering, S. A., Brown, C. M., Moffat, J. G., Dalphin, M. E., … Major, L. L., & Wilson, D. N. (1995). Translational termination efficiency in both bacteria and mammals is regulated by the base following the stop codon. Biochemistry & Cell Biology, 73, 1095-1103. doi: 10.1139/o95-118